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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ENAH
Full Name:
Protein enabled homolog
Alias:
Enabled; FLJ10773; MENA; NDPP1
Type:
Adapter/scaffold protein
Mass (Da):
66510
Number AA:
591
UniProt ID:
Q8N8S7
International Prot ID:
IPI00411623
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005856
GO:0005829
GO:0030175
Uniprot
OncoNet
Molecular Function:
GO:0017124
GO:0050699
GO:0003779
PhosphoSite+
KinaseNET
Biological Process:
GO:0046907
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y16
A
R
A
A
V
M
V
Y
D
D
A
N
K
K
W
Site 2
S29
K
W
V
P
A
G
G
S
T
G
F
S
R
V
H
Site 3
S33
A
G
G
S
T
G
F
S
R
V
H
I
Y
H
H
Site 4
Y38
G
F
S
R
V
H
I
Y
H
H
T
G
N
N
T
Site 5
T45
Y
H
H
T
G
N
N
T
F
R
V
V
G
R
K
Site 6
Y70
A
I
P
K
G
L
K
Y
N
Q
A
T
Q
T
F
Site 7
Y87
W
R
D
A
R
Q
V
Y
G
L
N
F
G
S
K
Site 8
S113
H
A
L
E
V
L
N
S
Q
E
T
G
P
T
L
Site 9
T119
N
S
Q
E
T
G
P
T
L
P
R
Q
N
S
Q
Site 10
S125
P
T
L
P
R
Q
N
S
Q
L
P
A
Q
V
Q
Site 11
S265
W
E
R
E
R
R
I
S
S
A
A
A
P
A
S
Site 12
S266
E
R
E
R
R
I
S
S
A
A
A
P
A
S
V
Site 13
S272
S
S
A
A
A
P
A
S
V
E
T
P
L
N
S
Site 14
S279
S
V
E
T
P
L
N
S
V
L
G
D
S
S
A
Site 15
S284
L
N
S
V
L
G
D
S
S
A
S
E
P
G
L
Site 16
S285
N
S
V
L
G
D
S
S
A
S
E
P
G
L
Q
Site 17
S295
E
P
G
L
Q
A
A
S
Q
P
A
E
T
P
S
Site 18
T300
A
A
S
Q
P
A
E
T
P
S
Q
Q
G
I
V
Site 19
S302
S
Q
P
A
E
T
P
S
Q
Q
G
I
V
L
G
Site 20
S327
P
P
G
P
A
Q
A
S
V
A
L
P
P
P
P
Site 21
S344
P
P
P
P
P
L
P
S
T
G
P
P
P
P
P
Site 22
T345
P
P
P
P
L
P
S
T
G
P
P
P
P
P
P
Site 23
S381
A
S
G
F
F
L
A
S
M
S
E
D
N
R
P
Site 24
S383
G
F
F
L
A
S
M
S
E
D
N
R
P
L
T
Site 25
T390
S
E
D
N
R
P
L
T
G
L
A
A
A
I
A
Site 26
S405
G
A
K
L
R
K
V
S
R
M
E
D
T
S
F
Site 27
T410
K
V
S
R
M
E
D
T
S
F
P
S
G
G
N
Site 28
S411
V
S
R
M
E
D
T
S
F
P
S
G
G
N
A
Site 29
S423
G
N
A
I
G
V
N
S
A
S
S
K
T
D
T
Site 30
S426
I
G
V
N
S
A
S
S
K
T
D
T
G
R
G
Site 31
T430
S
A
S
S
K
T
D
T
G
R
G
N
G
P
L
Site 32
S442
G
P
L
P
L
G
G
S
G
L
M
E
E
M
S
Site 33
S449
S
G
L
M
E
E
M
S
A
L
L
A
R
R
R
Site 34
T464
R
I
A
E
K
G
S
T
I
E
T
E
Q
K
E
Site 35
T467
E
K
G
S
T
I
E
T
E
Q
K
E
D
K
G
Site 36
S477
K
E
D
K
G
E
D
S
E
P
V
T
S
K
A
Site 37
T481
G
E
D
S
E
P
V
T
S
K
A
S
S
T
S
Site 38
S482
E
D
S
E
P
V
T
S
K
A
S
S
T
S
T
Site 39
S485
E
P
V
T
S
K
A
S
S
T
S
T
P
E
P
Site 40
S486
P
V
T
S
K
A
S
S
T
S
T
P
E
P
T
Site 41
T487
V
T
S
K
A
S
S
T
S
T
P
E
P
T
R
Site 42
S488
T
S
K
A
S
S
T
S
T
P
E
P
T
R
K
Site 43
T489
S
K
A
S
S
T
S
T
P
E
P
T
R
K
P
Site 44
T500
T
R
K
P
W
E
R
T
N
T
M
N
G
S
K
Site 45
T502
K
P
W
E
R
T
N
T
M
N
G
S
K
S
P
Site 46
S506
R
T
N
T
M
N
G
S
K
S
P
V
I
S
R
Site 47
S508
N
T
M
N
G
S
K
S
P
V
I
S
R
R
D
Site 48
S512
G
S
K
S
P
V
I
S
R
R
D
S
P
R
K
Site 49
S516
P
V
I
S
R
R
D
S
P
R
K
N
Q
I
V
Site 50
S528
Q
I
V
F
D
N
R
S
Y
D
S
L
H
R
P
Site 51
Y529
I
V
F
D
N
R
S
Y
D
S
L
H
R
P
K
Site 52
S531
F
D
N
R
S
Y
D
S
L
H
R
P
K
S
T
Site 53
S537
D
S
L
H
R
P
K
S
T
P
L
S
Q
P
S
Site 54
T538
S
L
H
R
P
K
S
T
P
L
S
Q
P
S
A
Site 55
S541
R
P
K
S
T
P
L
S
Q
P
S
A
N
G
V
Site 56
Y555
V
Q
T
E
G
L
D
Y
D
R
L
K
Q
D
I
Site 57
S586
D
A
I
R
Q
E
L
S
K
S
N
T
A
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation