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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
VPS8
Full Name:
Vacuolar protein sorting-associated protein 8 homolog
Alias:
KIAA0804
Type:
Uncharacterized
Mass (Da):
161740
Number AA:
1428
UniProt ID:
Q8N3P4
International Prot ID:
IPI00464985
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
D
H
E
N
V
E
Q
S
L
C
A
K
T
S
E
Site 2
S19
Q
S
L
C
A
K
T
S
E
E
E
L
N
K
S
Site 3
S26
S
E
E
E
L
N
K
S
F
N
L
E
A
S
L
Site 4
S32
K
S
F
N
L
E
A
S
L
S
K
F
S
Y
I
Site 5
Y38
A
S
L
S
K
F
S
Y
I
D
M
D
K
E
L
Site 6
T64
F
D
I
P
Q
V
D
T
P
P
T
L
E
S
I
Site 7
T67
P
Q
V
D
T
P
P
T
L
E
S
I
L
N
E
Site 8
S81
E
T
D
D
E
D
E
S
F
V
L
E
D
P
T
Site 9
T94
P
T
L
L
N
I
D
T
I
D
S
H
S
Y
D
Site 10
S97
L
N
I
D
T
I
D
S
H
S
Y
D
T
S
S
Site 11
S99
I
D
T
I
D
S
H
S
Y
D
T
S
S
V
A
Site 12
Y100
D
T
I
D
S
H
S
Y
D
T
S
S
V
A
S
Site 13
T102
I
D
S
H
S
Y
D
T
S
S
V
A
S
S
D
Site 14
S103
D
S
H
S
Y
D
T
S
S
V
A
S
S
D
S
Site 15
S104
S
H
S
Y
D
T
S
S
V
A
S
S
D
S
G
Site 16
S107
Y
D
T
S
S
V
A
S
S
D
S
G
D
R
T
Site 17
S108
D
T
S
S
V
A
S
S
D
S
G
D
R
T
N
Site 18
S110
S
S
V
A
S
S
D
S
G
D
R
T
N
L
K
Site 19
T114
S
S
D
S
G
D
R
T
N
L
K
R
K
K
K
Site 20
S125
R
K
K
K
L
P
D
S
F
S
L
H
G
S
V
Site 21
S127
K
K
L
P
D
S
F
S
L
H
G
S
V
M
R
Site 22
S131
D
S
F
S
L
H
G
S
V
M
R
H
S
L
L
Site 23
S136
H
G
S
V
M
R
H
S
L
L
K
G
I
S
A
Site 24
S206
Y
G
A
I
S
A
L
S
I
N
N
D
C
S
R
Site 25
S236
A
S
G
K
L
L
R
S
I
T
D
A
H
P
P
Site 26
T238
G
K
L
L
R
S
I
T
D
A
H
P
P
G
T
Site 27
T257
I
K
F
T
D
D
P
T
L
A
I
C
N
D
S
Site 28
S284
M
G
V
R
T
C
E
S
R
C
L
F
S
G
S
Site 29
S303
C
C
I
E
P
L
H
S
K
P
E
L
K
D
H
Site 30
Y343
K
V
W
M
T
F
P
Y
G
R
M
D
P
S
S
Site 31
S349
P
Y
G
R
M
D
P
S
S
V
P
L
L
A
W
Site 32
S350
Y
G
R
M
D
P
S
S
V
P
L
L
A
W
H
Site 33
S387
L
L
V
K
R
D
E
S
G
A
I
H
V
T
K
Site 34
Y401
K
Q
K
H
L
H
L
Y
Y
D
L
I
N
F
T
Site 35
Y402
Q
K
H
L
H
L
Y
Y
D
L
I
N
F
T
W
Site 36
T431
L
H
V
I
D
R
Q
T
Q
E
E
L
E
T
V
Site 37
T437
Q
T
Q
E
E
L
E
T
V
E
I
S
E
V
Q
Site 38
Y447
I
S
E
V
Q
L
V
Y
N
S
S
H
F
K
S
Site 39
S449
E
V
Q
L
V
Y
N
S
S
H
F
K
S
L
A
Site 40
S450
V
Q
L
V
Y
N
S
S
H
F
K
S
L
A
T
Site 41
S454
Y
N
S
S
H
F
K
S
L
A
T
G
G
N
V
Site 42
Y474
L
V
G
E
K
A
C
Y
Q
S
I
S
S
Y
G
Site 43
S476
G
E
K
A
C
Y
Q
S
I
S
S
Y
G
G
Q
Site 44
S478
K
A
C
Y
Q
S
I
S
S
Y
G
G
Q
I
F
Site 45
Y486
S
Y
G
G
Q
I
F
Y
L
G
T
K
S
V
Y
Site 46
S522
E
A
L
A
L
A
W
S
F
H
E
G
K
A
K
Site 47
S535
A
K
A
V
V
G
L
S
G
D
A
S
K
R
K
Site 48
S599
Q
R
K
D
L
L
F
S
Q
M
Y
D
K
L
S
Site 49
Y602
D
L
L
F
S
Q
M
Y
D
K
L
S
E
N
S
Site 50
S606
S
Q
M
Y
D
K
L
S
E
N
S
V
A
K
G
Site 51
T632
S
D
K
L
V
G
I
T
P
Q
V
M
K
D
L
Site 52
Y684
R
L
Y
D
A
M
I
Y
V
Y
N
R
G
M
N
Site 53
Y686
Y
D
A
M
I
Y
V
Y
N
R
G
M
N
E
F
Site 54
S695
R
G
M
N
E
F
I
S
P
M
E
K
L
F
R
Site 55
T713
P
P
L
N
A
G
K
T
L
T
D
E
Q
V
V
Site 56
S764
E
F
L
I
R
L
H
S
A
E
A
S
P
E
E
Site 57
S768
R
L
H
S
A
E
A
S
P
E
E
E
I
Y
P
Site 58
Y774
A
S
P
E
E
E
I
Y
P
Y
I
R
T
L
L
Site 59
Y776
P
E
E
E
I
Y
P
Y
I
R
T
L
L
H
F
Site 60
S824
L
K
V
M
V
E
N
S
D
F
T
P
S
Q
V
Site 61
T827
M
V
E
N
S
D
F
T
P
S
Q
V
G
C
L
Site 62
S829
E
N
S
D
F
T
P
S
Q
V
G
C
L
F
T
Site 63
S865
Q
V
L
E
F
L
C
S
P
D
D
D
S
R
H
Site 64
S870
L
C
S
P
D
D
D
S
R
H
S
E
R
Q
Q
Site 65
S873
P
D
D
D
S
R
H
S
E
R
Q
Q
V
L
L
Site 66
Y919
M
Y
E
R
E
H
Q
Y
D
K
I
I
D
C
Y
Site 67
Y926
Y
D
K
I
I
D
C
Y
L
R
D
P
L
R
E
Site 68
Y939
R
E
E
E
V
F
N
Y
I
H
N
I
L
S
I
Site 69
S945
N
Y
I
H
N
I
L
S
I
P
G
H
S
A
E
Site 70
S970
D
H
I
E
E
L
V
S
L
K
P
C
K
A
A
Site 71
T990
H
F
S
G
H
I
E
T
V
I
K
K
L
Q
N
Site 72
S1025
N
Q
E
L
L
Q
I
S
P
C
I
T
E
Q
F
Site 73
Y1066
T
I
Q
I
T
Q
K
Y
Q
L
H
E
V
T
A
Site 74
Y1074
Q
L
H
E
V
T
A
Y
L
L
E
K
K
G
D
Site 75
S1095
I
M
L
E
R
L
Q
S
K
L
Q
E
V
T
H
Site 76
S1112
E
N
T
K
E
D
P
S
L
K
D
V
E
D
T
Site 77
S1157
M
M
A
P
Q
K
L
S
S
S
A
I
P
H
L
Site 78
S1158
M
A
P
Q
K
L
S
S
S
A
I
P
H
L
H
Site 79
S1159
A
P
Q
K
L
S
S
S
A
I
P
H
L
H
S
Site 80
Y1199
R
I
L
Q
D
P
V
Y
G
K
G
K
L
G
E
Site 81
Y1220
G
M
L
D
T
F
N
Y
E
Q
T
L
L
E
T
Site 82
S1230
T
L
L
E
T
T
T
S
L
L
N
Q
D
L
H
Site 83
S1246
S
L
C
N
L
R
A
S
V
T
R
G
L
N
P
Site 84
Y1257
G
L
N
P
K
Q
D
Y
C
S
I
C
L
Q
Q
Site 85
Y1265
C
S
I
C
L
Q
Q
Y
K
R
R
Q
E
M
A
Site 86
Y1307
G
Q
T
R
W
T
C
Y
K
C
S
S
S
N
K
Site 87
S1312
T
C
Y
K
C
S
S
S
N
K
V
G
K
L
S
Site 88
S1319
S
N
K
V
G
K
L
S
E
N
S
S
E
I
K
Site 89
S1322
V
G
K
L
S
E
N
S
S
E
I
K
K
G
R
Site 90
S1323
G
K
L
S
E
N
S
S
E
I
K
K
G
R
I
Site 91
T1331
E
I
K
K
G
R
I
T
P
S
Q
V
K
M
S
Site 92
S1333
K
K
G
R
I
T
P
S
Q
V
K
M
S
P
S
Site 93
S1338
T
P
S
Q
V
K
M
S
P
S
Y
H
Q
S
K
Site 94
S1340
S
Q
V
K
M
S
P
S
Y
H
Q
S
K
G
D
Site 95
Y1341
Q
V
K
M
S
P
S
Y
H
Q
S
K
G
D
P
Site 96
S1344
M
S
P
S
Y
H
Q
S
K
G
D
P
T
A
K
Site 97
T1349
H
Q
S
K
G
D
P
T
A
K
K
G
T
S
E
Site 98
Y1374
F
D
Q
L
C
R
L
Y
R
G
S
S
R
L
A
Site 99
S1378
C
R
L
Y
R
G
S
S
R
L
A
L
L
T
E
Site 100
T1384
S
S
R
L
A
L
L
T
E
L
S
Q
N
R
S
Site 101
S1387
L
A
L
L
T
E
L
S
Q
N
R
S
S
E
S
Site 102
S1391
T
E
L
S
Q
N
R
S
S
E
S
Y
R
P
F
Site 103
S1392
E
L
S
Q
N
R
S
S
E
S
Y
R
P
F
S
Site 104
S1394
S
Q
N
R
S
S
E
S
Y
R
P
F
S
G
S
Site 105
Y1395
Q
N
R
S
S
E
S
Y
R
P
F
S
G
S
Q
Site 106
S1399
S
E
S
Y
R
P
F
S
G
S
Q
S
A
P
A
Site 107
S1401
S
Y
R
P
F
S
G
S
Q
S
A
P
A
F
N
Site 108
S1403
R
P
F
S
G
S
Q
S
A
P
A
F
N
S
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation