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Updated November 2019
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Protein Info
Short Name:
ANKRD31
Full Name:
Ankyrin repeat domain-containing protein 31
Alias:
Type:
Mass (Da):
210816
Number AA:
1873
UniProt ID:
Q8N7Z5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
V
Q
A
P
D
W
D
S
D
E
T
V
I
E
G
Site 2
T15
P
D
W
D
S
D
E
T
V
I
E
G
S
V
T
Site 3
S20
D
E
T
V
I
E
G
S
V
T
E
S
D
L
E
Site 4
T22
T
V
I
E
G
S
V
T
E
S
D
L
E
E
K
Site 5
S24
I
E
G
S
V
T
E
S
D
L
E
E
K
E
L
Site 6
S43
L
L
F
D
Q
D
A
S
L
K
S
E
F
S
L
Site 7
S46
D
Q
D
A
S
L
K
S
E
F
S
L
H
P
D
Site 8
S49
A
S
L
K
S
E
F
S
L
H
P
D
T
R
G
Site 9
T54
E
F
S
L
H
P
D
T
R
G
M
C
K
G
M
Site 10
S63
G
M
C
K
G
M
P
S
P
E
I
Q
L
G
F
Site 11
S90
N
K
M
M
P
V
L
S
E
D
T
I
L
Q
S
Site 12
S97
S
E
D
T
I
L
Q
S
Q
D
E
T
E
R
N
Site 13
T101
I
L
Q
S
Q
D
E
T
E
R
N
Q
A
L
L
Site 14
S120
N
C
S
M
F
I
G
S
F
R
Q
S
G
L
S
Site 15
S124
F
I
G
S
F
R
Q
S
G
L
S
L
N
H
Q
Site 16
S127
S
F
R
Q
S
G
L
S
L
N
H
Q
N
I
E
Site 17
S140
I
E
G
P
E
A
E
S
P
E
V
L
P
H
I
Site 18
S152
P
H
I
E
K
E
L
S
E
G
R
D
S
P
E
Site 19
S157
E
L
S
E
G
R
D
S
P
E
V
S
L
L
S
Site 20
S161
G
R
D
S
P
E
V
S
L
L
S
G
T
A
I
Site 21
T193
K
I
L
A
A
P
N
T
F
F
E
P
R
K
E
Site 22
T204
P
R
K
E
V
T
M
T
M
T
S
E
E
T
K
Site 23
S207
E
V
T
M
T
M
T
S
E
E
T
K
D
E
E
Site 24
T210
M
T
M
T
S
E
E
T
K
D
E
E
S
S
L
Site 25
T219
D
E
E
S
S
L
E
T
F
V
S
A
L
E
S
Site 26
T229
S
A
L
E
S
L
L
T
S
P
E
S
T
Q
E
Site 27
S230
A
L
E
S
L
L
T
S
P
E
S
T
Q
E
E
Site 28
S233
S
L
L
T
S
P
E
S
T
Q
E
E
R
L
F
Site 29
T234
L
L
T
S
P
E
S
T
Q
E
E
R
L
F
E
Site 30
S244
E
R
L
F
E
L
V
S
D
F
D
R
K
E
L
Site 31
S256
K
E
L
M
N
P
L
S
D
S
L
S
S
I
S
Site 32
S260
N
P
L
S
D
S
L
S
S
I
S
I
P
L
N
Site 33
S263
S
D
S
L
S
S
I
S
I
P
L
N
S
W
S
Site 34
S268
S
I
S
I
P
L
N
S
W
S
A
C
H
R
D
Site 35
S270
S
I
P
L
N
S
W
S
A
C
H
R
D
L
L
Site 36
T295
E
L
L
E
A
L
N
T
L
S
E
A
K
V
E
Site 37
S312
C
H
R
K
E
G
G
S
S
L
I
A
R
N
E
Site 38
S313
H
R
K
E
G
G
S
S
L
I
A
R
N
E
C
Site 39
S328
L
E
V
E
F
N
T
S
Q
T
N
E
D
C
T
Site 40
T335
S
Q
T
N
E
D
C
T
Q
I
A
E
T
L
Q
Site 41
T351
P
N
P
S
G
L
Q
T
L
A
H
Q
N
I
T
Site 42
S359
L
A
H
Q
N
I
T
S
C
E
P
L
S
N
K
Site 43
S364
I
T
S
C
E
P
L
S
N
K
R
N
S
N
S
Site 44
S369
P
L
S
N
K
R
N
S
N
S
V
T
N
S
S
Site 45
S371
S
N
K
R
N
S
N
S
V
T
N
S
S
D
Q
Site 46
T373
K
R
N
S
N
S
V
T
N
S
S
D
Q
E
T
Site 47
S375
N
S
N
S
V
T
N
S
S
D
Q
E
T
A
C
Site 48
S376
S
N
S
V
T
N
S
S
D
Q
E
T
A
C
V
Site 49
T380
T
N
S
S
D
Q
E
T
A
C
V
L
R
R
S
Site 50
S387
T
A
C
V
L
R
R
S
S
R
L
E
K
L
K
Site 51
S388
A
C
V
L
R
R
S
S
R
L
E
K
L
K
V
Site 52
Y401
K
V
S
R
D
A
K
Y
S
D
H
M
Y
K
M
Site 53
Y406
A
K
Y
S
D
H
M
Y
K
M
P
E
K
I
L
Site 54
T423
I
L
G
C
E
D
L
T
N
N
N
S
S
A
Q
Site 55
S427
E
D
L
T
N
N
N
S
S
A
Q
N
F
R
M
Site 56
S450
G
K
E
K
N
M
H
S
A
R
F
K
N
G
K
Site 57
S478
K
M
K
V
N
K
I
S
L
H
S
I
N
R
R
Site 58
S481
V
N
K
I
S
L
H
S
I
N
R
R
N
I
F
Site 59
Y494
I
F
G
E
N
L
V
Y
K
A
A
L
H
D
D
Site 60
S519
G
G
N
V
N
Q
P
S
Y
A
G
W
T
A
L
Site 61
Y520
G
N
V
N
Q
P
S
Y
A
G
W
T
A
L
H
Site 62
S530
W
T
A
L
H
E
A
S
V
G
G
F
Y
R
T
Site 63
S539
G
G
F
Y
R
T
A
S
E
L
L
K
G
G
A
Site 64
Y554
D
V
N
I
K
G
L
Y
Q
I
T
P
L
H
D
Site 65
Y607
M
K
R
L
L
E
R
Y
I
P
K
H
Q
K
C
Site 66
T616
P
K
H
Q
K
C
L
T
S
A
Q
R
S
S
I
Site 67
S617
K
H
Q
K
C
L
T
S
A
Q
R
S
S
I
D
Site 68
S621
C
L
T
S
A
Q
R
S
S
I
D
P
L
D
I
Site 69
S622
L
T
S
A
Q
R
S
S
I
D
P
L
D
I
E
Site 70
Y632
P
L
D
I
E
D
V
Y
Q
H
K
K
P
K
F
Site 71
Y679
F
I
N
K
E
D
V
Y
E
Y
Y
Q
K
D
P
Site 72
Y681
N
K
E
D
V
Y
E
Y
Y
Q
K
D
P
K
N
Site 73
Y682
K
E
D
V
Y
E
Y
Y
Q
K
D
P
K
N
T
Site 74
S694
K
N
T
K
F
G
K
S
K
H
K
Q
S
T
L
Site 75
S699
G
K
S
K
H
K
Q
S
T
L
D
Q
I
Y
S
Site 76
T700
K
S
K
H
K
Q
S
T
L
D
Q
I
Y
S
T
Site 77
Y705
Q
S
T
L
D
Q
I
Y
S
T
G
L
R
K
G
Site 78
S706
S
T
L
D
Q
I
Y
S
T
G
L
R
K
G
N
Site 79
T722
H
N
V
K
D
P
N
T
N
V
P
K
G
I
G
Site 80
T733
K
G
I
G
R
R
K
T
Q
H
K
R
T
Q
V
Site 81
S754
P
R
K
I
L
A
V
S
P
S
R
R
I
N
R
Site 82
T764
R
R
I
N
R
L
V
T
Y
Q
Q
H
I
P
E
Site 83
Y765
R
I
N
R
L
V
T
Y
Q
Q
H
I
P
E
T
Site 84
S784
P
E
E
L
C
E
P
S
S
L
T
L
S
S
L
Site 85
S785
E
E
L
C
E
P
S
S
L
T
L
S
S
L
R
Site 86
T787
L
C
E
P
S
S
L
T
L
S
S
L
R
N
G
Site 87
S789
E
P
S
S
L
T
L
S
S
L
R
N
G
L
D
Site 88
S790
P
S
S
L
T
L
S
S
L
R
N
G
L
D
S
Site 89
S797
S
L
R
N
G
L
D
S
S
T
E
A
C
S
V
Site 90
S798
L
R
N
G
L
D
S
S
T
E
A
C
S
V
S
Site 91
T799
R
N
G
L
D
S
S
T
E
A
C
S
V
S
K
Site 92
S803
D
S
S
T
E
A
C
S
V
S
K
E
K
H
I
Site 93
S816
H
I
Q
N
L
D
L
S
D
S
Q
E
V
Q
C
Site 94
S818
Q
N
L
D
L
S
D
S
Q
E
V
Q
C
L
E
Site 95
T832
E
L
E
S
V
D
Q
T
E
A
V
S
F
P
G
Site 96
T859
T
T
D
K
Q
P
H
T
L
Q
E
Q
H
H
V
Site 97
Y868
Q
E
Q
H
H
V
L
Y
K
S
H
E
N
S
N
Site 98
S874
L
Y
K
S
H
E
N
S
N
L
V
P
K
D
E
Site 99
S889
R
F
N
K
W
E
N
S
F
L
S
F
V
K
E
Site 100
S892
K
W
E
N
S
F
L
S
F
V
K
E
N
S
D
Site 101
S898
L
S
F
V
K
E
N
S
D
N
D
D
D
D
D
Site 102
S907
N
D
D
D
D
D
C
S
T
S
E
K
A
I
T
Site 103
T908
D
D
D
D
D
C
S
T
S
E
K
A
I
T
S
Site 104
S909
D
D
D
D
C
S
T
S
E
K
A
I
T
S
K
Site 105
T914
S
T
S
E
K
A
I
T
S
K
K
V
L
C
S
Site 106
S915
T
S
E
K
A
I
T
S
K
K
V
L
C
S
T
Site 107
S921
T
S
K
K
V
L
C
S
T
G
G
K
K
H
Y
Site 108
Y928
S
T
G
G
K
K
H
Y
N
F
K
E
N
L
T
Site 109
S948
G
F
Q
Q
F
L
L
S
E
D
H
L
S
Q
E
Site 110
S953
L
L
S
E
D
H
L
S
Q
E
N
E
L
K
A
Site 111
S977
E
A
V
N
F
S
Y
S
D
N
A
V
I
S
E
Site 112
S1001
F
G
P
S
F
D
H
S
N
G
N
P
E
Q
N
Site 113
S1009
N
G
N
P
E
Q
N
S
L
A
C
M
R
T
L
Site 114
Y1037
L
F
K
K
P
Q
D
Y
I
P
R
A
P
T
F
Site 115
T1043
D
Y
I
P
R
A
P
T
F
L
M
N
Q
T
D
Site 116
Y1067
N
C
D
T
E
R
N
Y
I
D
R
D
Q
K
I
Site 117
Y1076
D
R
D
Q
K
I
I
Y
S
N
E
P
L
S
I
Site 118
S1077
R
D
Q
K
I
I
Y
S
N
E
P
L
S
I
V
Site 119
S1115
I
H
N
I
D
S
H
S
T
D
N
M
S
K
E
Site 120
S1120
S
H
S
T
D
N
M
S
K
E
L
A
N
I
S
Site 121
S1130
L
A
N
I
S
K
L
S
Q
R
E
K
K
E
I
Site 122
S1157
K
R
N
A
R
G
E
S
Q
L
H
L
A
V
R
Site 123
T1190
L
N
D
N
A
G
W
T
P
L
H
E
A
S
N
Site 124
S1200
H
E
A
S
N
E
G
S
I
D
I
I
V
E
L
Site 125
S1256
Q
K
D
Q
K
Q
K
S
A
L
D
E
A
D
D
Site 126
S1272
K
M
K
E
L
L
R
S
Y
G
A
I
E
T
V
Site 127
Y1273
M
K
E
L
L
R
S
Y
G
A
I
E
T
V
N
Site 128
T1278
R
S
Y
G
A
I
E
T
V
N
R
D
E
S
D
Site 129
S1284
E
T
V
N
R
D
E
S
D
A
I
V
N
E
K
Site 130
S1297
E
K
I
P
A
V
R
S
K
R
H
K
Q
C
F
Site 131
T1310
C
F
C
D
D
G
K
T
I
D
S
S
S
L
S
Site 132
S1313
D
D
G
K
T
I
D
S
S
S
L
S
H
Q
E
Site 133
S1314
D
G
K
T
I
D
S
S
S
L
S
H
Q
E
R
Site 134
S1315
G
K
T
I
D
S
S
S
L
S
H
Q
E
R
S
Site 135
S1317
T
I
D
S
S
S
L
S
H
Q
E
R
S
R
E
Site 136
S1322
S
L
S
H
Q
E
R
S
R
E
S
L
S
V
H
Site 137
S1325
H
Q
E
R
S
R
E
S
L
S
V
H
Q
T
L
Site 138
S1327
E
R
S
R
E
S
L
S
V
H
Q
T
L
S
A
Site 139
T1331
E
S
L
S
V
H
Q
T
L
S
A
I
L
Q
D
Site 140
Y1345
D
I
E
E
K
Q
E
Y
L
L
E
F
E
I
R
Site 141
Y1389
R
D
D
L
A
K
K
Y
R
V
S
I
E
S
F
Site 142
S1392
L
A
K
K
Y
R
V
S
I
E
S
F
K
H
G
Site 143
S1395
K
Y
R
V
S
I
E
S
F
K
H
G
A
L
R
Site 144
S1414
N
L
A
A
R
Q
K
S
L
L
V
V
A
K
K
Site 145
S1426
A
K
K
Q
K
K
I
S
L
K
I
Q
N
C
R
Site 146
S1437
Q
N
C
R
N
V
T
S
L
P
C
L
S
L
R
Site 147
S1442
V
T
S
L
P
C
L
S
L
R
K
L
P
P
R
Site 148
S1450
L
R
K
L
P
P
R
S
E
I
S
S
E
K
D
Site 149
S1454
P
P
R
S
E
I
S
S
E
K
D
S
Q
E
L
Site 150
S1458
E
I
S
S
E
K
D
S
Q
E
L
T
S
L
E
Site 151
T1462
E
K
D
S
Q
E
L
T
S
L
E
N
L
E
H
Site 152
S1463
K
D
S
Q
E
L
T
S
L
E
N
L
E
H
P
Site 153
S1472
E
N
L
E
H
P
Q
S
G
S
L
S
P
V
S
Site 154
S1474
L
E
H
P
Q
S
G
S
L
S
P
V
S
G
S
Site 155
S1476
H
P
Q
S
G
S
L
S
P
V
S
G
S
M
Q
Site 156
S1479
S
G
S
L
S
P
V
S
G
S
M
Q
E
T
Q
Site 157
S1481
S
L
S
P
V
S
G
S
M
Q
E
T
Q
L
S
Site 158
T1485
V
S
G
S
M
Q
E
T
Q
L
S
L
E
T
W
Site 159
S1488
S
M
Q
E
T
Q
L
S
L
E
T
W
N
Y
S
Site 160
Y1494
L
S
L
E
T
W
N
Y
S
Q
N
T
N
I
C
Site 161
S1504
N
T
N
I
C
L
N
S
E
A
V
R
R
G
E
Site 162
S1513
A
V
R
R
G
E
F
S
G
N
D
M
N
S
K
Site 163
T1527
K
Q
N
G
S
D
C
T
L
D
G
F
P
K
S
Site 164
S1534
T
L
D
G
F
P
K
S
R
H
S
D
G
T
E
Site 165
S1537
G
F
P
K
S
R
H
S
D
G
T
E
K
N
K
Site 166
T1540
K
S
R
H
S
D
G
T
E
K
N
K
L
P
S
Site 167
S1547
T
E
K
N
K
L
P
S
Q
P
V
A
F
I
G
Site 168
T1566
S
Q
K
E
N
D
L
T
E
A
T
D
K
D
H
Site 169
Y1576
T
D
K
D
H
E
F
Y
V
S
S
P
V
I
G
Site 170
S1578
K
D
H
E
F
Y
V
S
S
P
V
I
G
K
L
Site 171
S1579
D
H
E
F
Y
V
S
S
P
V
I
G
K
L
N
Site 172
T1590
G
K
L
N
I
S
E
T
A
S
V
L
A
E
N
Site 173
Y1613
C
D
Q
D
L
S
N
Y
D
P
K
R
G
N
R
Site 174
T1622
P
K
R
G
N
R
K
T
S
S
Q
Q
S
P
T
Site 175
S1623
K
R
G
N
R
K
T
S
S
Q
Q
S
P
T
G
Site 176
S1624
R
G
N
R
K
T
S
S
Q
Q
S
P
T
G
A
Site 177
S1627
R
K
T
S
S
Q
Q
S
P
T
G
A
S
E
S
Site 178
S1634
S
P
T
G
A
S
E
S
L
A
H
Q
G
I
A
Site 179
Y1654
T
V
H
Q
M
K
P
Y
L
K
K
S
V
S
V
Site 180
S1660
P
Y
L
K
K
S
V
S
V
V
P
C
A
D
D
Site 181
S1668
V
V
P
C
A
D
D
S
Q
I
S
S
S
S
G
Site 182
S1671
C
A
D
D
S
Q
I
S
S
S
S
G
S
G
Q
Site 183
S1672
A
D
D
S
Q
I
S
S
S
S
G
S
G
Q
Q
Site 184
S1673
D
D
S
Q
I
S
S
S
S
G
S
G
Q
Q
D
Site 185
S1674
D
S
Q
I
S
S
S
S
G
S
G
Q
Q
D
T
Site 186
S1676
Q
I
S
S
S
S
G
S
G
Q
Q
D
T
I
K
Site 187
T1681
S
G
S
G
Q
Q
D
T
I
K
K
A
L
N
Y
Site 188
Y1742
K
V
E
S
G
Q
I
Y
K
N
P
V
T
W
L
Site 189
T1747
Q
I
Y
K
N
P
V
T
W
L
K
D
L
L
G
Site 190
Y1758
D
L
L
G
G
N
S
Y
V
T
W
N
Y
A
W
Site 191
Y1770
Y
A
W
S
K
V
T
Y
L
G
K
E
L
L
R
Site 192
Y1778
L
G
K
E
L
L
R
Y
V
S
E
D
A
P
I
Site 193
S1780
K
E
L
L
R
Y
V
S
E
D
A
P
I
L
P
Site 194
S1791
P
I
L
P
E
P
N
S
V
P
Q
Q
Y
Q
P
Site 195
Y1796
P
N
S
V
P
Q
Q
Y
Q
P
C
L
P
E
V
Site 196
S1816
P
V
Q
E
P
N
K
S
M
F
E
K
T
K
F
Site 197
T1827
K
T
K
F
G
Q
G
T
S
R
E
S
M
Q
S
Site 198
S1828
T
K
F
G
Q
G
T
S
R
E
S
M
Q
S
S
Site 199
S1831
G
Q
G
T
S
R
E
S
M
Q
S
S
P
R
Y
Site 200
S1834
T
S
R
E
S
M
Q
S
S
P
R
Y
L
Q
I
Site 201
S1835
S
R
E
S
M
Q
S
S
P
R
Y
L
Q
I
N
Site 202
Y1838
S
M
Q
S
S
P
R
Y
L
Q
I
N
E
I
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation