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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DCAMKL2
Full Name:
Serine/threonine-protein kinase DCLK2
Alias:
DCAK2; DCDC3; DCDC3B; DCK2; DCLK2; Doublecortin-like kinase 2; EC 2.7.11.1; MGC45428; Serine/threonine-protein kinase DCLK2
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1;
CAMK
group; DCAMKL family
Mass (Da):
83612
Number AA:
766
UniProt ID:
Q8N568
International Prot ID:
IPI00552471
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
DCAMKLSubtide - DCAMKL2 protein kinase substrate peptide - Powder PE-01BHA90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BHA90
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
A
S
T
R
S
I
E
L
E
H
F
E
Site 2
S23
D
K
R
P
R
P
G
S
R
R
G
A
P
S
S
Site 3
S29
G
S
R
R
G
A
P
S
S
S
G
G
S
S
S
Site 4
S30
S
R
R
G
A
P
S
S
S
G
G
S
S
S
S
Site 5
S31
R
R
G
A
P
S
S
S
G
G
S
S
S
S
G
Site 6
S34
A
P
S
S
S
G
G
S
S
S
S
G
P
K
G
Site 7
S35
P
S
S
S
G
G
S
S
S
S
G
P
K
G
N
Site 8
S36
S
S
S
G
G
S
S
S
S
G
P
K
G
N
G
Site 9
S37
S
S
G
G
S
S
S
S
G
P
K
G
N
G
L
Site 10
S47
K
G
N
G
L
I
P
S
P
A
H
S
A
H
C
Site 11
S51
L
I
P
S
P
A
H
S
A
H
C
S
F
Y
R
Site 12
S55
P
A
H
S
A
H
C
S
F
Y
R
T
R
T
L
Site 13
T61
C
S
F
Y
R
T
R
T
L
Q
A
L
S
S
E
Site 14
S67
R
T
L
Q
A
L
S
S
E
K
K
A
K
K
A
Site 15
Y77
K
A
K
K
A
R
F
Y
R
N
G
D
R
Y
F
Site 16
Y83
F
Y
R
N
G
D
R
Y
F
K
G
L
V
F
A
Site 17
S93
G
L
V
F
A
I
S
S
D
R
F
R
S
F
D
Site 18
S98
I
S
S
D
R
F
R
S
F
D
A
L
L
I
E
Site 19
T107
D
A
L
L
I
E
L
T
R
S
L
S
D
N
V
Site 20
S111
I
E
L
T
R
S
L
S
D
N
V
N
L
P
Q
Site 21
Y124
P
Q
G
V
R
T
I
Y
T
I
D
G
S
R
K
Site 22
T125
Q
G
V
R
T
I
Y
T
I
D
G
S
R
K
V
Site 23
S129
T
I
Y
T
I
D
G
S
R
K
V
T
S
L
D
Site 24
T133
I
D
G
S
R
K
V
T
S
L
D
E
L
L
E
Site 25
S134
D
G
S
R
K
V
T
S
L
D
E
L
L
E
G
Site 26
S143
D
E
L
L
E
G
E
S
Y
V
C
A
S
N
E
Site 27
Y144
E
L
L
E
G
E
S
Y
V
C
A
S
N
E
P
Site 28
Y157
E
P
F
R
K
V
D
Y
T
K
N
I
N
P
N
Site 29
T173
S
V
N
I
K
G
G
T
S
R
A
L
A
A
A
Site 30
S181
S
R
A
L
A
A
A
S
S
V
K
S
E
V
K
Site 31
S182
R
A
L
A
A
A
S
S
V
K
S
E
V
K
E
Site 32
S185
A
A
A
S
S
V
K
S
E
V
K
E
S
K
D
Site 33
T220
R
I
L
L
N
K
K
T
A
H
S
F
E
Q
V
Site 34
S223
L
N
K
K
T
A
H
S
F
E
Q
V
L
T
D
Site 35
T229
H
S
F
E
Q
V
L
T
D
I
T
E
A
I
K
Site 36
T232
E
Q
V
L
T
D
I
T
E
A
I
K
L
D
S
Site 37
Y276
C
G
P
E
K
F
R
Y
A
Q
D
D
F
V
L
Site 38
S286
D
D
F
V
L
D
H
S
E
C
R
V
L
K
S
Site 39
S293
S
E
C
R
V
L
K
S
S
Y
S
R
S
S
A
Site 40
S294
E
C
R
V
L
K
S
S
Y
S
R
S
S
A
V
Site 41
S296
R
V
L
K
S
S
Y
S
R
S
S
A
V
K
Y
Site 42
S298
L
K
S
S
Y
S
R
S
S
A
V
K
Y
S
G
Site 43
S299
K
S
S
Y
S
R
S
S
A
V
K
Y
S
G
S
Site 44
Y303
S
R
S
S
A
V
K
Y
S
G
S
K
S
P
G
Site 45
S304
R
S
S
A
V
K
Y
S
G
S
K
S
P
G
P
Site 46
S306
S
A
V
K
Y
S
G
S
K
S
P
G
P
S
R
Site 47
S308
V
K
Y
S
G
S
K
S
P
G
P
S
R
R
S
Site 48
S312
G
S
K
S
P
G
P
S
R
R
S
K
S
P
A
Site 49
S315
S
P
G
P
S
R
R
S
K
S
P
A
S
V
N
Site 50
S317
G
P
S
R
R
S
K
S
P
A
S
V
N
G
T
Site 51
S320
R
R
S
K
S
P
A
S
V
N
G
T
P
S
S
Site 52
T324
S
P
A
S
V
N
G
T
P
S
S
Q
L
S
T
Site 53
S326
A
S
V
N
G
T
P
S
S
Q
L
S
T
P
K
Site 54
S327
S
V
N
G
T
P
S
S
Q
L
S
T
P
K
S
Site 55
S330
G
T
P
S
S
Q
L
S
T
P
K
S
T
K
S
Site 56
T331
T
P
S
S
Q
L
S
T
P
K
S
T
K
S
S
Site 57
S334
S
Q
L
S
T
P
K
S
T
K
S
S
S
S
S
Site 58
T335
Q
L
S
T
P
K
S
T
K
S
S
S
S
S
P
Site 59
S337
S
T
P
K
S
T
K
S
S
S
S
S
P
T
S
Site 60
S338
T
P
K
S
T
K
S
S
S
S
S
P
T
S
P
Site 61
S339
P
K
S
T
K
S
S
S
S
S
P
T
S
P
G
Site 62
S340
K
S
T
K
S
S
S
S
S
P
T
S
P
G
S
Site 63
S341
S
T
K
S
S
S
S
S
P
T
S
P
G
S
F
Site 64
T343
K
S
S
S
S
S
P
T
S
P
G
S
F
R
G
Site 65
S344
S
S
S
S
S
P
T
S
P
G
S
F
R
G
L
Site 66
S347
S
S
P
T
S
P
G
S
F
R
G
L
K
Q
I
Site 67
S355
F
R
G
L
K
Q
I
S
A
H
G
R
S
S
S
Site 68
S360
Q
I
S
A
H
G
R
S
S
S
N
V
N
G
G
Site 69
S361
I
S
A
H
G
R
S
S
S
N
V
N
G
G
P
Site 70
S362
S
A
H
G
R
S
S
S
N
V
N
G
G
P
E
Site 71
S375
P
E
L
D
R
C
I
S
P
E
G
V
N
G
N
Site 72
S385
G
V
N
G
N
R
C
S
E
S
S
T
L
L
E
Site 73
S387
N
G
N
R
C
S
E
S
S
T
L
L
E
K
Y
Site 74
S388
G
N
R
C
S
E
S
S
T
L
L
E
K
Y
K
Site 75
T389
N
R
C
S
E
S
S
T
L
L
E
K
Y
K
I
Site 76
Y394
S
S
T
L
L
E
K
Y
K
I
G
K
V
I
G
Site 77
S415
V
K
E
C
I
D
R
S
T
G
K
E
F
A
L
Site 78
T416
K
E
C
I
D
R
S
T
G
K
E
F
A
L
K
Site 79
S442
H
L
I
E
N
E
V
S
I
L
R
R
V
K
H
Site 80
T482
G
D
L
F
D
A
I
T
S
S
T
K
Y
T
E
Site 81
S484
L
F
D
A
I
T
S
S
T
K
Y
T
E
R
D
Site 82
Y487
A
I
T
S
S
T
K
Y
T
E
R
D
G
S
A
Site 83
T488
I
T
S
S
T
K
Y
T
E
R
D
G
S
A
M
Site 84
S493
K
Y
T
E
R
D
G
S
A
M
V
Y
N
L
A
Site 85
Y497
R
D
G
S
A
M
V
Y
N
L
A
N
A
L
R
Site 86
Y505
N
L
A
N
A
L
R
Y
L
H
G
L
S
I
V
Site 87
S510
L
R
Y
L
H
G
L
S
I
V
H
R
D
I
K
Site 88
Y526
E
N
L
L
V
C
E
Y
P
D
G
T
K
S
L
Site 89
T530
V
C
E
Y
P
D
G
T
K
S
L
K
L
G
D
Site 90
S532
E
Y
P
D
G
T
K
S
L
K
L
G
D
F
G
Site 91
T621
A
P
Y
W
D
N
I
T
D
S
A
K
E
L
I
Site 92
S623
Y
W
D
N
I
T
D
S
A
K
E
L
I
S
Q
Site 93
S629
D
S
A
K
E
L
I
S
Q
M
L
Q
V
N
V
Site 94
S647
C
T
A
G
Q
I
L
S
H
P
W
V
S
D
D
Site 95
S652
I
L
S
H
P
W
V
S
D
D
A
S
Q
E
N
Site 96
S656
P
W
V
S
D
D
A
S
Q
E
N
N
M
Q
A
Site 97
T666
N
N
M
Q
A
E
V
T
G
K
L
K
Q
H
F
Site 98
T685
P
K
Q
N
S
T
T
T
G
V
S
V
I
M
N
Site 99
S710
C
S
K
H
C
Q
D
S
G
R
P
G
M
E
P
Site 100
S719
R
P
G
M
E
P
I
S
P
V
P
P
S
V
E
Site 101
T739
G
E
A
V
P
A
P
T
P
P
E
S
P
T
P
Site 102
S743
P
A
P
T
P
P
E
S
P
T
P
H
C
P
P
Site 103
T745
P
T
P
P
E
S
P
T
P
H
C
P
P
A
A
Site 104
T760
P
G
G
E
R
A
G
T
W
R
R
H
R
D
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation