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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZNF289
Full Name:
ADP-ribosylation factor GTPase-activating protein 2
Alias:
ADP-ribosylation factor GTPase activating protein 2; ARFG2; FLJ14576; ID1 regulated; ID1 regulated zinc finger protein 289; IRZ; Zfp289
Type:
Transcription protein, GTPase activating protein
Mass (Da):
56720
Number AA:
521
UniProt ID:
Q8N6H7
International Prot ID:
IPI00297322
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0008060
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0015031
GO:0032312
GO:0016192
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
A
A
E
P
N
K
T
E
I
Q
T
L
F
K
Site 2
S35
D
C
G
A
K
N
P
S
W
A
S
I
T
Y
G
Site 3
S65
V
H
L
S
F
I
R
S
T
E
L
D
S
N
W
Site 4
T66
H
L
S
F
I
R
S
T
E
L
D
S
N
W
N
Site 5
T89
V
G
G
N
A
N
A
T
A
F
F
R
Q
H
G
Site 6
Y106
A
N
D
A
N
T
K
Y
N
S
R
A
A
Q
M
Site 7
Y114
N
S
R
A
A
Q
M
Y
R
E
K
I
R
Q
L
Site 8
S123
E
K
I
R
Q
L
G
S
A
A
L
A
R
H
G
Site 9
T131
A
A
L
A
R
H
G
T
D
L
W
I
D
N
M
Site 10
S139
D
L
W
I
D
N
M
S
S
A
V
P
N
H
S
Site 11
S140
L
W
I
D
N
M
S
S
A
V
P
N
H
S
P
Site 12
S146
S
S
A
V
P
N
H
S
P
E
K
K
D
S
D
Site 13
S152
H
S
P
E
K
K
D
S
D
F
F
T
E
H
T
Site 14
T156
K
K
D
S
D
F
F
T
E
H
T
Q
P
P
A
Site 15
T159
S
D
F
F
T
E
H
T
Q
P
P
A
W
D
A
Site 16
T169
P
A
W
D
A
P
A
T
E
P
S
G
T
Q
Q
Site 17
S172
D
A
P
A
T
E
P
S
G
T
Q
Q
P
A
P
Site 18
T174
P
A
T
E
P
S
G
T
Q
Q
P
A
P
S
T
Site 19
S180
G
T
Q
Q
P
A
P
S
T
E
S
S
G
L
A
Site 20
T181
T
Q
Q
P
A
P
S
T
E
S
S
G
L
A
Q
Site 21
S184
P
A
P
S
T
E
S
S
G
L
A
Q
P
E
H
Site 22
T195
Q
P
E
H
G
P
N
T
D
L
L
G
T
S
P
Site 23
S201
N
T
D
L
L
G
T
S
P
K
A
S
L
E
L
Site 24
S205
L
G
T
S
P
K
A
S
L
E
L
K
S
S
I
Site 25
S210
K
A
S
L
E
L
K
S
S
I
I
G
K
K
K
Site 26
S211
A
S
L
E
L
K
S
S
I
I
G
K
K
K
P
Site 27
S238
L
G
A
Q
K
V
S
S
Q
S
F
S
E
I
E
Site 28
S240
A
Q
K
V
S
S
Q
S
F
S
E
I
E
R
Q
Site 29
S242
K
V
S
S
Q
S
F
S
E
I
E
R
Q
A
Q
Site 30
S269
A
K
K
Q
A
E
E
S
M
V
A
S
M
R
L
Site 31
S273
A
E
E
S
M
V
A
S
M
R
L
A
Y
Q
E
Site 32
Y278
V
A
S
M
R
L
A
Y
Q
E
L
Q
I
D
R
Site 33
S312
R
L
G
M
G
L
V
S
R
S
S
V
S
H
S
Site 34
S314
G
M
G
L
V
S
R
S
S
V
S
H
S
V
L
Site 35
S319
S
R
S
S
V
S
H
S
V
L
S
E
M
Q
V
Site 36
T331
M
Q
V
I
E
Q
E
T
P
V
S
A
K
S
S
Site 37
S334
I
E
Q
E
T
P
V
S
A
K
S
S
R
S
Q
Site 38
S337
E
T
P
V
S
A
K
S
S
R
S
Q
L
D
L
Site 39
S338
T
P
V
S
A
K
S
S
R
S
Q
L
D
L
F
Site 40
S340
V
S
A
K
S
S
R
S
Q
L
D
L
F
D
D
Site 41
T350
D
L
F
D
D
V
G
T
F
A
S
G
P
P
K
Site 42
S353
D
D
V
G
T
F
A
S
G
P
P
K
Y
K
D
Site 43
Y358
F
A
S
G
P
P
K
Y
K
D
N
P
F
S
L
Site 44
S364
K
Y
K
D
N
P
F
S
L
G
E
S
F
G
S
Site 45
S368
N
P
F
S
L
G
E
S
F
G
S
R
W
D
T
Site 46
S371
S
L
G
E
S
F
G
S
R
W
D
T
D
A
A
Site 47
T392
E
E
K
E
P
E
V
T
I
S
S
I
R
P
I
Site 48
S394
K
E
P
E
V
T
I
S
S
I
R
P
I
S
E
Site 49
S395
E
P
E
V
T
I
S
S
I
R
P
I
S
E
R
Site 50
S400
I
S
S
I
R
P
I
S
E
R
A
T
N
R
R
Site 51
T404
R
P
I
S
E
R
A
T
N
R
R
E
V
E
S
Site 52
S411
T
N
R
R
E
V
E
S
R
S
S
G
L
E
S
Site 53
S413
R
R
E
V
E
S
R
S
S
G
L
E
S
S
E
Site 54
S414
R
E
V
E
S
R
S
S
G
L
E
S
S
E
A
Site 55
S418
S
R
S
S
G
L
E
S
S
E
A
R
Q
K
F
Site 56
S419
R
S
S
G
L
E
S
S
E
A
R
Q
K
F
A
Site 57
S432
F
A
G
A
K
A
I
S
S
D
M
F
F
G
R
Site 58
S433
A
G
A
K
A
I
S
S
D
M
F
F
G
R
E
Site 59
Y445
G
R
E
V
D
A
E
Y
E
A
R
S
R
L
Q
Site 60
S455
R
S
R
L
Q
Q
L
S
G
S
S
A
I
S
S
Site 61
S457
R
L
Q
Q
L
S
G
S
S
A
I
S
S
S
D
Site 62
S458
L
Q
Q
L
S
G
S
S
A
I
S
S
S
D
L
Site 63
S461
L
S
G
S
S
A
I
S
S
S
D
L
F
G
D
Site 64
S462
S
G
S
S
A
I
S
S
S
D
L
F
G
D
M
Site 65
S463
G
S
S
A
I
S
S
S
D
L
F
G
D
M
D
Site 66
S498
Q
F
K
Q
G
V
K
S
V
A
G
K
M
A
V
Site 67
S513
L
A
N
G
V
M
N
S
L
Q
D
R
Y
G
S
Site 68
S520
S
L
Q
D
R
Y
G
S
Y
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation