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Updated November 2019
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Protein Info
Short Name:
UNC13C
Full Name:
Protein unc-13 homolog C
Alias:
Munc13-3; UN13C; Unc-13 homologue C
Type:
Plasma membrane, Cytoplasm, Synapse, Cell junction protein
Mass (Da):
250911
Number AA:
2214
UniProt ID:
Q8NB66
International Prot ID:
IPI00739565
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0005737
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006887
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T46
K
K
D
Q
D
F
P
T
A
G
Q
T
K
S
P
Site 2
T50
D
F
P
T
A
G
Q
T
K
S
P
K
F
S
Y
Site 3
S52
P
T
A
G
Q
T
K
S
P
K
F
S
Y
T
F
Site 4
S56
Q
T
K
S
P
K
F
S
Y
T
F
K
S
T
V
Site 5
Y57
T
K
S
P
K
F
S
Y
T
F
K
S
T
V
K
Site 6
T58
K
S
P
K
F
S
Y
T
F
K
S
T
V
K
K
Site 7
S61
K
F
S
Y
T
F
K
S
T
V
K
K
I
A
K
Site 8
S71
K
K
I
A
K
C
S
S
T
H
N
L
S
T
E
Site 9
T72
K
I
A
K
C
S
S
T
H
N
L
S
T
E
E
Site 10
S76
C
S
S
T
H
N
L
S
T
E
E
D
E
A
S
Site 11
S83
S
T
E
E
D
E
A
S
K
E
F
S
L
S
P
Site 12
S87
D
E
A
S
K
E
F
S
L
S
P
T
F
S
Y
Site 13
S89
A
S
K
E
F
S
L
S
P
T
F
S
Y
R
V
Site 14
T91
K
E
F
S
L
S
P
T
F
S
Y
R
V
A
I
Site 15
S111
K
N
A
K
V
T
N
S
D
N
E
D
L
L
Q
Site 16
S121
E
D
L
L
Q
E
L
S
S
I
E
S
S
Y
S
Site 17
S122
D
L
L
Q
E
L
S
S
I
E
S
S
Y
S
E
Site 18
S125
Q
E
L
S
S
I
E
S
S
Y
S
E
S
L
N
Site 19
S126
E
L
S
S
I
E
S
S
Y
S
E
S
L
N
E
Site 20
S128
S
S
I
E
S
S
Y
S
E
S
L
N
E
L
R
Site 21
S130
I
E
S
S
Y
S
E
S
L
N
E
L
R
S
S
Site 22
S136
E
S
L
N
E
L
R
S
S
T
E
N
Q
A
Q
Site 23
S137
S
L
N
E
L
R
S
S
T
E
N
Q
A
Q
S
Site 24
T138
L
N
E
L
R
S
S
T
E
N
Q
A
Q
S
T
Site 25
S156
P
V
R
R
N
R
K
S
S
S
S
L
A
P
S
Site 26
S157
V
R
R
N
R
K
S
S
S
S
L
A
P
S
E
Site 27
S158
R
R
N
R
K
S
S
S
S
L
A
P
S
E
G
Site 28
S159
R
N
R
K
S
S
S
S
L
A
P
S
E
G
S
Site 29
S163
S
S
S
S
L
A
P
S
E
G
S
S
D
G
E
Site 30
S167
L
A
P
S
E
G
S
S
D
G
E
R
T
L
H
Site 31
S190
K
L
R
K
W
K
K
S
Q
E
C
V
S
S
D
Site 32
S195
K
K
S
Q
E
C
V
S
S
D
S
E
L
S
T
Site 33
S196
K
S
Q
E
C
V
S
S
D
S
E
L
S
T
M
Site 34
S198
Q
E
C
V
S
S
D
S
E
L
S
T
M
K
K
Site 35
S201
V
S
S
D
S
E
L
S
T
M
K
K
S
W
G
Site 36
T202
S
S
D
S
E
L
S
T
M
K
K
S
W
G
I
Site 37
S206
E
L
S
T
M
K
K
S
W
G
I
R
S
K
S
Site 38
S213
S
W
G
I
R
S
K
S
L
D
R
T
V
R
N
Site 39
T217
R
S
K
S
L
D
R
T
V
R
N
P
K
T
N
Site 40
T223
R
T
V
R
N
P
K
T
N
A
L
E
P
G
F
Site 41
S231
N
A
L
E
P
G
F
S
S
S
G
C
I
S
Q
Site 42
S233
L
E
P
G
F
S
S
S
G
C
I
S
Q
T
H
Site 43
S237
F
S
S
S
G
C
I
S
Q
T
H
D
V
M
E
Site 44
T258
Q
G
I
S
Q
I
E
T
E
L
S
E
L
R
G
Site 45
S261
S
Q
I
E
T
E
L
S
E
L
R
G
H
V
N
Site 46
S273
H
V
N
A
L
K
H
S
I
D
E
I
S
S
S
Site 47
S280
S
I
D
E
I
S
S
S
V
E
V
V
Q
S
E
Site 48
S286
S
S
V
E
V
V
Q
S
E
I
E
Q
L
R
T
Site 49
T293
S
E
I
E
Q
L
R
T
G
F
V
Q
S
R
R
Site 50
S298
L
R
T
G
F
V
Q
S
R
R
E
T
R
D
I
Site 51
T302
F
V
Q
S
R
R
E
T
R
D
I
H
D
Y
I
Site 52
Y308
E
T
R
D
I
H
D
Y
I
K
H
L
G
H
M
Site 53
S317
K
H
L
G
H
M
G
S
K
A
S
L
R
F
L
Site 54
S320
G
H
M
G
S
K
A
S
L
R
F
L
N
V
T
Site 55
T327
S
L
R
F
L
N
V
T
E
E
R
F
E
Y
V
Site 56
Y333
V
T
E
E
R
F
E
Y
V
E
S
V
V
Y
Q
Site 57
S349
L
I
D
K
M
G
F
S
D
A
P
N
A
I
K
Site 58
Y380
K
P
R
P
I
L
V
Y
F
E
T
P
Q
Q
R
Site 59
T383
P
I
L
V
Y
F
E
T
P
Q
Q
R
D
S
V
Site 60
S389
E
T
P
Q
Q
R
D
S
V
L
K
K
S
Y
K
Site 61
S394
R
D
S
V
L
K
K
S
Y
K
L
K
G
T
G
Site 62
S405
K
G
T
G
I
G
I
S
T
D
I
L
T
H
D
Site 63
T410
G
I
S
T
D
I
L
T
H
D
I
R
E
R
K
Site 64
S424
K
E
K
G
I
P
S
S
Q
T
Y
E
S
M
A
Site 65
Y427
G
I
P
S
S
Q
T
Y
E
S
M
A
I
K
L
Site 66
S429
P
S
S
Q
T
Y
E
S
M
A
I
K
L
S
T
Site 67
S435
E
S
M
A
I
K
L
S
T
P
E
P
K
I
K
Site 68
T436
S
M
A
I
K
L
S
T
P
E
P
K
I
K
K
Site 69
S448
I
K
K
N
N
W
Q
S
P
D
D
S
D
E
D
Site 70
S452
N
W
Q
S
P
D
D
S
D
E
D
L
E
S
D
Site 71
S458
D
S
D
E
D
L
E
S
D
L
N
R
N
S
Y
Site 72
S464
E
S
D
L
N
R
N
S
Y
A
V
L
S
K
S
Site 73
Y465
S
D
L
N
R
N
S
Y
A
V
L
S
K
S
E
Site 74
S469
R
N
S
Y
A
V
L
S
K
S
E
L
L
T
K
Site 75
S471
S
Y
A
V
L
S
K
S
E
L
L
T
K
G
S
Site 76
T475
L
S
K
S
E
L
L
T
K
G
S
T
S
K
P
Site 77
S478
S
E
L
L
T
K
G
S
T
S
K
P
S
S
K
Site 78
T479
E
L
L
T
K
G
S
T
S
K
P
S
S
K
S
Site 79
S480
L
L
T
K
G
S
T
S
K
P
S
S
K
S
H
Site 80
S483
K
G
S
T
S
K
P
S
S
K
S
H
S
A
R
Site 81
S484
G
S
T
S
K
P
S
S
K
S
H
S
A
R
S
Site 82
S486
T
S
K
P
S
S
K
S
H
S
A
R
S
K
N
Site 83
S488
K
P
S
S
K
S
H
S
A
R
S
K
N
K
T
Site 84
T495
S
A
R
S
K
N
K
T
A
N
S
S
R
I
S
Site 85
S498
S
K
N
K
T
A
N
S
S
R
I
S
N
K
S
Site 86
S502
T
A
N
S
S
R
I
S
N
K
S
D
Y
D
K
Site 87
S505
S
S
R
I
S
N
K
S
D
Y
D
K
I
S
S
Site 88
Y507
R
I
S
N
K
S
D
Y
D
K
I
S
S
Q
L
Site 89
S511
K
S
D
Y
D
K
I
S
S
Q
L
P
E
S
D
Site 90
S512
S
D
Y
D
K
I
S
S
Q
L
P
E
S
D
I
Site 91
S517
I
S
S
Q
L
P
E
S
D
I
L
E
K
Q
T
Site 92
T525
D
I
L
E
K
Q
T
T
T
H
Y
A
D
A
T
Site 93
Y528
E
K
Q
T
T
T
H
Y
A
D
A
T
P
L
W
Site 94
T532
T
T
H
Y
A
D
A
T
P
L
W
H
S
Q
S
Site 95
S537
D
A
T
P
L
W
H
S
Q
S
D
F
F
T
A
Site 96
S539
T
P
L
W
H
S
Q
S
D
F
F
T
A
K
L
Site 97
T543
H
S
Q
S
D
F
F
T
A
K
L
S
R
S
E
Site 98
S547
D
F
F
T
A
K
L
S
R
S
E
S
D
F
S
Site 99
S549
F
T
A
K
L
S
R
S
E
S
D
F
S
K
L
Site 100
S551
A
K
L
S
R
S
E
S
D
F
S
K
L
C
Q
Site 101
S554
S
R
S
E
S
D
F
S
K
L
C
Q
S
Y
S
Site 102
S559
D
F
S
K
L
C
Q
S
Y
S
E
D
F
S
E
Site 103
S561
S
K
L
C
Q
S
Y
S
E
D
F
S
E
N
Q
Site 104
S565
Q
S
Y
S
E
D
F
S
E
N
Q
F
F
T
R
Site 105
T573
E
N
Q
F
F
T
R
T
N
G
S
S
L
L
S
Site 106
S576
F
F
T
R
T
N
G
S
S
L
L
S
S
S
D
Site 107
S577
F
T
R
T
N
G
S
S
L
L
S
S
S
D
R
Site 108
S580
T
N
G
S
S
L
L
S
S
S
D
R
E
L
W
Site 109
S581
N
G
S
S
L
L
S
S
S
D
R
E
L
W
Q
Site 110
S582
G
S
S
L
L
S
S
S
D
R
E
L
W
Q
R
Site 111
T596
R
K
Q
E
G
T
A
T
L
Y
D
S
P
K
D
Site 112
Y598
Q
E
G
T
A
T
L
Y
D
S
P
K
D
Q
H
Site 113
S600
G
T
A
T
L
Y
D
S
P
K
D
Q
H
L
N
Site 114
T622
G
Q
T
E
T
E
N
T
E
T
V
D
S
G
M
Site 115
T624
T
E
T
E
N
T
E
T
V
D
S
G
M
S
N
Site 116
S627
E
N
T
E
T
V
D
S
G
M
S
N
G
M
V
Site 117
S637
S
N
G
M
V
C
A
S
G
D
R
S
H
Y
S
Site 118
S641
V
C
A
S
G
D
R
S
H
Y
S
D
S
Q
L
Site 119
Y643
A
S
G
D
R
S
H
Y
S
D
S
Q
L
S
L
Site 120
S644
S
G
D
R
S
H
Y
S
D
S
Q
L
S
L
H
Site 121
S646
D
R
S
H
Y
S
D
S
Q
L
S
L
H
E
D
Site 122
S649
H
Y
S
D
S
Q
L
S
L
H
E
D
L
S
P
Site 123
S655
L
S
L
H
E
D
L
S
P
W
K
E
W
N
Q
Site 124
S670
G
A
D
L
G
L
D
S
S
T
Q
E
G
F
D
Site 125
S671
A
D
L
G
L
D
S
S
T
Q
E
G
F
D
Y
Site 126
T672
D
L
G
L
D
S
S
T
Q
E
G
F
D
Y
E
Site 127
Y678
S
T
Q
E
G
F
D
Y
E
T
N
S
L
F
D
Site 128
T680
Q
E
G
F
D
Y
E
T
N
S
L
F
D
Q
Q
Site 129
S682
G
F
D
Y
E
T
N
S
L
F
D
Q
Q
L
D
Site 130
Y691
F
D
Q
Q
L
D
V
Y
N
K
D
L
E
Y
L
Site 131
Y697
V
Y
N
K
D
L
E
Y
L
G
K
C
H
S
D
Site 132
S703
E
Y
L
G
K
C
H
S
D
L
Q
D
D
S
E
Site 133
S709
H
S
D
L
Q
D
D
S
E
S
Y
D
L
T
Q
Site 134
S711
D
L
Q
D
D
S
E
S
Y
D
L
T
Q
D
D
Site 135
T715
D
S
E
S
Y
D
L
T
Q
D
D
N
S
S
P
Site 136
S720
D
L
T
Q
D
D
N
S
S
P
C
P
G
L
D
Site 137
S721
L
T
Q
D
D
N
S
S
P
C
P
G
L
D
N
Site 138
Y738
Q
G
Q
W
V
G
Q
Y
D
S
Y
Q
G
A
N
Site 139
Y741
W
V
G
Q
Y
D
S
Y
Q
G
A
N
S
N
E
Site 140
Y750
G
A
N
S
N
E
L
Y
Q
N
Q
N
Q
L
S
Site 141
S762
Q
L
S
M
M
Y
R
S
Q
S
E
L
Q
S
D
Site 142
S764
S
M
M
Y
R
S
Q
S
E
L
Q
S
D
D
S
Site 143
S768
R
S
Q
S
E
L
Q
S
D
D
S
E
D
A
P
Site 144
S771
S
E
L
Q
S
D
D
S
E
D
A
P
P
K
S
Site 145
S778
S
E
D
A
P
P
K
S
W
H
S
R
L
S
I
Site 146
S781
A
P
P
K
S
W
H
S
R
L
S
I
D
L
S
Site 147
S784
K
S
W
H
S
R
L
S
I
D
L
S
D
K
T
Site 148
S788
S
R
L
S
I
D
L
S
D
K
T
F
S
F
P
Site 149
T791
S
I
D
L
S
D
K
T
F
S
F
P
K
F
G
Site 150
S793
D
L
S
D
K
T
F
S
F
P
K
F
G
S
T
Site 151
S799
F
S
F
P
K
F
G
S
T
L
Q
R
A
K
S
Site 152
T800
S
F
P
K
F
G
S
T
L
Q
R
A
K
S
A
Site 153
S806
S
T
L
Q
R
A
K
S
A
L
E
V
V
W
N
Site 154
S815
L
E
V
V
W
N
K
S
T
Q
S
L
S
G
Y
Site 155
T816
E
V
V
W
N
K
S
T
Q
S
L
S
G
Y
E
Site 156
S818
V
W
N
K
S
T
Q
S
L
S
G
Y
E
D
S
Site 157
S820
N
K
S
T
Q
S
L
S
G
Y
E
D
S
G
S
Site 158
Y822
S
T
Q
S
L
S
G
Y
E
D
S
G
S
S
L
Site 159
S825
S
L
S
G
Y
E
D
S
G
S
S
L
M
G
R
Site 160
S827
S
G
Y
E
D
S
G
S
S
L
M
G
R
F
R
Site 161
S828
G
Y
E
D
S
G
S
S
L
M
G
R
F
R
T
Site 162
T835
S
L
M
G
R
F
R
T
L
S
Q
S
T
A
N
Site 163
S837
M
G
R
F
R
T
L
S
Q
S
T
A
N
E
S
Site 164
S839
R
F
R
T
L
S
Q
S
T
A
N
E
S
S
T
Site 165
S844
S
Q
S
T
A
N
E
S
S
T
T
L
D
S
D
Site 166
T846
S
T
A
N
E
S
S
T
T
L
D
S
D
V
Y
Site 167
T847
T
A
N
E
S
S
T
T
L
D
S
D
V
Y
T
Site 168
S850
E
S
S
T
T
L
D
S
D
V
Y
T
E
P
Y
Site 169
Y853
T
T
L
D
S
D
V
Y
T
E
P
Y
Y
Y
K
Site 170
T854
T
L
D
S
D
V
Y
T
E
P
Y
Y
Y
K
A
Site 171
Y858
D
V
Y
T
E
P
Y
Y
Y
K
A
E
D
E
E
Site 172
Y859
V
Y
T
E
P
Y
Y
Y
K
A
E
D
E
E
D
Site 173
Y867
K
A
E
D
E
E
D
Y
T
E
P
V
A
D
N
Site 174
T868
A
E
D
E
E
D
Y
T
E
P
V
A
D
N
E
Site 175
T876
E
P
V
A
D
N
E
T
D
Y
V
E
V
M
E
Site 176
Y878
V
A
D
N
E
T
D
Y
V
E
V
M
E
Q
V
Site 177
S894
A
K
L
E
N
R
T
S
I
T
E
T
D
E
Q
Site 178
T898
N
R
T
S
I
T
E
T
D
E
Q
M
Q
A
Y
Site 179
Y905
T
D
E
Q
M
Q
A
Y
D
H
L
S
Y
E
T
Site 180
Y910
Q
A
Y
D
H
L
S
Y
E
T
P
Y
E
T
P
Site 181
T912
Y
D
H
L
S
Y
E
T
P
Y
E
T
P
Q
D
Site 182
Y914
H
L
S
Y
E
T
P
Y
E
T
P
Q
D
E
G
Site 183
T916
S
Y
E
T
P
Y
E
T
P
Q
D
E
G
Y
D
Site 184
Y922
E
T
P
Q
D
E
G
Y
D
G
P
A
D
D
M
Site 185
S931
G
P
A
D
D
M
V
S
E
E
G
L
E
P
L
Site 186
S971
K
P
K
R
I
R
P
S
F
K
E
A
A
L
R
Site 187
Y980
K
E
A
A
L
R
A
Y
K
K
Q
M
A
E
L
Site 188
S997
K
I
L
A
G
D
S
S
S
V
D
E
K
A
R
Site 189
S998
I
L
A
G
D
S
S
S
V
D
E
K
A
R
I
Site 190
S1007
D
E
K
A
R
I
V
S
G
N
D
L
D
A
S
Site 191
S1014
S
G
N
D
L
D
A
S
K
F
S
A
L
Q
V
Site 192
Y1030
G
G
A
G
G
G
L
Y
G
I
D
S
M
P
D
Site 193
S1034
G
G
L
Y
G
I
D
S
M
P
D
L
R
R
K
Site 194
T1043
P
D
L
R
R
K
K
T
L
P
I
V
R
D
V
Site 195
S1070
L
A
M
V
I
R
T
S
L
N
N
E
E
L
K
Site 196
T1107
F
E
V
W
T
A
T
T
P
T
Y
C
Y
E
C
Site 197
Y1110
W
T
A
T
T
P
T
Y
C
Y
E
C
E
G
L
Site 198
Y1112
A
T
T
P
T
Y
C
Y
E
C
E
G
L
L
W
Site 199
S1155
L
Q
R
A
A
E
K
S
S
K
H
G
A
E
D
Site 200
T1164
K
H
G
A
E
D
K
T
Q
T
I
I
T
A
M
Site 201
T1215
K
Q
S
V
L
D
G
T
S
K
W
S
A
K
I
Site 202
S1216
Q
S
V
L
D
G
T
S
K
W
S
A
K
I
T
Site 203
T1238
G
L
Q
A
K
D
K
T
G
S
S
D
P
Y
V
Site 204
S1240
Q
A
K
D
K
T
G
S
S
D
P
Y
V
T
V
Site 205
S1241
A
K
D
K
T
G
S
S
D
P
Y
V
T
V
Q
Site 206
Y1244
K
T
G
S
S
D
P
Y
V
T
V
Q
V
G
K
Site 207
T1246
G
S
S
D
P
Y
V
T
V
Q
V
G
K
N
K
Site 208
T1256
V
G
K
N
K
R
R
T
K
T
I
F
G
N
L
Site 209
T1258
K
N
K
R
R
T
K
T
I
F
G
N
L
N
P
Site 210
S1295
D
E
D
D
D
I
K
S
R
V
K
Q
H
F
K
Site 211
S1305
K
Q
H
F
K
K
E
S
D
D
F
L
G
Q
T
Site 212
Y1327
S
G
E
M
D
V
W
Y
N
L
E
K
R
T
D
Site 213
S1336
L
E
K
R
T
D
K
S
A
V
S
G
A
I
R
Site 214
S1339
R
T
D
K
S
A
V
S
G
A
I
R
L
K
I
Site 215
Y1363
V
A
P
Y
H
I
Q
Y
T
C
L
H
E
N
L
Site 216
Y1373
L
H
E
N
L
F
H
Y
L
T
E
V
K
S
N
Site 217
T1375
E
N
L
F
H
Y
L
T
E
V
K
S
N
G
G
Site 218
S1379
H
Y
L
T
E
V
K
S
N
G
G
V
K
I
P
Site 219
S1402
K
V
F
F
D
D
A
S
Q
E
I
V
D
E
F
Site 220
Y1413
V
D
E
F
A
M
R
Y
G
I
E
S
I
Y
Q
Site 221
Y1419
R
Y
G
I
E
S
I
Y
Q
A
M
T
H
F
S
Site 222
T1423
E
S
I
Y
Q
A
M
T
H
F
S
C
L
S
S
Site 223
S1466
T
N
I
Q
V
S
A
S
D
R
F
A
A
T
N
Site 224
S1489
L
L
D
Q
L
H
N
S
L
R
I
D
L
S
K
Site 225
S1495
N
S
L
R
I
D
L
S
K
Y
R
E
N
F
P
Site 226
Y1497
L
R
I
D
L
S
K
Y
R
E
N
F
P
A
S
Site 227
S1504
Y
R
E
N
F
P
A
S
N
T
E
R
L
Q
D
Site 228
S1514
E
R
L
Q
D
L
K
S
T
V
D
L
L
T
S
Site 229
T1515
R
L
Q
D
L
K
S
T
V
D
L
L
T
S
I
Site 230
S1534
M
K
V
L
E
L
Q
S
P
P
K
A
S
M
V
Site 231
Y1554
R
A
C
L
D
S
T
Y
K
Y
I
F
D
N
C
Site 232
Y1556
C
L
D
S
T
Y
K
Y
I
F
D
N
C
H
E
Site 233
S1566
D
N
C
H
E
L
Y
S
Q
L
T
D
P
S
K
Site 234
T1569
H
E
L
Y
S
Q
L
T
D
P
S
K
K
Q
D
Site 235
T1608
T
I
I
D
E
D
K
T
A
Y
T
P
V
L
N
Site 236
T1611
D
E
D
K
T
A
Y
T
P
V
L
N
Q
F
P
Site 237
Y1641
L
F
A
L
D
M
K
Y
A
L
E
E
H
E
N
Site 238
Y1657
R
L
C
K
S
T
D
Y
M
N
L
H
F
K
V
Site 239
Y1671
V
K
W
F
Y
N
E
Y
V
R
E
L
P
A
F
Site 240
Y1685
F
K
D
A
V
P
E
Y
S
L
W
F
E
P
F
Site 241
S1686
K
D
A
V
P
E
Y
S
L
W
F
E
P
F
V
Site 242
S1704
L
D
E
N
E
D
V
S
M
E
F
L
H
G
A
Site 243
S1782
Q
Y
A
A
I
V
S
S
D
F
S
S
H
C
D
Site 244
S1785
A
I
V
S
S
D
F
S
S
H
C
D
K
E
N
Site 245
S1786
I
V
S
S
D
F
S
S
H
C
D
K
E
N
V
Site 246
S1822
M
G
G
K
E
L
D
S
E
A
S
T
I
L
K
Site 247
T1826
E
L
D
S
E
A
S
T
I
L
K
E
L
Q
V
Site 248
T1874
Q
M
R
A
N
G
N
T
T
S
N
K
N
S
A
Site 249
S1876
R
A
N
G
N
T
T
S
N
K
N
S
A
A
M
Site 250
S1880
N
T
T
S
N
K
N
S
A
A
M
D
A
E
I
Site 251
S1903
L
D
K
T
L
S
L
S
A
K
I
C
E
K
T
Site 252
T1910
S
A
K
I
C
E
K
T
V
L
K
R
V
L
K
Site 253
T1937
Q
I
V
L
P
P
L
T
D
Q
T
G
P
Q
M
Site 254
S1956
A
K
D
L
G
Q
L
S
K
L
K
E
H
M
I
Site 255
T1971
R
E
D
A
R
G
L
T
P
R
Q
C
A
I
M
Site 256
S2004
K
K
N
F
L
E
K
S
P
D
L
Q
S
L
R
Site 257
S2009
E
K
S
P
D
L
Q
S
L
R
Y
A
L
S
L
Site 258
S2015
Q
S
L
R
Y
A
L
S
L
Y
T
Q
T
T
D
Site 259
T2031
L
I
K
K
F
I
D
T
Q
T
S
Q
S
R
S
Site 260
T2033
K
K
F
I
D
T
Q
T
S
Q
S
R
S
S
K
Site 261
S2034
K
F
I
D
T
Q
T
S
Q
S
R
S
S
K
D
Site 262
S2036
I
D
T
Q
T
S
Q
S
R
S
S
K
D
A
V
Site 263
S2038
T
Q
T
S
Q
S
R
S
S
K
D
A
V
G
Q
Site 264
S2039
Q
T
S
Q
S
R
S
S
K
D
A
V
G
Q
I
Site 265
T2055
V
H
V
D
I
T
A
T
P
G
T
G
D
H
K
Site 266
T2103
D
K
K
R
K
Q
G
T
K
T
K
S
N
T
W
Site 267
T2105
K
R
K
Q
G
T
K
T
K
S
N
T
W
S
P
Site 268
S2107
K
Q
G
T
K
T
K
S
N
T
W
S
P
K
Y
Site 269
T2109
G
T
K
T
K
S
N
T
W
S
P
K
Y
N
E
Site 270
S2111
K
T
K
S
N
T
W
S
P
K
Y
N
E
T
F
Site 271
Y2114
S
N
T
W
S
P
K
Y
N
E
T
F
Q
F
I
Site 272
Y2140
L
H
L
S
V
K
D
Y
C
F
A
R
E
D
R
Site 273
S2164
Q
N
I
A
E
K
G
S
Y
G
A
W
Y
P
L
Site 274
Y2165
N
I
A
E
K
G
S
Y
G
A
W
Y
P
L
L
Site 275
Y2169
K
G
S
Y
G
A
W
Y
P
L
L
K
N
I
S
Site 276
S2176
Y
P
L
L
K
N
I
S
M
D
E
T
G
L
T
Site 277
S2189
L
T
I
L
R
I
L
S
Q
R
T
S
D
D
V
Site 278
S2193
R
I
L
S
Q
R
T
S
D
D
V
A
K
E
F
Site 279
S2205
K
E
F
V
R
L
K
S
E
T
R
S
T
E
E
Site 280
T2207
F
V
R
L
K
S
E
T
R
S
T
E
E
S
A
Site 281
S2209
R
L
K
S
E
T
R
S
T
E
E
S
A
_
_
Site 282
T2210
L
K
S
E
T
R
S
T
E
E
S
A
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation