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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LRRC43
Full Name:
Leucine-rich repeat-containing protein 43
Alias:
Type:
Mass (Da):
73022
Number AA:
656
UniProt ID:
Q8N309
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
E
A
S
Y
E
S
E
S
E
S
E
S
E
Site 2
S9
E
A
S
Y
E
S
E
S
E
S
E
S
E
A
G
Site 3
S11
S
Y
E
S
E
S
E
S
E
S
E
A
G
P
G
Site 4
S13
E
S
E
S
E
S
E
S
E
A
G
P
G
T
Q
Site 5
T19
E
S
E
A
G
P
G
T
Q
R
P
G
T
G
T
Site 6
T24
P
G
T
Q
R
P
G
T
G
T
V
S
A
A
V
Site 7
T26
T
Q
R
P
G
T
G
T
V
S
A
A
V
R
E
Site 8
S28
R
P
G
T
G
T
V
S
A
A
V
R
E
H
L
Site 9
S49
E
F
P
C
G
A
G
S
W
N
K
S
R
F
L
Site 10
T59
K
S
R
F
L
P
Q
T
W
R
T
W
R
E
L
Site 11
S75
P
R
E
E
D
V
V
S
P
G
E
E
T
V
E
Site 12
S93
G
L
V
R
S
R
H
S
P
W
A
L
L
N
N
Site 13
S101
P
W
A
L
L
N
N
S
N
A
E
D
S
F
L
Site 14
S106
N
N
S
N
A
E
D
S
F
L
R
E
L
A
I
Site 15
T120
I
R
N
P
L
T
I
T
D
T
F
F
Y
S
Y
Site 16
T122
N
P
L
T
I
T
D
T
F
F
Y
S
Y
F
R
Site 17
Y125
T
I
T
D
T
F
F
Y
S
Y
F
R
S
L
R
Site 18
S130
F
F
Y
S
Y
F
R
S
L
R
V
I
D
K
K
Site 19
S157
K
L
E
E
L
V
L
S
A
N
R
I
K
E
V
Site 20
T167
R
I
K
E
V
D
A
T
N
L
P
P
T
L
K
Site 21
Y215
L
G
P
L
E
S
L
Y
V
T
A
N
H
W
P
Site 22
T217
P
L
E
S
L
Y
V
T
A
N
H
W
P
N
L
Site 23
T235
D
L
G
F
N
D
L
T
D
L
Q
S
M
V
T
Site 24
S239
N
D
L
T
D
L
Q
S
M
V
T
S
L
R
T
Site 25
S243
D
L
Q
S
M
V
T
S
L
R
T
L
R
H
L
Site 26
T284
L
C
V
L
D
D
I
T
V
S
P
N
E
K
H
Site 27
S286
V
L
D
D
I
T
V
S
P
N
E
K
H
L
F
Site 28
T322
N
I
R
G
V
L
D
T
S
V
L
D
P
E
P
Site 29
S323
I
R
G
V
L
D
T
S
V
L
D
P
E
P
R
Site 30
Y338
P
E
G
P
F
I
T
Y
N
Y
Y
V
T
Y
D
Site 31
Y341
P
F
I
T
Y
N
Y
Y
V
T
Y
D
F
V
K
Site 32
S357
E
E
G
E
M
N
E
S
A
G
V
L
A
E
I
Site 33
S378
L
E
L
L
V
E
E
S
P
E
E
V
V
E
D
Site 34
S401
V
T
E
E
V
E
G
S
L
E
S
E
V
E
E
Site 35
S404
E
V
E
G
S
L
E
S
E
V
E
E
S
G
E
Site 36
S409
L
E
S
E
V
E
E
S
G
E
S
E
L
S
V
Site 37
S412
E
V
E
E
S
G
E
S
E
L
S
V
I
S
G
Site 38
S415
E
S
G
E
S
E
L
S
V
I
S
G
P
S
T
Site 39
S455
S
P
G
T
V
L
F
S
T
A
H
K
P
W
A
Site 40
Y469
A
E
V
I
P
C
S
Y
E
M
Q
H
S
L
R
Site 41
S474
C
S
Y
E
M
Q
H
S
L
R
D
L
V
P
L
Site 42
S513
P
A
V
D
S
P
L
S
A
K
K
G
K
G
E
Site 43
T531
K
G
K
E
K
D
R
T
G
K
G
E
K
E
P
Site 44
S596
G
V
V
R
T
L
T
S
D
R
L
T
L
A
R
Site 45
T600
T
L
T
S
D
R
L
T
L
A
R
D
S
K
K
Site 46
S605
R
L
T
L
A
R
D
S
K
K
I
K
K
V
A
Site 47
Y624
P
K
A
V
I
P
I
Y
E
G
D
Y
H
P
E
Site 48
Y628
I
P
I
Y
E
G
D
Y
H
P
E
P
L
T
V
Site 49
T634
D
Y
H
P
E
P
L
T
V
E
V
Q
I
Q
L
Site 50
S646
I
Q
L
N
Q
C
R
S
A
E
E
A
L
R
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation