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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LTBP4
Full Name:
Latent-transforming growth factor beta-binding protein 4
Alias:
FLJ46318; FLJ90018; latent transforming growth factor beta binding protein 4; latent transforming growth factor-beta binding protein 4; latent transforming growth factor-beta binding protein 4L; LTBP-4; LTBP-4L
Type:
Extracellular matrix
Mass (Da):
173417
Number AA:
1624
UniProt ID:
Q8N2S1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005578
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005539
GO:0005178
PhosphoSite+
KinaseNET
Biological Process:
GO:0030252
GO:0007275
GO:0006457
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
P
R
P
G
T
S
G
R
R
P
L
L
Site 2
S7
_
M
P
R
P
G
T
S
G
R
R
P
L
L
L
Site 3
S29
A
A
A
T
S
A
A
S
P
S
P
S
P
S
Q
Site 4
S31
A
T
S
A
A
S
P
S
P
S
P
S
Q
V
V
Site 5
S33
S
A
A
S
P
S
P
S
P
S
Q
V
V
E
V
Site 6
S35
A
S
P
S
P
S
P
S
Q
V
V
E
V
P
G
Site 7
S61
R
C
C
P
G
Q
T
S
R
R
S
R
C
I
R
Site 8
S64
P
G
Q
T
S
R
R
S
R
C
I
R
A
F
C
Site 9
S96
N
P
V
P
A
V
P
S
P
S
P
S
V
R
K
Site 10
S98
V
P
A
V
P
S
P
S
P
S
V
R
K
R
Q
Site 11
S100
A
V
P
S
P
S
P
S
V
R
K
R
Q
V
S
Site 12
S107
S
V
R
K
R
Q
V
S
L
N
W
Q
P
L
T
Site 13
T114
S
L
N
W
Q
P
L
T
L
Q
E
A
R
A
L
Site 14
S185
K
F
C
Q
L
H
S
S
G
A
R
P
P
A
P
Site 15
Y202
P
G
L
T
R
S
V
Y
T
M
P
L
A
N
H
Site 16
S221
H
G
V
A
S
M
V
S
V
H
V
E
H
P
Q
Site 17
S241
V
H
Q
V
E
R
V
S
G
P
W
E
E
A
D
Site 18
S273
P
Y
T
V
L
A
Q
S
A
P
R
E
D
G
Y
Site 19
Y280
S
A
P
R
E
D
G
Y
S
D
A
S
G
F
G
Site 20
S281
A
P
R
E
D
G
Y
S
D
A
S
G
F
G
Y
Site 21
S284
E
D
G
Y
S
D
A
S
G
F
G
Y
C
F
R
Site 22
Y288
S
D
A
S
G
F
G
Y
C
F
R
E
L
R
G
Site 23
S300
L
R
G
G
E
C
A
S
P
L
P
G
L
R
T
Site 24
T307
S
P
L
P
G
L
R
T
Q
E
V
C
C
R
G
Site 25
S328
V
H
D
C
Q
L
C
S
E
R
L
G
N
S
E
Site 26
S334
C
S
E
R
L
G
N
S
E
R
V
S
A
P
D
Site 27
S338
L
G
N
S
E
R
V
S
A
P
D
G
P
C
P
Site 28
S354
G
F
E
R
V
N
G
S
C
E
D
V
D
E
C
Site 29
Y379
C
A
N
T
R
G
G
Y
T
C
V
C
P
D
G
Site 30
S391
P
D
G
F
L
L
D
S
S
R
S
S
C
I
S
Site 31
S392
D
G
F
L
L
D
S
S
R
S
S
C
I
S
Q
Site 32
S394
F
L
L
D
S
S
R
S
S
C
I
S
Q
H
V
Site 33
S398
S
S
R
S
S
C
I
S
Q
H
V
I
S
E
A
Site 34
Y465
I
C
P
A
G
P
G
Y
H
Y
S
A
S
D
L
Site 35
Y467
P
A
G
P
G
Y
H
Y
S
A
S
D
L
R
Y
Site 36
S468
A
G
P
G
Y
H
Y
S
A
S
D
L
R
Y
N
Site 37
S470
P
G
Y
H
Y
S
A
S
D
L
R
Y
N
T
R
Site 38
Y474
Y
S
A
S
D
L
R
Y
N
T
R
P
L
G
Q
Site 39
T476
A
S
D
L
R
Y
N
T
R
P
L
G
Q
E
P
Site 40
S487
G
Q
E
P
P
R
V
S
L
S
Q
P
R
T
L
Site 41
S489
E
P
P
R
V
S
L
S
Q
P
R
T
L
P
A
Site 42
T493
V
S
L
S
Q
P
R
T
L
P
A
T
S
R
P
Site 43
T497
Q
P
R
T
L
P
A
T
S
R
P
S
A
G
F
Site 44
S501
L
P
A
T
S
R
P
S
A
G
F
L
P
T
H
Site 45
T507
P
S
A
G
F
L
P
T
H
R
L
E
P
R
P
Site 46
S530
G
P
E
L
P
L
P
S
I
P
A
W
T
G
P
Site 47
S542
T
G
P
E
I
P
E
S
G
P
S
S
G
M
C
Site 48
S546
I
P
E
S
G
P
S
S
G
M
C
Q
R
N
P
Site 49
S563
C
G
P
G
R
C
I
S
R
P
S
G
Y
T
C
Site 50
T569
I
S
R
P
S
G
Y
T
C
A
C
D
S
G
F
Site 51
S574
G
Y
T
C
A
C
D
S
G
F
R
L
S
P
Q
Site 52
S579
C
D
S
G
F
R
L
S
P
Q
G
T
R
C
I
Site 53
S606
A
P
G
R
C
E
N
S
P
G
S
F
R
C
V
Site 54
S609
R
C
E
N
S
P
G
S
F
R
C
V
C
G
P
Site 55
T648
D
L
G
R
C
E
N
T
P
G
S
F
L
C
V
Site 56
S678
D
V
D
E
C
T
Q
S
P
G
L
C
G
R
G
Site 57
S705
C
P
A
G
F
R
G
S
A
C
E
E
D
V
D
Site 58
S743
A
C
P
A
G
F
R
S
R
G
P
G
A
P
C
Site 59
S759
D
V
D
E
C
A
R
S
P
P
P
C
T
Y
G
Site 60
T764
A
R
S
P
P
P
C
T
Y
G
R
C
E
N
T
Site 61
Y765
R
S
P
P
P
C
T
Y
G
R
C
E
N
T
E
Site 62
T787
P
M
G
F
Q
P
N
T
A
G
S
E
C
E
D
Site 63
S812
P
G
Q
E
C
V
N
S
P
G
S
F
Q
C
R
Site 64
T833
H
L
H
R
G
R
C
T
D
V
D
E
C
S
S
Site 65
S861
T
E
G
S
F
R
C
S
C
A
P
G
Y
R
A
Site 66
Y866
R
C
S
C
A
P
G
Y
R
A
P
S
G
R
P
Site 67
S870
A
P
G
Y
R
A
P
S
G
R
P
G
P
C
A
Site 68
T904
T
D
G
S
F
A
C
T
C
A
P
G
Y
R
P
Site 69
Y909
A
C
T
C
A
P
G
Y
R
P
G
P
R
G
A
Site 70
S917
R
P
G
P
R
G
A
S
C
L
D
V
D
E
C
Site 71
S925
C
L
D
V
D
E
C
S
E
E
D
L
C
Q
S
Site 72
T936
L
C
Q
S
G
I
C
T
N
T
D
G
S
F
E
Site 73
S975
R
G
P
A
L
C
G
S
Q
R
C
E
N
S
P
Site 74
S981
G
S
Q
R
C
E
N
S
P
G
S
Y
R
C
V
Site 75
Y985
C
E
N
S
P
G
S
Y
R
C
V
R
D
C
D
Site 76
Y995
V
R
D
C
D
P
G
Y
H
A
G
P
E
G
T
Site 77
Y1012
D
V
D
E
C
Q
E
Y
G
P
E
I
C
G
A
Site 78
T1025
G
A
Q
R
C
E
N
T
P
G
S
Y
R
C
T
Site 79
T1032
T
P
G
S
Y
R
C
T
P
A
C
D
P
G
Y
Site 80
Y1039
T
P
A
C
D
P
G
Y
Q
P
T
P
G
G
G
Site 81
T1042
C
D
P
G
Y
Q
P
T
P
G
G
G
C
Q
D
Site 82
Y1080
Q
C
L
C
D
Q
G
Y
E
G
A
R
D
G
R
Site 83
S1121
F
L
C
V
C
P
N
S
P
E
E
F
D
P
M
Site 84
T1129
P
E
E
F
D
P
M
T
G
R
C
V
P
P
R
Site 85
T1137
G
R
C
V
P
P
R
T
S
A
G
T
F
P
G
Site 86
S1138
R
C
V
P
P
R
T
S
A
G
T
F
P
G
S
Site 87
T1141
P
P
R
T
S
A
G
T
F
P
G
S
Q
P
Q
Site 88
S1145
S
A
G
T
F
P
G
S
Q
P
Q
A
P
A
S
Site 89
S1152
S
Q
P
Q
A
P
A
S
P
V
L
P
A
R
P
Site 90
S1169
P
P
L
P
R
R
P
S
T
P
R
Q
G
P
V
Site 91
T1170
P
L
P
R
R
P
S
T
P
R
Q
G
P
V
G
Site 92
S1178
P
R
Q
G
P
V
G
S
G
R
R
E
C
Y
F
Site 93
Y1184
G
S
G
R
R
E
C
Y
F
D
T
A
A
P
D
Site 94
T1226
R
I
Q
Q
C
P
G
T
E
T
A
E
Y
Q
S
Site 95
Y1231
P
G
T
E
T
A
E
Y
Q
S
L
C
P
H
G
Site 96
S1233
T
E
T
A
E
Y
Q
S
L
C
P
H
G
R
G
Site 97
Y1241
L
C
P
H
G
R
G
Y
L
A
P
S
G
D
L
Site 98
S1245
G
R
G
Y
L
A
P
S
G
D
L
S
L
R
R
Site 99
S1249
L
A
P
S
G
D
L
S
L
R
R
D
V
D
E
Site 100
T1273
K
S
G
V
C
V
N
T
A
P
G
Y
S
C
Y
Site 101
Y1277
C
V
N
T
A
P
G
Y
S
C
Y
C
S
N
G
Site 102
Y1280
T
A
P
G
Y
S
C
Y
C
S
N
G
Y
Y
Y
Site 103
Y1285
S
C
Y
C
S
N
G
Y
Y
Y
H
T
Q
R
L
Site 104
Y1286
C
Y
C
S
N
G
Y
Y
Y
H
T
Q
R
L
E
Site 105
S1332
P
P
L
V
L
D
G
S
Q
R
R
C
V
S
N
Site 106
S1338
G
S
Q
R
R
C
V
S
N
E
S
Q
S
L
D
Site 107
S1341
R
R
C
V
S
N
E
S
Q
S
L
D
D
N
L
Site 108
S1343
C
V
S
N
E
S
Q
S
L
D
D
N
L
G
V
Site 109
T1371
P
R
L
D
R
Q
A
T
Y
T
E
C
C
C
L
Site 110
Y1372
R
L
D
R
Q
A
T
Y
T
E
C
C
C
L
Y
Site 111
S1395
A
L
C
P
A
Q
D
S
D
D
F
E
A
L
C
Site 112
Y1410
N
V
L
R
P
P
A
Y
S
P
P
R
P
G
G
Site 113
S1411
V
L
R
P
P
A
Y
S
P
P
R
P
G
G
F
Site 114
Y1422
P
G
G
F
G
L
P
Y
E
Y
G
P
D
L
G
Site 115
Y1424
G
F
G
L
P
Y
E
Y
G
P
D
L
G
P
P
Site 116
Y1432
G
P
D
L
G
P
P
Y
Q
G
L
P
Y
G
P
Site 117
Y1442
L
P
Y
G
P
E
L
Y
P
P
P
A
L
P
Y
Site 118
Y1449
Y
P
P
P
A
L
P
Y
D
P
Y
P
P
P
P
Site 119
Y1452
P
A
L
P
Y
D
P
Y
P
P
P
P
G
P
F
Site 120
Y1466
F
A
R
R
E
A
P
Y
G
A
P
R
F
D
M
Site 121
S1486
D
G
G
P
Y
G
E
S
E
A
P
A
P
P
G
Site 122
T1496
P
A
P
P
G
P
G
T
R
W
P
Y
R
S
R
Site 123
Y1500
G
P
G
T
R
W
P
Y
R
S
R
D
T
R
R
Site 124
S1502
G
T
R
W
P
Y
R
S
R
D
T
R
R
S
F
Site 125
T1505
W
P
Y
R
S
R
D
T
R
R
S
F
P
E
P
Site 126
S1508
R
S
R
D
T
R
R
S
F
P
E
P
E
E
P
Site 127
S1520
E
E
P
P
E
G
G
S
Y
A
G
S
L
A
E
Site 128
Y1521
E
P
P
E
G
G
S
Y
A
G
S
L
A
E
P
Site 129
S1524
E
G
G
S
Y
A
G
S
L
A
E
P
Y
E
E
Site 130
Y1529
A
G
S
L
A
E
P
Y
E
E
L
E
A
E
E
Site 131
S1585
C
D
E
A
E
A
A
S
P
L
C
V
N
A
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation