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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZNF454
Full Name:
Zinc finger protein 454
Alias:
Type:
Mass (Da):
60008
Number AA:
522
UniProt ID:
Q8N9F8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S32
Q
E
E
W
G
Q
L
S
P
A
Q
R
A
L
Y
Site 2
Y39
S
P
A
Q
R
A
L
Y
R
D
V
M
L
E
N
Site 3
Y47
R
D
V
M
L
E
N
Y
S
N
L
V
S
L
G
Site 4
S52
E
N
Y
S
N
L
V
S
L
G
L
L
G
P
K
Site 5
T62
L
L
G
P
K
P
D
T
F
S
Q
L
E
K
R
Site 6
S64
G
P
K
P
D
T
F
S
Q
L
E
K
R
E
V
Site 7
T77
E
V
W
M
P
E
D
T
P
G
G
F
C
L
D
Site 8
S91
D
W
M
T
M
P
A
S
K
K
S
T
V
K
A
Site 9
T95
M
P
A
S
K
K
S
T
V
K
A
E
I
P
E
Site 10
S116
T
I
K
E
R
F
S
S
S
S
H
W
K
C
A
Site 11
S117
I
K
E
R
F
S
S
S
S
H
W
K
C
A
S
Site 12
S118
K
E
R
F
S
S
S
S
H
W
K
C
A
S
L
Site 13
T143
S
L
Q
R
V
V
L
T
H
P
N
T
P
S
Q
Site 14
T147
V
V
L
T
H
P
N
T
P
S
Q
E
Y
D
E
Site 15
S149
L
T
H
P
N
T
P
S
Q
E
Y
D
E
S
G
Site 16
Y152
P
N
T
P
S
Q
E
Y
D
E
S
G
S
T
M
Site 17
S155
P
S
Q
E
Y
D
E
S
G
S
T
M
S
S
S
Site 18
S157
Q
E
Y
D
E
S
G
S
T
M
S
S
S
L
H
Site 19
T158
E
Y
D
E
S
G
S
T
M
S
S
S
L
H
S
Site 20
S160
D
E
S
G
S
T
M
S
S
S
L
H
S
D
Q
Site 21
S161
E
S
G
S
T
M
S
S
S
L
H
S
D
Q
S
Site 22
S162
S
G
S
T
M
S
S
S
L
H
S
D
Q
S
Q
Site 23
S165
T
M
S
S
S
L
H
S
D
Q
S
Q
G
F
Q
Site 24
S168
S
S
L
H
S
D
Q
S
Q
G
F
Q
P
S
K
Site 25
S174
Q
S
Q
G
F
Q
P
S
K
N
A
F
E
C
S
Site 26
S181
S
K
N
A
F
E
C
S
E
C
G
K
V
F
S
Site 27
S188
S
E
C
G
K
V
F
S
K
S
S
T
L
N
K
Site 28
S190
C
G
K
V
F
S
K
S
S
T
L
N
K
H
Q
Site 29
S191
G
K
V
F
S
K
S
S
T
L
N
K
H
Q
K
Site 30
T192
K
V
F
S
K
S
S
T
L
N
K
H
Q
K
I
Site 31
Y216
I
H
I
K
E
K
R
Y
E
C
R
E
C
G
K
Site 32
T239
I
H
H
Q
R
I
H
T
G
E
K
P
Y
E
C
Site 33
Y244
I
H
T
G
E
K
P
Y
E
C
K
E
C
G
K
Site 34
S254
K
E
C
G
K
A
F
S
V
S
S
S
L
T
Y
Site 35
S256
C
G
K
A
F
S
V
S
S
S
L
T
Y
H
Q
Site 36
S258
K
A
F
S
V
S
S
S
L
T
Y
H
Q
K
I
Site 37
T260
F
S
V
S
S
S
L
T
Y
H
Q
K
I
H
T
Site 38
Y261
S
V
S
S
S
L
T
Y
H
Q
K
I
H
T
G
Site 39
T295
A
H
H
H
R
I
H
T
G
E
K
P
F
K
C
Site 40
Y328
I
H
S
G
E
K
P
Y
K
C
N
E
C
G
K
Site 41
S342
K
A
F
N
Q
S
T
S
F
L
Q
H
Q
R
I
Site 42
T351
L
Q
H
Q
R
I
H
T
G
E
K
P
F
E
C
Site 43
S369
G
K
A
F
R
V
N
S
S
L
T
E
H
Q
R
Site 44
T379
T
E
H
Q
R
I
H
T
G
E
K
P
Y
K
C
Site 45
Y384
I
H
T
G
E
K
P
Y
K
C
N
E
C
G
K
Site 46
S397
G
K
A
F
R
D
N
S
S
F
A
R
H
R
K
Site 47
S398
K
A
F
R
D
N
S
S
F
A
R
H
R
K
I
Site 48
T407
A
R
H
R
K
I
H
T
G
E
K
P
Y
R
C
Site 49
S425
E
K
A
F
R
D
Q
S
A
L
A
Q
H
Q
R
Site 50
T435
A
Q
H
Q
R
I
H
T
G
E
K
P
Y
T
C
Site 51
S450
N
I
C
E
K
A
F
S
D
H
S
A
L
T
Q
Site 52
T456
F
S
D
H
S
A
L
T
Q
H
K
R
I
H
T
Site 53
T463
T
Q
H
K
R
I
H
T
R
E
K
P
Y
K
C
Site 54
T481
E
K
A
F
I
R
S
T
H
L
T
Q
H
Q
R
Site 55
T491
T
Q
H
Q
R
I
H
T
G
E
K
P
Y
K
C
Site 56
T508
C
G
K
A
F
N
Q
T
A
N
L
I
Q
H
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation