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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PCSK9
Full Name:
Proprotein convertase subtilisin/kexin type 9
Alias:
FH3; HCHOLA3; NARC1; NARC-1; Proprotein convertase subtilisin/kexin type 9
Type:
Protease; EC 3.4.21.-; Secreted protein; Cell development/differentiation
Mass (Da):
74372
Number AA:
692
UniProt ID:
Q8NBP7
International Prot ID:
IPI00387168
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005615
GO:0031232
GO:0005770
Uniprot
OncoNet
Molecular Function:
GO:0034190
GO:0005509
GO:0042802
PhosphoSite+
KinaseNET
Biological Process:
GO:0032869
GO:0009267
GO:0042632
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
G
T
V
S
S
R
R
S
W
W
P
L
P
L
L
Site 2
Y38
Q
E
D
E
D
G
D
Y
E
E
L
V
L
A
L
Site 3
S47
E
L
V
L
A
L
R
S
E
E
D
G
L
A
E
Site 4
T61
E
A
P
E
H
G
T
T
A
T
F
H
R
C
A
Site 5
T63
P
E
H
G
T
T
A
T
F
H
R
C
A
K
D
Site 6
T77
D
P
W
R
L
P
G
T
Y
V
V
V
L
K
E
Site 7
Y78
P
W
R
L
P
G
T
Y
V
V
V
L
K
E
E
Site 8
T86
V
V
V
L
K
E
E
T
H
L
S
Q
S
E
R
Site 9
S89
L
K
E
E
T
H
L
S
Q
S
E
R
T
A
R
Site 10
S91
E
E
T
H
L
S
Q
S
E
R
T
A
R
R
L
Site 11
T94
H
L
S
Q
S
E
R
T
A
R
R
L
Q
A
Q
Site 12
Y107
A
Q
A
A
R
R
G
Y
L
T
K
I
L
H
V
Site 13
Y142
L
K
L
P
H
V
D
Y
I
E
E
D
S
S
V
Site 14
S148
D
Y
I
E
E
D
S
S
V
F
A
Q
S
I
P
Site 15
S153
D
S
S
V
F
A
Q
S
I
P
W
N
L
E
R
Site 16
T162
P
W
N
L
E
R
I
T
P
P
R
Y
R
A
D
Site 17
Y166
E
R
I
T
P
P
R
Y
R
A
D
E
Y
Q
P
Site 18
Y171
P
R
Y
R
A
D
E
Y
Q
P
P
D
G
G
S
Site 19
T187
V
E
V
Y
L
L
D
T
S
I
Q
S
D
H
R
Site 20
S191
L
L
D
T
S
I
Q
S
D
H
R
E
I
E
G
Site 21
T203
I
E
G
R
V
M
V
T
D
F
E
N
V
P
E
Site 22
T214
N
V
P
E
E
D
G
T
R
F
H
R
Q
A
S
Site 23
S221
T
R
F
H
R
Q
A
S
K
C
D
S
H
G
T
Site 24
S225
R
Q
A
S
K
C
D
S
H
G
T
H
L
A
G
Site 25
S235
T
H
L
A
G
V
V
S
G
R
D
A
G
V
A
Site 26
S249
A
K
G
A
S
M
R
S
L
R
V
L
N
C
Q
Site 27
S274
G
L
E
F
I
R
K
S
Q
L
V
Q
P
V
G
Site 28
Y325
F
R
D
D
A
C
L
Y
S
P
A
S
A
P
E
Site 29
S326
R
D
D
A
C
L
Y
S
P
A
S
A
P
E
V
Site 30
T377
G
A
S
S
D
C
S
T
C
F
V
S
Q
S
G
Site 31
S381
D
C
S
T
C
F
V
S
Q
S
G
T
S
Q
A
Site 32
S383
S
T
C
F
V
S
Q
S
G
T
S
Q
A
A
A
Site 33
T407
L
S
A
E
P
E
L
T
L
A
E
L
R
Q
R
Site 34
S419
R
Q
R
L
I
H
F
S
A
K
D
V
I
N
E
Site 35
T459
G
W
Q
L
F
C
R
T
V
W
S
A
H
S
G
Site 36
S462
L
F
C
R
T
V
W
S
A
H
S
G
P
T
R
Site 37
T472
S
G
P
T
R
M
A
T
A
I
A
R
C
A
P
Site 38
S485
A
P
D
E
E
L
L
S
C
S
S
F
S
R
S
Site 39
S487
D
E
E
L
L
S
C
S
S
F
S
R
S
G
K
Site 40
S488
E
E
L
L
S
C
S
S
F
S
R
S
G
K
R
Site 41
S490
L
L
S
C
S
S
F
S
R
S
G
K
R
R
G
Site 42
S492
S
C
S
S
F
S
R
S
G
K
R
R
G
E
R
Site 43
T573
W
E
V
E
D
L
G
T
H
K
P
P
V
L
R
Site 44
S599
R
E
A
S
I
H
A
S
C
C
H
A
P
G
L
Site 45
T623
P
A
P
Q
E
Q
V
T
V
A
C
E
E
G
W
Site 46
S636
G
W
T
L
T
G
C
S
A
L
P
G
T
S
H
Site 47
T653
G
A
Y
A
V
D
N
T
C
V
V
R
S
R
D
Site 48
S662
V
V
R
S
R
D
V
S
T
T
G
S
T
S
E
Site 49
T664
R
S
R
D
V
S
T
T
G
S
T
S
E
E
A
Site 50
S666
R
D
V
S
T
T
G
S
T
S
E
E
A
V
T
Site 51
S688
S
R
H
L
A
Q
A
S
Q
E
L
Q
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation