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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CPA6
Full Name:
Carboxypeptidase A6
Alias:
Carboxypeptidase B; CBPA6; CPAH; EC 3.4.17.1
Type:
Protease
Mass (Da):
51008
Number AA:
437
UniProt ID:
Q8N4T0
International Prot ID:
IPI00166764
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
Uniprot
OncoNet
Molecular Function:
GO:0004181
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y33
Q
P
G
H
S
H
L
Y
N
N
R
Y
A
G
D
Site 2
Y37
S
H
L
Y
N
N
R
Y
A
G
D
K
V
I
R
Site 3
Y54
P
K
T
E
E
E
A
Y
A
L
K
K
I
S
Y
Site 4
S72
V
D
L
W
Q
P
S
S
I
S
Y
V
S
E
G
Site 5
S74
L
W
Q
P
S
S
I
S
Y
V
S
E
G
T
V
Site 6
Y75
W
Q
P
S
S
I
S
Y
V
S
E
G
T
V
T
Site 7
S77
P
S
S
I
S
Y
V
S
E
G
T
V
T
D
V
Site 8
T82
Y
V
S
E
G
T
V
T
D
V
H
I
P
Q
N
Site 9
T115
L
I
E
D
L
Q
K
T
L
E
K
G
S
S
L
Site 10
S121
K
T
L
E
K
G
S
S
L
H
T
Q
R
N
R
Site 11
T124
E
K
G
S
S
L
H
T
Q
R
N
R
R
S
L
Site 12
S130
H
T
Q
R
N
R
R
S
L
S
G
Y
N
Y
E
Site 13
S132
Q
R
N
R
R
S
L
S
G
Y
N
Y
E
V
Y
Site 14
Y134
N
R
R
S
L
S
G
Y
N
Y
E
V
Y
H
S
Site 15
Y136
R
S
L
S
G
Y
N
Y
E
V
Y
H
S
L
E
Site 16
Y139
S
G
Y
N
Y
E
V
Y
H
S
L
E
E
I
Q
Site 17
S164
S
G
L
I
H
M
F
S
I
G
R
S
Y
E
G
Site 18
S168
H
M
F
S
I
G
R
S
Y
E
G
R
S
L
F
Site 19
S173
G
R
S
Y
E
G
R
S
L
F
I
L
K
L
G
Site 20
S183
I
L
K
L
G
R
R
S
R
L
K
R
A
V
W
Site 21
T216
F
V
K
E
A
L
L
T
Y
K
S
D
P
A
M
Site 22
S219
E
A
L
L
T
Y
K
S
D
P
A
M
R
K
M
Site 23
T256
N
D
R
F
W
R
K
T
R
S
R
N
S
R
F
Site 24
S258
R
F
W
R
K
T
R
S
R
N
S
R
F
R
C
Site 25
S261
R
K
T
R
S
R
N
S
R
F
R
C
R
G
V
Site 26
T291
S
M
H
P
C
D
D
T
Y
C
G
P
F
P
E
Site 27
Y292
M
H
P
C
D
D
T
Y
C
G
P
F
P
E
S
Site 28
S299
Y
C
G
P
F
P
E
S
E
P
E
V
K
A
V
Site 29
Y320
H
R
K
H
I
R
A
Y
L
S
F
H
A
Y
A
Site 30
Y326
A
Y
L
S
F
H
A
Y
A
Q
M
L
L
Y
P
Site 31
Y332
A
Y
A
Q
M
L
L
Y
P
Y
S
Y
K
Y
A
Site 32
Y334
A
Q
M
L
L
Y
P
Y
S
Y
K
Y
A
T
I
Site 33
Y336
M
L
L
Y
P
Y
S
Y
K
Y
A
T
I
P
N
Site 34
Y338
L
Y
P
Y
S
Y
K
Y
A
T
I
P
N
F
R
Site 35
Y352
R
C
V
E
S
A
A
Y
K
A
V
N
A
L
Q
Site 36
S360
K
A
V
N
A
L
Q
S
V
Y
G
V
R
Y
R
Site 37
Y368
V
Y
G
V
R
Y
R
Y
G
P
A
S
T
T
L
Site 38
S372
R
Y
R
Y
G
P
A
S
T
T
L
Y
V
S
S
Site 39
T374
R
Y
G
P
A
S
T
T
L
Y
V
S
S
G
S
Site 40
Y376
G
P
A
S
T
T
L
Y
V
S
S
G
S
S
M
Site 41
S378
A
S
T
T
L
Y
V
S
S
G
S
S
M
D
W
Site 42
S379
S
T
T
L
Y
V
S
S
G
S
S
M
D
W
A
Site 43
S382
L
Y
V
S
S
G
S
S
M
D
W
A
Y
K
N
Site 44
Y387
G
S
S
M
D
W
A
Y
K
N
G
I
P
Y
A
Site 45
Y393
A
Y
K
N
G
I
P
Y
A
F
A
F
E
L
R
Site 46
Y404
F
E
L
R
D
T
G
Y
F
G
F
L
L
P
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation