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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AFAP1L2
Full Name:
Actin filament-associated protein 1-like 2
Alias:
actin filament associated protein 1-like 2; AF1L2; Em:AC005383.4; FLJ14564; K1914; KIAA1914; XB130
Type:
Activator protein; Cell cycle regulation
Mass (Da):
91300
Number AA:
818
UniProt ID:
Q8N4X5
International Prot ID:
IPI00181905
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0042169
GO:0017124
GO:0030296
PhosphoSite+
KinaseNET
Biological Process:
GO:0006954
GO:0045742
GO:0032757
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
K
A
L
E
Q
L
L
T
E
L
D
D
F
L
K
Site 2
Y44
L
A
E
L
L
R
L
Y
T
K
S
S
S
S
D
Site 3
T45
A
E
L
L
R
L
Y
T
K
S
S
S
S
D
E
Site 4
S47
L
L
R
L
Y
T
K
S
S
S
S
D
E
E
Y
Site 5
S48
L
R
L
Y
T
K
S
S
S
S
D
E
E
Y
I
Site 6
S49
R
L
Y
T
K
S
S
S
S
D
E
E
Y
I
Y
Site 7
S50
L
Y
T
K
S
S
S
S
D
E
E
Y
I
Y
M
Site 8
Y54
S
S
S
S
D
E
E
Y
I
Y
M
N
K
V
T
Site 9
Y56
S
S
D
E
E
Y
I
Y
M
N
K
V
T
I
N
Site 10
T61
Y
I
Y
M
N
K
V
T
I
N
K
Q
Q
N
A
Site 11
S70
N
K
Q
Q
N
A
E
S
Q
G
K
A
P
E
E
Site 12
S87
L
L
P
N
G
E
P
S
Q
H
S
S
A
P
Q
Site 13
S90
N
G
E
P
S
Q
H
S
S
A
P
Q
K
S
L
Site 14
S91
G
E
P
S
Q
H
S
S
A
P
Q
K
S
L
P
Site 15
S96
H
S
S
A
P
Q
K
S
L
P
D
L
P
P
P
Site 16
T117
K
Q
L
A
I
P
K
T
E
S
P
E
G
Y
Y
Site 17
S119
L
A
I
P
K
T
E
S
P
E
G
Y
Y
E
E
Site 18
Y123
K
T
E
S
P
E
G
Y
Y
E
E
A
E
P
Y
Site 19
Y124
T
E
S
P
E
G
Y
Y
E
E
A
E
P
Y
D
Site 20
Y130
Y
Y
E
E
A
E
P
Y
D
T
S
L
N
E
D
Site 21
T132
E
E
A
E
P
Y
D
T
S
L
N
E
D
G
E
Site 22
S133
E
A
E
P
Y
D
T
S
L
N
E
D
G
E
A
Site 23
S142
N
E
D
G
E
A
V
S
S
S
Y
E
S
Y
D
Site 24
S143
E
D
G
E
A
V
S
S
S
Y
E
S
Y
D
E
Site 25
S144
D
G
E
A
V
S
S
S
Y
E
S
Y
D
E
E
Site 26
S147
A
V
S
S
S
Y
E
S
Y
D
E
E
D
G
S
Site 27
Y148
V
S
S
S
Y
E
S
Y
D
E
E
D
G
S
K
Site 28
S154
S
Y
D
E
E
D
G
S
K
G
K
S
A
P
Y
Site 29
S158
E
D
G
S
K
G
K
S
A
P
Y
Q
W
P
S
Site 30
Y161
S
K
G
K
S
A
P
Y
Q
W
P
S
P
E
A
Site 31
S165
S
A
P
Y
Q
W
P
S
P
E
A
G
I
E
L
Site 32
Y206
K
D
N
R
L
L
C
Y
K
S
S
K
D
H
S
Site 33
S208
N
R
L
L
C
Y
K
S
S
K
D
H
S
P
Q
Site 34
S209
R
L
L
C
Y
K
S
S
K
D
H
S
P
Q
L
Site 35
S213
Y
K
S
S
K
D
H
S
P
Q
L
D
V
N
L
Site 36
T242
K
E
H
K
L
K
I
T
P
M
N
A
D
V
I
Site 37
S274
Q
E
V
S
G
L
P
S
E
G
A
S
E
G
N
Site 38
S278
G
L
P
S
E
G
A
S
E
G
N
Q
Y
T
P
Site 39
Y283
G
A
S
E
G
N
Q
Y
T
P
D
A
Q
R
F
Site 40
T284
A
S
E
G
N
Q
Y
T
P
D
A
Q
R
F
N
Site 41
Y301
K
P
D
I
A
E
K
Y
L
S
A
S
E
Y
G
Site 42
S303
D
I
A
E
K
Y
L
S
A
S
E
Y
G
S
S
Site 43
S305
A
E
K
Y
L
S
A
S
E
Y
G
S
S
V
D
Site 44
Y307
K
Y
L
S
A
S
E
Y
G
S
S
V
D
G
H
Site 45
S309
L
S
A
S
E
Y
G
S
S
V
D
G
H
P
E
Site 46
S310
S
A
S
E
Y
G
S
S
V
D
G
H
P
E
V
Site 47
T320
G
H
P
E
V
P
E
T
K
D
V
K
K
K
C
Site 48
S344
M
N
L
G
R
K
K
S
T
S
L
E
P
V
E
Site 49
T345
N
L
G
R
K
K
S
T
S
L
E
P
V
E
R
Site 50
S346
L
G
R
K
K
S
T
S
L
E
P
V
E
R
S
Site 51
S353
S
L
E
P
V
E
R
S
L
E
T
S
S
Y
L
Site 52
S358
E
R
S
L
E
T
S
S
Y
L
N
V
L
V
N
Site 53
Y359
R
S
L
E
T
S
S
Y
L
N
V
L
V
N
S
Site 54
Y383
R
D
N
H
L
H
F
Y
Q
D
R
N
R
S
K
Site 55
S389
F
Y
Q
D
R
N
R
S
K
V
A
Q
Q
P
L
Site 56
S408
C
E
V
V
P
D
P
S
P
D
H
L
Y
S
F
Site 57
Y413
D
P
S
P
D
H
L
Y
S
F
R
I
L
H
K
Site 58
S414
P
S
P
D
H
L
Y
S
F
R
I
L
H
K
G
Site 59
S431
L
A
K
L
E
A
K
S
S
E
E
M
G
H
W
Site 60
S432
A
K
L
E
A
K
S
S
E
E
M
G
H
W
L
Site 61
S444
H
W
L
G
L
L
L
S
E
S
G
S
K
T
D
Site 62
S446
L
G
L
L
L
S
E
S
G
S
K
T
D
P
E
Site 63
S448
L
L
L
S
E
S
G
S
K
T
D
P
E
E
F
Site 64
T450
L
S
E
S
G
S
K
T
D
P
E
E
F
T
Y
Site 65
T456
K
T
D
P
E
E
F
T
Y
D
Y
V
D
A
D
Site 66
Y457
T
D
P
E
E
F
T
Y
D
Y
V
D
A
D
R
Site 67
Y459
P
E
E
F
T
Y
D
Y
V
D
A
D
R
V
S
Site 68
S466
Y
V
D
A
D
R
V
S
C
I
V
S
A
A
K
Site 69
S484
L
L
M
Q
R
K
F
S
E
P
N
T
Y
I
D
Site 70
T488
R
K
F
S
E
P
N
T
Y
I
D
G
L
P
S
Site 71
Y489
K
F
S
E
P
N
T
Y
I
D
G
L
P
S
Q
Site 72
S495
T
Y
I
D
G
L
P
S
Q
D
R
Q
E
E
L
Site 73
Y503
Q
D
R
Q
E
E
L
Y
D
D
V
D
L
S
E
Site 74
T522
V
E
P
T
E
E
A
T
P
V
A
D
D
P
N
Site 75
S533
D
D
P
N
E
R
E
S
D
R
V
Y
L
D
L
Site 76
Y537
E
R
E
S
D
R
V
Y
L
D
L
T
P
V
K
Site 77
T541
D
R
V
Y
L
D
L
T
P
V
K
S
F
L
H
Site 78
S545
L
D
L
T
P
V
K
S
F
L
H
G
P
S
S
Site 79
S552
S
F
L
H
G
P
S
S
A
Q
A
Q
A
S
S
Site 80
S558
S
S
A
Q
A
Q
A
S
S
P
T
L
S
C
L
Site 81
S559
S
A
Q
A
Q
A
S
S
P
T
L
S
C
L
D
Site 82
S563
Q
A
S
S
P
T
L
S
C
L
D
N
A
T
E
Site 83
S576
T
E
A
L
P
A
D
S
G
P
G
P
T
P
D
Site 84
T581
A
D
S
G
P
G
P
T
P
D
E
P
C
I
K
Site 85
S600
L
G
E
Q
Q
L
E
S
L
E
P
E
D
P
S
Site 86
S607
S
L
E
P
E
D
P
S
L
R
I
T
T
V
K
Site 87
T611
E
D
P
S
L
R
I
T
T
V
K
I
Q
T
E
Site 88
T612
D
P
S
L
R
I
T
T
V
K
I
Q
T
E
Q
Site 89
S623
Q
T
E
Q
Q
R
I
S
F
P
P
S
C
P
D
Site 90
S640
V
A
T
P
P
G
A
S
P
P
V
K
D
R
L
Site 91
T650
V
K
D
R
L
R
V
T
S
A
E
I
K
L
G
Site 92
S651
K
D
R
L
R
V
T
S
A
E
I
K
L
G
K
Site 93
Y668
T
E
A
E
V
K
R
Y
T
E
E
K
E
R
L
Site 94
T669
E
A
E
V
K
R
Y
T
E
E
K
E
R
L
E
Site 95
T699
E
K
R
E
L
K
E
T
L
L
K
C
T
D
K
Site 96
S711
T
D
K
E
V
L
A
S
L
E
Q
K
L
K
E
Site 97
S728
E
E
C
R
G
E
E
S
R
R
V
D
L
E
L
Site 98
T761
L
G
T
T
V
D
T
T
H
L
E
N
V
S
P
Site 99
S767
T
T
H
L
E
N
V
S
P
R
P
K
A
V
T
Site 100
T774
S
P
R
P
K
A
V
T
P
A
S
A
P
D
C
Site 101
S777
P
K
A
V
T
P
A
S
A
P
D
C
T
P
V
Site 102
T782
P
A
S
A
P
D
C
T
P
V
N
S
A
T
T
Site 103
T788
C
T
P
V
N
S
A
T
T
L
K
N
R
P
L
Site 104
S796
T
L
K
N
R
P
L
S
V
V
V
T
G
K
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation