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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
VPS52
Full Name:
Vacuolar protein sorting-associated protein 52 homolog
Alias:
ARE1; SAC2; SAC2 suppressor of actin mutations 2-like; SACM2L; vacuolar protein sorting 52; vacuolar protein sorting-associated 52
Type:
Mass (Da):
82220
Number AA:
UniProt ID:
Q8N1B4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005768
GO:0019898
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0015031
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T20
E
L
V
L
R
A
G
T
S
D
M
E
E
E
E
Site 2
S21
L
V
L
R
A
G
T
S
D
M
E
E
E
E
G
Site 3
T48
Q
L
G
E
L
D
I
T
S
D
E
F
I
L
D
Site 4
S49
L
G
E
L
D
I
T
S
D
E
F
I
L
D
E
Site 5
T76
L
V
K
E
A
L
K
T
G
V
D
L
R
H
Y
Site 6
Y83
T
G
V
D
L
R
H
Y
S
K
Q
V
E
L
E
Site 7
S84
G
V
D
L
R
H
Y
S
K
Q
V
E
L
E
L
Site 8
S98
L
Q
Q
I
E
Q
K
S
I
R
D
Y
I
Q
E
Site 9
Y102
E
Q
K
S
I
R
D
Y
I
Q
E
S
E
N
I
Site 10
S106
I
R
D
Y
I
Q
E
S
E
N
I
A
S
L
H
Site 11
S111
Q
E
S
E
N
I
A
S
L
H
N
Q
I
T
A
Site 12
S135
Q
M
L
G
A
F
Q
S
D
L
S
S
I
S
S
Site 13
S138
G
A
F
Q
S
D
L
S
S
I
S
S
E
I
R
Site 14
S139
A
F
Q
S
D
L
S
S
I
S
S
E
I
R
T
Site 15
S142
S
D
L
S
S
I
S
S
E
I
R
T
L
Q
E
Site 16
T146
S
I
S
S
E
I
R
T
L
Q
E
Q
S
G
A
Site 17
T191
A
I
L
E
A
P
V
T
E
P
R
F
L
E
Q
Site 18
T217
R
E
Q
E
A
R
G
T
A
A
C
A
D
V
R
Site 19
Y247
E
F
I
L
Q
K
I
Y
S
F
R
K
P
M
T
Site 20
T254
Y
S
F
R
K
P
M
T
N
Y
Q
I
P
Q
T
Site 21
Y256
F
R
K
P
M
T
N
Y
Q
I
P
Q
T
A
L
Site 22
T280
L
L
G
N
E
R
A
T
A
K
E
I
R
D
E
Site 23
Y288
A
K
E
I
R
D
E
Y
V
E
T
L
S
K
I
Site 24
T291
I
R
D
E
Y
V
E
T
L
S
K
I
Y
L
S
Site 25
S293
D
E
Y
V
E
T
L
S
K
I
Y
L
S
Y
Y
Site 26
Y296
V
E
T
L
S
K
I
Y
L
S
Y
Y
R
S
Y
Site 27
S298
T
L
S
K
I
Y
L
S
Y
Y
R
S
Y
L
G
Site 28
Y299
L
S
K
I
Y
L
S
Y
Y
R
S
Y
L
G
R
Site 29
Y300
S
K
I
Y
L
S
Y
Y
R
S
Y
L
G
R
L
Site 30
S302
I
Y
L
S
Y
Y
R
S
Y
L
G
R
L
M
K
Site 31
Y303
Y
L
S
Y
Y
R
S
Y
L
G
R
L
M
K
V
Site 32
Y312
G
R
L
M
K
V
Q
Y
E
E
V
A
E
K
D
Site 33
S334
T
A
K
K
G
F
F
S
K
P
S
L
R
S
R
Site 34
S337
K
G
F
F
S
K
P
S
L
R
S
R
N
T
I
Site 35
T343
P
S
L
R
S
R
N
T
I
F
T
L
G
T
R
Site 36
T346
R
S
R
N
T
I
F
T
L
G
T
R
G
S
V
Site 37
S352
F
T
L
G
T
R
G
S
V
I
S
P
T
E
L
Site 38
S355
G
T
R
G
S
V
I
S
P
T
E
L
E
A
P
Site 39
T368
A
P
I
L
V
P
H
T
A
Q
R
G
E
Q
R
Site 40
Y376
A
Q
R
G
E
Q
R
Y
P
F
E
A
L
F
R
Site 41
S384
P
F
E
A
L
F
R
S
Q
H
Y
A
L
L
D
Site 42
T426
M
G
R
T
L
S
M
T
L
K
H
L
D
S
Y
Site 43
Y433
T
L
K
H
L
D
S
Y
L
A
D
C
Y
D
A
Site 44
S490
I
L
E
M
N
V
Q
S
V
R
S
T
D
P
Q
Site 45
T494
N
V
Q
S
V
R
S
T
D
P
Q
R
L
G
G
Site 46
T504
Q
R
L
G
G
L
D
T
R
P
H
Y
I
T
R
Site 47
Y508
G
L
D
T
R
P
H
Y
I
T
R
R
Y
A
E
Site 48
T510
D
T
R
P
H
Y
I
T
R
R
Y
A
E
F
S
Site 49
Y513
P
H
Y
I
T
R
R
Y
A
E
F
S
S
A
L
Site 50
S517
T
R
R
Y
A
E
F
S
S
A
L
V
S
I
N
Site 51
S518
R
R
Y
A
E
F
S
S
A
L
V
S
I
N
Q
Site 52
S522
E
F
S
S
A
L
V
S
I
N
Q
T
I
P
N
Site 53
T526
A
L
V
S
I
N
Q
T
I
P
N
E
R
T
M
Site 54
S555
L
R
V
A
A
E
F
S
S
R
K
E
Q
L
V
Site 55
S583
M
E
R
A
A
D
D
S
K
E
V
E
S
F
Q
Site 56
S588
D
D
S
K
E
V
E
S
F
Q
Q
L
L
N
A
Site 57
S606
E
F
I
E
E
L
L
S
P
P
F
G
G
L
V
Site 58
T639
R
G
E
E
A
R
V
T
Q
L
I
R
G
F
G
Site 59
S647
Q
L
I
R
G
F
G
S
S
W
K
S
S
V
E
Site 60
S648
L
I
R
G
F
G
S
S
W
K
S
S
V
E
S
Site 61
S651
G
F
G
S
S
W
K
S
S
V
E
S
L
S
Q
Site 62
S652
F
G
S
S
W
K
S
S
V
E
S
L
S
Q
D
Site 63
S655
S
W
K
S
S
V
E
S
L
S
Q
D
V
M
R
Site 64
S657
K
S
S
V
E
S
L
S
Q
D
V
M
R
S
F
Site 65
S663
L
S
Q
D
V
M
R
S
F
T
N
F
R
N
G
Site 66
T665
Q
D
V
M
R
S
F
T
N
F
R
N
G
T
S
Site 67
S693
H
R
F
H
R
V
L
S
Q
P
Q
L
R
A
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation