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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MARCH-X
Full Name:
Probable E3 ubiquitin-protein ligase MARCH10
Alias:
Membrane-associated RING finger protein 10;Membrane-associated RING-CH protein X;RING finger protein 190
Type:
Mass (Da):
90511
Number AA:
808
UniProt ID:
Q8NA82
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
R
D
R
Q
K
F
F
S
D
V
Q
Y
L
R
D
Site 2
Y17
K
F
F
S
D
V
Q
Y
L
R
D
M
Q
H
K
Site 3
Y29
Q
H
K
V
D
S
E
Y
Q
A
C
L
R
R
Q
Site 4
Y38
A
C
L
R
R
Q
E
Y
R
R
D
P
N
E
K
Site 5
S56
Q
F
W
G
Q
E
T
S
F
E
R
S
R
F
S
Site 6
S60
Q
E
T
S
F
E
R
S
R
F
S
S
R
S
S
Site 7
S63
S
F
E
R
S
R
F
S
S
R
S
S
S
K
Q
Site 8
S64
F
E
R
S
R
F
S
S
R
S
S
S
K
Q
S
Site 9
S66
R
S
R
F
S
S
R
S
S
S
K
Q
S
S
S
Site 10
S67
S
R
F
S
S
R
S
S
S
K
Q
S
S
S
E
Site 11
S68
R
F
S
S
R
S
S
S
K
Q
S
S
S
E
E
Site 12
S71
S
R
S
S
S
K
Q
S
S
S
E
E
D
A
L
Site 13
S72
R
S
S
S
K
Q
S
S
S
E
E
D
A
L
T
Site 14
S73
S
S
S
K
Q
S
S
S
E
E
D
A
L
T
E
Site 15
T79
S
S
E
E
D
A
L
T
E
P
R
S
S
I
K
Site 16
S83
D
A
L
T
E
P
R
S
S
I
K
I
S
A
F
Site 17
S84
A
L
T
E
P
R
S
S
I
K
I
S
A
F
K
Site 18
S88
P
R
S
S
I
K
I
S
A
F
K
C
D
S
K
Site 19
T102
K
L
P
A
I
D
Q
T
S
V
K
Q
K
H
K
Site 20
S103
L
P
A
I
D
Q
T
S
V
K
Q
K
H
K
S
Site 21
S110
S
V
K
Q
K
H
K
S
T
M
T
V
R
K
A
Site 22
T113
Q
K
H
K
S
T
M
T
V
R
K
A
E
K
V
Site 23
S123
K
A
E
K
V
D
P
S
E
P
S
P
A
D
Q
Site 24
S126
K
V
D
P
S
E
P
S
P
A
D
Q
A
P
M
Site 25
T147
K
P
N
L
R
R
F
T
V
S
P
E
S
H
S
Site 26
S149
N
L
R
R
F
T
V
S
P
E
S
H
S
P
R
Site 27
S152
R
F
T
V
S
P
E
S
H
S
P
R
A
S
G
Site 28
S154
T
V
S
P
E
S
H
S
P
R
A
S
G
D
R
Site 29
S158
E
S
H
S
P
R
A
S
G
D
R
S
R
Q
K
Site 30
S162
P
R
A
S
G
D
R
S
R
Q
K
Q
Q
W
P
Site 31
S206
E
R
R
N
L
V
P
S
S
Q
P
M
T
E
N
Site 32
S207
R
R
N
L
V
P
S
S
Q
P
M
T
E
N
A
Site 33
T211
V
P
S
S
Q
P
M
T
E
N
A
P
D
R
A
Site 34
S224
R
A
K
K
G
D
P
S
A
P
S
Q
S
E
L
Site 35
S227
K
G
D
P
S
A
P
S
Q
S
E
L
H
P
A
Site 36
S236
S
E
L
H
P
A
L
S
Q
A
F
Q
G
K
N
Site 37
S244
Q
A
F
Q
G
K
N
S
P
Q
V
L
S
E
F
Site 38
S249
K
N
S
P
Q
V
L
S
E
F
S
G
P
P
L
Site 39
T257
E
F
S
G
P
P
L
T
P
T
T
V
G
G
P
Site 40
T259
S
G
P
P
L
T
P
T
T
V
G
G
P
R
K
Site 41
T260
G
P
P
L
T
P
T
T
V
G
G
P
R
K
A
Site 42
S268
V
G
G
P
R
K
A
S
F
R
F
R
D
E
D
Site 43
Y277
R
F
R
D
E
D
F
Y
S
I
L
S
L
N
S
Site 44
S278
F
R
D
E
D
F
Y
S
I
L
S
L
N
S
R
Site 45
S281
E
D
F
Y
S
I
L
S
L
N
S
R
R
E
S
Site 46
S284
Y
S
I
L
S
L
N
S
R
R
E
S
D
D
T
Site 47
S288
S
L
N
S
R
R
E
S
D
D
T
E
E
E
T
Site 48
T291
S
R
R
E
S
D
D
T
E
E
E
T
Q
S
E
Site 49
S297
D
T
E
E
E
T
Q
S
E
E
C
L
W
V
G
Site 50
S307
C
L
W
V
G
V
R
S
P
C
S
P
S
H
H
Site 51
S310
V
G
V
R
S
P
C
S
P
S
H
H
K
R
S
Site 52
S312
V
R
S
P
C
S
P
S
H
H
K
R
S
R
S
Site 53
S317
S
P
S
H
H
K
R
S
R
S
G
G
T
S
T
Site 54
S319
S
H
H
K
R
S
R
S
G
G
T
S
T
P
Q
Site 55
S323
R
S
R
S
G
G
T
S
T
P
Q
A
K
N
K
Site 56
T324
S
R
S
G
G
T
S
T
P
Q
A
K
N
K
N
Site 57
S343
A
E
N
C
R
G
H
S
S
R
R
S
E
P
S
Site 58
S344
E
N
C
R
G
H
S
S
R
R
S
E
P
S
H
Site 59
S347
R
G
H
S
S
R
R
S
E
P
S
H
G
S
L
Site 60
S350
S
S
R
R
S
E
P
S
H
G
S
L
R
I
S
Site 61
S353
R
S
E
P
S
H
G
S
L
R
I
S
N
A
M
Site 62
S357
S
H
G
S
L
R
I
S
N
A
M
E
P
A
T
Site 63
T364
S
N
A
M
E
P
A
T
E
R
P
S
A
G
Q
Site 64
S368
E
P
A
T
E
R
P
S
A
G
Q
R
L
S
Q
Site 65
S374
P
S
A
G
Q
R
L
S
Q
D
P
G
L
P
D
Site 66
S384
P
G
L
P
D
R
E
S
A
T
E
K
D
R
G
Site 67
S393
T
E
K
D
R
G
G
S
E
N
A
K
K
S
P
Site 68
S399
G
S
E
N
A
K
K
S
P
L
S
W
D
T
K
Site 69
S402
N
A
K
K
S
P
L
S
W
D
T
K
S
E
P
Site 70
T405
K
S
P
L
S
W
D
T
K
S
E
P
R
Q
E
Site 71
S407
P
L
S
W
D
T
K
S
E
P
R
Q
E
V
G
Site 72
T433
S
V
E
H
R
P
G
T
H
D
S
E
G
Y
W
Site 73
S436
H
R
P
G
T
H
D
S
E
G
Y
W
K
D
Y
Site 74
Y443
S
E
G
Y
W
K
D
Y
L
N
S
S
Q
N
S
Site 75
S450
Y
L
N
S
S
Q
N
S
L
D
Y
F
I
S
G
Site 76
Y453
S
S
Q
N
S
L
D
Y
F
I
S
G
R
P
I
Site 77
S456
N
S
L
D
Y
F
I
S
G
R
P
I
S
P
R
Site 78
S461
F
I
S
G
R
P
I
S
P
R
S
S
V
N
S
Site 79
S464
G
R
P
I
S
P
R
S
S
V
N
S
S
Y
N
Site 80
S465
R
P
I
S
P
R
S
S
V
N
S
S
Y
N
P
Site 81
S468
S
P
R
S
S
V
N
S
S
Y
N
P
P
A
S
Site 82
S469
P
R
S
S
V
N
S
S
Y
N
P
P
A
S
F
Site 83
Y470
R
S
S
V
N
S
S
Y
N
P
P
A
S
F
M
Site 84
S475
S
S
Y
N
P
P
A
S
F
M
H
S
A
L
R
Site 85
S479
P
P
A
S
F
M
H
S
A
L
R
D
D
I
P
Site 86
S490
D
D
I
P
V
D
L
S
M
S
S
T
S
V
H
Site 87
S492
I
P
V
D
L
S
M
S
S
T
S
V
H
S
S
Site 88
S493
P
V
D
L
S
M
S
S
T
S
V
H
S
S
D
Site 89
T494
V
D
L
S
M
S
S
T
S
V
H
S
S
D
S
Site 90
S495
D
L
S
M
S
S
T
S
V
H
S
S
D
S
E
Site 91
S499
S
S
T
S
V
H
S
S
D
S
E
G
N
S
G
Site 92
S501
T
S
V
H
S
S
D
S
E
G
N
S
G
F
H
Site 93
S505
S
S
D
S
E
G
N
S
G
F
H
V
C
Q
P
Site 94
S514
F
H
V
C
Q
P
L
S
P
I
R
N
R
T
P
Site 95
T520
L
S
P
I
R
N
R
T
P
F
A
S
A
E
N
Site 96
Y530
A
S
A
E
N
H
N
Y
F
P
V
N
S
A
H
Site 97
T547
A
V
R
E
A
E
D
T
T
L
T
S
Q
P
Q
Site 98
T548
V
R
E
A
E
D
T
T
L
T
S
Q
P
Q
G
Site 99
T550
E
A
E
D
T
T
L
T
S
Q
P
Q
G
A
P
Site 100
S551
A
E
D
T
T
L
T
S
Q
P
Q
G
A
P
L
Site 101
Y559
Q
P
Q
G
A
P
L
Y
T
D
L
L
L
N
P
Site 102
S571
L
N
P
Q
G
N
L
S
L
V
D
S
S
S
S
Site 103
S575
G
N
L
S
L
V
D
S
S
S
S
S
P
S
R
Site 104
S576
N
L
S
L
V
D
S
S
S
S
S
P
S
R
M
Site 105
S577
L
S
L
V
D
S
S
S
S
S
P
S
R
M
N
Site 106
S578
S
L
V
D
S
S
S
S
S
P
S
R
M
N
S
Site 107
S579
L
V
D
S
S
S
S
S
P
S
R
M
N
S
E
Site 108
S581
D
S
S
S
S
S
P
S
R
M
N
S
E
G
H
Site 109
S585
S
S
P
S
R
M
N
S
E
G
H
L
H
V
S
Site 110
S594
G
H
L
H
V
S
G
S
L
Q
E
N
T
P
F
Site 111
S617
P
N
Q
N
D
N
G
S
R
M
A
A
S
G
F
Site 112
S631
F
T
D
E
K
E
T
S
K
I
K
A
D
P
E
Site 113
S652
E
S
L
L
E
E
D
S
E
E
E
G
D
L
C
Site 114
S670
Q
I
A
G
G
S
P
S
N
P
L
L
E
P
C
Site 115
T710
A
D
L
G
A
V
K
T
C
E
M
C
K
Q
G
Site 116
Y731
D
F
N
M
I
E
F
Y
Q
K
H
Q
Q
S
Q
Site 117
Y749
E
L
M
N
S
G
L
Y
L
V
L
L
L
H
L
Site 118
S778
Q
V
E
R
E
R
L
S
R
N
Y
P
Q
P
R
Site 119
Y781
R
E
R
L
S
R
N
Y
P
Q
P
R
T
E
E
Site 120
T786
R
N
Y
P
Q
P
R
T
E
E
N
E
S
S
E
Site 121
S791
P
R
T
E
E
N
E
S
S
E
L
G
D
G
N
Site 122
S792
R
T
E
E
N
E
S
S
E
L
G
D
G
N
E
Site 123
S801
L
G
D
G
N
E
G
S
I
S
Q
S
Q
V
V
Site 124
S803
D
G
N
E
G
S
I
S
Q
S
Q
V
V
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation