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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NHLRC2
Full Name:
NHL repeat-containing protein 2
Alias:
DKFZp779F115; FLJ20147; FLJ25621; FLJ33312; MGC45492; NHL repeat containing 2; NHLC2
Type:
Unknown function
Mass (Da):
79444
Number AA:
726
UniProt ID:
Q8NBF2
International Prot ID:
IPI00301051
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0009987
GO:0019725
GO:0042592
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
A
P
G
G
R
G
R
S
L
S
G
L
L
P
A
Site 2
S12
G
G
R
G
R
S
L
S
G
L
L
P
A
Q
T
Site 3
T30
Y
A
L
L
D
A
V
T
Q
Q
E
K
D
S
L
Site 4
S36
V
T
Q
Q
E
K
D
S
L
V
Y
Q
Y
L
Q
Site 5
Y41
K
D
S
L
V
Y
Q
Y
L
Q
K
V
D
G
W
Site 6
S53
D
G
W
E
Q
D
L
S
V
P
E
F
P
E
G
Site 7
T66
E
G
L
E
W
L
N
T
E
E
P
I
S
V
Y
Site 8
S71
L
N
T
E
E
P
I
S
V
Y
K
D
L
C
G
Site 9
Y73
T
E
E
P
I
S
V
Y
K
D
L
C
G
K
I
Site 10
S108
H
A
L
E
H
T
Y
S
D
K
D
G
L
L
I
Site 11
S152
M
V
N
D
A
D
A
S
L
W
Q
E
L
E
V
Site 12
S177
P
R
G
N
M
L
F
S
L
I
G
E
G
H
K
Site 13
Y190
H
K
D
K
L
F
L
Y
T
S
I
A
L
K
Y
Site 14
S192
D
K
L
F
L
Y
T
S
I
A
L
K
Y
Y
K
Site 15
Y197
Y
T
S
I
A
L
K
Y
Y
K
D
R
G
Q
I
Site 16
Y198
T
S
I
A
L
K
Y
Y
K
D
R
G
Q
I
R
Site 17
Y214
N
K
I
G
I
K
L
Y
K
D
S
L
P
P
S
Site 18
S217
G
I
K
L
Y
K
D
S
L
P
P
S
P
L
L
Site 19
S221
Y
K
D
S
L
P
P
S
P
L
L
F
P
G
K
Site 20
S260
K
N
G
Q
I
Q
Y
S
I
G
G
P
N
P
G
Site 21
S274
G
R
K
D
G
I
F
S
E
S
T
F
N
S
P
Site 22
S276
K
D
G
I
F
S
E
S
T
F
N
S
P
Q
G
Site 23
T277
D
G
I
F
S
E
S
T
F
N
S
P
Q
G
V
Site 24
S280
F
S
E
S
T
F
N
S
P
Q
G
V
A
I
M
Site 25
Y292
A
I
M
N
N
I
I
Y
V
A
D
T
E
N
H
Site 26
T296
N
I
I
Y
V
A
D
T
E
N
H
L
I
R
K
Site 27
T322
A
G
I
G
I
Q
G
T
D
K
E
G
G
A
K
Site 28
S336
K
G
E
Q
Q
P
I
S
S
P
W
D
V
V
F
Site 29
S337
G
E
Q
Q
P
I
S
S
P
W
D
V
V
F
G
Site 30
S348
V
V
F
G
T
S
G
S
E
V
Q
R
G
D
I
Site 31
S393
T
C
L
R
F
A
G
S
G
N
E
E
N
R
N
Site 32
Y403
E
E
N
R
N
N
A
Y
P
H
K
A
G
F
A
Site 33
S413
K
A
G
F
A
Q
P
S
G
L
S
L
A
S
E
Site 34
S416
F
A
Q
P
S
G
L
S
L
A
S
E
D
P
W
Site 35
S419
P
S
G
L
S
L
A
S
E
D
P
W
S
C
L
Site 36
S431
S
C
L
F
V
A
D
S
E
S
S
T
V
R
T
Site 37
T435
V
A
D
S
E
S
S
T
V
R
T
V
S
L
K
Site 38
T438
S
E
S
S
T
V
R
T
V
S
L
K
D
G
A
Site 39
S440
S
S
T
V
R
T
V
S
L
K
D
G
A
V
K
Site 40
Y490
D
K
K
R
N
L
L
Y
V
A
D
S
Y
N
H
Site 41
T506
I
K
V
V
D
P
K
T
K
N
C
T
T
L
A
Site 42
T511
P
K
T
K
N
C
T
T
L
A
G
T
G
D
T
Site 43
T518
T
L
A
G
T
G
D
T
N
N
V
T
S
S
S
Site 44
T522
T
G
D
T
N
N
V
T
S
S
S
F
T
E
S
Site 45
S524
D
T
N
N
V
T
S
S
S
F
T
E
S
T
F
Site 46
S525
T
N
N
V
T
S
S
S
F
T
E
S
T
F
N
Site 47
T527
N
V
T
S
S
S
F
T
E
S
T
F
N
E
P
Site 48
S529
T
S
S
S
F
T
E
S
T
F
N
E
P
G
G
Site 49
T530
S
S
S
F
T
E
S
T
F
N
E
P
G
G
L
Site 50
Y547
G
E
N
G
E
L
L
Y
V
A
D
T
N
N
H
Site 51
S567
D
L
E
T
K
M
V
S
V
L
P
I
F
R
S
Site 52
T590
F
L
V
E
K
Q
K
T
L
P
K
L
P
K
S
Site 53
S597
T
L
P
K
L
P
K
S
A
P
S
I
R
L
S
Site 54
S600
K
L
P
K
S
A
P
S
I
R
L
S
P
V
T
Site 55
S624
K
L
R
L
D
L
P
S
G
S
K
L
T
E
G
Site 56
T629
L
P
S
G
S
K
L
T
E
G
V
S
S
C
W
Site 57
S660
A
G
D
I
E
N
I
S
S
Q
P
T
I
S
L
Site 58
S661
G
D
I
E
N
I
S
S
Q
P
T
I
S
L
Q
Site 59
T664
E
N
I
S
S
Q
P
T
I
S
L
Q
I
P
D
Site 60
S666
I
S
S
Q
P
T
I
S
L
Q
I
P
D
D
C
Site 61
T712
Q
P
L
Q
I
T
D
T
Q
Q
G
C
I
A
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation