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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
D2HGDH
Full Name:
D-2-hydroxyglutarate dehydrogenase, mitochondrial
Alias:
Type:
Mass (Da):
56416
Number AA:
521
UniProt ID:
Q8N465
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
G
A
P
G
A
A
G
S
W
G
R
P
V
G
P
Site 2
S38
L
A
R
R
G
C
C
S
A
P
G
T
P
E
V
Site 3
T42
G
C
C
S
A
P
G
T
P
E
V
P
L
T
R
Site 4
T48
G
T
P
E
V
P
L
T
R
E
R
Y
P
V
R
Site 5
Y52
V
P
L
T
R
E
R
Y
P
V
R
R
L
P
F
Site 6
S60
P
V
R
R
L
P
F
S
T
V
S
K
Q
D
L
Site 7
T61
V
R
R
L
P
F
S
T
V
S
K
Q
D
L
A
Site 8
S63
R
L
P
F
S
T
V
S
K
Q
D
L
A
A
F
Site 9
T95
P
N
V
D
W
L
R
T
L
R
G
C
S
K
V
Site 10
S100
L
R
T
L
R
G
C
S
K
V
L
L
R
P
R
Site 11
T108
K
V
L
L
R
P
R
T
S
E
E
V
S
H
I
Site 12
S109
V
L
L
R
P
R
T
S
E
E
V
S
H
I
L
Site 13
S113
P
R
T
S
E
E
V
S
H
I
L
R
H
C
H
Site 14
S178
G
C
V
L
E
E
L
S
R
Y
V
E
E
R
D
Site 15
Y180
V
L
E
E
L
S
R
Y
V
E
E
R
D
F
I
Site 16
T240
G
T
V
L
D
C
L
T
S
L
R
K
D
N
T
Site 17
S241
T
V
L
D
C
L
T
S
L
R
K
D
N
T
G
Site 18
T247
T
S
L
R
K
D
N
T
G
Y
D
L
K
Q
L
Site 19
Y249
L
R
K
D
N
T
G
Y
D
L
K
Q
L
F
I
Site 20
S329
G
R
H
L
H
L
A
S
P
V
Q
E
S
P
F
Site 21
Y337
P
V
Q
E
S
P
F
Y
V
L
I
E
T
S
G
Site 22
T371
S
G
L
V
T
D
G
T
M
A
T
D
Q
R
K
Site 23
T390
W
A
L
R
E
R
I
T
E
A
L
S
R
D
G
Site 24
Y398
E
A
L
S
R
D
G
Y
V
Y
K
Y
D
L
S
Site 25
Y400
L
S
R
D
G
Y
V
Y
K
Y
D
L
S
L
P
Site 26
Y402
R
D
G
Y
V
Y
K
Y
D
L
S
L
P
V
E
Site 27
S405
Y
V
Y
K
Y
D
L
S
L
P
V
E
R
L
Y
Site 28
Y412
S
L
P
V
E
R
L
Y
D
I
V
T
D
L
R
Site 29
T416
E
R
L
Y
D
I
V
T
D
L
R
A
R
L
G
Site 30
T445
G
N
L
H
L
N
V
T
A
E
A
F
S
P
S
Site 31
Y462
A
A
L
E
P
H
V
Y
E
W
T
A
G
Q
Q
Site 32
S471
W
T
A
G
Q
Q
G
S
V
S
A
E
H
G
V
Site 33
S473
A
G
Q
Q
G
S
V
S
A
E
H
G
V
G
F
Site 34
Y488
R
K
R
D
V
L
G
Y
S
K
P
P
G
A
L
Site 35
S489
K
R
D
V
L
G
Y
S
K
P
P
G
A
L
Q
Site 36
Y514
P
K
G
I
L
N
P
Y
K
T
L
P
S
Q
A
Site 37
T516
G
I
L
N
P
Y
K
T
L
P
S
Q
A
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation