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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ANKLE1
Full Name:
Ankyrin repeat and LEM domain-containing protein 1
Alias:
Ankyrin repeat domain-containing protein 41;LEM-domain containing protein 3
Type:
Mass (Da):
62235
Number AA:
575
UniProt ID:
Q8NAG6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
R
C
G
R
R
S
R
V
E
E
L
L
R
Site 2
S59
G
G
D
P
N
V
R
S
V
E
A
L
T
P
L
Site 3
T119
R
V
L
Q
D
L
D
T
R
T
R
T
R
T
R
Site 4
T121
L
Q
D
L
D
T
R
T
R
T
R
T
R
I
G
Site 5
T123
D
L
D
T
R
T
R
T
R
T
R
I
G
A
E
Site 6
T125
D
T
R
T
R
T
R
T
R
I
G
A
E
T
Q
Site 7
T131
R
T
R
I
G
A
E
T
Q
E
P
E
P
A
P
Site 8
T140
E
P
E
P
A
P
G
T
P
G
L
S
G
P
T
Site 9
T150
L
S
G
P
T
D
E
T
L
D
S
I
A
L
Q
Site 10
S153
P
T
D
E
T
L
D
S
I
A
L
Q
K
Q
P
Site 11
S178
E
A
D
P
G
P
P
S
L
P
V
P
L
E
T
Site 12
T185
S
L
P
V
P
L
E
T
V
D
K
H
G
S
S
Site 13
S191
E
T
V
D
K
H
G
S
S
A
S
P
P
G
H
Site 14
S192
T
V
D
K
H
G
S
S
A
S
P
P
G
H
W
Site 15
S194
D
K
H
G
S
S
A
S
P
P
G
H
W
D
Y
Site 16
Y201
S
P
P
G
H
W
D
Y
S
S
D
A
S
F
V
Site 17
S202
P
P
G
H
W
D
Y
S
S
D
A
S
F
V
T
Site 18
S203
P
G
H
W
D
Y
S
S
D
A
S
F
V
T
A
Site 19
S221
S
G
A
E
D
P
A
S
D
T
P
P
W
A
G
Site 20
T223
A
E
D
P
A
S
D
T
P
P
W
A
G
S
L
Site 21
S229
D
T
P
P
W
A
G
S
L
P
P
T
R
Q
G
Site 22
T233
W
A
G
S
L
P
P
T
R
Q
G
L
L
H
V
Site 23
S250
A
N
Q
R
V
P
R
S
Q
G
T
E
A
E
L
Site 24
T265
N
A
R
L
Q
A
L
T
L
T
P
P
N
A
A
Site 25
S276
P
N
A
A
G
F
Q
S
S
P
S
S
M
P
L
Site 26
S277
N
A
A
G
F
Q
S
S
P
S
S
M
P
L
L
Site 27
S279
A
G
F
Q
S
S
P
S
S
M
P
L
L
D
R
Site 28
S280
G
F
Q
S
S
P
S
S
M
P
L
L
D
R
S
Site 29
S287
S
M
P
L
L
D
R
S
P
A
H
S
P
P
R
Site 30
S291
L
D
R
S
P
A
H
S
P
P
R
T
P
P
P
Site 31
T295
P
A
H
S
P
P
R
T
P
P
P
G
A
S
D
Site 32
S315
E
H
Q
T
S
I
D
S
D
M
A
T
L
W
L
Site 33
T319
S
I
D
S
D
M
A
T
L
W
L
T
E
D
E
Site 34
T323
D
M
A
T
L
W
L
T
E
D
E
A
S
S
T
Site 35
S328
W
L
T
E
D
E
A
S
S
T
G
G
R
E
P
Site 36
T330
T
E
D
E
A
S
S
T
G
G
R
E
P
V
G
Site 37
S345
P
C
R
H
L
P
V
S
T
V
S
D
L
E
L
Site 38
S364
R
A
L
G
P
E
F
S
G
H
S
L
E
L
A
Site 39
Y413
V
V
K
S
S
F
T
Y
L
L
L
D
P
R
E
Site 40
T421
L
L
L
D
P
R
E
T
Q
D
L
P
A
R
A
Site 41
S430
D
L
P
A
R
A
F
S
L
T
P
A
E
R
L
Site 42
T432
P
A
R
A
F
S
L
T
P
A
E
R
L
Q
T
Site 43
Y456
K
G
T
R
A
R
P
Y
V
H
L
W
E
A
L
Site 44
T524
A
L
G
I
Q
T
L
T
N
Q
K
Q
G
H
C
Site 45
Y532
N
Q
K
Q
G
H
C
Y
G
V
V
A
G
W
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation