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Updated November 2019
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Protein Info
Short Name:
DOCK4
Full Name:
Dedicator of cytokinesis protein 4
Alias:
Dedicator of cytokinesis 4; FLJ34238; KIAA0716
Type:
Guanine nucleotide exchange factor, Ras
Mass (Da):
225148
Number AA:
1966
UniProt ID:
Q8N1I0
International Prot ID:
IPI00297415
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
GO:0032420
Uniprot
OncoNet
Molecular Function:
GO:0030165
GO:0030675
GO:0048365
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y43
L
E
K
C
D
G
W
Y
R
G
F
A
L
K
N
Site 2
S59
N
I
K
G
I
F
P
S
S
Y
V
H
L
K
N
Site 3
Y61
K
G
I
F
P
S
S
Y
V
H
L
K
N
A
C
Site 4
T92
V
I
T
E
M
T
S
T
L
R
D
W
G
T
M
Site 5
Y104
G
T
M
W
K
Q
L
Y
V
R
N
E
G
D
L
Site 6
T135
Q
V
L
V
G
H
L
T
H
D
R
M
K
D
V
Site 7
T147
K
D
V
K
R
H
I
T
A
R
L
D
W
G
N
Site 8
Y167
D
L
V
P
R
K
E
Y
A
M
V
D
P
E
D
Site 9
Y181
D
I
S
I
T
E
L
Y
R
L
M
E
H
R
H
Site 10
T193
H
R
H
R
K
K
D
T
P
V
Q
A
S
S
H
Site 11
S212
Q
M
K
S
L
M
C
S
N
L
G
E
E
L
E
Site 12
S223
E
E
L
E
V
I
F
S
L
F
D
S
K
E
N
Site 13
S227
V
I
F
S
L
F
D
S
K
E
N
R
P
I
S
Site 14
S234
S
K
E
N
R
P
I
S
E
R
F
F
L
R
L
Site 15
S258
D
K
P
E
R
H
C
S
L
F
V
D
L
G
S
Site 16
S265
S
L
F
V
D
L
G
S
S
E
L
R
K
D
I
Site 17
Y273
S
E
L
R
K
D
I
Y
I
T
V
H
I
I
R
Site 18
Y297
K
N
A
C
S
V
Q
Y
R
R
P
F
G
C
A
Site 19
T313
L
S
I
A
D
L
L
T
G
E
T
K
D
D
L
Site 20
Y325
D
D
L
I
L
K
V
Y
M
C
N
T
E
S
E
Site 21
Y375
I
E
Q
I
R
R
E
Y
S
S
V
F
S
H
G
Site 22
S376
E
Q
I
R
R
E
Y
S
S
V
F
S
H
G
V
Site 23
S377
Q
I
R
R
E
Y
S
S
V
F
S
H
G
V
S
Site 24
S380
R
E
Y
S
S
V
F
S
H
G
V
S
I
T
R
Site 25
Y405
G
E
M
R
N
D
L
Y
I
T
I
E
R
G
E
Site 26
S419
E
F
E
K
G
G
K
S
V
A
R
N
V
E
V
Site 27
S443
Q
T
L
K
D
F
I
S
F
G
S
G
E
P
P
Site 28
S446
K
D
F
I
S
F
G
S
G
E
P
P
A
S
E
Site 29
S452
G
S
G
E
P
P
A
S
E
Y
H
S
F
V
L
Site 30
Y454
G
E
P
P
A
S
E
Y
H
S
F
V
L
Y
H
Site 31
S456
P
P
A
S
E
Y
H
S
F
V
L
Y
H
N
N
Site 32
Y460
E
Y
H
S
F
V
L
Y
H
N
N
S
P
R
W
Site 33
S464
F
V
L
Y
H
N
N
S
P
R
W
S
E
L
L
Site 34
S468
H
N
N
S
P
R
W
S
E
L
L
K
L
P
I
Site 35
S493
R
F
E
F
R
H
C
S
T
K
E
K
G
E
K
Site 36
S506
E
K
K
L
F
G
F
S
F
V
P
L
M
Q
E
Site 37
T517
L
M
Q
E
D
G
R
T
L
P
D
G
T
H
E
Site 38
T522
G
R
T
L
P
D
G
T
H
E
L
I
V
H
K
Site 39
T539
E
N
T
N
L
Q
D
T
T
R
Y
L
K
L
P
Site 40
S548
R
Y
L
K
L
P
F
S
K
G
I
F
L
G
N
Site 41
S566
A
M
K
A
T
K
E
S
F
C
I
T
S
F
L
Site 42
S571
K
E
S
F
C
I
T
S
F
L
C
S
T
K
L
Site 43
T579
F
L
C
S
T
K
L
T
Q
N
G
D
M
L
D
Site 44
T592
L
D
L
L
K
W
R
T
H
P
D
K
I
T
G
Site 45
T598
R
T
H
P
D
K
I
T
G
C
L
S
K
L
K
Site 46
S602
D
K
I
T
G
C
L
S
K
L
K
E
I
D
G
Site 47
S610
K
L
K
E
I
D
G
S
E
I
V
K
F
L
Q
Site 48
S631
F
G
I
L
D
E
N
S
Q
K
Y
G
S
K
V
Site 49
S652
I
I
N
L
L
Q
D
S
K
F
H
H
F
K
P
Site 50
Y664
F
K
P
V
M
D
T
Y
I
E
S
H
F
A
G
Site 51
Y675
H
F
A
G
A
L
A
Y
R
D
L
I
K
V
L
Site 52
Y711
A
Q
E
Y
I
F
K
Y
I
V
Q
S
R
R
L
Site 53
S720
V
Q
S
R
R
L
F
S
L
A
T
G
G
Q
N
Site 54
S747
M
S
V
R
F
F
L
S
Q
E
S
K
G
S
G
Site 55
S753
L
S
Q
E
S
K
G
S
G
A
L
S
Q
S
Q
Site 56
S757
S
K
G
S
G
A
L
S
Q
S
Q
A
V
F
L
Site 57
T815
K
L
Q
C
I
G
K
T
V
E
S
Q
L
Y
T
Site 58
S818
C
I
G
K
T
V
E
S
Q
L
Y
T
N
P
D
Site 59
Y821
K
T
V
E
S
Q
L
Y
T
N
P
D
S
R
Y
Site 60
T822
T
V
E
S
Q
L
Y
T
N
P
D
S
R
Y
I
Site 61
S826
Q
L
Y
T
N
P
D
S
R
Y
I
L
L
P
V
Site 62
S866
F
C
L
I
K
K
N
S
S
E
K
S
V
L
E
Site 63
S870
K
K
N
S
S
E
K
S
V
L
E
E
I
D
V
Site 64
T889
L
L
D
I
L
L
R
T
I
L
E
I
T
S
R
Site 65
T894
L
R
T
I
L
E
I
T
S
R
P
Q
P
S
S
Site 66
S895
R
T
I
L
E
I
T
S
R
P
Q
P
S
S
S
Site 67
S900
I
T
S
R
P
Q
P
S
S
S
A
M
R
F
Q
Site 68
S901
T
S
R
P
Q
P
S
S
S
A
M
R
F
Q
F
Site 69
S902
S
R
P
Q
P
S
S
S
A
M
R
F
Q
F
Q
Site 70
T927
L
S
L
L
R
Q
M
T
D
R
H
Y
Q
Q
L
Site 71
Y931
R
Q
M
T
D
R
H
Y
Q
Q
L
L
D
S
F
Site 72
S937
H
Y
Q
Q
L
L
D
S
F
N
T
K
E
E
L
Site 73
Y1001
F
L
N
E
N
F
D
Y
K
I
W
D
S
Y
F
Site 74
T1026
C
L
Q
L
E
M
F
T
P
S
K
K
K
K
V
Site 75
Y1037
K
K
K
V
L
E
K
Y
G
D
M
R
V
T
M
Site 76
S1116
K
L
I
D
K
L
D
S
L
M
S
E
G
K
G
Site 77
S1119
D
K
L
D
S
L
M
S
E
G
K
G
D
E
T
Site 78
T1126
S
E
G
K
G
D
E
T
Y
R
E
L
F
N
S
Site 79
Y1127
E
G
K
G
D
E
T
Y
R
E
L
F
N
S
I
Site 80
S1133
T
Y
R
E
L
F
N
S
I
L
L
K
K
I
E
Site 81
T1143
L
K
K
I
E
R
E
T
W
R
E
S
G
V
S
Site 82
S1147
E
R
E
T
W
R
E
S
G
V
S
L
I
A
T
Site 83
S1150
T
W
R
E
S
G
V
S
L
I
A
T
V
T
R
Site 84
Y1165
L
M
E
R
L
L
D
Y
R
D
C
M
K
M
G
Site 85
T1191
S
L
L
N
F
Y
K
T
E
L
N
K
E
E
M
Site 86
Y1199
E
L
N
K
E
E
M
Y
I
R
Y
I
H
K
L
Site 87
Y1207
I
R
Y
I
H
K
L
Y
D
L
H
L
K
A
Q
Site 88
S1233
Y
D
E
L
L
E
W
S
D
R
P
L
R
E
F
Site 89
T1242
R
P
L
R
E
F
L
T
Y
P
M
Q
T
E
W
Site 90
Y1243
P
L
R
E
F
L
T
Y
P
M
Q
T
E
W
Q
Site 91
Y1287
A
E
Q
Y
E
S
Y
Y
D
Y
R
N
L
S
K
Site 92
Y1289
Q
Y
E
S
Y
Y
D
Y
R
N
L
S
K
M
R
Site 93
S1301
K
M
R
M
M
E
A
S
L
Y
D
K
I
M
D
Site 94
Y1303
R
M
M
E
A
S
L
Y
D
K
I
M
D
Q
Q
Site 95
Y1342
F
V
C
R
G
H
D
Y
E
R
L
E
A
F
Q
Site 96
T1386
Y
L
Q
I
Y
A
V
T
P
I
P
E
S
Q
E
Site 97
S1391
A
V
T
P
I
P
E
S
Q
E
V
L
Q
R
E
Site 98
Y1408
P
D
N
I
K
S
F
Y
K
V
N
H
I
W
K
Site 99
S1435
D
K
E
N
E
F
K
S
L
W
V
E
R
T
S
Site 100
Y1444
W
V
E
R
T
S
L
Y
L
V
Q
S
L
P
G
Site 101
S1467
K
R
E
V
V
E
M
S
P
L
E
N
A
I
E
Site 102
T1485
N
K
N
Q
Q
L
K
T
L
I
S
Q
C
Q
T
Site 103
S1488
Q
Q
L
K
T
L
I
S
Q
C
Q
T
R
Q
M
Site 104
Y1520
V
N
G
G
V
S
R
Y
Q
E
A
F
F
V
K
Site 105
Y1529
E
A
F
F
V
K
E
Y
I
L
S
H
P
E
D
Site 106
S1532
F
V
K
E
Y
I
L
S
H
P
E
D
G
E
K
Site 107
S1607
P
V
H
F
P
N
G
S
P
R
V
C
R
N
S
Site 108
S1614
S
P
R
V
C
R
N
S
A
P
A
S
V
S
P
Site 109
S1618
C
R
N
S
A
P
A
S
V
S
P
D
G
T
R
Site 110
S1620
N
S
A
P
A
S
V
S
P
D
G
T
R
V
I
Site 111
T1624
A
S
V
S
P
D
G
T
R
V
I
P
R
R
S
Site 112
S1631
T
R
V
I
P
R
R
S
P
L
S
Y
P
A
V
Site 113
S1634
I
P
R
R
S
P
L
S
Y
P
A
V
N
R
Y
Site 114
Y1635
P
R
R
S
P
L
S
Y
P
A
V
N
R
Y
S
Site 115
Y1641
S
Y
P
A
V
N
R
Y
S
S
S
S
L
S
S
Site 116
S1642
Y
P
A
V
N
R
Y
S
S
S
S
L
S
S
Q
Site 117
S1643
P
A
V
N
R
Y
S
S
S
S
L
S
S
Q
A
Site 118
S1644
A
V
N
R
Y
S
S
S
S
L
S
S
Q
A
S
Site 119
S1645
V
N
R
Y
S
S
S
S
L
S
S
Q
A
S
A
Site 120
S1647
R
Y
S
S
S
S
L
S
S
Q
A
S
A
E
V
Site 121
S1648
Y
S
S
S
S
L
S
S
Q
A
S
A
E
V
S
Site 122
S1651
S
S
L
S
S
Q
A
S
A
E
V
S
N
I
T
Site 123
S1655
S
Q
A
S
A
E
V
S
N
I
T
G
Q
S
E
Site 124
S1661
V
S
N
I
T
G
Q
S
E
S
S
D
E
V
F
Site 125
S1664
I
T
G
Q
S
E
S
S
D
E
V
F
N
M
Q
Site 126
S1673
E
V
F
N
M
Q
P
S
P
S
T
S
S
L
S
Site 127
S1675
F
N
M
Q
P
S
P
S
T
S
S
L
S
S
T
Site 128
T1676
N
M
Q
P
S
P
S
T
S
S
L
S
S
T
H
Site 129
S1677
M
Q
P
S
P
S
T
S
S
L
S
S
T
H
S
Site 130
S1678
Q
P
S
P
S
T
S
S
L
S
S
T
H
S
A
Site 131
S1680
S
P
S
T
S
S
L
S
S
T
H
S
A
S
P
Site 132
S1681
P
S
T
S
S
L
S
S
T
H
S
A
S
P
N
Site 133
T1682
S
T
S
S
L
S
S
T
H
S
A
S
P
N
V
Site 134
S1684
S
S
L
S
S
T
H
S
A
S
P
N
V
T
S
Site 135
S1686
L
S
S
T
H
S
A
S
P
N
V
T
S
S
A
Site 136
T1690
H
S
A
S
P
N
V
T
S
S
A
P
S
S
A
Site 137
S1691
S
A
S
P
N
V
T
S
S
A
P
S
S
A
R
Site 138
S1692
A
S
P
N
V
T
S
S
A
P
S
S
A
R
A
Site 139
S1695
N
V
T
S
S
A
P
S
S
A
R
A
S
P
L
Site 140
S1700
A
P
S
S
A
R
A
S
P
L
L
S
D
K
H
Site 141
S1704
A
R
A
S
P
L
L
S
D
K
H
K
H
S
R
Site 142
S1710
L
S
D
K
H
K
H
S
R
E
N
S
C
L
S
Site 143
S1714
H
K
H
S
R
E
N
S
C
L
S
P
R
E
R
Site 144
S1717
S
R
E
N
S
C
L
S
P
R
E
R
P
C
S
Site 145
S1724
S
P
R
E
R
P
C
S
A
I
Y
P
T
P
V
Site 146
Y1727
E
R
P
C
S
A
I
Y
P
T
P
V
E
P
S
Site 147
T1729
P
C
S
A
I
Y
P
T
P
V
E
P
S
Q
R
Site 148
S1734
Y
P
T
P
V
E
P
S
Q
R
M
L
F
N
H
Site 149
S1750
G
D
G
A
L
P
R
S
D
P
N
L
S
A
P
Site 150
S1755
P
R
S
D
P
N
L
S
A
P
E
K
A
V
N
Site 151
T1764
P
E
K
A
V
N
P
T
P
S
S
W
S
L
D
Site 152
S1766
K
A
V
N
P
T
P
S
S
W
S
L
D
S
G
Site 153
S1767
A
V
N
P
T
P
S
S
W
S
L
D
S
G
K
Site 154
S1769
N
P
T
P
S
S
W
S
L
D
S
G
K
E
A
Site 155
S1772
P
S
S
W
S
L
D
S
G
K
E
A
K
N
M
Site 156
S1780
G
K
E
A
K
N
M
S
D
S
G
K
L
I
S
Site 157
S1782
E
A
K
N
M
S
D
S
G
K
L
I
S
P
P
Site 158
S1787
S
D
S
G
K
L
I
S
P
P
V
P
P
R
P
Site 159
T1795
P
P
V
P
P
R
P
T
Q
T
A
S
P
A
R
Site 160
T1797
V
P
P
R
P
T
Q
T
A
S
P
A
R
H
T
Site 161
S1799
P
R
P
T
Q
T
A
S
P
A
R
H
T
T
S
Site 162
T1804
T
A
S
P
A
R
H
T
T
S
V
S
P
S
P
Site 163
T1805
A
S
P
A
R
H
T
T
S
V
S
P
S
P
A
Site 164
S1806
S
P
A
R
H
T
T
S
V
S
P
S
P
A
G
Site 165
S1808
A
R
H
T
T
S
V
S
P
S
P
A
G
R
S
Site 166
S1810
H
T
T
S
V
S
P
S
P
A
G
R
S
P
L
Site 167
S1815
S
P
S
P
A
G
R
S
P
L
K
G
S
V
Q
Site 168
S1820
G
R
S
P
L
K
G
S
V
Q
S
F
T
P
S
Site 169
S1823
P
L
K
G
S
V
Q
S
F
T
P
S
P
V
E
Site 170
T1825
K
G
S
V
Q
S
F
T
P
S
P
V
E
Y
H
Site 171
S1827
S
V
Q
S
F
T
P
S
P
V
E
Y
H
S
P
Site 172
Y1831
F
T
P
S
P
V
E
Y
H
S
P
G
L
I
S
Site 173
S1833
P
S
P
V
E
Y
H
S
P
G
L
I
S
N
S
Site 174
S1838
Y
H
S
P
G
L
I
S
N
S
P
V
L
S
G
Site 175
S1840
S
P
G
L
I
S
N
S
P
V
L
S
G
S
Y
Site 176
S1844
I
S
N
S
P
V
L
S
G
S
Y
S
S
G
I
Site 177
S1846
N
S
P
V
L
S
G
S
Y
S
S
G
I
S
S
Site 178
S1848
P
V
L
S
G
S
Y
S
S
G
I
S
S
L
S
Site 179
S1849
V
L
S
G
S
Y
S
S
G
I
S
S
L
S
R
Site 180
S1852
G
S
Y
S
S
G
I
S
S
L
S
R
C
S
T
Site 181
S1853
S
Y
S
S
G
I
S
S
L
S
R
C
S
T
S
Site 182
S1855
S
S
G
I
S
S
L
S
R
C
S
T
S
E
T
Site 183
S1858
I
S
S
L
S
R
C
S
T
S
E
T
S
G
F
Site 184
T1859
S
S
L
S
R
C
S
T
S
E
T
S
G
F
E
Site 185
S1860
S
L
S
R
C
S
T
S
E
T
S
G
F
E
N
Site 186
T1862
S
R
C
S
T
S
E
T
S
G
F
E
N
Q
V
Site 187
S1873
E
N
Q
V
N
E
Q
S
A
P
L
P
V
P
V
Site 188
S1886
P
V
P
V
P
V
P
S
Y
G
G
E
E
P
V
Site 189
Y1887
V
P
V
P
V
P
S
Y
G
G
E
E
P
V
R
Site 190
S1897
E
E
P
V
R
K
E
S
K
T
P
P
P
Y
S
Site 191
T1899
P
V
R
K
E
S
K
T
P
P
P
Y
S
V
Y
Site 192
Y1903
E
S
K
T
P
P
P
Y
S
V
Y
E
R
T
L
Site 193
S1904
S
K
T
P
P
P
Y
S
V
Y
E
R
T
L
R
Site 194
Y1906
T
P
P
P
Y
S
V
Y
E
R
T
L
R
R
P
Site 195
T1909
P
Y
S
V
Y
E
R
T
L
R
R
P
V
P
L
Site 196
T1925
H
S
L
S
I
P
V
T
S
E
P
P
A
L
P
Site 197
S1940
P
K
P
L
A
A
R
S
S
H
L
E
N
G
A
Site 198
S1941
K
P
L
A
A
R
S
S
H
L
E
N
G
A
R
Site 199
T1950
L
E
N
G
A
R
R
T
D
P
G
P
R
P
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation