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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MLKL
Full Name:
Mixed lineage kinase domain-like protein
Alias:
Mixed lineage kinase domain-like protein
Type:
Protein-serine kinase, TKL group, TKL-Unique family
Mass (Da):
54479
Number AA:
471
UniProt ID:
Q8NB16
International Prot ID:
IPI00783229
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0004713
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
GO:0006468
GO:0006793
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
E
N
L
K
H
I
I
T
L
G
Q
V
I
H
K
Site 2
Y23
K
R
C
E
E
M
K
Y
C
K
K
Q
C
R
R
Site 3
S52
L
Q
D
Q
G
K
R
S
V
P
S
E
K
L
T
Site 4
T59
S
V
P
S
E
K
L
T
T
A
M
N
R
F
K
Site 5
T60
V
P
S
E
K
L
T
T
A
M
N
R
F
K
A
Site 6
S80
N
G
E
I
E
K
F
S
N
R
S
N
I
C
R
Site 7
S106
K
D
V
N
R
K
L
S
D
V
W
K
E
L
S
Site 8
S125
V
E
Q
R
M
P
V
S
P
I
S
Q
G
A
S
Site 9
S128
R
M
P
V
S
P
I
S
Q
G
A
S
W
A
Q
Site 10
S132
S
P
I
S
Q
G
A
S
W
A
Q
E
D
Q
Q
Site 11
S161
D
N
E
K
I
E
A
S
L
R
R
L
E
I
N
Site 12
T175
N
M
K
E
I
K
E
T
L
R
Q
Y
L
P
P
Site 13
Y179
I
K
E
T
L
R
Q
Y
L
P
P
K
C
M
Q
Site 14
S202
E
I
K
K
E
Q
L
S
G
S
P
W
I
L
L
Site 15
S204
K
K
E
Q
L
S
G
S
P
W
I
L
L
R
E
Site 16
S215
L
L
R
E
N
E
V
S
T
L
Y
K
G
E
Y
Site 17
Y222
S
T
L
Y
K
G
E
Y
H
R
A
P
V
A
I
Site 18
T246
S
I
A
I
V
R
Q
T
F
N
K
E
I
K
T
Site 19
S259
K
T
M
K
K
F
E
S
P
N
I
L
R
I
F
Site 20
T302
L
D
R
E
K
D
L
T
L
G
K
R
M
V
L
Site 21
Y318
L
G
A
A
R
G
L
Y
R
L
H
H
S
E
A
Site 22
S323
G
L
Y
R
L
H
H
S
E
A
P
E
L
H
G
Site 23
S334
E
L
H
G
K
I
R
S
S
N
F
L
V
T
Q
Site 24
S335
L
H
G
K
I
R
S
S
N
F
L
V
T
Q
G
Site 25
T355
A
G
F
E
L
R
K
T
Q
T
S
M
S
L
G
Site 26
T357
F
E
L
R
K
T
Q
T
S
M
S
L
G
T
T
Site 27
S358
E
L
R
K
T
Q
T
S
M
S
L
G
T
T
R
Site 28
S360
R
K
T
Q
T
S
M
S
L
G
T
T
R
E
K
Site 29
T364
T
S
M
S
L
G
T
T
R
E
K
T
D
R
V
Site 30
T368
L
G
T
T
R
E
K
T
D
R
V
K
S
T
A
Site 31
S373
E
K
T
D
R
V
K
S
T
A
Y
L
S
P
Q
Site 32
T374
K
T
D
R
V
K
S
T
A
Y
L
S
P
Q
E
Site 33
Y376
D
R
V
K
S
T
A
Y
L
S
P
Q
E
L
E
Site 34
S378
V
K
S
T
A
Y
L
S
P
Q
E
L
E
D
V
Site 35
Y387
Q
E
L
E
D
V
F
Y
Q
Y
D
V
K
S
E
Site 36
Y389
L
E
D
V
F
Y
Q
Y
D
V
K
S
E
I
Y
Site 37
S393
F
Y
Q
Y
D
V
K
S
E
I
Y
S
F
G
I
Site 38
S417
I
P
F
Q
G
C
N
S
E
K
I
R
K
L
V
Site 39
S439
P
L
G
E
D
C
P
S
E
L
R
E
I
I
D
Site 40
S454
E
C
R
A
H
D
P
S
V
R
P
S
V
D
E
Site 41
S458
H
D
P
S
V
R
P
S
V
D
E
I
L
K
K
Site 42
S467
D
E
I
L
K
K
L
S
T
F
S
K
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation