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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FRMD1
Full Name:
FERM domain-containing protein 1
Alias:
Type:
Mass (Da):
62523
Number AA:
549
UniProt ID:
Q8N878
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T15
R
G
I
D
P
A
R
T
N
P
D
T
F
P
P
Site 2
T19
P
A
R
T
N
P
D
T
F
P
P
S
G
A
R
Site 3
S23
N
P
D
T
F
P
P
S
G
A
R
C
M
E
P
Site 4
S31
G
A
R
C
M
E
P
S
P
E
R
P
A
C
S
Site 5
S38
S
P
E
R
P
A
C
S
Q
Q
E
P
T
L
G
Site 6
Y117
L
E
Q
K
L
S
K
Y
F
S
K
D
W
K
K
Site 7
S119
Q
K
L
S
K
Y
F
S
K
D
W
K
K
E
R
Site 8
S154
V
E
N
G
R
V
I
S
D
H
R
A
R
H
L
Site 9
Y162
D
H
R
A
R
H
L
Y
Y
C
H
L
K
E
R
Site 10
S173
L
K
E
R
V
L
R
S
Q
C
A
H
R
E
E
Site 11
S200
D
L
G
E
H
R
E
S
A
H
A
G
R
Y
F
Site 12
Y206
E
S
A
H
A
G
R
Y
F
E
P
H
S
Y
F
Site 13
Y225
I
T
K
R
G
I
D
Y
I
L
R
H
M
P
T
Site 14
T232
Y
I
L
R
H
M
P
T
L
H
R
E
R
Q
G
Site 15
S241
H
R
E
R
Q
G
L
S
P
K
E
A
M
L
C
Site 16
T276
D
K
K
E
G
R
P
T
V
I
L
G
L
A
L
Site 17
Y289
A
L
R
G
V
H
I
Y
Q
G
K
K
L
E
I
Site 18
Y309
P
A
A
Q
K
L
V
Y
Y
T
G
C
T
W
R
Site 19
S327
L
L
H
L
L
R
A
S
H
Q
L
H
L
R
V
Site 20
T337
L
H
L
R
V
R
P
T
L
Q
Q
L
R
Q
R
Site 21
Y353
E
A
E
E
K
Q
H
Y
R
E
S
Y
I
S
D
Site 22
S356
E
K
Q
H
Y
R
E
S
Y
I
S
D
E
L
E
Site 23
Y357
K
Q
H
Y
R
E
S
Y
I
S
D
E
L
E
L
Site 24
S359
H
Y
R
E
S
Y
I
S
D
E
L
E
L
D
L
Site 25
S368
E
L
E
L
D
L
A
S
R
S
F
P
G
S
G
Site 26
S370
E
L
D
L
A
S
R
S
F
P
G
S
G
V
S
Site 27
S374
A
S
R
S
F
P
G
S
G
V
S
S
Q
H
C
Site 28
S377
S
F
P
G
S
G
V
S
S
Q
H
C
P
H
C
Site 29
S378
F
P
G
S
G
V
S
S
Q
H
C
P
H
C
L
Site 30
S389
P
H
C
L
S
R
H
S
A
D
S
H
G
S
S
Site 31
S392
L
S
R
H
S
A
D
S
H
G
S
S
Y
T
S
Site 32
S396
S
A
D
S
H
G
S
S
Y
T
S
G
I
K
A
Site 33
S399
S
H
G
S
S
Y
T
S
G
I
K
A
N
S
W
Site 34
S405
T
S
G
I
K
A
N
S
W
L
R
E
S
R
E
Site 35
S410
A
N
S
W
L
R
E
S
R
E
M
S
V
D
V
Site 36
S414
L
R
E
S
R
E
M
S
V
D
V
P
L
E
V
Site 37
S430
G
L
H
E
K
E
P
S
S
S
P
R
T
S
R
Site 38
S431
L
H
E
K
E
P
S
S
S
P
R
T
S
R
S
Site 39
S432
H
E
K
E
P
S
S
S
P
R
T
S
R
S
H
Site 40
T435
E
P
S
S
S
P
R
T
S
R
S
H
P
S
T
Site 41
S436
P
S
S
S
P
R
T
S
R
S
H
P
S
T
R
Site 42
S438
S
S
P
R
T
S
R
S
H
P
S
T
R
G
D
Site 43
S441
R
T
S
R
S
H
P
S
T
R
G
D
S
Q
A
Site 44
T442
T
S
R
S
H
P
S
T
R
G
D
S
Q
A
T
Site 45
S446
H
P
S
T
R
G
D
S
Q
A
T
R
Q
E
P
Site 46
T455
A
T
R
Q
E
P
C
T
Q
V
R
T
R
G
Q
Site 47
S463
Q
V
R
T
R
G
Q
S
A
E
A
V
H
Q
I
Site 48
S478
Q
E
M
T
A
G
V
S
E
E
Q
H
S
H
G
Site 49
S483
G
V
S
E
E
Q
H
S
H
G
L
D
D
M
Q
Site 50
S502
A
L
H
P
A
P
T
S
L
S
H
T
F
H
R
Site 51
S504
H
P
A
P
T
S
L
S
H
T
F
H
R
A
L
Site 52
T506
A
P
T
S
L
S
H
T
F
H
R
A
L
D
C
Site 53
T524
G
P
C
E
T
R
A
T
L
P
S
K
R
S
S
Site 54
S527
E
T
R
A
T
L
P
S
K
R
S
S
N
C
L
Site 55
S530
A
T
L
P
S
K
R
S
S
N
C
L
A
L
D
Site 56
S531
T
L
P
S
K
R
S
S
N
C
L
A
L
D
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation