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Updated November 2019
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Protein Info
Short Name:
INTS1
Full Name:
Integrator complex subunit 1
Alias:
DKFZp586J0619; INT1; INT1_HUMAN; KIAA1440; NET28
Type:
Membrane protein, integral, RNA processing
Mass (Da):
244297
Number AA:
2190
UniProt ID:
Q8N201
International Prot ID:
IPI00166215
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0032039
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0016180
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
N
R
A
K
P
T
T
V
R
R
P
S
A
A
Site 2
S13
P
T
T
V
R
R
P
S
A
A
A
K
P
S
G
Site 3
S19
P
S
A
A
A
K
P
S
G
H
P
P
P
G
D
Site 4
S39
S
K
G
Q
A
N
E
S
K
T
A
S
T
L
L
Site 5
T41
G
Q
A
N
E
S
K
T
A
S
T
L
L
K
P
Site 6
S43
A
N
E
S
K
T
A
S
T
L
L
K
P
A
P
Site 7
S51
T
L
L
K
P
A
P
S
G
L
P
S
E
R
K
Site 8
S55
P
A
P
S
G
L
P
S
E
R
K
R
D
A
A
Site 9
S66
R
D
A
A
A
A
L
S
S
A
S
A
L
T
G
Site 10
T75
A
S
A
L
T
G
L
T
K
R
P
K
L
S
S
Site 11
S81
L
T
K
R
P
K
L
S
S
T
P
P
L
S
A
Site 12
S82
T
K
R
P
K
L
S
S
T
P
P
L
S
A
L
Site 13
T83
K
R
P
K
L
S
S
T
P
P
L
S
A
L
G
Site 14
S87
L
S
S
T
P
P
L
S
A
L
G
R
L
A
E
Site 15
S104
V
A
E
K
R
A
I
S
P
S
I
K
E
P
S
Site 16
S106
E
K
R
A
I
S
P
S
I
K
E
P
S
V
V
Site 17
S158
V
T
R
A
K
P
D
S
T
L
Y
L
S
L
M
Site 18
T159
T
R
A
K
P
D
S
T
L
Y
L
S
L
M
Y
Site 19
Y161
A
K
P
D
S
T
L
Y
L
S
L
M
Y
L
A
Site 20
S193
S
L
L
R
R
D
A
S
I
N
F
K
A
K
G
Site 21
Y216
C
N
L
L
M
A
A
Y
E
E
D
E
N
W
P
Site 22
T248
V
D
S
P
H
C
K
T
F
V
D
N
I
Q
T
Site 23
S265
N
T
R
M
P
P
R
S
V
L
L
Q
G
E
A
Site 24
S283
A
G
D
L
G
A
G
S
S
P
H
P
S
L
T
Site 25
S284
G
D
L
G
A
G
S
S
P
H
P
S
L
T
E
Site 26
S288
A
G
S
S
P
H
P
S
L
T
E
E
E
D
S
Site 27
T290
S
S
P
H
P
S
L
T
E
E
E
D
S
Q
T
Site 28
S295
S
L
T
E
E
E
D
S
Q
T
E
L
L
I
A
Site 29
T297
T
E
E
E
D
S
Q
T
E
L
L
I
A
E
E
Site 30
S307
L
I
A
E
E
K
L
S
P
E
Q
E
G
Q
L
Site 31
Y318
E
G
Q
L
M
P
R
Y
E
E
L
A
E
S
V
Site 32
S324
R
Y
E
E
L
A
E
S
V
E
E
Y
V
L
D
Site 33
Y328
L
A
E
S
V
E
E
Y
V
L
D
M
L
R
D
Site 34
T355
R
N
L
L
R
L
L
T
S
T
C
G
Y
K
E
Site 35
S451
L
V
I
F
N
E
L
S
S
A
R
N
P
N
N
Site 36
S452
V
I
F
N
E
L
S
S
A
R
N
P
N
N
M
Site 37
Y463
P
N
N
M
Q
V
L
Y
T
A
L
Q
H
S
S
Site 38
T486
M
V
F
Q
D
L
L
T
N
K
D
D
Y
L
R
Site 39
Y491
L
L
T
N
K
D
D
Y
L
R
A
S
R
A
L
Site 40
S495
K
D
D
Y
L
R
A
S
R
A
L
L
R
E
I
Site 41
Y528
Q
E
R
K
E
P
Q
Y
L
E
M
E
F
K
E
Site 42
S577
R
N
L
E
V
L
R
S
F
Q
N
Q
I
A
A
Site 43
Y608
S
K
L
A
P
K
D
Y
V
H
C
L
H
K
V
Site 44
T618
C
L
H
K
V
L
F
T
E
Q
P
E
T
Y
Y
Site 45
Y711
A
V
L
N
L
C
T
Y
H
H
P
E
N
I
Q
Site 46
Y723
N
I
Q
L
P
P
G
Y
Q
P
P
N
L
A
I
Site 47
Y775
E
M
V
M
T
N
N
Y
S
Y
P
P
C
T
L
Site 48
Y777
V
M
T
N
N
Y
S
Y
P
P
C
T
L
T
D
Site 49
T781
N
Y
S
Y
P
P
C
T
L
T
D
E
E
T
R
Site 50
T783
S
Y
P
P
C
T
L
T
D
E
E
T
R
T
E
Site 51
T789
L
T
D
E
E
T
R
T
E
M
L
N
R
E
L
Site 52
T821
A
A
A
S
T
K
Q
T
I
T
E
S
S
S
L
Site 53
T823
A
S
T
K
Q
T
I
T
E
S
S
S
L
L
L
Site 54
S825
T
K
Q
T
I
T
E
S
S
S
L
L
L
S
Q
Site 55
S831
E
S
S
S
L
L
L
S
Q
L
T
S
L
D
P
Site 56
S835
L
L
L
S
Q
L
T
S
L
D
P
Q
G
P
P
Site 57
S855
H
I
L
D
Q
V
K
S
L
N
Q
S
L
R
L
Site 58
S859
Q
V
K
S
L
N
Q
S
L
R
L
G
H
L
L
Site 59
S884
H
I
I
Q
R
Q
A
S
S
Q
S
M
P
W
L
Site 60
S885
I
I
Q
R
Q
A
S
S
Q
S
M
P
W
L
A
Site 61
S924
D
A
V
D
D
A
A
S
G
E
E
D
D
E
G
Site 62
T967
G
P
K
A
D
E
Q
T
T
C
E
V
L
D
Y
Site 63
Y974
T
T
C
E
V
L
D
Y
F
L
R
R
L
G
S
Site 64
S981
Y
F
L
R
R
L
G
S
S
Q
V
A
S
R
V
Site 65
S999
K
G
L
S
L
V
L
S
E
G
S
L
R
D
G
Site 66
S1002
S
L
V
L
S
E
G
S
L
R
D
G
E
E
K
Site 67
T1020
M
E
E
D
V
G
D
T
D
V
L
Q
G
Y
Q
Site 68
S1041
P
R
L
P
L
F
D
S
V
R
S
T
T
A
L
Site 69
T1046
F
D
S
V
R
S
T
T
A
L
A
L
Q
Q
A
Site 70
T1062
H
M
E
T
D
P
Q
T
I
S
A
Y
L
I
Y
Site 71
Y1066
D
P
Q
T
I
S
A
Y
L
I
Y
L
S
Q
H
Site 72
S1071
S
A
Y
L
I
Y
L
S
Q
H
T
P
V
E
E
Site 73
T1074
L
I
Y
L
S
Q
H
T
P
V
E
E
Q
A
Q
Site 74
S1097
A
R
L
V
V
E
R
S
T
I
M
S
H
L
F
Site 75
S1101
V
E
R
S
T
I
M
S
H
L
F
S
K
L
S
Site 76
S1105
T
I
M
S
H
L
F
S
K
L
S
P
S
A
A
Site 77
S1108
S
H
L
F
S
K
L
S
P
S
A
A
S
D
A
Site 78
S1125
S
A
L
L
S
I
F
S
R
Y
V
R
R
M
R
Site 79
Y1127
L
L
S
I
F
S
R
Y
V
R
R
M
R
Q
S
Site 80
S1134
Y
V
R
R
M
R
Q
S
K
E
G
E
E
V
Y
Site 81
Y1141
S
K
E
G
E
E
V
Y
S
W
S
E
S
Q
D
Site 82
S1142
K
E
G
E
E
V
Y
S
W
S
E
S
Q
D
Q
Site 83
S1144
G
E
E
V
Y
S
W
S
E
S
Q
D
Q
V
F
Site 84
S1146
E
V
Y
S
W
S
E
S
Q
D
Q
V
F
L
R
Site 85
S1155
D
Q
V
F
L
R
W
S
S
G
E
T
A
T
M
Site 86
S1156
Q
V
F
L
R
W
S
S
G
E
T
A
T
M
H
Site 87
S1184
G
P
P
R
A
D
D
S
E
F
Q
A
L
L
D
Site 88
T1275
A
V
A
H
D
P
Q
T
L
E
Q
N
I
M
D
Site 89
Y1285
Q
N
I
M
D
K
N
Y
M
A
H
L
V
E
V
Site 90
S1299
V
Q
H
E
R
G
A
S
G
G
Q
T
F
H
S
Site 91
T1303
R
G
A
S
G
G
Q
T
F
H
S
L
L
T
A
Site 92
S1311
F
H
S
L
L
T
A
S
L
P
P
R
R
D
S
Site 93
S1318
S
L
P
P
R
R
D
S
T
E
A
P
K
P
K
Site 94
T1319
L
P
P
R
R
D
S
T
E
A
P
K
P
K
S
Site 95
S1326
T
E
A
P
K
P
K
S
S
P
E
Q
P
I
G
Site 96
S1327
E
A
P
K
P
K
S
S
P
E
Q
P
I
G
Q
Site 97
T1341
Q
G
R
I
R
V
G
T
Q
L
R
V
L
G
P
Site 98
S1363
F
L
Q
I
F
P
L
S
P
D
P
R
W
Q
S
Site 99
S1370
S
P
D
P
R
W
Q
S
S
S
P
R
P
V
A
Site 100
S1371
P
D
P
R
W
Q
S
S
S
P
R
P
V
A
L
Site 101
S1372
D
P
R
W
Q
S
S
S
P
R
P
V
A
L
A
Site 102
S1395
L
A
R
V
V
Q
G
S
P
E
V
P
G
I
T
Site 103
S1415
A
L
A
T
L
L
S
S
P
H
G
G
A
L
V
Site 104
Y1442
L
L
R
Q
L
C
Q
Y
Q
R
C
V
P
Q
D
Site 105
T1450
Q
R
C
V
P
Q
D
T
G
F
S
S
L
F
L
Site 106
S1469
Q
M
L
Q
W
L
D
S
P
G
V
E
G
G
P
Site 107
S1486
A
Q
L
R
M
L
A
S
Q
A
S
A
G
R
R
Site 108
S1489
R
M
L
A
S
Q
A
S
A
G
R
R
L
S
D
Site 109
S1495
A
S
A
G
R
R
L
S
D
V
R
G
G
L
L
Site 110
S1535
L
R
S
G
E
Q
C
S
V
E
P
D
L
I
S
Site 111
S1553
Q
G
L
I
E
V
R
S
P
H
L
E
E
L
L
Site 112
S1572
S
A
T
A
D
A
A
S
P
F
P
A
C
K
P
Site 113
S1605
K
P
G
A
D
G
G
S
L
E
A
V
R
L
G
Site 114
S1632
L
D
P
E
V
V
S
S
C
P
D
L
Q
L
R
Site 115
S1643
L
Q
L
R
L
L
F
S
R
R
K
G
K
G
Q
Site 116
S1655
K
G
Q
A
Q
V
P
S
F
R
P
Y
L
L
T
Site 117
T1662
S
F
R
P
Y
L
L
T
L
F
T
H
Q
S
S
Site 118
T1665
P
Y
L
L
T
L
F
T
H
Q
S
S
W
P
T
Site 119
S1692
R
E
Q
R
F
D
P
S
A
S
L
D
F
L
W
Site 120
S1694
Q
R
F
D
P
S
A
S
L
D
F
L
W
A
C
Site 121
T1715
W
Q
G
R
D
Q
R
T
P
Q
K
R
R
E
E
Site 122
T1752
T
R
S
Q
D
G
D
T
A
A
C
S
L
I
Q
Site 123
T1780
D
E
S
V
R
K
V
T
E
H
L
S
G
C
I
Site 124
Y1807
R
D
L
L
L
Q
L
Y
L
Q
R
P
E
L
R
Site 125
S1830
H
S
E
G
A
A
S
S
S
V
C
K
L
D
G
Site 126
S1831
S
E
G
A
A
S
S
S
V
C
K
L
D
G
L
Site 127
S1850
I
T
L
L
A
D
T
S
D
S
R
A
L
E
N
Site 128
S1863
E
N
R
G
A
D
A
S
M
A
C
R
K
L
A
Site 129
Y1945
F
I
R
L
L
L
N
Y
R
K
S
S
R
H
L
Site 130
S1948
L
L
L
N
Y
R
K
S
S
R
H
L
A
A
F
Site 131
S1949
L
L
N
Y
R
K
S
S
R
H
L
A
A
F
I
Site 132
S1976
Y
N
A
P
A
A
I
S
F
L
Q
K
H
A
D
Site 133
S1989
A
D
P
L
H
D
L
S
F
D
N
S
D
L
V
Site 134
S1993
H
D
L
S
F
D
N
S
D
L
V
M
L
K
S
Site 135
S2006
K
S
L
L
A
G
L
S
L
P
S
R
D
D
R
Site 136
T2014
L
P
S
R
D
D
R
T
D
R
G
L
D
E
E
Site 137
S2026
D
E
E
G
E
E
E
S
S
A
G
S
L
P
L
Site 138
S2027
E
E
G
E
E
E
S
S
A
G
S
L
P
L
V
Site 139
S2030
E
E
E
S
S
A
G
S
L
P
L
V
S
V
S
Site 140
Y2050
T
A
A
E
M
A
P
Y
M
K
R
L
S
R
G
Site 141
S2055
A
P
Y
M
K
R
L
S
R
G
Q
T
V
E
D
Site 142
T2059
K
R
L
S
R
G
Q
T
V
E
D
L
L
E
V
Site 143
S2068
E
D
L
L
E
V
L
S
D
I
D
E
M
S
R
Site 144
S2074
L
S
D
I
D
E
M
S
R
R
R
P
E
I
L
Site 145
S2082
R
R
R
P
E
I
L
S
F
F
S
T
N
L
Q
Site 146
S2093
T
N
L
Q
R
L
M
S
S
A
E
E
C
C
R
Site 147
S2116
R
S
M
Q
N
S
P
S
I
A
A
A
F
L
P
Site 148
T2139
Q
D
F
E
V
V
Q
T
A
L
R
N
L
P
E
Site 149
Y2147
A
L
R
N
L
P
E
Y
A
L
L
C
Q
E
H
Site 150
S2174
M
Y
G
Q
M
D
P
S
A
Q
I
S
E
A
L
Site 151
S2178
M
D
P
S
A
Q
I
S
E
A
L
R
I
L
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation