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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FBXW8
Full Name:
F-box/WD repeat-containing protein 8
Alias:
F-box and WD repeat domain containing 8; F-box and WD-40 domain-containing protein 8; F-box only protein 29; F-box/WD repeat-containing protein 8: F-box and WD-40 domain-containing protein 8: F-box only protein 29: F-box/WD repeat-containing protein 8: F-box and WD-40 domain-containing protein 8: F-box only protein 29; FBW6; FBW8; FBX29; FBXO29
Type:
Unknown function
Mass (Da):
67297
Number AA:
598
UniProt ID:
Q8N3Y1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S43
A
R
R
P
E
V
G
S
G
R
S
E
Q
A
S
Site 2
S46
P
E
V
G
S
G
R
S
E
Q
A
S
G
D
P
Site 3
S50
S
G
R
S
E
Q
A
S
G
D
P
A
L
A
Q
Site 4
T72
R
P
P
A
A
R
A
T
R
A
E
G
Q
D
V
Site 5
S81
A
E
G
Q
D
V
A
S
R
S
R
S
P
L
A
Site 6
S83
G
Q
D
V
A
S
R
S
R
S
P
L
A
R
E
Site 7
S85
D
V
A
S
R
S
R
S
P
L
A
R
E
G
A
Site 8
T145
R
C
A
Q
V
S
K
T
W
K
V
I
A
E
D
Site 9
Y157
A
E
D
E
V
L
W
Y
R
L
C
Q
Q
E
G
Site 10
S169
Q
E
G
H
L
P
D
S
S
I
S
D
Y
S
C
Site 11
S170
E
G
H
L
P
D
S
S
I
S
D
Y
S
C
W
Site 12
S172
H
L
P
D
S
S
I
S
D
Y
S
C
W
K
L
Site 13
Y174
P
D
S
S
I
S
D
Y
S
C
W
K
L
I
F
Site 14
S203
K
N
R
K
G
A
V
S
E
L
E
H
V
P
D
Site 15
T211
E
L
E
H
V
P
D
T
V
L
C
D
V
H
S
Site 16
Y242
W
D
T
R
T
W
D
Y
V
A
P
F
L
E
S
Site 17
S263
P
G
M
Q
P
N
V
S
F
V
R
I
N
S
S
Site 18
T288
L
N
I
W
D
L
R
T
G
K
Y
P
V
H
R
Site 19
Y291
W
D
L
R
T
G
K
Y
P
V
H
R
F
E
H
Site 20
S326
A
F
D
V
V
M
L
S
P
N
E
E
G
Y
W
Site 21
Y382
D
S
A
R
T
I
L
Y
A
H
G
P
P
V
T
Site 22
Y417
E
G
S
K
I
L
V
Y
S
L
E
A
G
R
R
Site 23
S418
G
S
K
I
L
V
Y
S
L
E
A
G
R
R
L
Site 24
T436
G
N
V
L
R
D
F
T
C
V
N
L
S
D
S
Site 25
S441
D
F
T
C
V
N
L
S
D
S
P
P
N
L
M
Site 26
S443
T
C
V
N
L
S
D
S
P
P
N
L
M
V
S
Site 27
S464
V
R
I
H
D
L
R
S
G
N
I
A
L
S
L
Site 28
S470
R
S
G
N
I
A
L
S
L
S
A
H
Q
L
R
Site 29
S472
G
N
I
A
L
S
L
S
A
H
Q
L
R
V
S
Site 30
S479
S
A
H
Q
L
R
V
S
A
V
Q
M
D
D
W
Site 31
S490
M
D
D
W
K
I
V
S
G
G
E
E
G
L
V
Site 32
Y502
G
L
V
S
V
W
D
Y
R
M
N
Q
K
L
W
Site 33
S521
G
H
P
V
Q
H
I
S
F
S
S
H
S
L
I
Site 34
S545
M
R
N
A
D
L
D
S
F
T
T
H
R
R
H
Site 35
T547
N
A
D
L
D
S
F
T
T
H
R
R
H
R
G
Site 36
T548
A
D
L
D
S
F
T
T
H
R
R
H
R
G
L
Site 37
Y559
H
R
G
L
I
R
A
Y
E
F
A
V
D
Q
L
Site 38
S578
P
L
P
V
C
R
S
S
C
D
A
M
A
T
H
Site 39
Y595
D
L
A
L
A
F
P
Y
N
H
V
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation