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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EFHB
Full Name:
EF-hand domain-containing family member B
Alias:
Type:
Mass (Da):
93557
Number AA:
831
UniProt ID:
Q8N7U6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T22
D
K
R
V
I
M
G
T
K
F
P
M
E
L
G
Site 2
S39
V
G
L
G
K
E
D
S
R
C
G
E
S
P
V
Site 3
S44
E
D
S
R
C
G
E
S
P
V
V
S
N
K
C
Site 4
S48
C
G
E
S
P
V
V
S
N
K
C
E
G
R
M
Site 5
T60
G
R
M
A
P
P
E
T
K
F
P
L
S
K
G
Site 6
S65
P
E
T
K
F
P
L
S
K
G
L
E
M
G
L
Site 7
T80
E
R
Q
N
I
S
R
T
V
M
Q
R
G
S
L
Site 8
S86
R
T
V
M
Q
R
G
S
L
G
V
D
S
V
S
Site 9
S91
R
G
S
L
G
V
D
S
V
S
A
S
Q
G
T
Site 10
S93
S
L
G
V
D
S
V
S
A
S
Q
G
T
K
P
Site 11
S95
G
V
D
S
V
S
A
S
Q
G
T
K
P
S
L
Site 12
S101
A
S
Q
G
T
K
P
S
L
L
P
G
R
M
G
Site 13
T119
E
S
L
L
A
G
Y
T
H
E
R
I
I
Q
P
Site 14
S134
P
L
G
R
V
C
G
S
S
Q
A
A
G
S
R
Site 15
S135
L
G
R
V
C
G
S
S
Q
A
A
G
S
R
R
Site 16
S140
G
S
S
Q
A
A
G
S
R
R
A
P
L
A
S
Site 17
S147
S
R
R
A
P
L
A
S
G
P
E
G
V
E
E
Site 18
T174
Q
E
M
E
K
E
S
T
C
V
L
M
K
P
N
Site 19
T203
Q
A
E
G
P
D
E
T
K
N
T
E
P
Q
M
Site 20
T206
G
P
D
E
T
K
N
T
E
P
Q
M
G
L
V
Site 21
Y248
P
D
R
I
R
P
I
Y
S
G
K
F
F
D
R
Site 22
S249
D
R
I
R
P
I
Y
S
G
K
F
F
D
R
T
Site 23
T256
S
G
K
F
F
D
R
T
P
C
W
P
S
A
G
Site 24
T285
E
K
L
P
R
L
I
T
P
P
E
A
K
K
Y
Site 25
Y292
T
P
P
E
A
K
K
Y
F
N
F
R
Y
P
P
Site 26
Y297
K
K
Y
F
N
F
R
Y
P
P
A
G
V
E
R
Site 27
Y307
A
G
V
E
R
V
F
Y
G
R
A
N
D
P
Q
Site 28
Y318
N
D
P
Q
I
A
P
Y
L
T
H
G
I
R
S
Site 29
T320
P
Q
I
A
P
Y
L
T
H
G
I
R
S
K
I
Site 30
T342
I
N
P
Q
P
I
T
T
F
Q
Q
K
I
K
D
Site 31
S353
K
I
K
D
K
K
E
S
I
Y
L
S
N
R
R
Site 32
Y355
K
D
K
K
E
S
I
Y
L
S
N
R
R
A
P
Site 33
S357
K
K
E
S
I
Y
L
S
N
R
R
A
P
L
G
Site 34
T379
G
L
P
K
G
M
D
T
T
N
T
T
F
G
T
Site 35
T380
L
P
K
G
M
D
T
T
N
T
T
F
G
T
A
Site 36
T383
G
M
D
T
T
N
T
T
F
G
T
A
V
I
K
Site 37
S403
D
V
V
N
P
P
K
S
Y
E
E
V
F
K
E
Site 38
Y418
G
N
E
G
H
D
L
Y
V
V
S
H
N
D
Y
Site 39
Y425
Y
V
V
S
H
N
D
Y
Y
A
G
E
A
K
N
Site 40
Y426
V
V
S
H
N
D
Y
Y
A
G
E
A
K
N
R
Site 41
Y435
G
E
A
K
N
R
K
Y
N
P
S
S
F
H
R
Site 42
S438
K
N
R
K
Y
N
P
S
S
F
H
R
C
S
V
Site 43
S444
P
S
S
F
H
R
C
S
V
Y
G
V
P
T
P
Site 44
Y446
S
F
H
R
C
S
V
Y
G
V
P
T
P
H
F
Site 45
T450
C
S
V
Y
G
V
P
T
P
H
F
N
D
G
R
Site 46
S462
D
G
R
A
M
A
K
S
L
Y
W
L
H
E
L
Site 47
Y464
R
A
M
A
K
S
L
Y
W
L
H
E
L
Q
M
Site 48
S479
K
R
G
A
K
F
V
S
K
R
A
D
D
F
K
Site 49
Y521
A
C
L
R
P
E
E
Y
G
V
G
D
L
I
H
Site 50
Y535
H
N
R
L
P
D
E
Y
L
R
G
K
D
R
Q
Site 51
Y558
H
H
L
K
K
V
N
Y
Q
K
F
D
T
L
L
Site 52
T563
V
N
Y
Q
K
F
D
T
L
L
A
A
F
R
H
Site 53
Y571
L
L
A
A
F
R
H
Y
D
K
K
G
D
G
M
Site 54
S594
A
C
D
Q
A
N
L
S
L
D
D
K
L
L
D
Site 55
Y606
L
L
D
Q
L
F
D
Y
C
D
V
D
N
D
G
Site 56
Y617
D
N
D
G
F
I
N
Y
L
E
F
A
N
F
L
Site 57
Y635
D
K
M
L
L
K
E
Y
E
E
R
V
I
I
K
Site 58
T662
N
V
E
E
P
E
Q
T
L
L
I
K
P
E
D
Site 59
S677
I
V
L
K
E
A
G
S
T
E
K
T
L
R
T
Site 60
T681
E
A
G
S
T
E
K
T
L
R
T
L
L
R
P
Site 61
T684
S
T
E
K
T
L
R
T
L
L
R
P
S
D
K
Site 62
S689
L
R
T
L
L
R
P
S
D
K
V
S
N
Y
Y
Site 63
S693
L
R
P
S
D
K
V
S
N
Y
Y
K
T
T
S
Site 64
Y695
P
S
D
K
V
S
N
Y
Y
K
T
T
S
S
E
Site 65
Y696
S
D
K
V
S
N
Y
Y
K
T
T
S
S
E
I
Site 66
T698
K
V
S
N
Y
Y
K
T
T
S
S
E
I
N
A
Site 67
S736
A
P
R
I
R
R
I
S
D
R
T
N
Y
G
E
Site 68
T739
I
R
R
I
S
D
R
T
N
Y
G
E
E
G
S
Site 69
Y741
R
I
S
D
R
T
N
Y
G
E
E
G
S
A
Y
Site 70
S746
T
N
Y
G
E
E
G
S
A
Y
S
L
L
Y
P
Site 71
Y748
Y
G
E
E
G
S
A
Y
S
L
L
Y
P
T
I
Site 72
T769
F
E
R
D
F
F
K
T
R
S
K
E
E
I
A
Site 73
S771
R
D
F
F
K
T
R
S
K
E
E
I
A
E
I
Site 74
S787
C
N
I
G
V
K
L
S
D
E
E
F
E
N
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation