KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
TMTC2
Full Name:
Transmembrane and TPR repeat-containing protein 2
Alias:
Type:
Mass (Da):
94130
Number AA:
836
UniProt ID:
Q8N394
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y15
S
A
L
G
L
A
L
Y
L
N
T
L
S
A
D
Site 2
Y25
T
L
S
A
D
F
C
Y
D
D
S
R
A
I
K
Site 3
T57
D
F
W
G
T
L
L
T
H
S
G
S
H
K
S
Site 4
S59
W
G
T
L
L
T
H
S
G
S
H
K
S
Y
R
Site 5
S61
T
L
L
T
H
S
G
S
H
K
S
Y
R
P
L
Site 6
S64
T
H
S
G
S
H
K
S
Y
R
P
L
C
T
L
Site 7
Y65
H
S
G
S
H
K
S
Y
R
P
L
C
T
L
S
Site 8
T70
K
S
Y
R
P
L
C
T
L
S
F
R
L
N
H
Site 9
Y217
K
Q
I
L
P
T
I
Y
K
R
K
N
L
S
L
Site 10
Y244
S
L
L
G
A
R
L
Y
W
M
G
N
K
P
P
Site 11
S252
W
M
G
N
K
P
P
S
F
S
N
S
D
N
P
Site 12
S254
G
N
K
P
P
S
F
S
N
S
D
N
P
A
A
Site 13
S256
K
P
P
S
F
S
N
S
D
N
P
A
A
D
S
Site 14
S263
S
D
N
P
A
A
D
S
D
S
L
L
T
R
T
Site 15
S265
N
P
A
A
D
S
D
S
L
L
T
R
T
L
T
Site 16
Y275
T
R
T
L
T
F
F
Y
L
P
T
K
N
L
W
Site 17
S330
L
A
Y
Y
G
L
K
S
P
S
V
D
R
E
C
Site 18
S332
Y
Y
G
L
K
S
P
S
V
D
R
E
C
N
G
Site 19
T341
D
R
E
C
N
G
K
T
V
T
N
G
K
Q
N
Site 20
S356
A
N
G
H
S
C
L
S
D
V
E
Y
Q
N
S
Site 21
Y360
S
C
L
S
D
V
E
Y
Q
N
S
E
T
K
S
Site 22
S363
S
D
V
E
Y
Q
N
S
E
T
K
S
S
F
A
Site 23
S367
Y
Q
N
S
E
T
K
S
S
F
A
S
K
V
E
Site 24
S368
Q
N
S
E
T
K
S
S
F
A
S
K
V
E
N
Site 25
S371
E
T
K
S
S
F
A
S
K
V
E
N
G
I
K
Site 26
S382
N
G
I
K
N
D
V
S
Q
R
T
Q
L
P
S
Site 27
T385
K
N
D
V
S
Q
R
T
Q
L
P
S
T
E
N
Site 28
S389
S
Q
R
T
Q
L
P
S
T
E
N
I
V
V
L
Site 29
Y425
V
I
A
E
R
V
L
Y
I
P
S
M
G
F
C
Site 30
Y443
T
V
G
A
R
A
L
Y
V
K
V
Q
K
R
F
Site 31
Y484
W
Q
N
E
E
M
L
Y
R
S
G
I
K
V
N
Site 32
S505
N
L
G
N
V
L
K
S
Q
S
K
I
S
E
A
Site 33
S510
L
K
S
Q
S
K
I
S
E
A
E
S
A
Y
R
Site 34
S514
S
K
I
S
E
A
E
S
A
Y
R
N
A
L
Y
Site 35
Y521
S
A
Y
R
N
A
L
Y
Y
R
S
N
M
A
D
Site 36
Y522
A
Y
R
N
A
L
Y
Y
R
S
N
M
A
D
M
Site 37
S541
G
L
L
L
Q
E
N
S
R
F
A
E
A
L
H
Site 38
S562
G
S
R
P
T
L
A
S
A
Y
L
N
T
G
I
Site 39
T583
R
T
E
E
A
R
R
T
F
L
K
C
S
E
I
Site 40
S603
K
D
P
H
A
H
K
S
S
V
T
S
C
L
Y
Site 41
S604
D
P
H
A
H
K
S
S
V
T
S
C
L
Y
N
Site 42
S607
A
H
K
S
S
V
T
S
C
L
Y
N
L
G
K
Site 43
Y610
S
S
V
T
S
C
L
Y
N
L
G
K
L
Y
H
Site 44
Y616
L
Y
N
L
G
K
L
Y
H
E
Q
G
H
Y
E
Site 45
Y622
L
Y
H
E
Q
G
H
Y
E
E
A
L
S
V
Y
Site 46
S627
G
H
Y
E
E
A
L
S
V
Y
K
E
A
I
Q
Site 47
S644
P
R
Q
F
A
P
Q
S
L
Y
N
M
M
G
E
Site 48
Y646
Q
F
A
P
Q
S
L
Y
N
M
M
G
E
A
Y
Site 49
Y653
Y
N
M
M
G
E
A
Y
M
R
L
S
K
L
P
Site 50
S657
G
E
A
Y
M
R
L
S
K
L
P
E
A
E
H
Site 51
Y666
L
P
E
A
E
H
W
Y
M
E
S
L
R
S
K
Site 52
T674
M
E
S
L
R
S
K
T
D
H
I
P
A
H
L
Site 53
T690
Y
G
K
L
L
A
L
T
G
R
K
S
E
A
E
Site 54
S694
L
A
L
T
G
R
K
S
E
A
E
K
L
F
L
Site 55
Y714
D
P
T
K
G
N
C
Y
M
H
Y
G
Q
F
L
Site 56
Y717
K
G
N
C
Y
M
H
Y
G
Q
F
L
L
E
E
Site 57
S742
K
K
A
A
E
L
D
S
T
E
F
D
V
V
F
Site 58
T743
K
A
A
E
L
D
S
T
E
F
D
V
V
F
N
Site 59
S759
A
H
M
L
R
Q
A
S
L
N
E
A
A
E
K
Site 60
Y778
A
A
R
L
R
P
N
Y
P
A
A
L
M
N
L
Site 61
Y802
L
Q
K
A
E
A
N
Y
L
R
A
L
Q
L
K
Site 62
T815
L
K
P
D
D
V
I
T
Q
S
N
L
R
K
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation