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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SHEP1
Full Name:
SH2 domain-containing protein 3C
Alias:
CHAT; CHAT- H; Novel SH2-containing protein 3; NSP3; SH2 domain containing 3C; SH2 domain-containing Eph receptor-binding protein 1; SH2 domain-containing EPH receptor-binding protein SHEP1; SH2D3; SH2D3C
Type:
Adapter/scaffold protein
Mass (Da):
94411
Number AA:
860
UniProt ID:
Q8N5H7
International Prot ID:
IPI00171093
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0005070
GO:0005085
PhosphoSite+
KinaseNET
Biological Process:
GO:0007254
GO:0007264
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
F
K
F
K
G
F
G
S
L
S
N
L
P
R
S
Site 2
S24
F
K
G
F
G
S
L
S
N
L
P
R
S
F
T
Site 3
S29
S
L
S
N
L
P
R
S
F
T
L
R
R
S
S
Site 4
T31
S
N
L
P
R
S
F
T
L
R
R
S
S
A
S
Site 5
S35
R
S
F
T
L
R
R
S
S
A
S
I
S
R
Q
Site 6
S36
S
F
T
L
R
R
S
S
A
S
I
S
R
Q
S
Site 7
S38
T
L
R
R
S
S
A
S
I
S
R
Q
S
H
L
Site 8
S40
R
R
S
S
A
S
I
S
R
Q
S
H
L
E
P
Site 9
S43
S
A
S
I
S
R
Q
S
H
L
E
P
D
T
F
Site 10
T49
Q
S
H
L
E
P
D
T
F
E
A
T
Q
D
D
Site 11
T59
A
T
Q
D
D
M
V
T
V
P
K
S
P
P
A
Site 12
S63
D
M
V
T
V
P
K
S
P
P
A
Y
A
R
S
Site 13
Y67
V
P
K
S
P
P
A
Y
A
R
S
S
D
M
Y
Site 14
S70
S
P
P
A
Y
A
R
S
S
D
M
Y
S
H
M
Site 15
S71
P
P
A
Y
A
R
S
S
D
M
Y
S
H
M
G
Site 16
Y74
Y
A
R
S
S
D
M
Y
S
H
M
G
T
M
P
Site 17
S75
A
R
S
S
D
M
Y
S
H
M
G
T
M
P
R
Site 18
T79
D
M
Y
S
H
M
G
T
M
P
R
P
S
I
K
Site 19
S84
M
G
T
M
P
R
P
S
I
K
K
A
Q
N
S
Site 20
S91
S
I
K
K
A
Q
N
S
Q
A
A
R
Q
A
Q
Site 21
T134
A
T
G
P
L
E
D
T
P
A
M
E
P
N
P
Site 22
S142
P
A
M
E
P
N
P
S
A
V
E
V
D
P
I
Site 23
S170
R
P
P
R
D
V
H
S
E
R
A
A
G
E
P
Site 24
Y183
E
P
E
A
G
S
D
Y
V
K
F
S
K
E
K
Site 25
Y191
V
K
F
S
K
E
K
Y
I
L
D
S
S
P
E
Site 26
S195
K
E
K
Y
I
L
D
S
S
P
E
K
L
H
K
Site 27
S196
E
K
Y
I
L
D
S
S
P
E
K
L
H
K
E
Site 28
S211
L
E
E
E
L
K
L
S
S
T
D
L
R
S
H
Site 29
S212
E
E
E
L
K
L
S
S
T
D
L
R
S
H
A
Site 30
T213
E
E
L
K
L
S
S
T
D
L
R
S
H
A
W
Site 31
S217
L
S
S
T
D
L
R
S
H
A
W
Y
H
G
R
Site 32
Y221
D
L
R
S
H
A
W
Y
H
G
R
I
P
R
E
Site 33
S230
G
R
I
P
R
E
V
S
E
T
L
V
Q
R
N
Site 34
T232
I
P
R
E
V
S
E
T
L
V
Q
R
N
G
D
Site 35
S245
G
D
F
L
I
R
D
S
L
T
S
L
G
D
Y
Site 36
Y252
S
L
T
S
L
G
D
Y
V
L
T
C
R
W
R
Site 37
Y278
V
V
K
A
G
E
S
Y
T
H
I
Q
Y
L
F
Site 38
Y283
E
S
Y
T
H
I
Q
Y
L
F
E
Q
E
S
F
Site 39
S289
Q
Y
L
F
E
Q
E
S
F
D
H
V
P
A
L
Site 40
Y299
H
V
P
A
L
V
R
Y
H
V
G
S
R
K
A
Site 41
S303
L
V
R
Y
H
V
G
S
R
K
A
V
S
E
Q
Site 42
S308
V
G
S
R
K
A
V
S
E
Q
S
G
A
I
I
Site 43
Y316
E
Q
S
G
A
I
I
Y
C
P
V
N
R
T
F
Site 44
Y327
N
R
T
F
P
L
R
Y
L
E
A
S
Y
G
L
Site 45
S331
P
L
R
Y
L
E
A
S
Y
G
L
G
Q
G
S
Site 46
S338
S
Y
G
L
G
Q
G
S
S
K
P
A
S
P
V
Site 47
S339
Y
G
L
G
Q
G
S
S
K
P
A
S
P
V
S
Site 48
S343
Q
G
S
S
K
P
A
S
P
V
S
P
S
G
P
Site 49
S346
S
K
P
A
S
P
V
S
P
S
G
P
K
G
S
Site 50
S348
P
A
S
P
V
S
P
S
G
P
K
G
S
H
M
Site 51
S353
S
P
S
G
P
K
G
S
H
M
K
R
R
S
V
Site 52
S359
G
S
H
M
K
R
R
S
V
T
M
T
D
G
L
Site 53
T361
H
M
K
R
R
S
V
T
M
T
D
G
L
T
A
Site 54
T363
K
R
R
S
V
T
M
T
D
G
L
T
A
D
K
Site 55
T367
V
T
M
T
D
G
L
T
A
D
K
V
T
R
S
Site 56
S374
T
A
D
K
V
T
R
S
D
G
C
P
T
S
T
Site 57
S380
R
S
D
G
C
P
T
S
T
S
L
P
R
P
R
Site 58
T381
S
D
G
C
P
T
S
T
S
L
P
R
P
R
D
Site 59
S382
D
G
C
P
T
S
T
S
L
P
R
P
R
D
S
Site 60
S389
S
L
P
R
P
R
D
S
I
R
S
C
A
L
S
Site 61
S392
R
P
R
D
S
I
R
S
C
A
L
S
M
D
Q
Site 62
S405
D
Q
I
P
D
L
H
S
P
M
S
P
I
S
E
Site 63
S408
P
D
L
H
S
P
M
S
P
I
S
E
S
P
S
Site 64
S411
H
S
P
M
S
P
I
S
E
S
P
S
S
P
A
Site 65
S413
P
M
S
P
I
S
E
S
P
S
S
P
A
Y
S
Site 66
S415
S
P
I
S
E
S
P
S
S
P
A
Y
S
T
V
Site 67
S416
P
I
S
E
S
P
S
S
P
A
Y
S
T
V
T
Site 68
Y419
E
S
P
S
S
P
A
Y
S
T
V
T
R
V
H
Site 69
S420
S
P
S
S
P
A
Y
S
T
V
T
R
V
H
A
Site 70
T421
P
S
S
P
A
Y
S
T
V
T
R
V
H
A
A
Site 71
S440
S
A
T
A
L
P
A
S
P
V
A
R
R
S
S
Site 72
S446
A
S
P
V
A
R
R
S
S
E
P
Q
L
C
P
Site 73
S447
S
P
V
A
R
R
S
S
E
P
Q
L
C
P
G
Site 74
S455
E
P
Q
L
C
P
G
S
A
P
K
T
H
G
E
Site 75
T459
C
P
G
S
A
P
K
T
H
G
E
S
D
K
G
Site 76
T469
E
S
D
K
G
P
H
T
S
P
S
H
T
L
G
Site 77
S470
S
D
K
G
P
H
T
S
P
S
H
T
L
G
K
Site 78
S472
K
G
P
H
T
S
P
S
H
T
L
G
K
A
S
Site 79
T474
P
H
T
S
P
S
H
T
L
G
K
A
S
P
S
Site 80
S479
S
H
T
L
G
K
A
S
P
S
P
S
L
S
S
Site 81
S481
T
L
G
K
A
S
P
S
P
S
L
S
S
Y
S
Site 82
S483
G
K
A
S
P
S
P
S
L
S
S
Y
S
D
P
Site 83
S485
A
S
P
S
P
S
L
S
S
Y
S
D
P
D
S
Site 84
S486
S
P
S
P
S
L
S
S
Y
S
D
P
D
S
G
Site 85
Y487
P
S
P
S
L
S
S
Y
S
D
P
D
S
G
H
Site 86
S488
S
P
S
L
S
S
Y
S
D
P
D
S
G
H
Y
Site 87
S492
S
S
Y
S
D
P
D
S
G
H
Y
C
Q
L
Q
Site 88
Y495
S
D
P
D
S
G
H
Y
C
Q
L
Q
P
P
V
Site 89
S505
L
Q
P
P
V
R
G
S
R
E
W
A
A
T
E
Site 90
T511
G
S
R
E
W
A
A
T
E
T
S
S
Q
Q
A
Site 91
S515
W
A
A
T
E
T
S
S
Q
Q
A
R
S
Y
G
Site 92
Y521
S
S
Q
Q
A
R
S
Y
G
E
R
L
K
E
L
Site 93
S529
G
E
R
L
K
E
L
S
E
N
G
A
P
E
G
Site 94
T541
P
E
G
D
W
G
K
T
F
T
V
P
I
V
E
Site 95
T589
L
A
E
V
D
A
R
T
L
A
R
H
V
T
K
Site 96
T625
R
W
G
M
E
L
L
T
L
P
H
G
R
Q
L
Site 97
T712
V
T
L
R
Q
R
H
T
E
G
A
I
L
Y
E
Site 98
Y718
H
T
E
G
A
I
L
Y
E
K
K
L
K
P
F
Site 99
S728
K
L
K
P
F
L
K
S
L
N
E
G
K
E
G
Site 100
S739
G
K
E
G
P
P
L
S
N
T
T
F
P
H
V
Site 101
T741
E
G
P
P
L
S
N
T
T
F
P
H
V
L
P
Site 102
S757
I
T
L
L
E
C
D
S
A
P
P
E
G
P
E
Site 103
S768
E
G
P
E
P
W
G
S
T
E
H
G
V
E
V
Site 104
T785
A
H
L
E
A
A
R
T
V
A
H
H
G
G
L
Site 105
Y793
V
A
H
H
G
G
L
Y
H
T
N
A
E
V
K
Site 106
S826
Q
M
R
L
L
W
G
S
Q
G
A
S
S
S
Q
Site 107
S830
L
W
G
S
Q
G
A
S
S
S
Q
A
R
R
Y
Site 108
S832
G
S
Q
G
A
S
S
S
Q
A
R
R
Y
E
K
Site 109
Y837
S
S
S
Q
A
R
R
Y
E
K
F
D
K
V
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation