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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RYBP
Full Name:
RING1 and YY1-binding protein
Alias:
AAP1; APAP-1; Apoptin-associating 1; Apoptin-associating protein 1; Death effector domain-associated factor; DEDAF; DED-associated factor; RING1 and YY1 bindin; RING1 and YY1 binding protein; RING1 and YY1-binding protein: Death effector domain-associated factor: YY1 and E4TF1-associated factor 1: Apoptin-associating protein 1; Ring1 interactor RYBP; YEAF1; YY1 and E4TF1 associated factor 1
Type:
Transcription, coactivator/corepressor
Mass (Da):
24822
Number AA:
228
UniProt ID:
Q8N488
International Prot ID:
IPI00296594
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003714
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0007275
GO:0000122
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
T
M
G
D
K
K
S
P
T
R
P
K
R
Q
Site 2
S35
S
V
C
T
F
R
N
S
A
E
A
F
K
C
S
Site 3
T50
I
C
D
V
R
K
G
T
S
T
R
K
P
R
I
Site 4
S51
C
D
V
R
K
G
T
S
T
R
K
P
R
I
N
Site 5
T52
D
V
R
K
G
T
S
T
R
K
P
R
I
N
S
Site 6
S59
T
R
K
P
R
I
N
S
Q
L
V
A
Q
Q
V
Site 7
Y70
A
Q
Q
V
A
Q
Q
Y
A
T
P
P
P
P
K
Site 8
T72
Q
V
A
Q
Q
Y
A
T
P
P
P
P
K
K
E
Site 9
S99
P
E
K
D
K
E
I
S
P
S
V
T
K
K
N
Site 10
S101
K
D
K
E
I
S
P
S
V
T
K
K
N
T
N
Site 11
T103
K
E
I
S
P
S
V
T
K
K
N
T
N
K
K
Site 12
T107
P
S
V
T
K
K
N
T
N
K
K
T
K
P
K
Site 13
T111
K
K
N
T
N
K
K
T
K
P
K
S
D
I
L
Site 14
S115
N
K
K
T
K
P
K
S
D
I
L
K
D
P
P
Site 15
S123
D
I
L
K
D
P
P
S
E
A
N
S
I
Q
S
Site 16
S127
D
P
P
S
E
A
N
S
I
Q
S
A
N
A
T
Site 17
S130
S
E
A
N
S
I
Q
S
A
N
A
T
T
K
T
Site 18
T134
S
I
Q
S
A
N
A
T
T
K
T
S
E
T
N
Site 19
S138
A
N
A
T
T
K
T
S
E
T
N
H
T
S
R
Site 20
T143
K
T
S
E
T
N
H
T
S
R
P
R
L
K
N
Site 21
S154
R
L
K
N
V
D
R
S
T
A
Q
Q
L
A
V
Site 22
T155
L
K
N
V
D
R
S
T
A
Q
Q
L
A
V
T
Site 23
T162
T
A
Q
Q
L
A
V
T
V
G
N
V
T
V
I
Site 24
T171
G
N
V
T
V
I
I
T
D
F
K
E
K
T
R
Site 25
T177
I
T
D
F
K
E
K
T
R
S
S
S
T
S
S
Site 26
S179
D
F
K
E
K
T
R
S
S
S
T
S
S
S
T
Site 27
S180
F
K
E
K
T
R
S
S
S
T
S
S
S
T
V
Site 28
S181
K
E
K
T
R
S
S
S
T
S
S
S
T
V
T
Site 29
T182
E
K
T
R
S
S
S
T
S
S
S
T
V
T
S
Site 30
S183
K
T
R
S
S
S
T
S
S
S
T
V
T
S
S
Site 31
S184
T
R
S
S
S
T
S
S
S
T
V
T
S
S
A
Site 32
S185
R
S
S
S
T
S
S
S
T
V
T
S
S
A
G
Site 33
T186
S
S
S
T
S
S
S
T
V
T
S
S
A
G
S
Site 34
T188
S
T
S
S
S
T
V
T
S
S
A
G
S
E
Q
Site 35
S189
T
S
S
S
T
V
T
S
S
A
G
S
E
Q
Q
Site 36
S190
S
S
S
T
V
T
S
S
A
G
S
E
Q
Q
N
Site 37
S193
T
V
T
S
S
A
G
S
E
Q
Q
N
Q
S
S
Site 38
S199
G
S
E
Q
Q
N
Q
S
S
S
G
S
E
S
T
Site 39
S200
S
E
Q
Q
N
Q
S
S
S
G
S
E
S
T
D
Site 40
S201
E
Q
Q
N
Q
S
S
S
G
S
E
S
T
D
K
Site 41
S203
Q
N
Q
S
S
S
G
S
E
S
T
D
K
G
S
Site 42
S205
Q
S
S
S
G
S
E
S
T
D
K
G
S
S
R
Site 43
T206
S
S
S
G
S
E
S
T
D
K
G
S
S
R
S
Site 44
S210
S
E
S
T
D
K
G
S
S
R
S
S
T
P
K
Site 45
S211
E
S
T
D
K
G
S
S
R
S
S
T
P
K
G
Site 46
S213
T
D
K
G
S
S
R
S
S
T
P
K
G
D
M
Site 47
S214
D
K
G
S
S
R
S
S
T
P
K
G
D
M
S
Site 48
T215
K
G
S
S
R
S
S
T
P
K
G
D
M
S
A
Site 49
S221
S
T
P
K
G
D
M
S
A
V
N
D
E
S
F
Site 50
S227
M
S
A
V
N
D
E
S
F
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation