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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IGSF22
Full Name:
Immunoglobulin superfamily member 22
Alias:
Type:
Mass (Da):
100382
Number AA:
903
UniProt ID:
Q8N9C0
International Prot ID:
IPI00180325
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
Q
M
L
Q
E
H
V
S
M
E
F
S
S
S
T
Site 2
S19
E
H
V
S
M
E
F
S
S
S
T
T
H
V
Q
Site 3
S21
V
S
M
E
F
S
S
S
T
T
H
V
Q
T
F
Site 4
T23
M
E
F
S
S
S
T
T
H
V
Q
T
F
S
Q
Site 5
T27
S
S
T
T
H
V
Q
T
F
S
Q
T
T
K
I
Site 6
S29
T
T
H
V
Q
T
F
S
Q
T
T
K
I
V
G
Site 7
S44
E
E
V
V
R
R
K
S
S
S
I
V
E
F
F
Site 8
S45
E
V
V
R
R
K
S
S
S
I
V
E
F
F
S
Site 9
S58
F
S
L
V
T
R
S
S
N
I
P
A
G
D
S
Site 10
S65
S
N
I
P
A
G
D
S
V
P
E
F
V
E
K
Site 11
S99
G
N
A
K
P
H
I
S
W
K
R
E
S
G
I
Site 12
S104
H
I
S
W
K
R
E
S
G
I
P
I
K
E
S
Site 13
S111
S
G
I
P
I
K
E
S
A
K
I
F
Y
D
S
Site 14
Y116
K
E
S
A
K
I
F
Y
D
S
I
N
K
E
H
Site 15
S118
S
A
K
I
F
Y
D
S
I
N
K
E
H
V
L
Site 16
T131
V
L
K
L
E
P
L
T
S
D
D
S
D
N
Y
Site 17
S132
L
K
L
E
P
L
T
S
D
D
S
D
N
Y
K
Site 18
S135
E
P
L
T
S
D
D
S
D
N
Y
K
C
I
A
Site 19
Y138
T
S
D
D
S
D
N
Y
K
C
I
A
S
N
D
Site 20
T158
Y
T
V
S
L
L
V
T
E
G
Q
E
K
M
D
Site 21
S196
K
E
M
L
E
I
L
S
K
V
P
K
K
D
F
Site 22
T245
K
P
L
E
D
K
E
T
K
V
D
T
T
V
V
Site 23
Y279
T
E
P
L
R
I
Q
Y
S
L
G
K
Y
D
V
Site 24
S280
E
P
L
R
I
Q
Y
S
L
G
K
Y
D
V
K
Site 25
Y284
I
Q
Y
S
L
G
K
Y
D
V
K
Q
M
G
T
Site 26
S309
M
N
D
A
G
I
Y
S
L
S
V
G
D
K
R
Site 27
S311
D
A
G
I
Y
S
L
S
V
G
D
K
R
M
S
Site 28
S318
S
V
G
D
K
R
M
S
A
E
L
T
V
L
D
Site 29
T322
K
R
M
S
A
E
L
T
V
L
D
E
P
L
K
Site 30
S352
A
V
F
E
I
R
L
S
K
K
E
P
N
F
V
Site 31
Y373
E
L
K
R
D
D
K
Y
E
I
T
V
S
E
D
Site 32
T376
R
D
D
K
Y
E
I
T
V
S
E
D
G
L
T
Site 33
S378
D
K
Y
E
I
T
V
S
E
D
G
L
T
H
T
Site 34
T383
T
V
S
E
D
G
L
T
H
T
L
K
I
K
D
Site 35
T385
S
E
D
G
L
T
H
T
L
K
I
K
D
A
R
Site 36
S394
K
I
K
D
A
R
L
S
D
S
G
E
F
S
A
Site 37
S396
K
D
A
R
L
S
D
S
G
E
F
S
A
E
A
Site 38
S400
L
S
D
S
G
E
F
S
A
E
A
G
N
L
V
Site 39
S434
N
V
R
V
K
E
R
S
R
A
C
L
E
C
E
Site 40
T443
A
C
L
E
C
E
L
T
S
K
D
V
T
L
R
Site 41
T448
E
L
T
S
K
D
V
T
L
R
W
K
K
D
G
Site 42
Y464
L
L
M
H
G
T
K
Y
S
M
N
H
E
G
K
Site 43
S483
I
I
E
D
A
Q
L
S
D
G
G
E
Y
T
V
Site 44
T489
L
S
D
G
G
E
Y
T
V
V
A
M
Q
D
G
Site 45
T499
A
M
Q
D
G
D
P
T
E
Y
Y
S
T
A
I
Site 46
Y501
Q
D
G
D
P
T
E
Y
Y
S
T
A
I
V
T
Site 47
Y502
D
G
D
P
T
E
Y
Y
S
T
A
I
V
T
V
Site 48
T504
D
P
T
E
Y
Y
S
T
A
I
V
T
V
E
E
Site 49
T515
T
V
E
E
R
L
A
T
V
K
S
G
M
S
D
Site 50
S518
E
R
L
A
T
V
K
S
G
M
S
D
V
H
A
Site 51
T554
L
K
D
G
K
E
I
T
D
L
P
G
M
Q
I
Site 52
S574
V
H
K
L
I
F
P
S
M
G
P
E
H
E
G
Site 53
Y583
G
P
E
H
E
G
K
Y
T
F
R
A
K
G
T
Site 54
T584
P
E
H
E
G
K
Y
T
F
R
A
K
G
T
E
Site 55
S592
F
R
A
K
G
T
E
S
E
A
S
V
F
I
A
Site 56
S595
K
G
T
E
S
E
A
S
V
F
I
A
D
P
P
Site 57
S655
V
T
E
E
E
R
V
S
M
E
R
G
E
D
Q
Site 58
T666
G
E
D
Q
A
L
L
T
I
S
N
C
V
R
E
Site 59
S668
D
Q
A
L
L
T
I
S
N
C
V
R
E
D
S
Site 60
S688
K
L
K
N
D
H
G
S
A
T
A
T
L
H
L
Site 61
S705
L
E
P
P
G
F
A
S
Q
P
Q
V
T
D
V
Site 62
Y735
G
G
A
P
V
L
G
Y
I
V
E
R
R
K
K
Site 63
S744
V
E
R
R
K
K
G
S
N
L
W
V
P
V
N
Site 64
T761
P
I
Q
G
T
K
C
T
V
D
G
L
L
E
D
Site 65
T769
V
D
G
L
L
E
D
T
E
Y
E
F
R
V
I
Site 66
S787
K
A
G
P
G
Q
P
S
V
P
S
S
S
V
V
Site 67
S790
P
G
Q
P
S
V
P
S
S
S
V
V
A
K
D
Site 68
S791
G
Q
P
S
V
P
S
S
S
V
V
A
K
D
P
Site 69
S792
Q
P
S
V
P
S
S
S
V
V
A
K
D
P
V
Site 70
S811
L
V
Q
D
L
H
V
S
D
S
S
N
S
S
I
Site 71
S813
Q
D
L
H
V
S
D
S
S
N
S
S
I
S
L
Site 72
S814
D
L
H
V
S
D
S
S
N
S
S
I
S
L
A
Site 73
S817
V
S
D
S
S
N
S
S
I
S
L
A
W
R
E
Site 74
S819
D
S
S
N
S
S
I
S
L
A
W
R
E
P
A
Site 75
S832
P
A
E
G
D
P
P
S
G
Y
I
L
E
M
R
Site 76
Y834
E
G
D
P
P
S
G
Y
I
L
E
M
R
A
E
Site 77
Y870
G
L
I
E
R
Q
K
Y
F
F
R
I
R
A
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation