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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FLJ40584
Full Name:
Protein THEMIS
Alias:
Thymocyte-expressed molecule involved in selection
Type:
Uncharacterized protein
Mass (Da):
73452
Number AA:
643
UniProt ID:
Q8N1K5
International Prot ID:
IPI00166184
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0050852
GO:0006955
GO:0043383
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
S
L
E
E
F
V
H
S
L
D
L
R
T
L
P
Site 2
S72
E
Q
I
E
G
C
E
S
L
Q
P
F
E
L
P
Site 3
T93
F
K
I
V
A
D
K
T
P
Y
L
T
M
E
E
Site 4
T104
T
M
E
E
I
T
R
T
I
H
I
G
P
S
R
Site 5
Y118
R
L
G
H
P
C
F
Y
H
Q
K
D
I
K
L
Site 6
S140
G
E
Q
I
M
L
N
S
V
E
E
I
D
G
E
Site 7
S162
A
R
N
H
Q
T
H
S
F
N
L
P
L
S
Q
Site 8
S168
H
S
F
N
L
P
L
S
Q
E
G
E
F
Y
E
Site 9
Y174
L
S
Q
E
G
E
F
Y
E
C
E
D
E
R
I
Site 10
Y182
E
C
E
D
E
R
I
Y
T
L
K
E
I
V
E
Site 11
T183
C
E
D
E
R
I
Y
T
L
K
E
I
V
E
W
Site 12
T199
I
P
K
N
R
T
R
T
V
N
L
T
D
F
S
Site 13
T203
R
T
R
T
V
N
L
T
D
F
S
N
K
W
D
Site 14
S211
D
F
S
N
K
W
D
S
T
N
P
F
P
K
D
Site 15
Y220
N
P
F
P
K
D
F
Y
G
T
L
I
L
K
P
Site 16
T222
F
P
K
D
F
Y
G
T
L
I
L
K
P
V
Y
Site 17
T256
D
V
E
V
K
D
I
T
D
S
Y
D
A
N
W
Site 18
Y259
V
K
D
I
T
D
S
Y
D
A
N
W
F
L
Q
Site 19
S299
E
G
N
H
L
P
Q
S
I
L
Q
P
G
K
T
Site 20
T306
S
I
L
Q
P
G
K
T
I
V
I
H
K
K
Y
Site 21
S321
Q
A
S
R
I
L
A
S
E
I
R
S
N
F
P
Site 22
S325
I
L
A
S
E
I
R
S
N
F
P
K
R
H
F
Site 23
S337
R
H
F
L
I
P
T
S
Y
K
G
K
F
K
R
Site 24
Y338
H
F
L
I
P
T
S
Y
K
G
K
F
K
R
R
Site 25
S360
Y
D
L
E
I
A
K
S
E
K
E
P
L
H
V
Site 26
T370
E
P
L
H
V
V
A
T
K
A
F
H
S
P
H
Site 27
S375
V
A
T
K
A
F
H
S
P
H
D
K
L
S
S
Site 28
S381
H
S
P
H
D
K
L
S
S
V
S
V
G
D
Q
Site 29
S382
S
P
H
D
K
L
S
S
V
S
V
G
D
Q
F
Site 30
S384
H
D
K
L
S
S
V
S
V
G
D
Q
F
L
V
Site 31
Y444
V
I
H
D
K
K
Q
Y
P
I
S
E
L
C
K
Site 32
S447
D
K
K
Q
Y
P
I
S
E
L
C
K
Q
F
R
Site 33
T476
E
E
D
V
L
A
A
T
P
G
L
Q
L
E
E
Site 34
S488
L
E
E
D
I
T
D
S
Y
L
L
I
S
D
F
Site 35
Y489
E
E
D
I
T
D
S
Y
L
L
I
S
D
F
A
Site 36
S493
T
D
S
Y
L
L
I
S
D
F
A
N
P
T
E
Site 37
S520
V
Q
L
V
S
N
F
S
R
D
A
E
P
F
L
Site 38
Y540
E
E
I
T
E
E
Q
Y
Y
M
M
R
R
Y
E
Site 39
Y541
E
I
T
E
E
Q
Y
Y
M
M
R
R
Y
E
S
Site 40
Y546
Q
Y
Y
M
M
R
R
Y
E
S
S
A
S
H
P
Site 41
S548
Y
M
M
R
R
Y
E
S
S
A
S
H
P
P
P
Site 42
S549
M
M
R
R
Y
E
S
S
A
S
H
P
P
P
R
Site 43
S551
R
R
Y
E
S
S
A
S
H
P
P
P
R
P
P
Site 44
S562
P
R
P
P
K
H
P
S
V
E
E
T
K
L
T
Site 45
T566
K
H
P
S
V
E
E
T
K
L
T
L
L
T
L
Site 46
T569
S
V
E
E
T
K
L
T
L
L
T
L
A
E
E
Site 47
S584
R
T
V
D
L
P
K
S
P
K
R
H
H
V
D
Site 48
T593
K
R
H
H
V
D
I
T
K
K
L
H
P
N
Q
Site 49
S605
P
N
Q
A
G
L
D
S
K
V
L
I
G
S
Q
Site 50
S611
D
S
K
V
L
I
G
S
Q
N
D
L
V
D
E
Site 51
S623
V
D
E
E
K
E
R
S
N
R
G
A
T
A
I
Site 52
T628
E
R
S
N
R
G
A
T
A
I
A
E
T
F
K
Site 53
T633
G
A
T
A
I
A
E
T
F
K
N
E
K
H
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation