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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARHGAP24
Full Name:
Rho GTPase-activating protein 24
Alias:
DKFZP564B1162; Filamin-A-associated RhoGAP; FILGAP; FLJ33877; P73; P73RhoGAP; RAC1- and CDC42-specific GTPase-activating protein of 72 kDa; RAC1-and CDC42-specific GTPase-activating protein of 72 kDa; RCGAP72; RC-GAP72; RHG24; Rho GTPase activating protein 24; RhoGAP of 73 kDa; Rho-type GTPase-activating protein 24; Sarcoma antigen NY-SAR-88; Sarcoma NY-SAR-88
Type:
Mass (Da):
84258
Number AA:
748
UniProt ID:
Q8N264
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0042995
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005096
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0001525
GO:0030154
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
E
E
N
N
D
S
T
E
N
P
Q
Q
G
Site 2
T8
M
E
E
N
N
D
S
T
E
N
P
Q
Q
G
Q
Site 3
Y49
V
L
K
G
D
Q
L
Y
Y
F
K
D
E
D
E
Site 4
Y50
L
K
G
D
Q
L
Y
Y
F
K
D
E
D
E
T
Site 5
T57
Y
F
K
D
E
D
E
T
K
P
L
G
T
I
F
Site 6
S71
F
L
P
G
N
K
V
S
E
H
P
C
N
E
E
Site 7
T97
G
G
D
R
D
R
M
T
A
N
H
E
S
Y
L
Site 8
T140
F
G
Q
K
L
E
D
T
V
R
Y
E
K
R
Y
Site 9
Y143
K
L
E
D
T
V
R
Y
E
K
R
Y
G
N
R
Site 10
Y147
T
V
R
Y
E
K
R
Y
G
N
R
L
A
P
M
Site 11
S197
F
D
C
G
E
K
P
S
F
D
S
N
T
D
V
Site 12
S200
G
E
K
P
S
F
D
S
N
T
D
V
H
T
V
Site 13
T202
K
P
S
F
D
S
N
T
D
V
H
T
V
A
S
Site 14
T206
D
S
N
T
D
V
H
T
V
A
S
L
L
K
L
Site 15
S233
A
K
Y
E
D
F
L
S
C
A
K
L
L
S
K
Site 16
S239
L
S
C
A
K
L
L
S
K
E
E
E
A
G
V
Site 17
S255
E
L
A
K
Q
V
K
S
L
P
V
V
N
Y
N
Site 18
Y266
V
N
Y
N
L
L
K
Y
I
C
R
F
L
D
E
Site 19
S276
R
F
L
D
E
V
Q
S
Y
S
G
V
N
K
M
Site 20
Y277
F
L
D
E
V
Q
S
Y
S
G
V
N
K
M
S
Site 21
S278
L
D
E
V
Q
S
Y
S
G
V
N
K
M
S
V
Site 22
S337
P
K
D
A
E
L
Q
S
K
P
Q
D
G
V
S
Site 23
S344
S
K
P
Q
D
G
V
S
N
N
N
E
I
Q
K
Site 24
T354
N
E
I
Q
K
K
A
T
M
G
Q
L
Q
N
K
Site 25
S369
E
N
N
N
T
K
D
S
P
S
R
Q
C
S
W
Site 26
S371
N
N
T
K
D
S
P
S
R
Q
C
S
W
D
K
Site 27
S375
D
S
P
S
R
Q
C
S
W
D
K
S
E
S
P
Site 28
S379
R
Q
C
S
W
D
K
S
E
S
P
Q
R
S
S
Site 29
S381
C
S
W
D
K
S
E
S
P
Q
R
S
S
M
N
Site 30
S385
K
S
E
S
P
Q
R
S
S
M
N
N
G
S
P
Site 31
S386
S
E
S
P
Q
R
S
S
M
N
N
G
S
P
T
Site 32
S391
R
S
S
M
N
N
G
S
P
T
A
L
S
G
S
Site 33
T393
S
M
N
N
G
S
P
T
A
L
S
G
S
K
T
Site 34
S396
N
G
S
P
T
A
L
S
G
S
K
T
N
S
P
Site 35
S398
S
P
T
A
L
S
G
S
K
T
N
S
P
K
N
Site 36
T400
T
A
L
S
G
S
K
T
N
S
P
K
N
S
V
Site 37
S402
L
S
G
S
K
T
N
S
P
K
N
S
V
H
K
Site 38
S406
K
T
N
S
P
K
N
S
V
H
K
L
D
V
S
Site 39
S413
S
V
H
K
L
D
V
S
R
S
P
P
L
M
V
Site 40
S415
H
K
L
D
V
S
R
S
P
P
L
M
V
K
K
Site 41
S430
N
P
A
F
N
K
G
S
G
I
V
T
N
G
S
Site 42
T434
N
K
G
S
G
I
V
T
N
G
S
F
S
S
S
Site 43
S437
S
G
I
V
T
N
G
S
F
S
S
S
N
A
E
Site 44
S439
I
V
T
N
G
S
F
S
S
S
N
A
E
G
L
Site 45
S441
T
N
G
S
F
S
S
S
N
A
E
G
L
E
K
Site 46
T451
E
G
L
E
K
T
Q
T
T
P
N
G
S
L
Q
Site 47
T452
G
L
E
K
T
Q
T
T
P
N
G
S
L
Q
A
Site 48
S462
G
S
L
Q
A
R
R
S
S
S
L
K
V
S
G
Site 49
S463
S
L
Q
A
R
R
S
S
S
L
K
V
S
G
T
Site 50
S464
L
Q
A
R
R
S
S
S
L
K
V
S
G
T
K
Site 51
S468
R
S
S
S
L
K
V
S
G
T
K
M
G
T
H
Site 52
T470
S
S
L
K
V
S
G
T
K
M
G
T
H
S
V
Site 53
S476
G
T
K
M
G
T
H
S
V
Q
N
G
T
V
R
Site 54
T481
T
H
S
V
Q
N
G
T
V
R
M
G
I
L
N
Site 55
S489
V
R
M
G
I
L
N
S
D
T
L
G
N
P
T
Site 56
T491
M
G
I
L
N
S
D
T
L
G
N
P
T
N
V
Site 57
Y508
M
S
W
L
P
N
G
Y
V
T
L
R
D
N
K
Site 58
T510
W
L
P
N
G
Y
V
T
L
R
D
N
K
Q
K
Site 59
S530
L
G
Q
H
N
R
L
S
T
Y
D
N
V
H
Q
Site 60
T531
G
Q
H
N
R
L
S
T
Y
D
N
V
H
Q
Q
Site 61
Y532
Q
H
N
R
L
S
T
Y
D
N
V
H
Q
Q
F
Site 62
S549
M
N
L
D
D
K
Q
S
I
D
S
A
T
W
S
Site 63
S552
D
D
K
Q
S
I
D
S
A
T
W
S
T
S
S
Site 64
T554
K
Q
S
I
D
S
A
T
W
S
T
S
S
C
E
Site 65
S556
S
I
D
S
A
T
W
S
T
S
S
C
E
I
S
Site 66
S558
D
S
A
T
W
S
T
S
S
C
E
I
S
L
P
Site 67
S559
S
A
T
W
S
T
S
S
C
E
I
S
L
P
E
Site 68
S563
S
T
S
S
C
E
I
S
L
P
E
N
S
N
S
Site 69
S568
E
I
S
L
P
E
N
S
N
S
C
R
S
S
T
Site 70
S570
S
L
P
E
N
S
N
S
C
R
S
S
T
T
T
Site 71
S574
N
S
N
S
C
R
S
S
T
T
T
C
P
E
Q
Site 72
T575
S
N
S
C
R
S
S
T
T
T
C
P
E
Q
D
Site 73
T577
S
C
R
S
S
T
T
T
C
P
E
Q
D
F
F
Site 74
S602
G
P
P
Q
D
D
L
S
H
P
R
D
Y
E
S
Site 75
Y607
D
L
S
H
P
R
D
Y
E
S
K
S
D
H
R
Site 76
S609
S
H
P
R
D
Y
E
S
K
S
D
H
R
S
V
Site 77
S611
P
R
D
Y
E
S
K
S
D
H
R
S
V
G
G
Site 78
S615
E
S
K
S
D
H
R
S
V
G
G
R
S
S
R
Site 79
S620
H
R
S
V
G
G
R
S
S
R
A
T
S
S
S
Site 80
S621
R
S
V
G
G
R
S
S
R
A
T
S
S
S
D
Site 81
T624
G
G
R
S
S
R
A
T
S
S
S
D
N
S
E
Site 82
S625
G
R
S
S
R
A
T
S
S
S
D
N
S
E
T
Site 83
S626
R
S
S
R
A
T
S
S
S
D
N
S
E
T
F
Site 84
S627
S
S
R
A
T
S
S
S
D
N
S
E
T
F
V
Site 85
S630
A
T
S
S
S
D
N
S
E
T
F
V
G
N
S
Site 86
T632
S
S
S
D
N
S
E
T
F
V
G
N
S
S
S
Site 87
S637
S
E
T
F
V
G
N
S
S
S
N
H
S
A
L
Site 88
S638
E
T
F
V
G
N
S
S
S
N
H
S
A
L
H
Site 89
S639
T
F
V
G
N
S
S
S
N
H
S
A
L
H
S
Site 90
S642
G
N
S
S
S
N
H
S
A
L
H
S
L
V
S
Site 91
S646
S
N
H
S
A
L
H
S
L
V
S
S
L
K
Q
Site 92
S649
S
A
L
H
S
L
V
S
S
L
K
Q
E
M
T
Site 93
S650
A
L
H
S
L
V
S
S
L
K
Q
E
M
T
K
Site 94
T656
S
S
L
K
Q
E
M
T
K
Q
K
I
E
Y
E
Site 95
Y662
M
T
K
Q
K
I
E
Y
E
S
R
I
K
S
L
Site 96
S664
K
Q
K
I
E
Y
E
S
R
I
K
S
L
E
Q
Site 97
S668
E
Y
E
S
R
I
K
S
L
E
Q
R
N
L
T
Site 98
T675
S
L
E
Q
R
N
L
T
L
E
T
E
M
M
S
Site 99
T678
Q
R
N
L
T
L
E
T
E
M
M
S
L
H
D
Site 100
S682
T
L
E
T
E
M
M
S
L
H
D
E
L
D
Q
Site 101
S727
K
E
M
E
Q
F
F
S
T
F
G
E
L
T
V
Site 102
T728
E
M
E
Q
F
F
S
T
F
G
E
L
T
V
E
Site 103
T733
F
S
T
F
G
E
L
T
V
E
P
R
R
T
E
Site 104
T739
L
T
V
E
P
R
R
T
E
R
G
N
T
I
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation