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Updated November 2019
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Protein Info
Short Name:
SCML4
Full Name:
Sex comb on midleg-like protein 4
Alias:
Type:
Mass (Da):
45023
Number AA:
414
UniProt ID:
Q8N228
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
G
R
K
R
G
R
P
S
L
H
S
T
P
M
K
Site 2
S18
R
G
R
P
S
L
H
S
T
P
M
K
M
A
V
Site 3
T19
G
R
P
S
L
H
S
T
P
M
K
M
A
V
H
Site 4
Y51
K
R
G
R
K
P
G
Y
K
I
K
S
R
V
L
Site 5
S55
K
P
G
Y
K
I
K
S
R
V
L
M
T
P
L
Site 6
S65
L
M
T
P
L
A
L
S
P
P
R
S
T
P
E
Site 7
S69
L
A
L
S
P
P
R
S
T
P
E
P
D
L
S
Site 8
T70
A
L
S
P
P
R
S
T
P
E
P
D
L
S
S
Site 9
S76
S
T
P
E
P
D
L
S
S
I
P
Q
D
A
A
Site 10
S77
T
P
E
P
D
L
S
S
I
P
Q
D
A
A
T
Site 11
S128
H
F
G
P
E
R
P
S
A
V
L
Q
Q
A
V
Site 12
S150
H
Q
Q
K
L
V
F
S
L
V
K
Q
G
Y
G
Site 13
S162
G
Y
G
G
E
M
V
S
V
S
A
S
F
D
G
Site 14
S164
G
G
E
M
V
S
V
S
A
S
F
D
G
K
Q
Site 15
S166
E
M
V
S
V
S
A
S
F
D
G
K
Q
H
L
Site 16
S175
D
G
K
Q
H
L
R
S
L
P
V
V
N
S
I
Site 17
S203
L
L
C
D
D
L
F
S
H
Q
P
F
P
R
G
Site 18
S212
Q
P
F
P
R
G
C
S
A
S
E
K
V
Q
E
Site 19
S214
F
P
R
G
C
S
A
S
E
K
V
Q
E
K
E
Site 20
S227
K
E
E
G
R
M
E
S
V
K
T
V
T
T
E
Site 21
T230
G
R
M
E
S
V
K
T
V
T
T
E
E
Y
L
Site 22
Y236
K
T
V
T
T
E
E
Y
L
V
N
P
V
G
M
Site 23
S247
P
V
G
M
N
R
Y
S
V
D
T
S
A
S
T
Site 24
T250
M
N
R
Y
S
V
D
T
S
A
S
T
F
N
H
Site 25
S251
N
R
Y
S
V
D
T
S
A
S
T
F
N
H
R
Site 26
T254
S
V
D
T
S
A
S
T
F
N
H
R
G
S
L
Site 27
S260
S
T
F
N
H
R
G
S
L
H
P
S
S
S
L
Site 28
S264
H
R
G
S
L
H
P
S
S
S
L
Y
C
K
R
Site 29
S265
R
G
S
L
H
P
S
S
S
L
Y
C
K
R
Q
Site 30
S266
G
S
L
H
P
S
S
S
L
Y
C
K
R
Q
N
Site 31
Y268
L
H
P
S
S
S
L
Y
C
K
R
Q
N
S
G
Site 32
S274
L
Y
C
K
R
Q
N
S
G
D
S
H
L
G
G
Site 33
S277
K
R
Q
N
S
G
D
S
H
L
G
G
G
P
A
Site 34
T292
A
T
A
G
G
P
R
T
S
P
M
S
S
G
G
Site 35
S293
T
A
G
G
P
R
T
S
P
M
S
S
G
G
P
Site 36
S296
G
P
R
T
S
P
M
S
S
G
G
P
S
A
P
Site 37
S297
P
R
T
S
P
M
S
S
G
G
P
S
A
P
G
Site 38
S301
P
M
S
S
G
G
P
S
A
P
G
L
R
P
P
Site 39
S310
P
G
L
R
P
P
A
S
S
P
K
R
N
T
T
Site 40
S311
G
L
R
P
P
A
S
S
P
K
R
N
T
T
S
Site 41
T316
A
S
S
P
K
R
N
T
T
S
L
E
G
N
R
Site 42
T317
S
S
P
K
R
N
T
T
S
L
E
G
N
R
C
Site 43
S318
S
P
K
R
N
T
T
S
L
E
G
N
R
C
A
Site 44
S326
L
E
G
N
R
C
A
S
S
P
S
Q
D
A
Q
Site 45
S327
E
G
N
R
C
A
S
S
P
S
Q
D
A
Q
D
Site 46
S340
Q
D
A
R
R
P
R
S
R
N
P
S
A
W
T
Site 47
S344
R
P
R
S
R
N
P
S
A
W
T
V
E
D
V
Site 48
Y391
K
S
D
M
V
M
K
Y
L
G
L
K
L
G
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation