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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TDRD5
Full Name:
Tudor domain-containing protein 5
Alias:
FLJ34823; RP11-427G13.1; TUDOR3
Type:
Uncharacterized protein
Mass (Da):
109737
Number AA:
981
UniProt ID:
Q8NAT2
International Prot ID:
IPI00175977
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003676
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
C
L
R
K
E
I
R
S
L
L
I
S
T
K
D
Site 2
S21
E
I
R
S
L
L
I
S
T
K
D
G
L
S
P
Site 3
S27
I
S
T
K
D
G
L
S
P
Q
E
L
E
K
E
Site 4
Y35
P
Q
E
L
E
K
E
Y
L
L
M
V
G
N
H
Site 5
S89
E
S
T
K
G
I
A
S
L
V
A
K
Q
R
S
Site 6
S97
L
V
A
K
Q
R
S
S
H
K
L
R
N
S
M
Site 7
S103
S
S
H
K
L
R
N
S
M
H
K
G
R
P
S
Site 8
S110
S
M
H
K
G
R
P
S
I
Y
S
G
P
R
S
Site 9
Y112
H
K
G
R
P
S
I
Y
S
G
P
R
S
H
R
Site 10
S113
K
G
R
P
S
I
Y
S
G
P
R
S
H
R
R
Site 11
S117
S
I
Y
S
G
P
R
S
H
R
R
V
P
Y
R
Site 12
Y123
R
S
H
R
R
V
P
Y
R
G
R
V
A
P
I
Site 13
Y167
R
F
G
R
S
F
Q
Y
M
Q
Y
G
F
L
S
Site 14
Y170
R
S
F
Q
Y
M
Q
Y
G
F
L
S
M
F
E
Site 15
S187
N
A
A
S
D
V
I
S
V
E
Q
T
R
A
G
Site 16
S195
V
E
Q
T
R
A
G
S
L
L
M
L
K
K
S
Site 17
S202
S
L
L
M
L
K
K
S
V
T
E
E
K
P
R
Site 18
S227
P
F
R
M
K
Q
G
S
Y
S
T
G
F
P
V
Site 19
S240
P
V
A
K
P
C
F
S
Q
P
T
S
N
M
E
Site 20
S244
P
C
F
S
Q
P
T
S
N
M
E
P
P
K
Q
Site 21
S254
E
P
P
K
Q
I
M
S
M
E
K
T
S
K
L
Site 22
T266
S
K
L
N
V
V
E
T
S
R
L
N
H
T
E
Site 23
T281
K
L
N
Q
L
E
N
T
F
K
S
V
I
A
Q
Site 24
S284
Q
L
E
N
T
F
K
S
V
I
A
Q
I
G
P
Site 25
S296
I
G
P
G
G
T
I
S
S
E
L
K
H
K
I
Site 26
S297
G
P
G
G
T
I
S
S
E
L
K
H
K
I
K
Site 27
Y323
I
S
K
L
L
G
E
Y
E
V
I
F
K
E
Q
Site 28
S378
K
P
L
P
P
V
Q
S
D
K
K
I
E
A
K
Site 29
S389
I
E
A
K
A
C
V
S
S
P
P
R
N
S
L
Site 30
S390
E
A
K
A
C
V
S
S
P
P
R
N
S
L
S
Site 31
S395
V
S
S
P
P
R
N
S
L
S
T
A
A
V
K
Site 32
S397
S
P
P
R
N
S
L
S
T
A
A
V
K
E
T
Site 33
T398
P
P
R
N
S
L
S
T
A
A
V
K
E
T
V
Site 34
T404
S
T
A
A
V
K
E
T
V
W
N
C
P
S
K
Site 35
S440
L
Q
V
E
T
N
K
S
E
L
N
L
A
M
A
Site 36
Y487
I
I
S
P
S
Q
F
Y
I
R
I
Y
S
R
D
Site 37
Y491
S
Q
F
Y
I
R
I
Y
S
R
D
S
S
E
L
Site 38
S492
Q
F
Y
I
R
I
Y
S
R
D
S
S
E
L
L
Site 39
S495
I
R
I
Y
S
R
D
S
S
E
L
L
E
D
M
Site 40
S496
R
I
Y
S
R
D
S
S
E
L
L
E
D
M
M
Site 41
Y510
M
I
E
M
R
R
C
Y
S
N
Q
L
V
S
D
Site 42
S511
I
E
M
R
R
C
Y
S
N
Q
L
V
S
D
R
Site 43
S516
C
Y
S
N
Q
L
V
S
D
R
Y
V
M
P
E
Site 44
Y560
K
Q
E
V
E
V
F
Y
P
D
F
G
N
I
G
Site 45
T604
R
P
V
E
E
H
W
T
S
K
A
I
L
Q
F
Site 46
T639
L
N
I
F
L
C
D
T
S
S
N
E
D
V
Y
Site 47
Y646
T
S
S
N
E
D
V
Y
F
H
H
V
L
R
T
Site 48
S665
I
V
C
R
E
N
I
S
S
K
G
F
S
E
L
Site 49
S666
V
C
R
E
N
I
S
S
K
G
F
S
E
L
N
Site 50
S670
N
I
S
S
K
G
F
S
E
L
N
P
L
A
L
Site 51
Y678
E
L
N
P
L
A
L
Y
T
T
S
S
G
G
P
Site 52
T680
N
P
L
A
L
Y
T
T
S
S
G
G
P
E
D
Site 53
T691
G
P
E
D
I
V
L
T
E
L
G
Y
P
S
Q
Site 54
Y695
I
V
L
T
E
L
G
Y
P
S
Q
Q
H
Y
F
Site 55
S697
L
T
E
L
G
Y
P
S
Q
Q
H
Y
F
N
E
Site 56
Y701
G
Y
P
S
Q
Q
H
Y
F
N
E
D
R
K
I
Site 57
S709
F
N
E
D
R
K
I
S
P
Q
S
K
E
S
E
Site 58
S712
D
R
K
I
S
P
Q
S
K
E
S
E
L
R
I
Site 59
S715
I
S
P
Q
S
K
E
S
E
L
R
I
L
D
E
Site 60
T725
R
I
L
D
E
I
P
T
G
M
P
C
L
E
S
Site 61
S759
G
K
G
G
D
A
A
S
H
L
F
T
A
S
L
Site 62
T763
D
A
A
S
H
L
F
T
A
S
L
G
G
K
N
Site 63
S765
A
S
H
L
F
T
A
S
L
G
G
K
N
Q
Y
Site 64
Y772
S
L
G
G
K
N
Q
Y
S
S
C
K
E
M
P
Site 65
S773
L
G
G
K
N
Q
Y
S
S
C
K
E
M
P
Q
Site 66
S774
G
G
K
N
Q
Y
S
S
C
K
E
M
P
Q
K
Site 67
S795
P
K
D
T
W
D
D
S
W
Q
P
S
G
L
V
Site 68
T822
L
G
A
Q
E
K
N
T
G
T
N
R
T
Q
K
Site 69
T824
A
Q
E
K
N
T
G
T
N
R
T
Q
K
Q
L
Site 70
T827
K
N
T
G
T
N
R
T
Q
K
Q
L
D
I
N
Site 71
S836
K
Q
L
D
I
N
G
S
S
D
S
S
T
L
P
Site 72
S837
Q
L
D
I
N
G
S
S
D
S
S
T
L
P
K
Site 73
S840
I
N
G
S
S
D
S
S
T
L
P
K
L
E
E
Site 74
T841
N
G
S
S
D
S
S
T
L
P
K
L
E
E
F
Site 75
T850
P
K
L
E
E
F
C
T
S
L
T
Q
S
E
Q
Site 76
S851
K
L
E
E
F
C
T
S
L
T
Q
S
E
Q
S
Site 77
T853
E
E
F
C
T
S
L
T
Q
S
E
Q
S
A
D
Site 78
S855
F
C
T
S
L
T
Q
S
E
Q
S
A
D
G
S
Site 79
S858
S
L
T
Q
S
E
Q
S
A
D
G
S
Q
S
E
Site 80
S862
S
E
Q
S
A
D
G
S
Q
S
E
P
N
N
S
Site 81
S864
Q
S
A
D
G
S
Q
S
E
P
N
N
S
Q
T
Site 82
S869
S
Q
S
E
P
N
N
S
Q
T
Q
P
K
Q
I
Site 83
S879
Q
P
K
Q
I
Q
L
S
T
A
A
P
C
S
T
Site 84
T880
P
K
Q
I
Q
L
S
T
A
A
P
C
S
T
T
Site 85
S885
L
S
T
A
A
P
C
S
T
T
A
V
D
D
S
Site 86
S892
S
T
T
A
V
D
D
S
A
E
K
P
S
G
S
Site 87
S897
D
D
S
A
E
K
P
S
G
S
V
E
S
S
P
Site 88
S899
S
A
E
K
P
S
G
S
V
E
S
S
P
E
I
Site 89
S903
P
S
G
S
V
E
S
S
P
E
I
L
K
N
E
Site 90
S914
L
K
N
E
D
F
S
S
S
R
A
I
T
L
Y
Site 91
S915
K
N
E
D
F
S
S
S
R
A
I
T
L
Y
K
Site 92
T919
F
S
S
S
R
A
I
T
L
Y
K
D
K
R
Q
Site 93
Y921
S
S
R
A
I
T
L
Y
K
D
K
R
Q
E
S
Site 94
S928
Y
K
D
K
R
Q
E
S
V
D
Q
L
S
L
I
Site 95
S933
Q
E
S
V
D
Q
L
S
L
I
L
S
Y
E
C
Site 96
S937
D
Q
L
S
L
I
L
S
Y
E
C
Q
I
S
Q
Site 97
Y938
Q
L
S
L
I
L
S
Y
E
C
Q
I
S
Q
K
Site 98
S943
L
S
Y
E
C
Q
I
S
Q
K
L
Y
I
P
R
Site 99
Y947
C
Q
I
S
Q
K
L
Y
I
P
R
S
T
A
T
Site 100
S951
Q
K
L
Y
I
P
R
S
T
A
T
A
A
L
G
Site 101
S968
A
R
L
A
T
S
R
S
L
L
H
W
Y
P
S
Site 102
Y973
S
R
S
L
L
H
W
Y
P
S
V
K
R
M
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation