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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PIAS4
Full Name:
E3 SUMO-protein ligase PIAS4
Alias:
FLJ12419; PIASG; PIAS-gamma; PIASy; Protein inhibitor of activated STAT protein 4; Protein inhibitor of activated STAT protein gamma; Protein inhibitor of activated STAT protein PIASy; Protein inhibitor of activated STAT, 4; Zinc finger, MIZ-type containing 6; ZMIZ6
Type:
SUMO conjugating system; Transcription, coactivator/corepressor; Nuclear receptor co-regulator
Mass (Da):
56504
Number AA:
510
UniProt ID:
Q8N2W9
International Prot ID:
IPI00166500
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0019789
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0016055
GO:0019941
GO:0033235
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
E
A
K
N
M
V
M
S
F
R
V
S
D
L
Q
Site 2
S18
M
V
M
S
F
R
V
S
D
L
Q
M
L
L
G
Site 3
S30
L
L
G
F
V
G
R
S
K
S
G
L
K
H
E
Site 4
S32
G
F
V
G
R
S
K
S
G
L
K
H
E
L
V
Site 5
S51
Q
L
V
Q
F
D
C
S
P
E
L
F
K
K
I
Site 6
Y62
F
K
K
I
K
E
L
Y
E
T
R
Y
A
K
K
Site 7
T64
K
I
K
E
L
Y
E
T
R
Y
A
K
K
N
S
Site 8
Y66
K
E
L
Y
E
T
R
Y
A
K
K
N
S
E
P
Site 9
T85
H
R
P
L
D
P
L
T
M
H
S
T
Y
D
R
Site 10
T89
D
P
L
T
M
H
S
T
Y
D
R
A
G
A
V
Site 11
Y90
P
L
T
M
H
S
T
Y
D
R
A
G
A
V
P
Site 12
T99
R
A
G
A
V
P
R
T
P
L
A
G
P
N
I
Site 13
Y108
L
A
G
P
N
I
D
Y
P
V
L
Y
G
K
Y
Site 14
Y112
N
I
D
Y
P
V
L
Y
G
K
Y
L
N
G
L
Site 15
T126
L
G
R
L
P
A
K
T
L
K
P
E
V
R
L
Site 16
S162
N
N
E
K
L
Q
E
S
P
C
I
F
A
L
T
Site 17
S179
Q
V
E
L
I
R
N
S
R
E
L
Q
P
G
V
Site 18
Y197
Q
V
V
L
R
I
C
Y
S
D
T
S
C
P
Q
Site 19
S198
V
V
L
R
I
C
Y
S
D
T
S
C
P
Q
E
Site 20
T200
L
R
I
C
Y
S
D
T
S
C
P
Q
E
D
Q
Site 21
Y208
S
C
P
Q
E
D
Q
Y
P
P
N
I
A
V
K
Site 22
Y220
A
V
K
V
N
H
S
Y
C
S
V
P
G
Y
Y
Site 23
Y226
S
Y
C
S
V
P
G
Y
Y
P
S
N
K
P
G
Site 24
Y227
Y
C
S
V
P
G
Y
Y
P
S
N
K
P
G
V
Site 25
S229
S
V
P
G
Y
Y
P
S
N
K
P
G
V
E
P
Site 26
Y250
I
N
L
T
H
L
M
Y
L
S
S
A
T
N
R
Site 27
T259
S
S
A
T
N
R
I
T
V
T
W
G
N
Y
G
Site 28
S270
G
N
Y
G
K
S
Y
S
V
A
L
Y
L
V
R
Site 29
T280
L
Y
L
V
R
Q
L
T
S
S
E
L
L
Q
R
Site 30
S282
L
V
R
Q
L
T
S
S
E
L
L
Q
R
L
K
Site 31
T290
E
L
L
Q
R
L
K
T
I
G
V
K
H
P
E
Site 32
S313
K
L
R
L
D
P
D
S
E
I
A
T
T
G
V
Site 33
T317
D
P
D
S
E
I
A
T
T
G
V
R
V
S
L
Site 34
S334
P
L
V
K
M
R
L
S
V
P
C
R
A
E
T
Site 35
Y353
Q
C
F
D
A
V
F
Y
L
Q
M
N
E
K
K
Site 36
S388
G
L
L
S
K
I
L
S
E
C
E
D
A
D
E
Site 37
Y398
E
D
A
D
E
I
E
Y
L
V
D
G
S
W
C
Site 38
S414
I
R
A
E
K
E
R
S
C
S
P
Q
G
A
I
Site 39
S416
A
E
K
E
R
S
C
S
P
Q
G
A
I
L
V
Site 40
S441
P
A
P
S
V
N
G
S
G
A
L
G
S
T
G
Site 41
S446
N
G
S
G
A
L
G
S
T
G
G
G
G
P
V
Site 42
S455
G
G
G
G
P
V
G
S
M
E
N
G
K
P
G
Site 43
T469
G
A
D
V
V
D
L
T
L
D
S
S
S
S
S
Site 44
S472
V
V
D
L
T
L
D
S
S
S
S
S
E
D
E
Site 45
S473
V
D
L
T
L
D
S
S
S
S
S
E
D
E
E
Site 46
S476
T
L
D
S
S
S
S
S
E
D
E
E
E
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation