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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AFAP1
Full Name:
Actin filament-associated protein 1
Alias:
110 kDa actin filament-associated protein; Actin filament associated protein; Actin filament associated protein 1; AFAP; AFAP-110
Type:
Adapter/scaffold protein
Mass (Da):
80725
Number AA:
730
UniProt ID:
Q8N556
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
GO:0005925
Uniprot
OncoNet
Molecular Function:
GO:0003779
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y19
L
E
L
L
D
H
E
Y
L
T
S
T
V
R
E
Site 2
S22
L
D
H
E
Y
L
T
S
T
V
R
E
K
K
A
Site 3
T23
D
H
E
Y
L
T
S
T
V
R
E
K
K
A
V
Site 4
S40
N
I
L
L
R
I
Q
S
S
K
G
F
D
V
K
Site 5
S58
Q
K
Q
E
T
A
N
S
L
P
A
P
P
Q
M
Site 6
S79
Q
P
W
L
P
P
D
S
G
P
P
P
L
P
T
Site 7
T86
S
G
P
P
P
L
P
T
S
S
L
P
E
G
Y
Site 8
S87
G
P
P
P
L
P
T
S
S
L
P
E
G
Y
Y
Site 9
S88
P
P
P
L
P
T
S
S
L
P
E
G
Y
Y
E
Site 10
Y93
T
S
S
L
P
E
G
Y
Y
E
E
A
V
P
L
Site 11
Y94
S
S
L
P
E
G
Y
Y
E
E
A
V
P
L
S
Site 12
S101
Y
E
E
A
V
P
L
S
P
G
K
A
P
E
Y
Site 13
Y108
S
P
G
K
A
P
E
Y
I
T
S
N
Y
D
S
Site 14
S111
K
A
P
E
Y
I
T
S
N
Y
D
S
D
A
M
Site 15
Y113
P
E
Y
I
T
S
N
Y
D
S
D
A
M
S
S
Site 16
S115
Y
I
T
S
N
Y
D
S
D
A
M
S
S
S
Y
Site 17
S119
N
Y
D
S
D
A
M
S
S
S
Y
E
S
Y
D
Site 18
S120
Y
D
S
D
A
M
S
S
S
Y
E
S
Y
D
E
Site 19
S121
D
S
D
A
M
S
S
S
Y
E
S
Y
D
E
E
Site 20
S124
A
M
S
S
S
Y
E
S
Y
D
E
E
E
E
D
Site 21
Y125
M
S
S
S
Y
E
S
Y
D
E
E
E
E
D
G
Site 22
T137
E
D
G
K
G
K
K
T
R
H
Q
W
P
S
E
Site 23
S143
K
T
R
H
Q
W
P
S
E
E
A
S
M
D
L
Site 24
S147
Q
W
P
S
E
E
A
S
M
D
L
V
K
D
A
Site 25
S186
T
K
L
L
C
Y
K
S
S
K
D
Q
Q
P
Q
Site 26
S187
K
L
L
C
Y
K
S
S
K
D
Q
Q
P
Q
M
Site 27
T204
P
L
Q
G
C
N
I
T
Y
I
P
K
D
S
K
Site 28
Y205
L
Q
G
C
N
I
T
Y
I
P
K
D
S
K
K
Site 29
T220
K
K
H
E
L
K
I
T
Q
Q
G
T
D
P
L
Site 30
T224
L
K
I
T
Q
Q
G
T
D
P
L
V
L
A
V
Site 31
Y248
L
K
V
I
K
E
A
Y
S
G
C
S
G
P
V
Site 32
S249
K
V
I
K
E
A
Y
S
G
C
S
G
P
V
D
Site 33
S257
G
C
S
G
P
V
D
S
E
C
P
P
P
P
S
Site 34
S264
S
E
C
P
P
P
P
S
S
P
V
H
K
A
E
Site 35
S265
E
C
P
P
P
P
S
S
P
V
H
K
A
E
L
Site 36
S277
A
E
L
E
K
K
L
S
S
E
R
P
S
S
D
Site 37
S278
E
L
E
K
K
L
S
S
E
R
P
S
S
D
G
Site 38
S282
K
L
S
S
E
R
P
S
S
D
G
E
G
V
V
Site 39
S283
L
S
S
E
R
P
S
S
D
G
E
G
V
V
E
Site 40
T294
G
V
V
E
N
G
I
T
T
C
N
G
K
E
Q
Site 41
S307
E
Q
V
K
R
K
K
S
S
K
S
E
A
K
G
Site 42
S310
K
R
K
K
S
S
K
S
E
A
K
G
T
V
S
Site 43
T315
S
K
S
E
A
K
G
T
V
S
K
V
T
G
K
Site 44
S317
S
E
A
K
G
T
V
S
K
V
T
G
K
K
I
Site 45
S329
K
K
I
T
K
I
I
S
L
G
K
K
K
P
S
Site 46
S336
S
L
G
K
K
K
P
S
T
D
E
Q
T
S
S
Site 47
T337
L
G
K
K
K
P
S
T
D
E
Q
T
S
S
A
Site 48
T341
K
P
S
T
D
E
Q
T
S
S
A
E
E
D
V
Site 49
S342
P
S
T
D
E
Q
T
S
S
A
E
E
D
V
P
Site 50
S343
S
T
D
E
Q
T
S
S
A
E
E
D
V
P
T
Site 51
T350
S
A
E
E
D
V
P
T
C
G
Y
L
N
V
L
Site 52
Y353
E
D
V
P
T
C
G
Y
L
N
V
L
S
N
S
Site 53
S358
C
G
Y
L
N
V
L
S
N
S
R
W
R
E
R
Site 54
S360
Y
L
N
V
L
S
N
S
R
W
R
E
R
W
C
Site 55
T381
L
I
F
H
K
D
R
T
D
L
K
T
H
I
V
Site 56
T385
K
D
R
T
D
L
K
T
H
I
V
S
I
P
L
Site 57
S403
E
V
I
P
G
L
D
S
K
H
P
L
T
F
R
Site 58
T408
L
D
S
K
H
P
L
T
F
R
L
L
R
N
G
Site 59
S426
A
V
L
E
A
S
S
S
E
D
M
G
R
W
I
Site 60
S443
L
L
A
E
T
G
S
S
T
D
P
E
A
L
H
Site 61
T444
L
A
E
T
G
S
S
T
D
P
E
A
L
H
Y
Site 62
Y451
T
D
P
E
A
L
H
Y
D
Y
I
D
V
E
M
Site 63
Y453
P
E
A
L
H
Y
D
Y
I
D
V
E
M
S
A
Site 64
S479
F
M
N
R
R
V
I
S
A
N
P
Y
L
G
G
Site 65
Y483
R
V
I
S
A
N
P
Y
L
G
G
T
S
N
G
Site 66
T487
A
N
P
Y
L
G
G
T
S
N
G
Y
A
H
P
Site 67
S488
N
P
Y
L
G
G
T
S
N
G
Y
A
H
P
S
Site 68
Y491
L
G
G
T
S
N
G
Y
A
H
P
S
G
T
A
Site 69
S495
S
N
G
Y
A
H
P
S
G
T
A
L
H
Y
D
Site 70
T497
G
Y
A
H
P
S
G
T
A
L
H
Y
D
D
V
Site 71
Y501
P
S
G
T
A
L
H
Y
D
D
V
P
C
I
N
Site 72
S510
D
V
P
C
I
N
G
S
L
K
G
K
K
P
P
Site 73
S520
G
K
K
P
P
V
A
S
N
G
V
T
G
K
G
Site 74
T524
P
V
A
S
N
G
V
T
G
K
G
K
T
L
S
Site 75
T529
G
V
T
G
K
G
K
T
L
S
S
Q
P
K
K
Site 76
S531
T
G
K
G
K
T
L
S
S
Q
P
K
K
A
D
Site 77
S532
G
K
G
K
T
L
S
S
Q
P
K
K
A
D
P
Site 78
T546
P
A
A
V
V
K
R
T
G
S
N
A
A
Q
Y
Site 79
S548
A
V
V
K
R
T
G
S
N
A
A
Q
Y
K
Y
Site 80
Y553
T
G
S
N
A
A
Q
Y
K
Y
G
K
N
R
V
Site 81
T569
A
D
A
K
R
L
Q
T
K
E
E
E
L
L
K
Site 82
S631
Q
K
E
A
E
R
V
S
L
E
L
E
L
T
E
Site 83
T637
V
S
L
E
L
E
L
T
E
V
K
E
S
L
K
Site 84
S642
E
L
T
E
V
K
E
S
L
K
K
A
L
A
G
Site 85
S661
G
L
A
I
E
P
K
S
G
T
S
S
P
Q
S
Site 86
T663
A
I
E
P
K
S
G
T
S
S
P
Q
S
P
V
Site 87
S664
I
E
P
K
S
G
T
S
S
P
Q
S
P
V
F
Site 88
S665
E
P
K
S
G
T
S
S
P
Q
S
P
V
F
R
Site 89
S668
S
G
T
S
S
P
Q
S
P
V
F
R
H
R
T
Site 90
T675
S
P
V
F
R
H
R
T
L
E
N
S
P
I
S
Site 91
S679
R
H
R
T
L
E
N
S
P
I
S
S
C
D
T
Site 92
S682
T
L
E
N
S
P
I
S
S
C
D
T
S
D
T
Site 93
S683
L
E
N
S
P
I
S
S
C
D
T
S
D
T
E
Site 94
T686
S
P
I
S
S
C
D
T
S
D
T
E
G
P
V
Site 95
S687
P
I
S
S
C
D
T
S
D
T
E
G
P
V
P
Site 96
T689
S
S
C
D
T
S
D
T
E
G
P
V
P
V
N
Site 97
S704
S
A
A
V
L
K
K
S
Q
A
A
P
G
S
S
Site 98
S710
K
S
Q
A
A
P
G
S
S
P
C
R
G
H
V
Site 99
S711
S
Q
A
A
P
G
S
S
P
C
R
G
H
V
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation