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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
METTL4
Full Name:
Methyltransferase-like protein 4
Alias:
Type:
Mass (Da):
54041
Number AA:
472
UniProt ID:
Q8N3J2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y24
S
F
I
N
K
I
N
Y
Q
L
H
Q
H
H
E
Site 2
T40
C
C
R
K
K
E
F
T
T
S
V
H
F
E
S
Site 3
S42
R
K
K
E
F
T
T
S
V
H
F
E
S
L
Q
Site 4
S47
T
T
S
V
H
F
E
S
L
Q
M
D
S
V
S
Site 5
S52
F
E
S
L
Q
M
D
S
V
S
S
S
G
V
C
Site 6
S55
L
Q
M
D
S
V
S
S
S
G
V
C
A
A
F
Site 7
S67
A
A
F
I
A
S
D
S
S
T
K
P
E
N
D
Site 8
S68
A
F
I
A
S
D
S
S
T
K
P
E
N
D
D
Site 9
T69
F
I
A
S
D
S
S
T
K
P
E
N
D
D
G
Site 10
Y79
E
N
D
D
G
G
N
Y
E
M
F
T
R
K
F
Site 11
T96
R
P
E
L
F
D
V
T
K
P
Y
I
T
P
A
Site 12
T101
D
V
T
K
P
Y
I
T
P
A
V
H
K
E
C
Site 13
S126
N
G
V
K
K
E
I
S
I
S
I
I
G
K
K
Site 14
S128
V
K
K
E
I
S
I
S
I
I
G
K
K
R
K
Site 15
Y150
G
E
L
D
A
M
E
Y
H
T
K
I
R
E
L
Site 16
S162
R
E
L
I
L
D
G
S
L
Q
L
I
Q
E
G
Site 17
Y176
G
L
K
S
G
F
L
Y
P
L
F
E
K
Q
D
Site 18
T190
D
K
G
S
K
P
I
T
L
P
L
D
A
C
S
Site 19
S210
E
M
A
K
H
L
P
S
L
N
E
M
E
H
Q
Site 20
S227
Q
L
V
E
E
D
T
S
V
T
E
Q
D
L
F
Site 21
S243
R
V
V
E
N
N
S
S
F
T
K
V
I
T
L
Site 22
Y255
I
T
L
M
G
Q
K
Y
L
L
P
P
K
S
S
Site 23
S266
P
K
S
S
F
L
L
S
D
I
S
C
M
Q
P
Site 24
S294
D
P
P
W
Q
N
K
S
V
K
R
S
N
R
Y
Site 25
S298
Q
N
K
S
V
K
R
S
N
R
Y
S
Y
L
S
Site 26
Y301
S
V
K
R
S
N
R
Y
S
Y
L
S
P
L
Q
Site 27
S302
V
K
R
S
N
R
Y
S
Y
L
S
P
L
Q
I
Site 28
Y303
K
R
S
N
R
Y
S
Y
L
S
P
L
Q
I
K
Site 29
S305
S
N
R
Y
S
Y
L
S
P
L
Q
I
K
Q
I
Site 30
Y343
R
F
I
K
E
E
L
Y
P
S
W
S
V
E
V
Site 31
S347
E
E
L
Y
P
S
W
S
V
E
V
V
A
E
W
Site 32
S371
E
F
V
F
P
L
D
S
P
H
K
K
P
Y
E
Site 33
Y377
D
S
P
H
K
K
P
Y
E
G
L
I
L
G
R
Site 34
T389
L
G
R
V
Q
E
K
T
A
L
P
L
R
N
A
Site 35
S418
S
V
P
C
T
L
H
S
H
K
P
P
L
A
E
Site 36
Y430
L
A
E
V
L
K
D
Y
I
K
P
D
G
E
Y
Site 37
Y437
Y
I
K
P
D
G
E
Y
L
E
L
F
A
R
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation