KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PYROXD2
Full Name:
Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2
Alias:
Type:
Mass (Da):
63068
Number AA:
581
UniProt ID:
Q8N2H3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T25
P
A
W
R
R
D
N
T
E
A
R
G
G
L
K
Site 2
T60
L
Q
R
L
G
V
N
T
A
V
F
E
R
R
H
Site 3
S92
S
R
A
S
Y
L
L
S
L
L
R
P
Q
I
Y
Site 4
Y99
S
L
L
R
P
Q
I
Y
T
D
L
E
L
K
K
Site 5
T100
L
L
R
P
Q
I
Y
T
D
L
E
L
K
K
H
Site 6
Y117
R
L
H
L
R
N
P
Y
S
F
T
P
M
L
E
Site 7
S118
L
H
L
R
N
P
Y
S
F
T
P
M
L
E
E
Site 8
T120
L
R
N
P
Y
S
F
T
P
M
L
E
E
G
A
Site 9
S152
Q
K
Q
I
A
Q
F
S
Q
K
D
A
Q
V
F
Site 10
Y162
D
A
Q
V
F
P
K
Y
E
E
F
M
H
R
L
Site 11
S198
S
L
L
Q
R
M
R
S
L
S
T
L
K
P
L
Site 12
S200
L
Q
R
M
R
S
L
S
T
L
K
P
L
L
K
Site 13
T201
Q
R
M
R
S
L
S
T
L
K
P
L
L
K
A
Site 14
T258
G
A
M
T
S
P
H
T
P
G
S
G
Y
V
L
Site 15
S261
T
S
P
H
T
P
G
S
G
Y
V
L
L
H
H
Site 16
Y282
G
M
Q
G
A
W
G
Y
V
Q
G
G
M
G
A
Site 17
T331
G
V
V
L
E
D
G
T
E
V
R
S
K
M
V
Site 18
S340
V
R
S
K
M
V
L
S
N
T
S
P
Q
I
T
Site 19
S343
K
M
V
L
S
N
T
S
P
Q
I
T
F
L
K
Site 20
T347
S
N
T
S
P
Q
I
T
F
L
K
L
T
P
Q
Site 21
T352
Q
I
T
F
L
K
L
T
P
Q
E
W
L
P
E
Site 22
S366
E
E
F
L
E
R
I
S
Q
L
D
T
R
S
P
Site 23
T370
E
R
I
S
Q
L
D
T
R
S
P
V
T
K
I
Site 24
S372
I
S
Q
L
D
T
R
S
P
V
T
K
I
N
V
Site 25
S429
D
A
M
D
G
L
P
S
H
R
P
V
I
E
L
Site 26
T445
I
P
S
S
L
D
P
T
L
A
P
P
G
C
H
Site 27
Y479
D
E
Q
E
R
D
A
Y
A
D
R
V
F
D
C
Site 28
S540
A
R
P
V
P
L
H
S
G
Y
R
C
P
L
Q
Site 29
Y542
P
V
P
L
H
S
G
Y
R
C
P
L
Q
G
L
Site 30
S554
Q
G
L
Y
L
C
G
S
G
A
H
P
G
G
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation