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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TSEN2
Full Name:
tRNA-splicing endonuclease subunit Sen2
Alias:
HsSen2 protein; MGC2776; SEN2; SEN2L; TRNA splicing endonuclease 2; TRNA-intron endonuclease Sen2
Type:
RNA processing; EC 3.1.27.9; Ribonuclease
Mass (Da):
53247
Number AA:
465
UniProt ID:
Q8NCE0
International Prot ID:
IPI00427037
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
GO:0000214
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0000213
PhosphoSite+
KinaseNET
Biological Process:
GO:0006397
GO:0006388
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y16
P
K
R
K
R
R
V
Y
E
T
Y
E
S
P
L
Site 2
T18
R
K
R
R
V
Y
E
T
Y
E
S
P
L
P
I
Site 3
Y19
K
R
R
V
Y
E
T
Y
E
S
P
L
P
I
P
Site 4
S21
R
V
Y
E
T
Y
E
S
P
L
P
I
P
F
G
Site 5
Y61
A
E
D
I
E
Q
L
Y
G
K
G
Y
F
G
K
Site 6
Y65
E
Q
L
Y
G
K
G
Y
F
G
K
G
I
L
S
Site 7
S72
Y
F
G
K
G
I
L
S
R
S
R
P
S
F
T
Site 8
S74
G
K
G
I
L
S
R
S
R
P
S
F
T
I
S
Site 9
S77
I
L
S
R
S
R
P
S
F
T
I
S
D
P
K
Site 10
T79
S
R
S
R
P
S
F
T
I
S
D
P
K
L
V
Site 11
S81
S
R
P
S
F
T
I
S
D
P
K
L
V
A
K
Site 12
S123
R
R
Q
G
Q
D
E
S
T
V
R
R
I
L
K
Site 13
T124
R
Q
G
Q
D
E
S
T
V
R
R
I
L
K
D
Site 14
Y132
V
R
R
I
L
K
D
Y
T
K
P
L
E
H
P
Site 15
T133
R
R
I
L
K
D
Y
T
K
P
L
E
H
P
P
Site 16
S155
Q
V
H
D
K
L
N
S
G
M
V
S
N
M
E
Site 17
S159
K
L
N
S
G
M
V
S
N
M
E
G
T
A
G
Site 18
S171
T
A
G
G
E
R
P
S
V
V
N
G
D
S
G
Site 19
S177
P
S
V
V
N
G
D
S
G
K
S
G
G
V
G
Site 20
S180
V
N
G
D
S
G
K
S
G
G
V
G
D
P
R
Site 21
S197
L
G
C
L
Q
E
G
S
G
C
H
P
T
T
E
Site 22
T202
E
G
S
G
C
H
P
T
T
E
S
F
E
K
S
Site 23
T203
G
S
G
C
H
P
T
T
E
S
F
E
K
S
V
Site 24
S205
G
C
H
P
T
T
E
S
F
E
K
S
V
R
E
Site 25
S209
T
T
E
S
F
E
K
S
V
R
E
D
A
S
P
Site 26
S215
K
S
V
R
E
D
A
S
P
L
P
H
V
C
C
Site 27
S240
G
L
H
H
E
D
G
S
Q
H
I
G
L
L
H
Site 28
Y257
D
R
G
P
D
H
E
Y
V
L
V
E
E
A
E
Site 29
S268
E
E
A
E
C
A
M
S
E
R
E
A
A
P
N
Site 30
Y291
L
I
C
R
R
N
P
Y
R
I
F
E
Y
L
Q
Site 31
Y296
N
P
Y
R
I
F
E
Y
L
Q
L
S
L
E
E
Site 32
T324
Y
Y
E
K
E
P
L
T
I
V
K
L
W
K
A
Site 33
Y343
Q
P
T
F
R
T
T
Y
M
A
Y
H
Y
F
R
Site 34
Y346
F
R
T
T
Y
M
A
Y
H
Y
F
R
S
K
G
Site 35
Y348
T
T
Y
M
A
Y
H
Y
F
R
S
K
G
W
V
Site 36
Y362
V
P
K
V
G
L
K
Y
G
T
D
L
L
L
Y
Site 37
Y369
Y
G
T
D
L
L
L
Y
R
K
G
P
P
F
Y
Site 38
Y376
Y
R
K
G
P
P
F
Y
H
A
S
Y
S
V
I
Site 39
S379
G
P
P
F
Y
H
A
S
Y
S
V
I
I
E
L
Site 40
Y380
P
P
F
Y
H
A
S
Y
S
V
I
I
E
L
V
Site 41
S394
V
D
D
H
F
E
G
S
L
R
R
P
L
S
W
Site 42
S400
G
S
L
R
R
P
L
S
W
K
S
L
A
A
L
Site 43
S403
R
R
P
L
S
W
K
S
L
A
A
L
S
R
V
Site 44
S408
W
K
S
L
A
A
L
S
R
V
S
V
N
V
S
Site 45
S411
L
A
A
L
S
R
V
S
V
N
V
S
K
E
L
Site 46
S415
S
R
V
S
V
N
V
S
K
E
L
M
L
C
Y
Site 47
T428
C
Y
L
I
K
P
S
T
M
T
D
K
E
M
E
Site 48
S436
M
T
D
K
E
M
E
S
P
E
C
M
K
R
I
Site 49
S451
K
V
Q
E
V
I
L
S
R
W
V
S
S
R
E
Site 50
S455
V
I
L
S
R
W
V
S
S
R
E
R
S
D
Q
Site 51
S456
I
L
S
R
W
V
S
S
R
E
R
S
D
Q
D
Site 52
S460
W
V
S
S
R
E
R
S
D
Q
D
D
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation