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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TTLL6
Full Name:
Tubulin polyglutamylase TTLL6
Alias:
Tubulin--tyrosine ligase-like protein 6
Type:
Mass (Da):
96401
Number AA:
843
UniProt ID:
Q8N841
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
P
Q
C
P
T
L
E
S
Q
E
G
E
N
S
E
Site 2
S15
E
S
Q
E
G
E
N
S
E
E
K
G
D
S
S
Site 3
S21
N
S
E
E
K
G
D
S
S
K
E
D
P
K
E
Site 4
S22
S
E
E
K
G
D
S
S
K
E
D
P
K
E
T
Site 5
T29
S
K
E
D
P
K
E
T
V
A
L
A
F
V
R
Site 6
S66
K
R
L
V
I
N
L
S
S
C
R
Y
E
S
V
Site 7
S67
R
L
V
I
N
L
S
S
C
R
Y
E
S
V
R
Site 8
Y70
I
N
L
S
S
C
R
Y
E
S
V
R
R
A
A
Site 9
S72
L
S
S
C
R
Y
E
S
V
R
R
A
A
Q
Q
Site 10
Y80
V
R
R
A
A
Q
Q
Y
G
F
R
E
G
G
E
Site 11
Y94
E
D
D
D
W
T
L
Y
W
T
D
Y
S
V
S
Site 12
Y98
W
T
L
Y
W
T
D
Y
S
V
S
L
E
R
V
Site 13
Y111
R
V
M
E
M
K
S
Y
Q
K
I
N
H
F
P
Site 14
S134
D
L
L
A
R
N
M
S
R
M
L
K
M
F
P
Site 15
T162
A
D
W
G
D
L
Q
T
Y
S
R
S
R
K
N
Site 16
Y163
D
W
G
D
L
Q
T
Y
S
R
S
R
K
N
K
Site 17
S164
W
G
D
L
Q
T
Y
S
R
S
R
K
N
K
T
Site 18
S166
D
L
Q
T
Y
S
R
S
R
K
N
K
T
Y
I
Site 19
T171
S
R
S
R
K
N
K
T
Y
I
C
K
P
D
S
Site 20
Y172
R
S
R
K
N
K
T
Y
I
C
K
P
D
S
G
Site 21
T188
Q
G
K
G
I
F
I
T
R
T
V
K
E
I
K
Site 22
T190
K
G
I
F
I
T
R
T
V
K
E
I
K
P
G
Site 23
T245
E
G
L
A
R
F
A
T
T
S
Y
S
R
P
C
Site 24
S247
L
A
R
F
A
T
T
S
Y
S
R
P
C
T
D
Site 25
Y248
A
R
F
A
T
T
S
Y
S
R
P
C
T
D
N
Site 26
S249
R
F
A
T
T
S
Y
S
R
P
C
T
D
N
L
Site 27
T253
T
S
Y
S
R
P
C
T
D
N
L
D
D
I
C
Site 28
Y266
I
C
M
H
L
T
N
Y
S
I
N
K
H
S
S
Site 29
S273
Y
S
I
N
K
H
S
S
N
F
S
R
D
A
H
Site 30
S276
N
K
H
S
S
N
F
S
R
D
A
H
S
G
S
Site 31
S281
N
F
S
R
D
A
H
S
G
S
K
R
K
L
S
Site 32
S283
S
R
D
A
H
S
G
S
K
R
K
L
S
T
F
Site 33
S288
S
G
S
K
R
K
L
S
T
F
S
A
Y
L
E
Site 34
T289
G
S
K
R
K
L
S
T
F
S
A
Y
L
E
D
Site 35
S291
K
R
K
L
S
T
F
S
A
Y
L
E
D
H
S
Site 36
Y293
K
L
S
T
F
S
A
Y
L
E
D
H
S
Y
N
Site 37
Y299
A
Y
L
E
D
H
S
Y
N
V
E
Q
I
W
R
Site 38
S364
W
L
L
E
V
N
H
S
P
S
F
S
T
D
S
Site 39
S366
L
E
V
N
H
S
P
S
F
S
T
D
S
R
L
Site 40
S368
V
N
H
S
P
S
F
S
T
D
S
R
L
D
K
Site 41
S371
S
P
S
F
S
T
D
S
R
L
D
K
E
V
K
Site 42
Y449
C
G
G
F
R
L
I
Y
P
S
L
N
S
E
K
Site 43
S451
G
F
R
L
I
Y
P
S
L
N
S
E
K
Y
E
Site 44
Y457
P
S
L
N
S
E
K
Y
E
K
F
F
Q
D
N
Site 45
S474
L
F
Q
N
T
V
A
S
R
A
R
E
E
Y
A
Site 46
Y480
A
S
R
A
R
E
E
Y
A
R
Q
L
I
Q
E
Site 47
Y540
A
T
Q
A
S
K
Q
Y
I
Q
P
L
T
L
V
Site 48
T545
K
Q
Y
I
Q
P
L
T
L
V
S
Y
T
P
D
Site 49
S556
Y
T
P
D
L
L
L
S
V
R
G
E
R
K
N
Site 50
T565
R
G
E
R
K
N
E
T
D
S
S
L
N
Q
E
Site 51
S568
R
K
N
E
T
D
S
S
L
N
Q
E
A
P
T
Site 52
T575
S
L
N
Q
E
A
P
T
E
E
A
S
S
V
F
Site 53
S580
A
P
T
E
E
A
S
S
V
F
P
K
L
T
S
Site 54
T586
S
S
V
F
P
K
L
T
S
A
K
P
F
S
S
Site 55
S592
L
T
S
A
K
P
F
S
S
L
P
D
L
R
N
Site 56
S593
T
S
A
K
P
F
S
S
L
P
D
L
R
N
I
Site 57
S603
D
L
R
N
I
N
L
S
S
S
K
L
E
P
S
Site 58
S605
R
N
I
N
L
S
S
S
K
L
E
P
S
K
P
Site 59
S610
S
S
S
K
L
E
P
S
K
P
N
F
S
I
K
Site 60
S615
E
P
S
K
P
N
F
S
I
K
E
A
K
S
A
Site 61
S636
T
G
T
V
H
L
T
S
V
E
T
T
P
E
S
Site 62
T640
H
L
T
S
V
E
T
T
P
E
S
T
T
Q
L
Site 63
S643
S
V
E
T
T
P
E
S
T
T
Q
L
S
I
S
Site 64
S648
P
E
S
T
T
Q
L
S
I
S
P
K
S
P
P
Site 65
S650
S
T
T
Q
L
S
I
S
P
K
S
P
P
T
L
Site 66
S653
Q
L
S
I
S
P
K
S
P
P
T
L
A
V
T
Site 67
T656
I
S
P
K
S
P
P
T
L
A
V
T
A
S
S
Site 68
T660
S
P
P
T
L
A
V
T
A
S
S
E
Y
S
G
Site 69
S662
P
T
L
A
V
T
A
S
S
E
Y
S
G
P
E
Site 70
S663
T
L
A
V
T
A
S
S
E
Y
S
G
P
E
T
Site 71
Y665
A
V
T
A
S
S
E
Y
S
G
P
E
T
D
R
Site 72
S666
V
T
A
S
S
E
Y
S
G
P
E
T
D
R
V
Site 73
T670
S
E
Y
S
G
P
E
T
D
R
V
V
S
F
K
Site 74
S675
P
E
T
D
R
V
V
S
F
K
C
K
K
Q
Q
Site 75
T683
F
K
C
K
K
Q
Q
T
P
P
H
L
T
Q
K
Site 76
S695
T
Q
K
K
M
L
K
S
F
L
P
T
K
S
K
Site 77
T699
M
L
K
S
F
L
P
T
K
S
K
S
F
W
E
Site 78
S701
K
S
F
L
P
T
K
S
K
S
F
W
E
S
P
Site 79
S703
F
L
P
T
K
S
K
S
F
W
E
S
P
N
T
Site 80
S707
K
S
K
S
F
W
E
S
P
N
T
N
W
T
L
Site 81
T710
S
F
W
E
S
P
N
T
N
W
T
L
L
K
S
Site 82
T713
E
S
P
N
T
N
W
T
L
L
K
S
D
M
N
Site 83
S739
L
Q
L
S
G
K
L
S
F
F
P
A
H
Y
N
Site 84
Y745
L
S
F
F
P
A
H
Y
N
P
K
L
G
M
N
Site 85
S755
K
L
G
M
N
N
L
S
Q
N
P
S
L
P
G
Site 86
S759
N
N
L
S
Q
N
P
S
L
P
G
E
C
H
S
Site 87
S766
S
L
P
G
E
C
H
S
R
S
D
S
S
G
E
Site 88
S768
P
G
E
C
H
S
R
S
D
S
S
G
E
K
R
Site 89
S770
E
C
H
S
R
S
D
S
S
G
E
K
R
Q
L
Site 90
S780
E
K
R
Q
L
D
V
S
S
L
L
L
Q
S
P
Site 91
S781
K
R
Q
L
D
V
S
S
L
L
L
Q
S
P
Q
Site 92
S786
V
S
S
L
L
L
Q
S
P
Q
S
Y
N
V
T
Site 93
S789
L
L
L
Q
S
P
Q
S
Y
N
V
T
L
R
D
Site 94
T802
R
D
L
L
V
I
A
T
P
A
Q
L
D
P
R
Site 95
S813
L
D
P
R
P
C
R
S
H
A
S
A
M
R
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation