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Updated November 2019
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Protein Info
Short Name:
EXD3
Full Name:
Probable exonuclease mut-7 homolog
Alias:
Exonuclease 3'-5' domain-containing protein 3
Type:
Mass (Da):
96676
Number AA:
876
UniProt ID:
Q8N9H8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T31
L
L
L
Q
A
L
Q
T
L
W
S
T
R
E
R
Site 2
S34
Q
A
L
Q
T
L
W
S
T
R
E
R
K
Q
L
Site 3
S65
G
L
L
D
M
L
E
S
C
R
G
Q
R
G
E
Site 4
S75
G
Q
R
G
E
G
P
S
L
A
A
W
I
S
H
Site 5
S95
L
Q
A
Q
P
C
P
S
L
A
Q
H
S
L
R
Site 6
S100
C
P
S
L
A
Q
H
S
L
R
L
K
Q
L
Q
Site 7
S137
Q
L
Q
D
A
D
R
S
C
L
L
A
H
V
H
Site 8
Y221
I
K
D
V
A
R
Q
Y
P
E
V
T
S
L
S
Site 9
S226
R
Q
Y
P
E
V
T
S
L
S
L
E
K
L
S
Site 10
S228
Y
P
E
V
T
S
L
S
L
E
K
L
S
P
K
Site 11
S233
S
L
S
L
E
K
L
S
P
K
A
L
S
R
Q
Site 12
S238
K
L
S
P
K
A
L
S
R
Q
V
L
R
L
Q
Site 13
S249
L
R
L
Q
E
R
Y
S
V
A
P
A
L
C
P
Site 14
S279
H
K
R
F
V
E
K
S
L
S
Q
E
N
W
T
Site 15
S281
R
F
V
E
K
S
L
S
Q
E
N
W
T
D
H
Site 16
S296
V
Q
G
L
V
G
Q
S
P
W
L
Q
E
Q
L
Site 17
S304
P
W
L
Q
E
Q
L
S
Q
L
L
V
S
H
S
Site 18
S311
S
Q
L
L
V
S
H
S
D
P
V
T
A
A
Q
Site 19
T315
V
S
H
S
D
P
V
T
A
A
Q
C
A
M
D
Site 20
T348
F
R
L
Q
G
R
A
T
E
A
D
S
R
L
E
Site 21
Y363
V
K
D
M
K
D
R
Y
Y
Q
L
P
I
P
R
Site 22
Y364
K
D
M
K
D
R
Y
Y
Q
L
P
I
P
R
E
Site 23
T383
L
A
S
W
E
D
L
T
R
H
E
G
A
L
L
Site 24
S415
A
G
G
R
P
R
P
S
L
L
Q
V
A
V
E
Site 25
T438
L
A
L
S
Q
P
P
T
G
Q
G
A
Q
A
F
Site 26
S457
A
Q
L
L
S
D
P
S
I
T
K
L
G
Y
G
Site 27
T474
G
D
L
Q
K
L
G
T
S
C
P
A
L
A
H
Site 28
S503
H
R
Q
M
R
V
A
S
V
P
A
P
A
V
D
Site 29
T533
L
G
T
A
L
D
K
T
Q
Q
L
S
N
W
D
Site 30
S537
L
D
K
T
Q
Q
L
S
N
W
D
R
R
P
L
Site 31
Y545
N
W
D
R
R
P
L
Y
E
E
Q
V
I
Y
A
Site 32
S576
E
P
A
R
F
H
L
S
E
D
L
A
G
S
R
Site 33
S582
L
S
E
D
L
A
G
S
R
R
P
R
H
R
E
Site 34
S603
P
P
G
L
Q
K
A
S
A
P
A
A
P
R
Q
Site 35
S678
E
G
R
I
I
L
T
S
G
Q
P
F
H
K
L
Site 36
S700
R
C
L
S
V
D
C
S
L
K
A
Q
Q
Q
A
Site 37
T719
K
H
F
N
V
R
V
T
H
A
D
I
F
S
R
Site 38
Y735
Q
A
C
N
C
D
Q
Y
L
K
V
S
R
D
M
Site 39
S750
M
K
Q
L
M
W
L
S
S
H
Q
E
G
P
R
Site 40
S751
K
Q
L
M
W
L
S
S
H
Q
E
G
P
R
S
Site 41
S758
S
H
Q
E
G
P
R
S
S
G
D
E
A
T
Q
Site 42
S759
H
Q
E
G
P
R
S
S
G
D
E
A
T
Q
S
Site 43
S766
S
G
D
E
A
T
Q
S
Q
A
V
Q
E
P
G
Site 44
Y785
A
A
P
E
G
C
T
Y
D
R
P
C
R
W
L
Site 45
T801
M
A
D
L
R
A
E
T
P
D
M
L
A
D
G
Site 46
S843
G
K
V
F
W
D
G
S
H
L
G
R
V
A
T
Site 47
T850
S
H
L
G
R
V
A
T
H
F
R
D
M
L
E
Site 48
S858
H
F
R
D
M
L
E
S
A
P
S
P
C
E
P
Site 49
S861
D
M
L
E
S
A
P
S
P
C
E
P
S
P
A
Site 50
S866
A
P
S
P
C
E
P
S
P
A
P
S
P
A
S
Site 51
S870
C
E
P
S
P
A
P
S
P
A
S
S
P
F
_
Site 52
S873
S
P
A
P
S
P
A
S
S
P
F
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation