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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MAP3K7IP3
Full Name:
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
Alias:
Mitogen-activated protein kinase kinase kinase 7 interacting protein 3; Mitogen-activated protein kinase kinase kinase 7-interacting 3; NAP1; NF-kappa-B-activating 1; TAB3; TAK1 binding protein 3; TAK1-binding 3; TAK1-binding protein 3
Type:
Adapter/scaffold protein
Mass (Da):
78683
Number AA:
712
UniProt ID:
Q8N5C8
International Prot ID:
IPI00166840
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0044464
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008270
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
A
Q
S
S
P
Q
L
D
I
Q
V
Site 2
S47
E
A
C
C
R
A
L
S
Q
E
S
S
K
Y
L
Site 3
S51
R
A
L
S
Q
E
S
S
K
Y
L
Y
M
E
Y
Site 4
Y53
L
S
Q
E
S
S
K
Y
L
Y
M
E
Y
H
S
Site 5
Y55
Q
E
S
S
K
Y
L
Y
M
E
Y
H
S
P
D
Site 6
Y58
S
K
Y
L
Y
M
E
Y
H
S
P
D
D
N
R
Site 7
S60
Y
L
Y
M
E
Y
H
S
P
D
D
N
R
M
N
Site 8
S80
H
I
N
L
G
I
H
S
P
S
S
Y
H
P
G
Site 9
S82
N
L
G
I
H
S
P
S
S
Y
H
P
G
D
G
Site 10
S83
L
G
I
H
S
P
S
S
Y
H
P
G
D
G
A
Site 11
Y84
G
I
H
S
P
S
S
Y
H
P
G
D
G
A
Q
Site 12
T97
A
Q
L
N
G
G
R
T
L
V
H
S
S
S
D
Site 13
S101
G
G
R
T
L
V
H
S
S
S
D
G
H
I
D
Site 14
S103
R
T
L
V
H
S
S
S
D
G
H
I
D
P
Q
Site 15
Y137
V
V
A
A
T
P
N
Y
N
P
F
F
M
N
E
Site 16
S148
F
M
N
E
Q
N
R
S
A
A
T
P
P
S
Q
Site 17
T151
E
Q
N
R
S
A
A
T
P
P
S
Q
P
P
Q
Site 18
S154
R
S
A
A
T
P
P
S
Q
P
P
Q
Q
P
S
Site 19
S161
S
Q
P
P
Q
Q
P
S
S
M
Q
T
G
M
N
Site 20
S162
Q
P
P
Q
Q
P
S
S
M
Q
T
G
M
N
P
Site 21
T165
Q
Q
P
S
S
M
Q
T
G
M
N
P
S
A
M
Site 22
S170
M
Q
T
G
M
N
P
S
A
M
Q
G
P
S
P
Site 23
S176
P
S
A
M
Q
G
P
S
P
P
P
P
P
P
S
Site 24
S183
S
P
P
P
P
P
P
S
Y
M
H
I
P
R
Y
Site 25
Y184
P
P
P
P
P
P
S
Y
M
H
I
P
R
Y
S
Site 26
Y190
S
Y
M
H
I
P
R
Y
S
T
N
P
I
T
V
Site 27
T192
M
H
I
P
R
Y
S
T
N
P
I
T
V
T
V
Site 28
T196
R
Y
S
T
N
P
I
T
V
T
V
S
Q
N
L
Site 29
T198
S
T
N
P
I
T
V
T
V
S
Q
N
L
P
S
Site 30
S200
N
P
I
T
V
T
V
S
Q
N
L
P
S
G
Q
Site 31
S205
T
V
S
Q
N
L
P
S
G
Q
T
V
P
R
A
Site 32
T208
Q
N
L
P
S
G
Q
T
V
P
R
A
L
Q
I
Site 33
S221
Q
I
L
P
Q
I
P
S
N
L
Y
G
S
P
G
Site 34
Y224
P
Q
I
P
S
N
L
Y
G
S
P
G
S
I
Y
Site 35
S226
I
P
S
N
L
Y
G
S
P
G
S
I
Y
I
R
Site 36
S229
N
L
Y
G
S
P
G
S
I
Y
I
R
Q
T
S
Site 37
Y231
Y
G
S
P
G
S
I
Y
I
R
Q
T
S
Q
S
Site 38
T235
G
S
I
Y
I
R
Q
T
S
Q
S
S
S
G
R
Site 39
S236
S
I
Y
I
R
Q
T
S
Q
S
S
S
G
R
Q
Site 40
S238
Y
I
R
Q
T
S
Q
S
S
S
G
R
Q
T
P
Site 41
S240
R
Q
T
S
Q
S
S
S
G
R
Q
T
P
Q
S
Site 42
T244
Q
S
S
S
G
R
Q
T
P
Q
S
T
P
W
Q
Site 43
S247
S
G
R
Q
T
P
Q
S
T
P
W
Q
S
S
P
Site 44
T248
G
R
Q
T
P
Q
S
T
P
W
Q
S
S
P
Q
Site 45
S252
P
Q
S
T
P
W
Q
S
S
P
Q
G
P
V
P
Site 46
S253
Q
S
T
P
W
Q
S
S
P
Q
G
P
V
P
H
Site 47
Y261
P
Q
G
P
V
P
H
Y
S
Q
R
P
L
P
V
Site 48
S262
Q
G
P
V
P
H
Y
S
Q
R
P
L
P
V
Y
Site 49
Y269
S
Q
R
P
L
P
V
Y
P
H
Q
Q
N
Y
Q
Site 50
Y275
V
Y
P
H
Q
Q
N
Y
Q
P
S
Q
Y
S
P
Site 51
S278
H
Q
Q
N
Y
Q
P
S
Q
Y
S
P
K
Q
Q
Site 52
S281
N
Y
Q
P
S
Q
Y
S
P
K
Q
Q
Q
I
P
Site 53
S290
K
Q
Q
Q
I
P
Q
S
A
Y
H
S
P
P
P
Site 54
Y292
Q
Q
I
P
Q
S
A
Y
H
S
P
P
P
S
Q
Site 55
S294
I
P
Q
S
A
Y
H
S
P
P
P
S
Q
C
P
Site 56
S298
A
Y
H
S
P
P
P
S
Q
C
P
S
P
F
S
Site 57
S302
P
P
P
S
Q
C
P
S
P
F
S
S
P
Q
H
Site 58
S305
S
Q
C
P
S
P
F
S
S
P
Q
H
Q
V
Q
Site 59
S306
Q
C
P
S
P
F
S
S
P
Q
H
Q
V
Q
P
Site 60
S324
G
H
I
F
M
P
P
S
P
S
T
T
P
P
H
Site 61
S326
I
F
M
P
P
S
P
S
T
T
P
P
H
P
Y
Site 62
T327
F
M
P
P
S
P
S
T
T
P
P
H
P
Y
Q
Site 63
T328
M
P
P
S
P
S
T
T
P
P
H
P
Y
Q
Q
Site 64
Y333
S
T
T
P
P
H
P
Y
Q
Q
G
P
P
S
Y
Site 65
S339
P
Y
Q
Q
G
P
P
S
Y
Q
K
Q
G
S
H
Site 66
Y340
Y
Q
Q
G
P
P
S
Y
Q
K
Q
G
S
H
S
Site 67
S345
P
S
Y
Q
K
Q
G
S
H
S
V
A
Y
L
P
Site 68
S347
Y
Q
K
Q
G
S
H
S
V
A
Y
L
P
Y
T
Site 69
Y350
Q
G
S
H
S
V
A
Y
L
P
Y
T
A
S
S
Site 70
Y353
H
S
V
A
Y
L
P
Y
T
A
S
S
L
S
K
Site 71
T354
S
V
A
Y
L
P
Y
T
A
S
S
L
S
K
G
Site 72
S356
A
Y
L
P
Y
T
A
S
S
L
S
K
G
S
M
Site 73
S357
Y
L
P
Y
T
A
S
S
L
S
K
G
S
M
K
Site 74
S359
P
Y
T
A
S
S
L
S
K
G
S
M
K
K
I
Site 75
T369
S
M
K
K
I
E
I
T
V
E
P
S
Q
R
P
Site 76
S373
I
E
I
T
V
E
P
S
Q
R
P
G
T
A
I
Site 77
T378
E
P
S
Q
R
P
G
T
A
I
N
R
S
P
S
Site 78
S383
P
G
T
A
I
N
R
S
P
S
P
I
S
N
Q
Site 79
S385
T
A
I
N
R
S
P
S
P
I
S
N
Q
P
S
Site 80
S388
N
R
S
P
S
P
I
S
N
Q
P
S
P
W
N
Site 81
S392
S
P
I
S
N
Q
P
S
P
W
N
Q
H
S
L
Site 82
S398
P
S
P
W
N
Q
H
S
L
Y
T
A
T
T
P
Site 83
Y400
P
W
N
Q
H
S
L
Y
T
A
T
T
P
P
S
Site 84
T403
Q
H
S
L
Y
T
A
T
T
P
P
S
S
S
P
Site 85
T404
H
S
L
Y
T
A
T
T
P
P
S
S
S
P
S
Site 86
S407
Y
T
A
T
T
P
P
S
S
S
P
S
R
G
I
Site 87
S408
T
A
T
T
P
P
S
S
S
P
S
R
G
I
S
Site 88
S409
A
T
T
P
P
S
S
S
P
S
R
G
I
S
S
Site 89
S411
T
P
P
S
S
S
P
S
R
G
I
S
S
Q
P
Site 90
S415
S
S
P
S
R
G
I
S
S
Q
P
K
P
P
F
Site 91
S416
S
P
S
R
G
I
S
S
Q
P
K
P
P
F
S
Site 92
S423
S
Q
P
K
P
P
F
S
V
N
P
V
Y
I
T
Site 93
Y428
P
F
S
V
N
P
V
Y
I
T
Y
T
Q
P
T
Site 94
Y431
V
N
P
V
Y
I
T
Y
T
Q
P
T
G
P
S
Site 95
T432
N
P
V
Y
I
T
Y
T
Q
P
T
G
P
S
C
Site 96
S438
Y
T
Q
P
T
G
P
S
C
T
P
S
P
S
P
Site 97
T440
Q
P
T
G
P
S
C
T
P
S
P
S
P
R
V
Site 98
S442
T
G
P
S
C
T
P
S
P
S
P
R
V
I
P
Site 99
S444
P
S
C
T
P
S
P
S
P
R
V
I
P
N
P
Site 100
T458
P
T
T
V
F
K
I
T
V
G
R
A
T
T
E
Site 101
T463
K
I
T
V
G
R
A
T
T
E
N
L
L
N
L
Site 102
S477
L
V
D
Q
E
E
R
S
A
A
P
E
P
I
Q
Site 103
S487
P
E
P
I
Q
P
I
S
V
I
P
G
S
G
G
Site 104
S492
P
I
S
V
I
P
G
S
G
G
E
K
G
S
H
Site 105
S498
G
S
G
G
E
K
G
S
H
K
Y
Q
R
S
S
Site 106
Y501
G
E
K
G
S
H
K
Y
Q
R
S
S
S
S
G
Site 107
S504
G
S
H
K
Y
Q
R
S
S
S
S
G
S
D
D
Site 108
S505
S
H
K
Y
Q
R
S
S
S
S
G
S
D
D
Y
Site 109
S506
H
K
Y
Q
R
S
S
S
S
G
S
D
D
Y
A
Site 110
S507
K
Y
Q
R
S
S
S
S
G
S
D
D
Y
A
Y
Site 111
S509
Q
R
S
S
S
S
G
S
D
D
Y
A
Y
T
Q
Site 112
Y512
S
S
S
G
S
D
D
Y
A
Y
T
Q
A
L
L
Site 113
Y514
S
G
S
D
D
Y
A
Y
T
Q
A
L
L
L
H
Site 114
T515
G
S
D
D
Y
A
Y
T
Q
A
L
L
L
H
Q
Site 115
S545
E
E
L
E
R
L
K
S
E
V
N
G
M
E
H
Site 116
S563
Q
R
R
L
R
R
V
S
C
T
T
A
I
P
T
Site 117
T565
R
L
R
R
V
S
C
T
T
A
I
P
T
P
E
Site 118
T566
L
R
R
V
S
C
T
T
A
I
P
T
P
E
E
Site 119
T570
S
C
T
T
A
I
P
T
P
E
E
M
T
R
L
Site 120
S579
E
E
M
T
R
L
R
S
M
N
R
Q
L
Q
I
Site 121
Y613
P
K
A
M
N
N
F
Y
D
N
I
E
P
G
P
Site 122
S627
P
V
V
P
P
K
P
S
K
K
D
S
S
D
P
Site 123
S631
P
K
P
S
K
K
D
S
S
D
P
C
T
I
E
Site 124
S632
K
P
S
K
K
D
S
S
D
P
C
T
I
E
R
Site 125
T636
K
D
S
S
D
P
C
T
I
E
R
K
A
R
R
Site 126
S645
E
R
K
A
R
R
I
S
V
T
S
K
V
Q
A
Site 127
T647
K
A
R
R
I
S
V
T
S
K
V
Q
A
D
I
Site 128
S648
A
R
R
I
S
V
T
S
K
V
Q
A
D
I
H
Site 129
S669
A
D
E
H
R
T
G
S
T
Q
S
P
R
T
Q
Site 130
T670
D
E
H
R
T
G
S
T
Q
S
P
R
T
Q
P
Site 131
S672
H
R
T
G
S
T
Q
S
P
R
T
Q
P
R
D
Site 132
T675
G
S
T
Q
S
P
R
T
Q
P
R
D
E
D
Y
Site 133
Y682
T
Q
P
R
D
E
D
Y
E
G
A
P
W
N
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation