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Updated November 2019
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Protein Info
Short Name:
AHI1
Full Name:
Jouberin
Alias:
Abelson helper integration site 1; AHI-1; FLJ20069; JBTS3; Jouberin; ORF1
Type:
Adaptor/scaffold
Mass (Da):
137115
Number AA:
1196
UniProt ID:
Q8N157
International Prot ID:
IPI00165004
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
E
S
E
A
K
V
K
T
K
V
R
F
E
E
L
Site 2
T22
R
F
E
E
L
L
K
T
H
S
D
L
M
R
E
Site 3
S24
E
E
L
L
K
T
H
S
D
L
M
R
E
K
K
Site 4
S40
L
K
K
K
L
V
R
S
E
E
N
I
S
P
D
Site 5
S45
V
R
S
E
E
N
I
S
P
D
T
I
R
S
N
Site 6
T48
E
E
N
I
S
P
D
T
I
R
S
N
L
H
Y
Site 7
Y55
T
I
R
S
N
L
H
Y
M
K
E
T
T
S
D
Site 8
S61
H
Y
M
K
E
T
T
S
D
D
P
D
T
I
R
Site 9
T66
T
T
S
D
D
P
D
T
I
R
S
N
L
P
H
Site 10
S79
P
H
I
K
E
T
T
S
D
D
V
S
A
A
N
Site 11
S83
E
T
T
S
D
D
V
S
A
A
N
T
N
N
L
Site 12
T87
D
D
V
S
A
A
N
T
N
N
L
K
K
S
T
Site 13
S93
N
T
N
N
L
K
K
S
T
R
V
T
K
N
K
Site 14
T97
L
K
K
S
T
R
V
T
K
N
K
L
R
N
T
Site 15
T104
T
K
N
K
L
R
N
T
Q
L
A
T
E
N
P
Site 16
S116
E
N
P
N
G
D
A
S
V
E
E
D
K
Q
G
Site 17
T132
P
N
K
K
V
I
K
T
V
P
Q
L
T
T
Q
Site 18
T145
T
Q
D
L
K
P
E
T
P
E
N
K
V
D
S
Site 19
T153
P
E
N
K
V
D
S
T
H
Q
K
T
H
T
K
Site 20
S170
P
G
V
D
H
Q
K
S
E
K
A
N
E
G
R
Site 21
T180
A
N
E
G
R
E
E
T
D
L
E
E
D
E
E
Site 22
Y192
D
E
E
L
M
Q
A
Y
Q
C
H
V
T
E
E
Site 23
T217
K
K
L
K
E
Q
L
T
Y
F
P
S
D
T
L
Site 24
Y218
K
L
K
E
Q
L
T
Y
F
P
S
D
T
L
F
Site 25
S221
E
Q
L
T
Y
F
P
S
D
T
L
F
H
D
D
Site 26
T223
L
T
Y
F
P
S
D
T
L
F
H
D
D
K
L
Site 27
S231
L
F
H
D
D
K
L
S
S
E
K
R
K
K
K
Site 28
S232
F
H
D
D
K
L
S
S
E
K
R
K
K
K
K
Site 29
S245
K
K
E
V
P
V
F
S
K
A
E
T
S
T
L
Site 30
S250
V
F
S
K
A
E
T
S
T
L
T
I
S
G
D
Site 31
T251
F
S
K
A
E
T
S
T
L
T
I
S
G
D
T
Site 32
T258
T
L
T
I
S
G
D
T
V
E
G
E
Q
K
K
Site 33
S267
E
G
E
Q
K
K
E
S
S
V
R
S
V
S
S
Site 34
S268
G
E
Q
K
K
E
S
S
V
R
S
V
S
S
D
Site 35
S271
K
K
E
S
S
V
R
S
V
S
S
D
S
H
Q
Site 36
S273
E
S
S
V
R
S
V
S
S
D
S
H
Q
D
D
Site 37
S274
S
S
V
R
S
V
S
S
D
S
H
Q
D
D
E
Site 38
S276
V
R
S
V
S
S
D
S
H
Q
D
D
E
I
S
Site 39
S283
S
H
Q
D
D
E
I
S
S
M
E
Q
S
T
E
Site 40
S284
H
Q
D
D
E
I
S
S
M
E
Q
S
T
E
D
Site 41
S288
E
I
S
S
M
E
Q
S
T
E
D
S
M
Q
D
Site 42
S292
M
E
Q
S
T
E
D
S
M
Q
D
D
T
K
P
Site 43
T297
E
D
S
M
Q
D
D
T
K
P
K
P
K
K
T
Site 44
T327
G
D
G
V
H
E
I
T
S
R
D
S
P
V
Y
Site 45
S331
H
E
I
T
S
R
D
S
P
V
Y
P
K
C
L
Site 46
Y334
T
S
R
D
S
P
V
Y
P
K
C
L
L
D
D
Site 47
Y348
D
D
L
V
L
G
V
Y
I
H
R
T
D
R
L
Site 48
T352
L
G
V
Y
I
H
R
T
D
R
L
K
S
D
F
Site 49
S357
H
R
T
D
R
L
K
S
D
F
M
I
S
H
P
Site 50
Y378
V
D
E
H
T
G
Q
Y
V
K
K
D
D
S
G
Site 51
S384
Q
Y
V
K
K
D
D
S
G
R
P
V
S
S
Y
Site 52
S389
D
D
S
G
R
P
V
S
S
Y
Y
E
K
E
N
Site 53
S390
D
S
G
R
P
V
S
S
Y
Y
E
K
E
N
V
Site 54
Y391
S
G
R
P
V
S
S
Y
Y
E
K
E
N
V
D
Site 55
Y399
Y
E
K
E
N
V
D
Y
I
L
P
I
M
T
Q
Site 56
Y408
L
P
I
M
T
Q
P
Y
D
F
K
Q
L
K
S
Site 57
S415
Y
D
F
K
Q
L
K
S
R
L
P
E
W
E
E
Site 58
Y432
V
F
N
E
N
F
P
Y
L
L
R
G
S
D
E
Site 59
S437
F
P
Y
L
L
R
G
S
D
E
S
P
K
V
I
Site 60
S454
F
E
I
L
D
F
L
S
V
D
E
I
K
N
N
Site 61
S492
N
G
N
A
N
I
N
S
K
L
R
L
Q
L
Y
Site 62
Y499
S
K
L
R
L
Q
L
Y
Y
P
P
T
K
P
R
Site 63
Y500
K
L
R
L
Q
L
Y
Y
P
P
T
K
P
R
S
Site 64
T503
L
Q
L
Y
Y
P
P
T
K
P
R
S
P
L
S
Site 65
S507
Y
P
P
T
K
P
R
S
P
L
S
V
V
E
A
Site 66
S510
T
K
P
R
S
P
L
S
V
V
E
A
F
E
W
Site 67
Y526
S
K
C
P
R
N
H
Y
P
S
T
L
Y
V
T
Site 68
T529
P
R
N
H
Y
P
S
T
L
Y
V
T
V
R
G
Site 69
Y531
N
H
Y
P
S
T
L
Y
V
T
V
R
G
L
K
Site 70
Y547
P
D
C
I
K
P
S
Y
R
S
M
M
A
L
Q
Site 71
S570
C
E
R
H
H
E
S
S
S
V
D
T
E
P
G
Site 72
S571
E
R
H
H
E
S
S
S
V
D
T
E
P
G
L
Site 73
T574
H
E
S
S
S
V
D
T
E
P
G
L
E
E
S
Site 74
S581
T
E
P
G
L
E
E
S
K
E
V
I
K
W
K
Site 75
S604
I
P
N
K
H
L
F
S
L
N
A
G
E
R
G
Site 76
Y639
D
G
Y
P
I
I
L
Y
E
I
P
S
G
R
F
Site 77
Y658
C
G
H
L
N
I
I
Y
D
L
S
W
S
K
D
Site 78
Y668
S
W
S
K
D
D
H
Y
I
L
T
S
S
S
D
Site 79
T671
K
D
D
H
Y
I
L
T
S
S
S
D
G
T
A
Site 80
S672
D
D
H
Y
I
L
T
S
S
S
D
G
T
A
R
Site 81
S673
D
H
Y
I
L
T
S
S
S
D
G
T
A
R
I
Site 82
S674
H
Y
I
L
T
S
S
S
D
G
T
A
R
I
W
Site 83
T677
L
T
S
S
S
D
G
T
A
R
I
W
K
N
E
Site 84
T690
N
E
I
N
N
T
N
T
F
R
V
L
P
H
P
Site 85
Y701
L
P
H
P
S
F
V
Y
T
A
K
F
H
P
A
Site 86
T702
P
H
P
S
F
V
Y
T
A
K
F
H
P
A
V
Site 87
S733
K
V
E
M
R
E
D
S
A
I
L
V
R
Q
F
Site 88
S749
V
H
K
S
F
I
N
S
L
C
F
D
T
E
G
Site 89
Y760
D
T
E
G
H
H
M
Y
S
G
D
C
T
G
V
Site 90
T796
I
N
K
E
I
K
E
T
E
F
K
G
I
P
I
Site 91
S804
E
F
K
G
I
P
I
S
Y
L
E
I
H
P
N
Site 92
Y805
F
K
G
I
P
I
S
Y
L
E
I
H
P
N
G
Site 93
T819
G
K
R
L
L
I
H
T
K
D
S
T
L
R
I
Site 94
T823
L
I
H
T
K
D
S
T
L
R
I
M
D
L
R
Site 95
S849
N
Y
R
E
K
I
H
S
T
L
T
P
C
G
T
Site 96
T850
Y
R
E
K
I
H
S
T
L
T
P
C
G
T
F
Site 97
Y868
G
S
E
D
G
I
V
Y
V
W
N
P
E
T
G
Site 98
S882
G
E
Q
V
A
M
Y
S
D
L
P
F
K
S
P
Site 99
S888
Y
S
D
L
P
F
K
S
P
I
R
D
I
S
Y
Site 100
S894
K
S
P
I
R
D
I
S
Y
H
P
F
E
N
M
Site 101
Y895
S
P
I
R
D
I
S
Y
H
P
F
E
N
M
V
Site 102
Y933
E
A
E
M
F
K
R
Y
N
G
T
F
P
L
P
Site 103
T936
M
F
K
R
Y
N
G
T
F
P
L
P
G
I
H
Site 104
S945
P
L
P
G
I
H
Q
S
Q
D
A
L
C
T
C
Site 105
T951
Q
S
Q
D
A
L
C
T
C
P
K
L
P
H
Q
Site 106
S960
P
K
L
P
H
Q
G
S
F
Q
I
D
E
F
V
Site 107
T969
Q
I
D
E
F
V
H
T
E
S
S
S
T
K
M
Site 108
S972
E
F
V
H
T
E
S
S
S
T
K
M
Q
L
V
Site 109
T985
L
V
K
Q
R
L
E
T
V
T
E
V
I
R
S
Site 110
T987
K
Q
R
L
E
T
V
T
E
V
I
R
S
C
A
Site 111
S1002
A
K
V
N
K
N
L
S
F
T
S
P
P
A
V
Site 112
S1005
N
K
N
L
S
F
T
S
P
P
A
V
S
S
Q
Site 113
S1010
F
T
S
P
P
A
V
S
S
Q
Q
S
K
L
K
Site 114
S1011
T
S
P
P
A
V
S
S
Q
Q
S
K
L
K
Q
Site 115
S1014
P
A
V
S
S
Q
Q
S
K
L
K
Q
S
N
M
Site 116
T1023
L
K
Q
S
N
M
L
T
A
Q
E
I
L
H
Q
Site 117
Y1062
T
V
V
A
L
Y
D
Y
T
A
N
R
S
D
E
Site 118
T1063
V
V
A
L
Y
D
Y
T
A
N
R
S
D
E
L
Site 119
S1067
Y
D
Y
T
A
N
R
S
D
E
L
T
I
H
R
Site 120
T1071
A
N
R
S
D
E
L
T
I
H
R
G
D
I
I
Site 121
Y1090
K
D
N
E
D
W
W
Y
G
S
I
G
K
G
Q
Site 122
Y1100
I
G
K
G
Q
E
G
Y
F
P
A
N
H
V
A
Site 123
Y1112
H
V
A
S
E
T
L
Y
Q
E
L
P
P
E
I
Site 124
S1123
P
P
E
I
K
E
R
S
P
P
L
S
P
E
E
Site 125
S1127
K
E
R
S
P
P
L
S
P
E
E
K
T
K
I
Site 126
S1137
E
K
T
K
I
E
K
S
P
A
P
Q
K
Q
S
Site 127
S1144
S
P
A
P
Q
K
Q
S
I
N
K
N
K
S
Q
Site 128
S1150
Q
S
I
N
K
N
K
S
Q
D
F
R
L
G
S
Site 129
S1157
S
Q
D
F
R
L
G
S
E
S
M
T
H
S
E
Site 130
S1159
D
F
R
L
G
S
E
S
M
T
H
S
E
M
R
Site 131
T1161
R
L
G
S
E
S
M
T
H
S
E
M
R
K
E
Site 132
S1163
G
S
E
S
M
T
H
S
E
M
R
K
E
Q
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation