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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DOS
Full Name:
Protein Dos
Alias:
C19orf26; Chromosome 19 open reading frame 26; Downstream of Stk11; MGC40084; Protein Dos: Protein Dos
Type:
Membrane protein, integral
Mass (Da):
75822
Number AA:
725
UniProt ID:
Q8N350
International Prot ID:
IPI00420019
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
A
T
V
A
L
T
T
S
W
D
N
A
T
G
R
Site 2
T25
T
T
S
W
D
N
A
T
G
R
P
T
A
E
P
Site 3
T29
D
N
A
T
G
R
P
T
A
E
P
D
P
I
L
Site 4
T84
A
M
E
E
A
E
K
T
T
T
T
Y
L
D
N
Site 5
T86
E
E
A
E
K
T
T
T
T
Y
L
D
N
G
T
Site 6
Y88
A
E
K
T
T
T
T
Y
L
D
N
G
T
H
P
Site 7
T113
P
E
C
Q
D
A
E
T
E
R
F
L
S
T
S
Site 8
S118
A
E
T
E
R
F
L
S
T
S
S
T
G
R
R
Site 9
T119
E
T
E
R
F
L
S
T
S
S
T
G
R
R
V
Site 10
S120
T
E
R
F
L
S
T
S
S
T
G
R
R
V
S
Site 11
S121
E
R
F
L
S
T
S
S
T
G
R
R
V
S
F
Site 12
T122
R
F
L
S
T
S
S
T
G
R
R
V
S
F
N
Site 13
S127
S
S
T
G
R
R
V
S
F
N
E
A
A
L
F
Site 14
S137
E
A
A
L
F
E
Q
S
R
K
T
Q
D
K
G
Site 15
T140
L
F
E
Q
S
R
K
T
Q
D
K
G
R
Q
G
Site 16
S151
G
R
Q
G
G
W
Q
S
T
A
A
G
A
S
G
Site 17
T152
R
Q
G
G
W
Q
S
T
A
A
G
A
S
G
M
Site 18
Y173
M
A
R
C
C
R
R
Y
T
L
T
E
G
D
F
Site 19
T174
A
R
C
C
R
R
Y
T
L
T
E
G
D
F
H
Site 20
T176
C
C
R
R
Y
T
L
T
E
G
D
F
H
H
L
Site 21
T189
H
L
K
N
A
R
L
T
H
L
H
L
P
P
L
Site 22
S206
V
T
I
H
E
C
D
S
G
E
A
S
S
A
T
Site 23
S210
E
C
D
S
G
E
A
S
S
A
T
T
P
H
P
Site 24
T214
G
E
A
S
S
A
T
T
P
H
P
A
T
S
P
Site 25
S220
T
T
P
H
P
A
T
S
P
K
A
T
L
A
I
Site 26
T224
P
A
T
S
P
K
A
T
L
A
I
F
Q
P
P
Site 27
T236
Q
P
P
G
K
A
L
T
G
R
S
V
G
P
S
Site 28
S239
G
K
A
L
T
G
R
S
V
G
P
S
S
A
L
Site 29
S243
T
G
R
S
V
G
P
S
S
A
L
P
G
D
P
Site 30
S244
G
R
S
V
G
P
S
S
A
L
P
G
D
P
Y
Site 31
Y251
S
A
L
P
G
D
P
Y
N
S
A
A
G
A
T
Site 32
S253
L
P
G
D
P
Y
N
S
A
A
G
A
T
D
F
Site 33
S264
A
T
D
F
A
E
I
S
P
S
A
S
S
D
S
Site 34
S266
D
F
A
E
I
S
P
S
A
S
S
D
S
G
E
Site 35
S268
A
E
I
S
P
S
A
S
S
D
S
G
E
G
T
Site 36
S269
E
I
S
P
S
A
S
S
D
S
G
E
G
T
S
Site 37
S271
S
P
S
A
S
S
D
S
G
E
G
T
S
L
D
Site 38
T275
S
S
D
S
G
E
G
T
S
L
D
A
G
T
R
Site 39
S276
S
D
S
G
E
G
T
S
L
D
A
G
T
R
S
Site 40
S283
S
L
D
A
G
T
R
S
T
K
A
G
G
P
G
Site 41
T284
L
D
A
G
T
R
S
T
K
A
G
G
P
G
A
Site 42
S302
P
G
E
A
G
P
G
S
G
A
G
T
V
L
Q
Site 43
S319
T
R
L
R
R
H
A
S
L
D
G
A
S
P
Y
Site 44
S324
H
A
S
L
D
G
A
S
P
Y
F
K
V
K
K
Site 45
Y326
S
L
D
G
A
S
P
Y
F
K
V
K
K
W
K
Site 46
S337
K
K
W
K
L
E
P
S
Q
R
A
A
S
L
D
Site 47
S342
E
P
S
Q
R
A
A
S
L
D
T
R
G
S
P
Site 48
T345
Q
R
A
A
S
L
D
T
R
G
S
P
K
R
H
Site 49
S348
A
S
L
D
T
R
G
S
P
K
R
H
H
F
Q
Site 50
S361
F
Q
R
Q
R
A
A
S
E
S
T
E
Q
E
E
Site 51
S363
R
Q
R
A
A
S
E
S
T
E
Q
E
E
G
D
Site 52
T364
Q
R
A
A
S
E
S
T
E
Q
E
E
G
D
A
Site 53
Y379
P
Q
E
D
F
I
Q
Y
I
A
R
A
G
D
A
Site 54
S398
H
P
R
P
F
L
A
S
P
P
P
A
L
G
R
Site 55
S416
A
E
A
A
G
G
A
S
P
D
S
P
P
E
R
Site 56
S419
A
G
G
A
S
P
D
S
P
P
E
R
G
A
G
Site 57
T452
A
G
P
E
Q
A
Q
T
S
Y
R
D
L
W
S
Site 58
S453
G
P
E
Q
A
Q
T
S
Y
R
D
L
W
S
L
Site 59
S459
T
S
Y
R
D
L
W
S
L
R
A
S
L
E
L
Site 60
S463
D
L
W
S
L
R
A
S
L
E
L
H
A
A
A
Site 61
S471
L
E
L
H
A
A
A
S
D
H
S
S
S
G
N
Site 62
S474
H
A
A
A
S
D
H
S
S
S
G
N
D
R
D
Site 63
S475
A
A
A
S
D
H
S
S
S
G
N
D
R
D
S
Site 64
S476
A
A
S
D
H
S
S
S
G
N
D
R
D
S
V
Site 65
S482
S
S
G
N
D
R
D
S
V
R
S
G
D
S
S
Site 66
S485
N
D
R
D
S
V
R
S
G
D
S
S
G
S
G
Site 67
S488
D
S
V
R
S
G
D
S
S
G
S
G
S
G
G
Site 68
S489
S
V
R
S
G
D
S
S
G
S
G
S
G
G
A
Site 69
S491
R
S
G
D
S
S
G
S
G
S
G
G
A
A
P
Site 70
S493
G
D
S
S
G
S
G
S
G
G
A
A
P
A
F
Site 71
S504
A
P
A
F
P
P
P
S
P
P
A
P
R
P
K
Site 72
S523
R
R
L
L
Q
M
D
S
G
Y
A
S
I
E
G
Site 73
Y525
L
L
Q
M
D
S
G
Y
A
S
I
E
G
R
G
Site 74
S527
Q
M
D
S
G
Y
A
S
I
E
G
R
G
A
G
Site 75
T537
G
R
G
A
G
D
D
T
E
P
P
A
A
P
A
Site 76
S548
A
A
P
A
R
P
R
S
P
R
A
W
P
R
R
Site 77
Y560
P
R
R
P
R
R
D
Y
S
I
D
E
K
T
D
Site 78
S561
R
R
P
R
R
D
Y
S
I
D
E
K
T
D
A
Site 79
T566
D
Y
S
I
D
E
K
T
D
A
L
F
H
E
F
Site 80
T583
H
D
P
H
F
D
D
T
P
A
A
A
R
H
R
Site 81
S608
W
Q
R
G
R
Q
H
S
D
P
G
A
R
A
A
Site 82
S641
A
P
L
R
R
G
D
S
V
D
G
P
P
D
G
Site 83
T650
D
G
P
P
D
G
R
T
L
G
G
A
G
D
D
Site 84
T709
L
A
E
P
V
V
A
T
P
A
L
V
A
A
A
Site 85
T718
A
L
V
A
A
A
P
T
S
P
D
H
S
P
A
Site 86
S719
L
V
A
A
A
P
T
S
P
D
H
S
P
A
_
Site 87
S723
A
P
T
S
P
D
H
S
P
A
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation