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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USP38
Full Name:
Ubiquitin carboxyl-terminal hydrolase 38
Alias:
Deubiquitinating enzyme 38; HP43.8KD; KIAA1891; Ubiquitin specific peptidase 38; Ubiquitin specific protease 38; Ubiquitin thiolesterase 38; Ubiquitin-specific-processing protease 38; UBP38
Type:
EC 3.1.2.15; Protease
Mass (Da):
116546
Number AA:
1042
UniProt ID:
Q8NB14
International Prot ID:
IPI00168084
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0008234
GO:0004221
PhosphoSite+
KinaseNET
Biological Process:
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
L
E
G
L
V
S
S
S
H
P
L
P
L
K
R
Site 2
S28
I
V
R
K
V
V
E
S
A
E
H
W
L
D
E
Site 3
Y68
G
H
Q
V
L
E
A
Y
A
R
Y
H
R
P
E
Site 4
Y71
V
L
E
A
Y
A
R
Y
H
R
P
E
F
E
S
Site 5
Y93
L
G
L
L
H
Q
G
Y
H
S
L
D
R
K
D
Site 6
S95
L
L
H
Q
G
Y
H
S
L
D
R
K
D
V
A
Site 7
T166
P
K
G
K
L
S
I
T
F
C
Q
Q
L
V
R
Site 8
S182
I
G
H
F
Q
C
V
S
T
Q
E
R
E
L
R
Site 9
T183
G
H
F
Q
C
V
S
T
Q
E
R
E
L
R
E
Site 10
Y191
Q
E
R
E
L
R
E
Y
V
S
Q
V
T
K
V
Site 11
S193
R
E
L
R
E
Y
V
S
Q
V
T
K
V
S
N
Site 12
T212
I
W
K
A
E
P
A
T
L
L
P
S
L
Q
E
Site 13
S223
S
L
Q
E
V
F
A
S
I
S
S
T
D
A
S
Site 14
S225
Q
E
V
F
A
S
I
S
S
T
D
A
S
F
E
Site 15
T257
T
V
L
I
R
S
L
T
T
D
P
N
V
K
D
Site 16
S266
D
P
N
V
K
D
A
S
M
T
Q
A
L
C
R
Site 17
S361
H
V
V
N
L
V
H
S
F
K
N
D
G
L
P
Site 18
S369
F
K
N
D
G
L
P
S
S
T
A
F
L
V
Q
Site 19
S370
K
N
D
G
L
P
S
S
T
A
F
L
V
Q
L
Site 20
S420
I
K
L
I
L
N
Q
S
A
W
T
S
Q
S
N
Site 21
S424
L
N
Q
S
A
W
T
S
Q
S
N
S
L
A
S
Site 22
S426
Q
S
A
W
T
S
Q
S
N
S
L
A
S
C
L
Site 23
S428
A
W
T
S
Q
S
N
S
L
A
S
C
L
S
R
Site 24
S431
S
Q
S
N
S
L
A
S
C
L
S
R
L
S
G
Site 25
S434
N
S
L
A
S
C
L
S
R
L
S
G
K
S
E
Site 26
S437
A
S
C
L
S
R
L
S
G
K
S
E
T
G
K
Site 27
S440
L
S
R
L
S
G
K
S
E
T
G
K
T
G
L
Site 28
T445
G
K
S
E
T
G
K
T
G
L
I
N
L
G
N
Site 29
S475
D
F
R
R
Q
V
L
S
L
N
L
N
G
C
N
Site 30
S483
L
N
L
N
G
C
N
S
L
M
K
K
L
Q
H
Site 31
Y503
A
H
T
Q
R
E
A
Y
A
P
R
I
F
F
E
Site 32
S512
P
R
I
F
F
E
A
S
R
P
P
W
F
T
P
Site 33
T518
A
S
R
P
P
W
F
T
P
R
S
Q
Q
D
C
Site 34
S521
P
P
W
F
T
P
R
S
Q
Q
D
C
S
E
Y
Site 35
S526
P
R
S
Q
Q
D
C
S
E
Y
L
R
F
L
L
Site 36
Y528
S
Q
Q
D
C
S
E
Y
L
R
F
L
L
D
R
Site 37
S548
K
I
L
K
V
Q
A
S
H
K
P
S
E
I
L
Site 38
S552
V
Q
A
S
H
K
P
S
E
I
L
E
C
S
E
Site 39
S558
P
S
E
I
L
E
C
S
E
T
S
L
Q
E
V
Site 40
T560
E
I
L
E
C
S
E
T
S
L
Q
E
V
A
S
Site 41
T573
A
S
K
A
A
V
L
T
E
T
P
R
T
S
D
Site 42
T575
K
A
A
V
L
T
E
T
P
R
T
S
D
G
E
Site 43
T578
V
L
T
E
T
P
R
T
S
D
G
E
K
T
L
Site 44
S579
L
T
E
T
P
R
T
S
D
G
E
K
T
L
I
Site 45
T584
R
T
S
D
G
E
K
T
L
I
E
K
M
F
G
Site 46
T606
R
C
L
N
C
R
S
T
S
Q
K
V
E
A
F
Site 47
S607
C
L
N
C
R
S
T
S
Q
K
V
E
A
F
T
Site 48
S630
S
S
S
L
E
N
M
S
V
Q
D
P
A
S
S
Site 49
S636
M
S
V
Q
D
P
A
S
S
P
S
I
Q
D
G
Site 50
S637
S
V
Q
D
P
A
S
S
P
S
I
Q
D
G
G
Site 51
S639
Q
D
P
A
S
S
P
S
I
Q
D
G
G
L
M
Site 52
S649
D
G
G
L
M
Q
A
S
V
P
G
P
S
E
E
Site 53
S654
Q
A
S
V
P
G
P
S
E
E
P
V
V
Y
N
Site 54
Y660
P
S
E
E
P
V
V
Y
N
P
T
T
A
A
F
Site 55
T677
D
S
L
V
N
E
K
T
I
G
S
P
P
N
E
Site 56
S680
V
N
E
K
T
I
G
S
P
P
N
E
F
Y
C
Site 57
Y686
G
S
P
P
N
E
F
Y
C
S
E
N
T
S
V
Site 58
S688
P
P
N
E
F
Y
C
S
E
N
T
S
V
P
N
Site 59
S692
F
Y
C
S
E
N
T
S
V
P
N
E
S
N
K
Site 60
T715
Q
K
P
G
G
E
T
T
P
S
V
T
D
L
L
Site 61
S717
P
G
G
E
T
T
P
S
V
T
D
L
L
N
Y
Site 62
Y737
I
L
T
G
D
N
Q
Y
Y
C
E
N
C
A
S
Site 63
Y738
L
T
G
D
N
Q
Y
Y
C
E
N
C
A
S
L
Site 64
T755
A
E
K
T
M
Q
I
T
E
E
P
E
Y
L
I
Site 65
S769
I
L
T
L
L
R
F
S
Y
D
Q
K
Y
H
V
Site 66
Y770
L
T
L
L
R
F
S
Y
D
Q
K
Y
H
V
R
Site 67
Y774
R
F
S
Y
D
Q
K
Y
H
V
R
R
K
I
L
Site 68
T798
E
L
P
V
K
R
I
T
S
F
S
S
L
S
E
Site 69
S799
L
P
V
K
R
I
T
S
F
S
S
L
S
E
S
Site 70
S801
V
K
R
I
T
S
F
S
S
L
S
E
S
W
S
Site 71
S802
K
R
I
T
S
F
S
S
L
S
E
S
W
S
V
Site 72
S806
S
F
S
S
L
S
E
S
W
S
V
D
V
D
F
Site 73
S808
S
S
L
S
E
S
W
S
V
D
V
D
F
T
D
Site 74
S817
D
V
D
F
T
D
L
S
E
N
L
A
K
K
L
Site 75
T829
K
K
L
K
P
S
G
T
D
E
A
S
C
T
K
Site 76
S833
P
S
G
T
D
E
A
S
C
T
K
L
V
P
Y
Site 77
S853
V
V
H
S
G
I
S
S
E
S
G
H
Y
Y
S
Site 78
S855
H
S
G
I
S
S
E
S
G
H
Y
Y
S
Y
A
Site 79
Y858
I
S
S
E
S
G
H
Y
Y
S
Y
A
R
N
I
Site 80
Y859
S
S
E
S
G
H
Y
Y
S
Y
A
R
N
I
T
Site 81
S860
S
E
S
G
H
Y
Y
S
Y
A
R
N
I
T
S
Site 82
Y861
E
S
G
H
Y
Y
S
Y
A
R
N
I
T
S
T
Site 83
T866
Y
S
Y
A
R
N
I
T
S
T
D
S
S
Y
Q
Site 84
S867
S
Y
A
R
N
I
T
S
T
D
S
S
Y
Q
M
Site 85
T868
Y
A
R
N
I
T
S
T
D
S
S
Y
Q
M
Y
Site 86
Y872
I
T
S
T
D
S
S
Y
Q
M
Y
H
Q
S
E
Site 87
Y875
T
D
S
S
Y
Q
M
Y
H
Q
S
E
A
L
A
Site 88
S878
S
Y
Q
M
Y
H
Q
S
E
A
L
A
L
A
S
Site 89
S888
L
A
L
A
S
S
Q
S
H
L
L
G
R
D
S
Site 90
S895
S
H
L
L
G
R
D
S
P
S
A
V
F
E
Q
Site 91
T922
L
F
N
D
S
R
V
T
F
T
S
F
Q
S
V
Site 92
S925
D
S
R
V
T
F
T
S
F
Q
S
V
Q
K
I
Site 93
S928
V
T
F
T
S
F
Q
S
V
Q
K
I
T
S
R
Site 94
T940
T
S
R
F
P
K
D
T
A
Y
V
L
L
Y
K
Site 95
Y942
R
F
P
K
D
T
A
Y
V
L
L
Y
K
K
Q
Site 96
Y946
D
T
A
Y
V
L
L
Y
K
K
Q
H
S
T
N
Site 97
S951
L
L
Y
K
K
Q
H
S
T
N
G
L
S
G
N
Site 98
T952
L
Y
K
K
Q
H
S
T
N
G
L
S
G
N
N
Site 99
S956
Q
H
S
T
N
G
L
S
G
N
N
P
T
S
G
Site 100
S962
L
S
G
N
N
P
T
S
G
L
W
I
N
G
D
Site 101
T981
K
E
L
M
D
A
I
T
K
D
N
K
L
Y
L
Site 102
Y987
I
T
K
D
N
K
L
Y
L
Q
E
Q
E
L
N
Site 103
S1004
A
R
A
L
Q
A
A
S
A
S
C
S
F
R
P
Site 104
S1006
A
L
Q
A
A
S
A
S
C
S
F
R
P
N
G
Site 105
S1008
Q
A
A
S
A
S
C
S
F
R
P
N
G
F
D
Site 106
S1022
D
D
N
D
P
P
G
S
C
G
P
T
G
G
G
Site 107
T1026
P
P
G
S
C
G
P
T
G
G
G
G
G
G
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation