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Updated November 2019
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Protein Info
Short Name:
REXO1
Full Name:
RNA exonuclease 1 homolog
Alias:
Elongin-A-binding protein 1;Transcription elongation factor B polypeptide 3-binding protein 1
Type:
Mass (Da):
131510
Number AA:
1221
UniProt ID:
Q8N1G1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0004527
GO:0003676
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y15
F
R
A
I
D
C
P
Y
W
S
G
A
P
G
G
Site 2
Y28
G
G
P
C
R
R
P
Y
C
H
F
R
H
R
G
Site 3
Y56
P
P
A
A
G
L
G
Y
D
P
Y
N
P
E
L
Site 4
Y59
A
G
L
G
Y
D
P
Y
N
P
E
L
P
K
P
Site 5
S100
Q
A
I
E
A
V
R
S
E
V
E
L
E
Q
R
Site 6
Y109
V
E
L
E
Q
R
R
Y
R
E
L
L
E
T
T
Site 7
T115
R
Y
R
E
L
L
E
T
T
R
E
H
R
S
A
Site 8
S135
A
P
R
G
P
N
A
S
P
T
V
G
P
D
E
Site 9
T137
R
G
P
N
A
S
P
T
V
G
P
D
E
D
A
Site 10
S155
A
F
D
Y
S
P
G
S
H
G
L
L
S
P
D
Site 11
S160
P
G
S
H
G
L
L
S
P
D
A
G
Y
Q
P
Site 12
T168
P
D
A
G
Y
Q
P
T
P
L
A
A
P
A
E
Site 13
S178
A
A
P
A
E
P
G
S
K
Y
S
L
A
S
L
Site 14
Y180
P
A
E
P
G
S
K
Y
S
L
A
S
L
D
R
Site 15
S181
A
E
P
G
S
K
Y
S
L
A
S
L
D
R
G
Site 16
S184
G
S
K
Y
S
L
A
S
L
D
R
G
Q
G
R
Site 17
Y201
G
G
G
G
A
L
E
Y
V
P
K
A
V
S
Q
Site 18
S207
E
Y
V
P
K
A
V
S
Q
P
R
R
H
S
R
Site 19
S213
V
S
Q
P
R
R
H
S
R
P
V
P
S
G
K
Site 20
Y221
R
P
V
P
S
G
K
Y
V
V
D
N
S
R
P
Site 21
S226
G
K
Y
V
V
D
N
S
R
P
P
T
D
L
E
Site 22
T230
V
D
N
S
R
P
P
T
D
L
E
Y
D
P
L
Site 23
Y234
R
P
P
T
D
L
E
Y
D
P
L
S
N
Y
S
Site 24
S238
D
L
E
Y
D
P
L
S
N
Y
S
A
R
H
L
Site 25
Y240
E
Y
D
P
L
S
N
Y
S
A
R
H
L
S
R
Site 26
S241
Y
D
P
L
S
N
Y
S
A
R
H
L
S
R
A
Site 27
S246
N
Y
S
A
R
H
L
S
R
A
S
S
R
D
E
Site 28
S249
A
R
H
L
S
R
A
S
S
R
D
E
R
A
A
Site 29
S250
R
H
L
S
R
A
S
S
R
D
E
R
A
A
K
Site 30
S262
A
A
K
R
P
R
G
S
R
G
S
E
P
Y
T
Site 31
S265
R
P
R
G
S
R
G
S
E
P
Y
T
P
A
P
Site 32
T269
S
R
G
S
E
P
Y
T
P
A
P
K
K
L
C
Site 33
S287
G
S
C
D
A
R
F
S
D
S
E
D
E
A
A
Site 34
S289
C
D
A
R
F
S
D
S
E
D
E
A
A
T
V
Site 35
S305
G
N
E
P
T
T
A
S
T
P
K
A
R
A
D
Site 36
T306
N
E
P
T
T
A
S
T
P
K
A
R
A
D
P
Site 37
T318
A
D
P
E
I
K
A
T
G
Q
P
P
S
K
E
Site 38
S323
K
A
T
G
Q
P
P
S
K
E
G
L
E
A
E
Site 39
T337
E
G
G
G
L
R
E
T
K
E
T
A
V
Q
C
Site 40
T340
G
L
R
E
T
K
E
T
A
V
Q
C
D
V
G
Site 41
S358
P
P
P
A
K
P
A
S
P
A
Q
V
Q
S
S
Site 42
S364
A
S
P
A
Q
V
Q
S
S
Q
D
G
G
C
P
Site 43
S365
S
P
A
Q
V
Q
S
S
Q
D
G
G
C
P
K
Site 44
T381
G
K
P
K
K
K
K
T
G
A
P
P
A
P
S
Site 45
S388
T
G
A
P
P
A
P
S
C
K
D
G
A
Q
G
Site 46
T399
G
A
Q
G
K
D
K
T
K
D
K
G
R
G
R
Site 47
S421
D
K
K
G
P
Q
A
S
S
P
R
R
K
A
E
Site 48
S422
K
K
G
P
Q
A
S
S
P
R
R
K
A
E
R
Site 49
S439
G
T
K
K
K
P
S
S
A
T
P
V
A
T
S
Site 50
T441
K
K
K
P
S
S
A
T
P
V
A
T
S
G
K
Site 51
T445
S
S
A
T
P
V
A
T
S
G
K
G
R
P
D
Site 52
S446
S
A
T
P
V
A
T
S
G
K
G
R
P
D
R
Site 53
S459
D
R
P
A
R
R
P
S
P
T
S
G
D
S
R
Site 54
T461
P
A
R
R
P
S
P
T
S
G
D
S
R
P
A
Site 55
S462
A
R
R
P
S
P
T
S
G
D
S
R
P
A
A
Site 56
S465
P
S
P
T
S
G
D
S
R
P
A
A
G
R
G
Site 57
S484
L
Q
L
P
D
R
K
S
T
K
A
P
S
G
K
Site 58
T485
Q
L
P
D
R
K
S
T
K
A
P
S
G
K
L
Site 59
S499
L
V
E
R
K
A
R
S
L
D
E
G
A
S
Q
Site 60
S505
R
S
L
D
E
G
A
S
Q
D
A
P
K
L
K
Site 61
S517
K
L
K
K
R
A
L
S
H
A
D
L
F
G
D
Site 62
S526
A
D
L
F
G
D
E
S
E
D
E
A
A
G
P
Site 63
S545
V
W
P
S
A
L
P
S
L
S
S
D
S
D
S
Site 64
S547
P
S
A
L
P
S
L
S
S
D
S
D
S
D
S
Site 65
S548
S
A
L
P
S
L
S
S
D
S
D
S
D
S
D
Site 66
S550
L
P
S
L
S
S
D
S
D
S
D
S
D
S
S
Site 67
S552
S
L
S
S
D
S
D
S
D
S
D
S
S
L
G
Site 68
S554
S
S
D
S
D
S
D
S
D
S
S
L
G
F
P
Site 69
S556
D
S
D
S
D
S
D
S
S
L
G
F
P
E
A
Site 70
S557
S
D
S
D
S
D
S
S
L
G
F
P
E
A
Q
Site 71
S573
P
P
K
R
L
K
A
S
P
P
P
S
P
A
P
Site 72
S577
L
K
A
S
P
P
P
S
P
A
P
S
S
S
S
Site 73
S581
P
P
P
S
P
A
P
S
S
S
S
S
S
S
S
Site 74
S582
P
P
S
P
A
P
S
S
S
S
S
S
S
S
S
Site 75
S583
P
S
P
A
P
S
S
S
S
S
S
S
S
S
T
Site 76
S584
S
P
A
P
S
S
S
S
S
S
S
S
S
T
S
Site 77
S585
P
A
P
S
S
S
S
S
S
S
S
S
T
S
S
Site 78
S586
A
P
S
S
S
S
S
S
S
S
S
T
S
S
A
Site 79
S587
P
S
S
S
S
S
S
S
S
S
T
S
S
A
G
Site 80
S588
S
S
S
S
S
S
S
S
S
T
S
S
A
G
A
Site 81
S589
S
S
S
S
S
S
S
S
T
S
S
A
G
A
D
Site 82
T590
S
S
S
S
S
S
S
T
S
S
A
G
A
D
V
Site 83
S591
S
S
S
S
S
S
T
S
S
A
G
A
D
V
D
Site 84
S592
S
S
S
S
S
T
S
S
A
G
A
D
V
D
Y
Site 85
Y599
S
A
G
A
D
V
D
Y
S
A
L
E
K
E
V
Site 86
S600
A
G
A
D
V
D
Y
S
A
L
E
K
E
V
D
Site 87
S610
E
K
E
V
D
F
D
S
D
P
M
E
E
C
L
Site 88
S623
C
L
R
I
F
N
E
S
T
S
V
K
T
E
D
Site 89
S625
R
I
F
N
E
S
T
S
V
K
T
E
D
R
G
Site 90
S644
Q
P
P
K
E
E
K
S
E
E
K
G
L
S
G
Site 91
S650
K
S
E
E
K
G
L
S
G
L
T
T
L
F
P
Site 92
T654
K
G
L
S
G
L
T
T
L
F
P
G
Q
K
R
Site 93
S664
P
G
Q
K
R
R
I
S
H
L
S
K
Q
G
Q
Site 94
S667
K
R
R
I
S
H
L
S
K
Q
G
Q
E
V
E
Site 95
T689
V
P
P
A
R
P
P
T
A
Q
E
V
C
Y
L
Site 96
Y695
P
T
A
Q
E
V
C
Y
L
R
A
Q
Q
A
Q
Site 97
S705
A
Q
Q
A
Q
R
A
S
A
S
L
L
Q
A
P
Site 98
S719
P
A
R
L
A
E
K
S
P
S
V
H
I
S
A
Site 99
S721
R
L
A
E
K
S
P
S
V
H
I
S
A
P
G
Site 100
S725
K
S
P
S
V
H
I
S
A
P
G
E
K
R
R
Site 101
T751
A
P
T
G
A
K
R
T
L
A
A
S
G
S
Q
Site 102
S755
A
K
R
T
L
A
A
S
G
S
Q
P
S
N
G
Site 103
S757
R
T
L
A
A
S
G
S
Q
P
S
N
G
P
E
Site 104
S760
A
A
S
G
S
Q
P
S
N
G
P
E
P
G
G
Site 105
T772
P
G
G
Q
Q
L
K
T
R
T
L
S
G
M
A
Site 106
T774
G
Q
Q
L
K
T
R
T
L
S
G
M
A
S
K
Site 107
S776
Q
L
K
T
R
T
L
S
G
M
A
S
K
T
T
Site 108
T783
S
G
M
A
S
K
T
T
T
T
I
I
P
K
R
Site 109
T784
G
M
A
S
K
T
T
T
T
I
I
P
K
R
I
Site 110
S794
I
P
K
R
I
A
H
S
P
S
L
Q
S
L
K
Site 111
S796
K
R
I
A
H
S
P
S
L
Q
S
L
K
K
P
Site 112
S799
A
H
S
P
S
L
Q
S
L
K
K
P
I
I
P
Site 113
T815
E
F
G
G
K
V
P
T
V
I
R
Q
R
Y
L
Site 114
Y821
P
T
V
I
R
Q
R
Y
L
N
L
F
I
E
E
Site 115
Y851
L
N
E
E
K
V
A
Y
D
R
S
P
S
K
N
Site 116
S854
E
K
V
A
Y
D
R
S
P
S
K
N
I
Y
L
Site 117
S856
V
A
Y
D
R
S
P
S
K
N
I
Y
L
N
V
Site 118
Y860
R
S
P
S
K
N
I
Y
L
N
V
A
V
N
T
Site 119
S877
K
L
R
G
L
A
P
S
A
V
P
G
L
S
K
Site 120
S883
P
S
A
V
P
G
L
S
K
T
S
G
R
R
V
Site 121
T885
A
V
P
G
L
S
K
T
S
G
R
R
V
V
S
Site 122
S886
V
P
G
L
S
K
T
S
G
R
R
V
V
S
H
Site 123
S892
T
S
G
R
R
V
V
S
H
E
V
V
L
G
G
Site 124
T905
G
G
R
L
A
A
K
T
S
F
S
L
S
R
P
Site 125
S906
G
R
L
A
A
K
T
S
F
S
L
S
R
P
S
Site 126
S908
L
A
A
K
T
S
F
S
L
S
R
P
S
S
P
Site 127
S910
A
K
T
S
F
S
L
S
R
P
S
S
P
R
V
Site 128
S913
S
F
S
L
S
R
P
S
S
P
R
V
E
D
L
Site 129
S914
F
S
L
S
R
P
S
S
P
R
V
E
D
L
K
Site 130
Y926
D
L
K
G
A
A
L
Y
S
R
L
R
E
Y
L
Site 131
Y932
L
Y
S
R
L
R
E
Y
L
L
T
Q
D
Q
L
Site 132
T935
R
L
R
E
Y
L
L
T
Q
D
Q
L
K
E
N
Site 133
Y944
D
Q
L
K
E
N
G
Y
P
F
P
H
P
E
R
Site 134
S968
E
E
K
R
P
K
D
S
S
C
R
T
C
C
R
Site 135
S969
E
K
R
P
K
D
S
S
C
R
T
C
C
R
C
Site 136
T972
P
K
D
S
S
C
R
T
C
C
R
C
G
T
E
Site 137
T978
R
T
C
C
R
C
G
T
E
Y
L
V
S
S
S
Site 138
Y980
C
C
R
C
G
T
E
Y
L
V
S
S
S
G
R
Site 139
S983
C
G
T
E
Y
L
V
S
S
S
G
R
C
I
R
Site 140
S985
T
E
Y
L
V
S
S
S
G
R
C
I
R
D
E
Site 141
Y996
I
R
D
E
E
C
Y
Y
H
W
G
R
L
R
R
Site 142
T1047
R
L
E
G
F
V
K
T
F
E
K
E
L
S
G
Site 143
S1053
K
T
F
E
K
E
L
S
G
D
T
H
P
G
I
Site 144
T1070
L
D
C
E
M
S
Y
T
T
Y
G
L
E
L
T
Site 145
T1071
D
C
E
M
S
Y
T
T
Y
G
L
E
L
T
R
Site 146
Y1090
D
T
D
V
H
V
V
Y
D
T
F
V
K
P
D
Site 147
T1092
D
V
H
V
V
Y
D
T
F
V
K
P
D
N
E
Site 148
Y1103
P
D
N
E
I
V
D
Y
N
T
R
F
S
G
V
Site 149
S1108
V
D
Y
N
T
R
F
S
G
V
T
E
A
D
L
Site 150
S1119
E
A
D
L
A
D
T
S
V
T
L
R
D
V
Q
Site 151
Y1173
P
H
R
L
G
L
P
Y
K
R
S
L
R
N
L
Site 152
S1176
L
G
L
P
Y
K
R
S
L
R
N
L
M
A
D
Site 153
Y1184
L
R
N
L
M
A
D
Y
L
R
Q
I
I
Q
D
Site 154
S1199
N
V
D
G
H
S
S
S
E
D
A
G
A
C
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation