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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CK1a2
Full Name:
Casein kinase I isoform alpha-like
Alias:
CK1; CK1-alpha2; CKI-alpha; CSNK1A1L; EC 2.7.11.1; KC1AL
Type:
Protein-serine kinase, CK1 group, CK1 family
Mass (Da):
39072
Number AA:
337
UniProt ID:
Q8N752
International Prot ID:
IPI00167096
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0016055
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
CK1apSelectide - CK1a2 (CSNK1A2) protein kinase substrate peptide - Powder PE-04AXJ95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AXJ95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
K
L
V
R
K
I
G
S
G
S
F
G
D
V
Y
Site 2
Y32
S
G
S
F
G
D
V
Y
L
G
I
T
T
T
N
Site 3
S49
D
V
A
V
K
L
E
S
Q
K
V
K
H
P
Q
Site 4
Y59
V
K
H
P
Q
L
L
Y
E
S
K
L
Y
T
I
Site 5
T112
S
R
R
F
T
M
K
T
V
L
M
L
A
D
Q
Site 6
Y126
Q
M
I
S
R
I
E
Y
V
H
T
K
N
F
L
Site 7
T129
S
R
I
E
Y
V
H
T
K
N
F
L
H
R
D
Site 8
T146
P
D
N
F
L
M
G
T
G
R
H
C
N
K
L
Site 9
Y164
D
F
G
L
A
K
K
Y
R
D
N
R
T
R
Q
Site 10
T169
K
K
Y
R
D
N
R
T
R
Q
H
I
P
Y
R
Site 11
Y175
R
T
R
Q
H
I
P
Y
R
E
D
K
H
L
I
Site 12
T184
E
D
K
H
L
I
G
T
V
R
Y
A
S
I
N
Site 13
S199
A
H
L
G
I
E
Q
S
R
R
D
D
M
E
S
Site 14
S206
S
R
R
D
D
M
E
S
L
G
Y
V
F
M
Y
Site 15
Y209
D
D
M
E
S
L
G
Y
V
F
M
Y
F
N
R
Site 16
Y213
S
L
G
Y
V
F
M
Y
F
N
R
T
S
L
P
Site 17
T228
W
Q
G
L
R
A
M
T
K
K
Q
K
Y
E
K
Site 18
Y233
A
M
T
K
K
Q
K
Y
E
K
I
S
E
K
K
Site 19
S242
K
I
S
E
K
K
M
S
T
P
V
E
V
L
C
Site 20
T243
I
S
E
K
K
M
S
T
P
V
E
V
L
C
K
Site 21
Y262
E
F
A
M
Y
L
N
Y
C
R
G
L
R
F
E
Site 22
Y274
R
F
E
E
V
P
D
Y
M
Y
L
R
Q
L
F
Site 23
Y276
E
E
V
P
D
Y
M
Y
L
R
Q
L
F
R
I
Site 24
T287
L
F
R
I
L
F
R
T
L
N
H
Q
Y
D
Y
Site 25
Y292
F
R
T
L
N
H
Q
Y
D
Y
T
F
D
W
T
Site 26
Y294
T
L
N
H
Q
Y
D
Y
T
F
D
W
T
M
L
Site 27
S311
K
A
A
Q
Q
A
A
S
S
S
G
Q
G
Q
Q
Site 28
S312
A
A
Q
Q
A
A
S
S
S
G
Q
G
Q
Q
A
Site 29
T321
G
Q
G
Q
Q
A
Q
T
Q
T
G
K
Q
T
E
Site 30
T323
G
Q
Q
A
Q
T
Q
T
G
K
Q
T
E
K
N
Site 31
T327
Q
T
Q
T
G
K
Q
T
E
K
N
K
N
N
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation