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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SirT6
Full Name:
NAD-dependent deacetylase sirtuin-6
Alias:
Mono-ADP-ribosyltransferase sirtuin-6; Silent mating type information regulation 2; SIR2L6; SIR2-like protein 6; Sirtuin (silent mating type information regulation 2) 6; Sirtuin 6
Type:
Deacetylase; Transferase; EC 2.4.2.31
Mass (Da):
39119
Number AA:
355
UniProt ID:
Q8N6T7
International Prot ID:
IPI00383640
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005724
GO:0005654
GO:0016585
Uniprot
OncoNet
Molecular Function:
GO:0070403
GO:0003956
GO:0003950
PhosphoSite+
KinaseNET
Biological Process:
GO:0006342
GO:0006471
GO:0006476
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
V
N
Y
A
A
G
L
S
P
Y
A
D
K
G
K
Site 2
S59
G
A
G
I
S
T
A
S
G
I
P
D
F
R
G
Site 3
T72
R
G
P
H
G
V
W
T
M
E
E
R
G
L
A
Site 4
T84
G
L
A
P
K
F
D
T
T
F
E
S
A
R
P
Site 5
T85
L
A
P
K
F
D
T
T
F
E
S
A
R
P
T
Site 6
S88
K
F
D
T
T
F
E
S
A
R
P
T
Q
T
H
Site 7
T92
T
F
E
S
A
R
P
T
Q
T
H
M
A
L
V
Site 8
Y148
C
A
K
C
K
T
Q
Y
V
R
D
T
V
V
G
Site 9
T152
K
T
Q
Y
V
R
D
T
V
V
G
T
M
G
L
Site 10
T184
C
R
G
E
L
R
D
T
I
L
D
W
E
D
S
Site 11
S191
T
I
L
D
W
E
D
S
L
P
D
R
D
L
A
Site 12
S222
T
S
L
Q
I
R
P
S
G
N
L
P
L
A
T
Site 13
T229
S
G
N
L
P
L
A
T
K
R
R
G
G
R
L
Site 14
Y257
A
D
L
R
I
H
G
Y
V
D
E
V
M
T
R
Site 15
T294
P
P
L
P
R
P
P
T
P
K
L
E
P
K
E
Site 16
S303
K
L
E
P
K
E
E
S
P
T
R
I
N
G
S
Site 17
T305
E
P
K
E
E
S
P
T
R
I
N
G
S
I
P
Site 18
S310
S
P
T
R
I
N
G
S
I
P
A
G
P
K
Q
Site 19
S326
P
C
A
Q
H
N
G
S
E
P
A
S
P
K
R
Site 20
S330
H
N
G
S
E
P
A
S
P
K
R
E
R
P
T
Site 21
T337
S
P
K
R
E
R
P
T
S
P
A
P
H
R
P
Site 22
S338
P
K
R
E
R
P
T
S
P
A
P
H
R
P
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation