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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MIER2
Full Name:
Mesoderm induction early response protein 2
Alias:
Type:
Mass (Da):
59926
Number AA:
545
UniProt ID:
Q8N344
International Prot ID:
IPI00297301
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003677
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006350
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
A
E
A
S
S
L
G
R
Q
S
P
R
Site 2
S11
A
S
S
L
G
R
Q
S
P
R
V
V
S
C
L
Site 3
S16
R
Q
S
P
R
V
V
S
C
L
E
H
S
L
C
Site 4
S51
F
N
L
A
E
I
L
S
Q
N
Y
S
V
R
G
Site 5
S55
E
I
L
S
Q
N
Y
S
V
R
G
E
C
E
E
Site 6
S80
E
L
E
K
D
F
I
S
Q
S
N
D
M
P
F
Site 7
S99
A
L
Y
G
Y
E
A
S
D
P
I
S
D
R
E
Site 8
S103
Y
E
A
S
D
P
I
S
D
R
E
S
E
G
G
Site 9
S107
D
P
I
S
D
R
E
S
E
G
G
D
V
A
P
Site 10
T120
A
P
N
L
P
D
M
T
L
D
K
E
Q
I
A
Site 11
S132
Q
I
A
K
D
L
L
S
G
E
E
E
E
E
T
Site 12
T139
S
G
E
E
E
E
E
T
Q
S
S
A
D
D
L
Site 13
S141
E
E
E
E
E
T
Q
S
S
A
D
D
L
T
P
Site 14
S142
E
E
E
E
T
Q
S
S
A
D
D
L
T
P
S
Site 15
T147
Q
S
S
A
D
D
L
T
P
S
V
T
S
H
E
Site 16
S149
S
A
D
D
L
T
P
S
V
T
S
H
E
A
S
Site 17
S152
D
L
T
P
S
V
T
S
H
E
A
S
D
L
F
Site 18
S156
S
V
T
S
H
E
A
S
D
L
F
P
N
R
S
Site 19
S163
S
D
L
F
P
N
R
S
G
S
R
F
L
A
D
Site 20
S165
L
F
P
N
R
S
G
S
R
F
L
A
D
E
D
Site 21
S177
D
E
D
R
E
P
G
S
S
A
S
S
D
T
E
Site 22
S178
E
D
R
E
P
G
S
S
A
S
S
D
T
E
E
Site 23
S181
E
P
G
S
S
A
S
S
D
T
E
E
D
S
L
Site 24
T183
G
S
S
A
S
S
D
T
E
E
D
S
L
P
A
Site 25
S187
S
S
D
T
E
E
D
S
L
P
A
N
K
C
K
Site 26
S208
P
Q
F
Q
A
D
L
S
N
L
H
L
N
R
H
Site 27
S231
D
Q
L
L
W
D
P
S
V
L
P
E
R
E
V
Site 28
Y243
R
E
V
E
E
F
L
Y
R
A
V
K
R
R
W
Site 29
S267
E
G
E
A
V
K
D
S
E
Q
A
L
Y
E
L
Site 30
Y272
K
D
S
E
Q
A
L
Y
E
L
V
K
C
N
F
Site 31
S333
A
N
K
V
R
T
R
S
V
G
E
C
V
E
Y
Site 32
Y340
S
V
G
E
C
V
E
Y
Y
Y
L
W
K
K
S
Site 33
Y341
V
G
E
C
V
E
Y
Y
Y
L
W
K
K
S
E
Site 34
Y342
G
E
C
V
E
Y
Y
Y
L
W
K
K
S
E
R
Site 35
Y352
K
K
S
E
R
Y
D
Y
F
A
Q
Q
T
R
L
Site 36
Y364
T
R
L
G
R
R
K
Y
V
P
S
G
T
T
D
Site 37
S367
G
R
R
K
Y
V
P
S
G
T
T
D
A
D
Q
Site 38
S379
A
D
Q
D
L
D
G
S
D
P
D
G
P
G
R
Site 39
T393
R
P
R
P
E
Q
D
T
L
T
G
M
R
T
D
Site 40
T395
R
P
E
Q
D
T
L
T
G
M
R
T
D
P
L
Site 41
T399
D
T
L
T
G
M
R
T
D
P
L
S
V
D
G
Site 42
S403
G
M
R
T
D
P
L
S
V
D
G
T
A
G
G
Site 43
T407
D
P
L
S
V
D
G
T
A
G
G
L
D
E
P
Site 44
S418
L
D
E
P
G
V
A
S
D
G
L
P
S
S
E
Site 45
S423
V
A
S
D
G
L
P
S
S
E
P
G
P
C
S
Site 46
S424
A
S
D
G
L
P
S
S
E
P
G
P
C
S
F
Site 47
S430
S
S
E
P
G
P
C
S
F
Q
Q
L
D
E
S
Site 48
S437
S
F
Q
Q
L
D
E
S
P
A
V
P
L
S
H
Site 49
S443
E
S
P
A
V
P
L
S
H
R
P
P
A
L
A
Site 50
S467
T
A
P
E
P
D
A
S
P
R
L
A
V
D
F
Site 51
S484
P
K
E
L
P
L
I
S
S
H
V
D
L
S
G
Site 52
S485
K
E
L
P
L
I
S
S
H
V
D
L
S
G
D
Site 53
S490
I
S
S
H
V
D
L
S
G
D
P
E
E
T
V
Site 54
T496
L
S
G
D
P
E
E
T
V
A
P
A
Q
V
A
Site 55
S534
C
P
A
P
G
L
H
S
E
P
L
S
H
C
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation