KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
SIX6OS1
Full Name:
Protein SIX6OS1
Alias:
Six6 opposite strand transcript 1
Type:
Mass (Da):
68166
Number AA:
587
UniProt ID:
Q8N1H7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y20
L
L
E
F
V
F
Q
Y
E
Q
D
I
S
T
K
Site 2
T47
D
I
K
E
N
K
V
T
I
C
R
I
H
E
T
Site 3
Y65
T
D
E
E
I
D
H
Y
C
K
H
S
E
E
I
Site 4
Y92
V
F
R
K
H
E
D
Y
M
Q
D
Q
F
T
V
Site 5
Y100
M
Q
D
Q
F
T
V
Y
Q
G
T
V
E
K
D
Site 6
Y111
V
E
K
D
K
E
M
Y
H
D
Y
I
C
Q
Y
Site 7
Y114
D
K
E
M
Y
H
D
Y
I
C
Q
Y
K
E
V
Site 8
Y118
Y
H
D
Y
I
C
Q
Y
K
E
V
L
K
Q
Y
Site 9
Y129
L
K
Q
Y
Q
L
K
Y
S
E
T
P
F
S
R
Site 10
S130
K
Q
Y
Q
L
K
Y
S
E
T
P
F
S
R
E
Site 11
T132
Y
Q
L
K
Y
S
E
T
P
F
S
R
E
Y
Y
Site 12
S135
K
Y
S
E
T
P
F
S
R
E
Y
Y
E
K
K
Site 13
Y138
E
T
P
F
S
R
E
Y
Y
E
K
K
R
E
H
Site 14
Y139
T
P
F
S
R
E
Y
Y
E
K
K
R
E
H
E
Site 15
T156
Q
S
R
V
L
A
C
T
E
Q
L
K
M
N
E
Site 16
S177
R
V
P
A
P
F
P
S
L
T
K
W
T
L
N
Site 17
T192
I
V
N
L
R
C
E
T
Q
D
I
L
K
H
A
Site 18
S200
Q
D
I
L
K
H
A
S
N
L
T
K
S
S
S
Site 19
T203
L
K
H
A
S
N
L
T
K
S
S
S
E
L
K
Site 20
S205
H
A
S
N
L
T
K
S
S
S
E
L
K
K
E
Site 21
S207
S
N
L
T
K
S
S
S
E
L
K
K
E
V
D
Site 22
Y222
E
M
E
I
E
I
N
Y
L
N
Q
Q
I
S
R
Site 23
T266
G
K
D
E
H
V
L
T
L
N
K
T
Q
S
S
Site 24
T270
H
V
L
T
L
N
K
T
Q
S
S
Q
L
F
L
Site 25
S272
L
T
L
N
K
T
Q
S
S
Q
L
F
L
P
Y
Site 26
S273
T
L
N
K
T
Q
S
S
Q
L
F
L
P
Y
E
Site 27
Y279
S
S
Q
L
F
L
P
Y
E
S
Q
K
L
V
R
Site 28
S293
R
P
I
K
M
H
S
S
E
P
R
V
A
D
I
Site 29
S304
V
A
D
I
K
E
E
S
S
V
K
Q
S
K
L
Site 30
S305
A
D
I
K
E
E
S
S
V
K
Q
S
K
L
A
Site 31
S309
E
E
S
S
V
K
Q
S
K
L
A
N
I
D
F
Site 32
S329
D
T
Q
I
F
N
D
S
A
V
D
N
H
S
K
Site 33
S335
D
S
A
V
D
N
H
S
K
C
S
H
I
T
T
Site 34
T342
S
K
C
S
H
I
T
T
I
T
S
S
Q
K
F
Site 35
S345
S
H
I
T
T
I
T
S
S
Q
K
F
M
Q
V
Site 36
S346
H
I
T
T
I
T
S
S
Q
K
F
M
Q
V
R
Site 37
T356
F
M
Q
V
R
L
L
T
P
Q
K
Q
S
N
S
Site 38
S363
T
P
Q
K
Q
S
N
S
N
Q
W
S
E
K
G
Site 39
S367
Q
S
N
S
N
Q
W
S
E
K
G
D
K
D
A
Site 40
Y376
K
G
D
K
D
A
E
Y
G
D
K
G
T
V
R
Site 41
T381
A
E
Y
G
D
K
G
T
V
R
Q
V
R
E
S
Site 42
S388
T
V
R
Q
V
R
E
S
K
C
T
S
Q
A
I
Site 43
T391
Q
V
R
E
S
K
C
T
S
Q
A
I
Y
T
E
Site 44
S392
V
R
E
S
K
C
T
S
Q
A
I
Y
T
E
H
Site 45
Y396
K
C
T
S
Q
A
I
Y
T
E
H
F
G
K
S
Site 46
S403
Y
T
E
H
F
G
K
S
I
E
N
D
S
D
E
Site 47
S408
G
K
S
I
E
N
D
S
D
E
V
E
E
R
A
Site 48
S422
A
E
N
F
P
R
T
S
E
I
P
I
F
L
G
Site 49
S439
K
A
V
K
A
P
E
S
L
E
K
I
K
F
P
Site 50
T448
E
K
I
K
F
P
K
T
P
P
F
E
I
N
R
Site 51
T465
N
A
V
P
E
V
Q
T
E
K
E
S
P
G
L
Site 52
S469
E
V
Q
T
E
K
E
S
P
G
L
S
F
L
M
Site 53
S473
E
K
E
S
P
G
L
S
F
L
M
S
Y
T
S
Site 54
S477
P
G
L
S
F
L
M
S
Y
T
S
R
S
P
G
Site 55
T479
L
S
F
L
M
S
Y
T
S
R
S
P
G
L
N
Site 56
S480
S
F
L
M
S
Y
T
S
R
S
P
G
L
N
L
Site 57
S482
L
M
S
Y
T
S
R
S
P
G
L
N
L
F
D
Site 58
T495
F
D
S
S
V
F
D
T
E
I
S
S
D
Q
F
Site 59
S498
S
V
F
D
T
E
I
S
S
D
Q
F
N
E
H
Site 60
Y506
S
D
Q
F
N
E
H
Y
S
A
R
N
L
N
P
Site 61
S507
D
Q
F
N
E
H
Y
S
A
R
N
L
N
P
L
Site 62
S515
A
R
N
L
N
P
L
S
S
E
Q
E
I
G
N
Site 63
S516
R
N
L
N
P
L
S
S
E
Q
E
I
G
N
L
Site 64
T534
P
E
G
E
D
G
F
T
F
S
F
P
S
D
T
Site 65
S536
G
E
D
G
F
T
F
S
F
P
S
D
T
S
T
Site 66
S539
G
F
T
F
S
F
P
S
D
T
S
T
H
T
F
Site 67
T541
T
F
S
F
P
S
D
T
S
T
H
T
F
G
A
Site 68
S542
F
S
F
P
S
D
T
S
T
H
T
F
G
A
G
Site 69
T543
S
F
P
S
D
T
S
T
H
T
F
G
A
G
K
Site 70
T545
P
S
D
T
S
T
H
T
F
G
A
G
K
D
D
Site 71
S554
G
A
G
K
D
D
F
S
F
P
F
S
F
G
Q
Site 72
S558
D
D
F
S
F
P
F
S
F
G
Q
G
Q
N
S
Site 73
S565
S
F
G
Q
G
Q
N
S
I
P
S
S
S
L
K
Site 74
S568
Q
G
Q
N
S
I
P
S
S
S
L
K
G
F
S
Site 75
S569
G
Q
N
S
I
P
S
S
S
L
K
G
F
S
S
Site 76
S570
Q
N
S
I
P
S
S
S
L
K
G
F
S
S
S
Site 77
S575
S
S
S
L
K
G
F
S
S
S
S
Q
N
T
T
Site 78
S576
S
S
L
K
G
F
S
S
S
S
Q
N
T
T
Q
Site 79
S577
S
L
K
G
F
S
S
S
S
Q
N
T
T
Q
F
Site 80
S578
L
K
G
F
S
S
S
S
Q
N
T
T
Q
F
T
Site 81
T581
F
S
S
S
S
Q
N
T
T
Q
F
T
F
F
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation