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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MARVELD2
Full Name:
MARVEL domain-containing protein 2
Alias:
DFNB49; FLJ30532; MALD2; MARVEL domain containing 2; MRVLDC2; TRIC; tricellulin
Type:
Membrane protein, integral
Mass (Da):
64180
Number AA:
558
UniProt ID:
Q8N4S9
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005923
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0007605
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y14
S
R
N
R
D
R
R
Y
D
E
V
P
S
D
L
Site 2
Y23
E
V
P
S
D
L
P
Y
Q
D
T
T
I
R
T
Site 3
T26
S
D
L
P
Y
Q
D
T
T
I
R
T
H
P
I
Site 4
T27
D
L
P
Y
Q
D
T
T
I
R
T
H
P
I
L
Site 5
S37
T
H
P
I
L
H
D
S
E
R
A
V
S
A
D
Site 6
S42
H
D
S
E
R
A
V
S
A
D
P
L
P
P
P
Site 7
Y62
P
P
F
G
P
D
F
Y
S
S
D
T
E
E
P
Site 8
S63
P
F
G
P
D
F
Y
S
S
D
T
E
E
P
A
Site 9
S64
F
G
P
D
F
Y
S
S
D
T
E
E
P
A
I
Site 10
T66
P
D
F
Y
S
S
D
T
E
E
P
A
I
A
P
Site 11
S104
P
E
W
D
K
P
V
S
D
I
R
Y
I
S
D
Site 12
Y108
K
P
V
S
D
I
R
Y
I
S
D
G
V
E
C
Site 13
S110
V
S
D
I
R
Y
I
S
D
G
V
E
C
S
P
Site 14
S116
I
S
D
G
V
E
C
S
P
P
A
S
P
A
R
Site 15
S120
V
E
C
S
P
P
A
S
P
A
R
P
N
H
R
Site 16
S128
P
A
R
P
N
H
R
S
P
L
N
S
C
K
D
Site 17
S132
N
H
R
S
P
L
N
S
C
K
D
P
Y
G
G
Site 18
Y137
L
N
S
C
K
D
P
Y
G
G
S
E
G
T
F
Site 19
S140
C
K
D
P
Y
G
G
S
E
G
T
F
S
S
R
Site 20
T143
P
Y
G
G
S
E
G
T
F
S
S
R
K
E
A
Site 21
S145
G
G
S
E
G
T
F
S
S
R
K
E
A
D
A
Site 22
Y159
A
V
F
P
R
D
P
Y
G
S
L
D
R
H
T
Site 23
S161
F
P
R
D
P
Y
G
S
L
D
R
H
T
Q
T
Site 24
T166
Y
G
S
L
D
R
H
T
Q
T
V
R
T
Y
S
Site 25
T168
S
L
D
R
H
T
Q
T
V
R
T
Y
S
E
K
Site 26
Y172
H
T
Q
T
V
R
T
Y
S
E
K
V
E
E
Y
Site 27
S173
T
Q
T
V
R
T
Y
S
E
K
V
E
E
Y
N
Site 28
Y179
Y
S
E
K
V
E
E
Y
N
L
R
Y
S
Y
M
Site 29
Y185
E
Y
N
L
R
Y
S
Y
M
K
S
W
A
G
L
Site 30
S188
L
R
Y
S
Y
M
K
S
W
A
G
L
L
R
I
Site 31
Y227
E
W
Y
N
L
F
G
Y
S
Q
P
Y
G
M
G
Site 32
S241
G
G
V
G
G
L
G
S
M
Y
G
G
Y
Y
Y
Site 33
Y243
V
G
G
L
G
S
M
Y
G
G
Y
Y
Y
T
G
Site 34
Y246
L
G
S
M
Y
G
G
Y
Y
Y
T
G
P
K
T
Site 35
Y247
G
S
M
Y
G
G
Y
Y
Y
T
G
P
K
T
P
Site 36
Y248
S
M
Y
G
G
Y
Y
Y
T
G
P
K
T
P
F
Site 37
Y304
N
V
A
L
F
I
L
Y
M
A
A
A
I
V
Y
Site 38
Y322
T
N
R
G
G
L
C
Y
Y
P
L
F
N
T
P
Site 39
Y323
N
R
G
G
L
C
Y
Y
P
L
F
N
T
P
V
Site 40
Y377
A
A
R
R
H
R
E
Y
M
E
Q
Q
E
I
N
Site 41
S387
Q
Q
E
I
N
E
P
S
L
S
S
K
R
K
M
Site 42
S389
E
I
N
E
P
S
L
S
S
K
R
K
M
C
E
Site 43
S390
I
N
E
P
S
L
S
S
K
R
K
M
C
E
M
Site 44
S400
K
M
C
E
M
A
T
S
G
D
R
Q
R
D
S
Site 45
S407
S
G
D
R
Q
R
D
S
E
V
N
F
K
E
L
Site 46
S425
K
M
K
P
E
L
L
S
G
H
I
P
P
G
H
Site 47
Y442
K
P
I
V
M
P
D
Y
V
A
K
Y
P
V
I
Site 48
Y446
M
P
D
Y
V
A
K
Y
P
V
I
Q
T
D
D
Site 49
Y458
T
D
D
E
R
E
R
Y
K
A
V
F
Q
D
Q
Site 50
S467
A
V
F
Q
D
Q
F
S
E
Y
K
E
L
S
A
Site 51
Y469
F
Q
D
Q
F
S
E
Y
K
E
L
S
A
E
V
Site 52
S491
D
E
L
D
A
V
M
S
R
L
P
H
H
S
E
Site 53
S497
M
S
R
L
P
H
H
S
E
S
R
Q
E
H
E
Site 54
S499
R
L
P
H
H
S
E
S
R
Q
E
H
E
R
I
Site 55
S507
R
Q
E
H
E
R
I
S
R
I
H
E
E
F
K
Site 56
T521
K
K
K
K
N
D
P
T
F
L
E
K
K
E
R
Site 57
Y531
E
K
K
E
R
C
D
Y
L
K
N
K
L
S
H
Site 58
S537
D
Y
L
K
N
K
L
S
H
I
K
Q
R
I
Q
Site 59
Y546
I
K
Q
R
I
Q
E
Y
D
K
V
M
N
W
D
Site 60
Y557
M
N
W
D
V
Q
G
Y
S
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation