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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LYPLA3
Full Name:
Group XV phospholipase A2
Alias:
ACS; EC 2.3.1.-; LCAT-like lysophospholipase; LLPL; LPLA2; LYPA3; Lysophospholipase 3; Lysosomal phospholipase A2
Type:
Enzyme - Synthase; Extracellular region, lysosome, soluble fraction protein
Mass (Da):
46658
Number AA:
412
UniProt ID:
Q8NCC3
International Prot ID:
IPI00301459
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
GO:0005764
Uniprot
OncoNet
Molecular Function:
GO:0004622
GO:0004607
GO:0005543
PhosphoSite+
KinaseNET
Biological Process:
GO:0009062
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y8
M
G
L
H
L
R
P
Y
R
V
G
L
L
P
D
Site 2
T59
E
A
K
L
D
K
P
T
V
V
H
Y
L
C
S
Site 3
Y63
D
K
P
T
V
V
H
Y
L
C
S
K
K
T
E
Site 4
Y72
C
S
K
K
T
E
S
Y
F
T
I
W
L
N
L
Site 5
T74
K
K
T
E
S
Y
F
T
I
W
L
N
L
E
L
Site 6
Y98
I
D
N
I
R
L
V
Y
N
K
T
S
R
A
T
Site 7
T101
I
R
L
V
Y
N
K
T
S
R
A
T
Q
F
P
Site 8
T105
Y
N
K
T
S
R
A
T
Q
F
P
D
G
V
D
Site 9
T121
R
V
P
G
F
G
K
T
F
S
L
E
F
L
D
Site 10
S123
P
G
F
G
K
T
F
S
L
E
F
L
D
P
S
Site 11
S130
S
L
E
F
L
D
P
S
K
S
S
V
G
S
Y
Site 12
S132
E
F
L
D
P
S
K
S
S
V
G
S
Y
F
H
Site 13
S133
F
L
D
P
S
K
S
S
V
G
S
Y
F
H
T
Site 14
S136
P
S
K
S
S
V
G
S
Y
F
H
T
M
V
E
Site 15
Y137
S
K
S
S
V
G
S
Y
F
H
T
M
V
E
S
Site 16
Y150
E
S
L
V
G
W
G
Y
T
R
G
E
D
V
R
Site 17
Y161
E
D
V
R
G
A
P
Y
D
W
R
R
A
P
N
Site 18
Y173
A
P
N
E
N
G
P
Y
F
L
A
L
R
E
M
Site 19
Y185
R
E
M
I
E
E
M
Y
Q
L
Y
G
G
P
V
Site 20
S198
P
V
V
L
V
A
H
S
M
G
N
M
Y
T
L
Site 21
Y203
A
H
S
M
G
N
M
Y
T
L
Y
F
L
Q
R
Site 22
Y206
M
G
N
M
Y
T
L
Y
F
L
Q
R
Q
P
Q
Site 23
Y219
P
Q
A
W
K
D
K
Y
I
R
A
F
V
S
L
Site 24
S242
K
T
L
R
V
L
A
S
G
D
N
N
R
I
P
Site 25
S262
K
I
R
E
Q
Q
R
S
A
V
S
T
S
W
L
Site 26
S265
E
Q
Q
R
S
A
V
S
T
S
W
L
L
P
Y
Site 27
T266
Q
Q
R
S
A
V
S
T
S
W
L
L
P
Y
N
Site 28
Y272
S
T
S
W
L
L
P
Y
N
Y
T
W
S
P
E
Site 29
Y274
S
W
L
L
P
Y
N
Y
T
W
S
P
E
K
V
Site 30
T285
P
E
K
V
F
V
Q
T
P
T
I
N
Y
T
L
Site 31
T291
Q
T
P
T
I
N
Y
T
L
R
D
Y
R
K
F
Site 32
Y295
I
N
Y
T
L
R
D
Y
R
K
F
F
Q
D
I
Site 33
T314
G
W
L
M
R
Q
D
T
E
G
L
V
E
A
T
Site 34
T334
Q
L
H
C
L
Y
G
T
G
V
P
T
P
D
S
Site 35
T338
L
Y
G
T
G
V
P
T
P
D
S
F
Y
Y
E
Site 36
S341
T
G
V
P
T
P
D
S
F
Y
Y
E
S
F
P
Site 37
Y343
V
P
T
P
D
S
F
Y
Y
E
S
F
P
D
R
Site 38
Y344
P
T
P
D
S
F
Y
Y
E
S
F
P
D
R
D
Site 39
S346
P
D
S
F
Y
Y
E
S
F
P
D
R
D
P
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation