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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SIX5
Full Name:
Homeobox protein SIX5
Alias:
DM locus-associated homeodomain protein;Sine oculis homeobox homolog 5
Type:
Mass (Da):
74562
Number AA:
739
UniProt ID:
Q8N196
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T38
E
A
R
Q
L
L
Q
T
L
Q
A
A
E
G
E
Site 2
S66
A
G
A
E
G
P
G
S
P
G
V
P
G
S
P
Site 3
S72
G
S
P
G
V
P
G
S
P
P
E
A
A
S
E
Site 4
S78
G
S
P
P
E
A
A
S
E
P
P
T
G
L
R
Site 5
T82
E
A
A
S
E
P
P
T
G
L
R
F
S
P
E
Site 6
S87
P
P
T
G
L
R
F
S
P
E
Q
V
A
C
V
Site 7
S123
P
A
E
R
L
R
G
S
D
P
V
L
R
A
R
Site 8
Y140
V
A
F
Q
R
G
E
Y
A
E
L
Y
R
L
L
Site 9
Y144
R
G
E
Y
A
E
L
Y
R
L
L
E
S
R
P
Site 10
Y164
H
A
F
L
Q
D
L
Y
L
R
A
R
Y
H
E
Site 11
Y169
D
L
Y
L
R
A
R
Y
H
E
A
E
R
A
R
Site 12
Y186
A
L
G
A
V
D
K
Y
R
L
R
K
K
F
P
Site 13
T197
K
K
F
P
L
P
K
T
I
W
D
G
E
E
T
Site 14
Y206
W
D
G
E
E
T
V
Y
C
F
K
E
R
S
R
Site 15
Y225
A
C
Y
R
G
N
R
Y
P
T
P
D
E
K
R
Site 16
T227
Y
R
G
N
R
Y
P
T
P
D
E
K
R
R
L
Site 17
T236
D
E
K
R
R
L
A
T
L
T
G
L
S
L
T
Site 18
T258
N
R
R
Q
R
D
R
T
G
A
G
G
G
A
P
Site 19
S268
G
G
G
A
P
C
K
S
E
S
D
G
N
P
T
Site 20
S270
G
A
P
C
K
S
E
S
D
G
N
P
T
T
E
Site 21
T276
E
S
D
G
N
P
T
T
E
D
E
S
S
R
S
Site 22
S281
P
T
T
E
D
E
S
S
R
S
P
E
D
L
E
Site 23
S283
T
E
D
E
S
S
R
S
P
E
D
L
E
R
G
Site 24
S295
E
R
G
A
A
P
V
S
A
E
A
A
A
Q
G
Site 25
S354
G
L
A
L
G
E
A
S
S
L
G
P
L
L
L
Site 26
S355
L
A
L
G
E
A
S
S
L
G
P
L
L
L
T
Site 27
S373
G
A
P
P
P
Q
P
S
P
Q
G
A
S
E
T
Site 28
S378
Q
P
S
P
Q
G
A
S
E
T
K
T
S
L
V
Site 29
T380
S
P
Q
G
A
S
E
T
K
T
S
L
V
L
D
Site 30
T382
Q
G
A
S
E
T
K
T
S
L
V
L
D
P
Q
Site 31
S383
G
A
S
E
T
K
T
S
L
V
L
D
P
Q
T
Site 32
T390
S
L
V
L
D
P
Q
T
G
E
V
R
L
E
E
Site 33
S400
V
R
L
E
E
A
Q
S
E
A
P
E
T
K
G
Site 34
T405
A
Q
S
E
A
P
E
T
K
G
A
Q
V
A
A
Site 35
T437
P
G
P
P
T
A
A
T
F
P
L
P
P
G
P
Site 36
S457
A
P
Q
V
V
P
L
S
P
P
P
G
Y
P
T
Site 37
Y462
P
L
S
P
P
P
G
Y
P
T
G
L
S
P
T
Site 38
T464
S
P
P
P
G
Y
P
T
G
L
S
P
T
S
P
Site 39
S467
P
G
Y
P
T
G
L
S
P
T
S
P
L
L
N
Site 40
S470
P
T
G
L
S
P
T
S
P
L
L
N
L
P
Q
Site 41
S594
L
K
P
E
T
A
I
S
V
P
E
G
G
L
P
Site 42
S618
A
H
A
L
G
T
L
S
A
Q
Q
P
P
P
A
Site 43
T628
Q
P
P
P
A
A
A
T
T
S
S
T
S
L
P
Site 44
T629
P
P
P
A
A
A
T
T
S
S
T
S
L
P
F
Site 45
S630
P
P
A
A
A
T
T
S
S
T
S
L
P
F
S
Site 46
S631
P
A
A
A
T
T
S
S
T
S
L
P
F
S
P
Site 47
T632
A
A
A
T
T
S
S
T
S
L
P
F
S
P
D
Site 48
S633
A
A
T
T
S
S
T
S
L
P
F
S
P
D
S
Site 49
S637
S
S
T
S
L
P
F
S
P
D
S
P
G
L
L
Site 50
S640
S
L
P
F
S
P
D
S
P
G
L
L
P
N
F
Site 51
T687
E
A
E
K
G
L
G
T
Q
A
P
H
T
V
L
Site 52
T692
L
G
T
Q
A
P
H
T
V
L
R
L
P
D
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation